Abstracts tagged "RNA and systemic sclerosis"

Abstract Number: 802 • 2016 ACR/ARHP Annual Meeting
Whole Transcriptome Profiling through RNA Sequencing Reveals Differentially Expressed Sense-Antisense Gene Pairs in Patients with Systemic Sclerosis
Tobias Messemaker^1,2, Loubna Chadli³, Varshna Goelela³, Maaike Boonstra⁴, Annemarie Dorjee⁴, Stefan Andersen³, Harald Mikkers², Tom WJ Huizinga⁴, Zhenghui Li⁵, Guoshuai Cai⁵, Michael Whitfield⁶, René Toes⁷, Jamil Aarbiou³, Jeroen De Groot³, Jeska K. de Vries-Bouwstra⁴ and Fina Kurreeman⁴, ¹Department of Rheumagoloty, Leiden University Medical Center, Leiden, Netherlands, ²Department of Molecular cell Biology, Leiden University Medical Center, Leiden, Netherlands, ³Charles River Nederland B.V., Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁶Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and multiple organs. Morbidity and mortality are high and pathogenesis is poorly…

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