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Abstracts tagged "Safety issues and rheumatoid arthritis (RA)"

  • Abstract Number: 2051 • ACR/ARHP Annual Meeting 2015

    Risk for Lower Intestinal Perforations in RA Patients Treated with Tocilizumab in Comparison to Treatment with TNF Inhibitors, Rituximab, Abatacept or Conventional Synthetic Dmards

    Anja Strangfeld1, Adrian Richter2, Peter Herzer3, Karin Rockwitz4, Winfried Demary5, Martin Aringer6, Angela Zink7 and Joachim Listing8, 1Epidemiology, German Rheumatism Research Center, Berlin, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Rheumatologist, Scientific Advisory Board, München, Germany, 4Rheumatologic Practice, Goslar, Germany, 5Rheumatologist, Hildesheim, Germany, 6Rheumatology, Medicine III, University Clinical Center, Technical University Dresden, Dresden, Germany, 7Epidemiologie, Deutsches Rheuma-Forschungszentrum, Berlin, Germany, 8Epidemiology, DRFZ, Berlin, Germany

    Background/Purpose: Interleukin-6 has a direct protective effect on intestinal cells. Although several cases of lower intestinal perforations (LIP) were reported in clinical trials of tocilizumab…

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