ACR Meeting Abstracts

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Abstracts tagged "rituximab and vasculitis"

  • Abstract Number: 2079 • 2016 ACR/ARHP Annual Meeting

    Incidence and Risk of Pneumocystis Jirovecii Pneumonia Following Rituximab Treatment in Granulomatosis with Polyangiitis in the United States: An Analysis from a National Database

    Sirada Panupattanapong1, Anthony R. French2, Andrew J. White2, Margaret A. Olsen3, Maya Rendulic4 and Mary E. Hartman5, 1Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, 2Division of Pediatric Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, 3Division of Infectious Disease, Washington University School of Medicine, St. Louis, MO, 4Center for Administrative Data Research, Washington University School of Medicine, St. Louis, MO, 5Division of Pediatric Critical Care Medicine, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO

    Background/Purpose: Pneumocystis Jirovecii pneumonia (PJP) is a life-threatening complication in granulomatosis with polyangiitis (GPA). Guidelines from EULAR for ANCA-associated vasculitis (AAV) recommend institution of PJP…
  • Abstract Number: 1991 • 2015 ACR/ARHP Annual Meeting

    Large Vessel Involvement By IgG4-Related Disease

    Cory Perugino1, Zachary Wallace1 and John H. Stone2, 1Rheumatology, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition of uncertain etiology. Reports have described inflammatory aortitis and peri-aortitis in the setting of retroperitoneal fibrosis…
  • Abstract Number: 2855 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety of Rituximab Retreatment Regimen at Clinical Relapse in Severe Cryoglobulinemic Vasculitis

    Luca Quartuccio1, Francesca Zuliani2, Patrizia Scaini3, Marco Lenzi4, Antonio Tavoni5, Marco Sebastiani6, Teresa Urraro7, Francesco Saccardo8, Costanza Sbreglia9, Pietro Pioltelli10, Paolo Fraticelli11, Davide Filippini12, Salvatore Scarpato13, Oreste Perrella9, Armando Gabrielli14, Dario Roccatello15, Anna Linda Zignego16, Clodoveo Ferri17, Stefano Bombardieri18, Maurizio Pietrogrande19, Massimo Galli20, Giuseppe Monti8 and Salvatore De Vita1, 1Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, 2Rheumatology Clinic, University Hospital of Udine, Udine, Italy, 3Nephrology, Spedali Civili di Brescia, Brescia, Italy, 4University of Bologna, Bologna, Italy, 5Rheumatology Clinic, University of Pisa, Pisa, Italy, 6Rheumatology Clinic, University of Modena and Reggio Emilia, Modena, Italy, 7Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 8Internal Medicine Unit, Saronno Hospital, Azienda Ospedaliera di Busto Arsizio, Saronno (VA), Italy, 9Rheumatology Unit, AO Cotugno, Naples, Italy, 10Hematology, S.Gerardo Hospital, Monza, Italy, 11Istituto di Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, 12Rheumatology Unit, Ospedale Niguarda Ca’ Granda, Milan, Italy, 13Rheumatology Unit, M. Scarlato Hospital, Scafati, Salerno, Italy, 14Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, 15CORSO RAFFAELLO 30, UNIVERSITY OF TURIN (ITALY), TURIN, Italy, 16University of Florence, Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 17Internal Med/Rheumatology, Univ Modena Reggio Emilia, Modena, Italy, 18Rheumatology Unit, University of Pisa, Pisa, Italy, 19Internal Medicine Unit, Policlinico San Marco, Bergamo, Italy, 20Istituto di Malattie Infettive e Tropicali, Università di Milano c/o Ospedale L. Sacco, Milano, Italy

    Background/Purpose: Two independent controlled randomized trials recently reported the efficacy and safety of rituximab (RTX) monotherapy in severe cryoglobulinemic vasculitis (CV) (1, 2), with one…
  • Abstract Number: 1776 • 2014 ACR/ARHP Annual Meeting

    Factors Predictive of ANCA-Associated Vasculitis Relapse in Patients Given Rituximab-Maintenance Therapy

    Benjamin Terrier1, Christian Pagnoux2, Guillaume Geri3, Alexandre Karras4, Chahéra Khouatra5, Olivier Aumaitre6, Pascal Cohen7, Francois Maurier8, Olivier Decaux9, Hélène Desmurs-Clavel10, Pierre Gobert11, Thomas Quemeneur12, Claire Blanchard-Delaunay13, Pascal Godmer14, Xavier Puéchal7, Luc Mouthon7 and Loïc Guillevin for the French Vasculitis Study Group7, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 2Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 3Intensive Care Unit, Cochin Hospital, Paris, France, 4Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 5CHU Louis Pradel, Lyon, Lyon, France, 6Internal Medicine, CHU, Clermont-Ferrand, France, 7National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 8HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 9Department of Internal Medicine, Rennes University Hospital, Rennes, France, 10University of Lyon, LYON, France, 11Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 12Internal Medicine, CH, Valenciennes, France, 13Internal Medicine, Hôpital de Niort, Niort, France, 14Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France

