Abstracts tagged "RNA and dermatomyositis"

Abstract Number: 273 • 2016 ACR/ARHP Annual Meeting
Juvenile Dermatomyositis Patient-Derived Induced Pluripotent Stem Cells Do Not Retain Disease Expression Signatures
Elisha D.O. Roberson^1,2, Li Cao¹, David J. Morales-Heil¹, Dong Xu^3,4, Yekaterina Galat⁵, Vasiliy Galat^5,6, Stacey Tarvin⁷, Chiang-Ching Huang⁸ and Lauren M. Pachman^4,9, ¹Department of Medicine, Washington University, St. Louis, MO, ²Department of Genetics, Washington University, St. Louis, MO, ³Program of Excellence in Cure-Juvenile Myositis (JM) Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁶Department of Pathology, Northwestern University, Chicago, IL, ⁷Riley Hospital for Children, Indiana University, Indianapolis, IN, ⁸Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI, ⁹Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: Monozygotic twins discordant for JDM are rare, composing only 1% of our entire registry of 525 JM patients. These individuals represent a unique opportunity…

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