Abstracts tagged "Scleredema and mouse model"

Abstract Number: 755 • 2014 ACR/ARHP Annual Meeting
Increased Degradation of BMPR2 in a TGFβ Dependent Transgenic Mouse Model of Scleroderma with Susceptibility to Pulmonary Arterial Hypertension
Adrian J Gilbane¹, Emma C. Derrett-Smith², Andrew Pearce³, Christopher P Denton⁴ and Alan M. Holmes⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ³Respiratory Disease Area, Novartis, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose Scleroderma patients are susceptible to development of pulmonary arterial hypertension (PAH) that has similarities to some forms of heritable PAH. The basis for this…

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Abstracts tagged "Scleredema and mouse model"

Increased Degradation of BMPR2 in a TGFβ Dependent Transgenic Mouse Model of Scleroderma with Susceptibility to Pulmonary Arterial Hypertension