Abstracts tagged "RNA sequencing"

Abstract Number: 0023 • ACR Convergence 2021
Investigating Temporal Changes in Pregnancy Among Women with Rheumatoid Arthritis and Healthy Women Using Co-expression Network Analysis
Matthew Wright¹, Dana Goin², Mette Smed³, J Lee Nelson⁴, Nicholas Jewell⁵, Jorn Olsen⁶, Merete Hetland⁷, Vibeke Zoffmann³ and Damini Jawaheer⁸, ¹UCSF Benioff Children's Hospital Oakland, Oakland, CA, ²University of California San Francisco, San Francisco, CA, ³Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark, ⁴Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, ⁵University of California Berkeley, Berkeley, CA, ⁶Aarhus University Hospital, Aarhus, Denmark, ⁷DANBIO and COPECARE, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁸UCSF Benioff Children's Hospital Oakland / University of California San Francisco, Oakland, CA
Background/Purpose: Rheumatoid arthritis (RA), while still an incurable disease, can often improve naturally during pregnancy. The specific mechanism(s) underlying this pregnancy-induced improvement, however, are not…
Abstract Number: 0987 • ACR Convergence 2021
Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren’s Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial
Elena Pontarini¹, Farzana Chowdhury¹, Elisabetta Sciacca¹, Sofia Grigoriadou¹, Felice Rivellese¹, Davide Lucchesi¹, Katriona Goldmann¹, Liliane Fossati-Jimack¹, Paul Emery², Wan-Fai NG³, Nurhan Sutcliffe⁴, Colin C Everett⁵, Catherine Fernandez⁵, Anwar Tappuni⁶, Myles Lewis¹, Costantino Pitzalis⁷, Simon J Bowman⁸ and Michele Bombardieri¹, ¹Queen Mary University of London, William Harvey Research Institute, London, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Leeds NIHR Biomedical Research Centre, Leeds, United Kingdom, ³Translational and Clinical Research Institute, Newcastle University,, Newcastle, United Kingdom, ⁴Royal London Hospital, Bart’s Health NHS Trust, London, United Kingdom, ⁵Leeds Institute for Clinical Trials Research, University of Leeds, Leeds, United Kingdom, ⁶Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Queen Mary University of London, London, United Kingdom, ⁷Queen Mary University of London, London, United Kingdom, ⁸Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Background/Purpose: The pathogenic role of B-cells in primary Sjögren’s Syndrome (pSS) is well established and B cell abnormalities are hallmarks of the disease. Because of…
Abstract Number: 1126 • ACR Convergence 2021
Synovial Cell Dysfunction in Obese Patients May Contribute to Poor Outcomes in Knee Osteoarthritis
Holly Philpott¹, Trevor Birmingham², Nicole Aye², Benoit Fiset³, Logan Walsh³, Brent Lanting² and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³McGill University, Montréal, QC, Canada
Background/Purpose: Obesity is a major risk factor for poor outcomes in knee osteoarthritis (OA) and may involve both mechanical and physiological stresses on joint tissues.…
Abstract Number: 1036 • 2019 ACR/ARP Annual Meeting
RNA Sequencing of PBMCs Reveals Estrogen-Mediated Upregulation of Micro-RNA Processing Machinery
Nicholas Young¹, Kyle Jablonski ², Ifeoma Okafor ³, Emily Schwarz ³, Peter Harb ³, Caitlin Henry ³, Lai-Chu Wu ³ and Wael Jarjour ⁴, ¹The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, OH, ²The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, ³Ohio State College of Medicine, Columbus, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Studies examining intracellular micro-RNA (miR) expression in PBMCs of patients with Systemic Lupus Erythematous (SLE) have identified distinct disease-associated changes in expression. We have…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].