    Background/Purpose Rituximab (RTX) was shown to be as effective as cyclophosphamide to induce remission in patients with ANCA-associated vasculitis (AAV). The prospective MAINRITSAN trial compared…
  • Abstract Number: 1754 • 2014 ACR/ARHP Annual Meeting

    Peripheral CD5+ b-Cells in ANCA-Associated Vasculitis

    Sebastian Unizony1, Noha Lim2, Vincent Carey3, Deborah J. Phippard2, Nadia Tchao2, Eli M. Miloslavsky4, Peter A. Merkel5, Paul Monach6, William St. Clair7, Robert F. Spiera8, Adam Asare2, Philip Seo9, Carol A. Langford10, Gary S. Hoffman11, Cees Kallenberg12, Ulrich Specks13 and John H. Stone4, 1Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 2Immune Tolerance Network, Bethesda, MD, 3Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, 4Rheumatology, Massachusetts General Hospital, Boston, MA, 5Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 6Rheumatology, Boston University, Boston, MA, 7Rheumatology and Immunology, Duke University, Durham, NC, 8Rheumatology, Hospital for Special Surgery, New York, NY, 9Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 10Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 11Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, 12Rheumatology and Clinical Immunology, University of Groningen, Groningen, Netherlands, 13Frederichs Dr NW, Mayo Clinic, Rochester, MN

    Background/Purpose We explored the utility of peripheral CD19+ CD5+ B-cells (CD5+ B-cells) as biomarkers in ANCA-associated vasculitis (AAV)   Methods CD5+ B-cells were measured longitudinally by…
  • Abstract Number: 2640 • 2013 ACR/ARHP Annual Meeting

    VERY LONG-TERM Effects Of The “4 PLUS2 Infusion PROTOCOL” Of Rituximabalone In Patients With HCV-Associatedmixed Cryoglobulinemia With Diffusemembranoproliferative Glomerulonephritis,Severe Polyneuropathy and Necrotic Ulcersof Skin

    Dario Roccatello1, Savino Sciascia1, Simone Baldovino2 and Daniela Rossi1, 1Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, 2Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy

    Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitischaracterized by multiple organ involvement due to the vascular deposition ofIgMk/IgG cryoglobulins. B cells expansion usually triggered…
  • Abstract Number: 1646 • 2013 ACR/ARHP Annual Meeting

    Alterations In Circulating T Follicular Helper Cells and T Regulatory Cells In Autoimmune Rheumatic Diseases Treated With B Cell Depletion Therapy: Rituximab

    Pamela M.K Lutalo1,2, Yuan Zhao2, Lee Meng Choong1, Shirish Sangle1, Jo Spencer3 and David P. D'Cruz4, 1Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 2Peter Gorer Department of Immunobiology, School of Medicine, King's College London, London, United Kingdom, 3Peter Gorer Department of Immunobiology, King's College London, School of Medicine, London, United Kingdom, 4Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom

    Background/Purpose: Granulomatosis with polyangiitis (GPA) and systemic lupus erythematosus (SLE) are autoimmune rheumatic diseases which develop due to failure of immune self-tolerance. T follicular helper…
  • Abstract Number: 744 • 2013 ACR/ARHP Annual Meeting

    Relationship Between Infectious Side Effects and Immunoglobulin Levels In The Maintenance Rituximab Vs Azathioprine For ANCA-Associated Vasculitides Trial

    Loic Guillevin1, Christian Pagnoux2, Alexandre Karras3, Chahera Khouatra4, Olivier Aumaître5, Pascal Cohen6, Olivier Decaux7, Hélène Desmurs-Clavel8, Pierre Gobert9, Thomas Quemeneur10, Claire Blanchard-Delaunay11, Pascal Godmer12, Xavier Puechal13, Pierre-Louis Carron14, Pierre-Yves Hatron15, Nicolas Limal16, Mohamed Hamidou17, Francois Maurier18, Thomas Papo19, Matthias Büchler20, Bernard Bonnotte21, Philippe Ravaud22 and Luc Mouthon23, 1Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, 2Internal Medicine, Hôpital Cochin, PARIS, France, 3Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 4CHU Lyon, Lyon, France, 5Division of internal Medicine, Centre Hospitalier Universitaire, Hôpital Gabriel Montpied, Clermont–Ferrand, Clermont–Ferrand, France, 6National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 7Department of Internal Medicine, Rennes University Hospital, Rennes, France, 8University of Lyon, LYON, France, 9Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 10Internal medicine, CHR de Valenciennes, Valenciennes, France, 11Internal Medicine, Hôpital de Niort, Niort, France, 12Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France, 13Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 14Internal Medicine, Centre Hospitalier de Grenoble, Grenoble, France, 15Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, 16Department of Internal Medicine, Hôpital Henri Mondor, APHP, Creteil, France, 17Internal Medicine Department, Nantes University Hospital, Nantes, France, 18HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 19Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, 20Nephrology, University Hospital of Tours, TOURS, France, 21Department of Internal Medicine, Centre Hospitalier de Dijon, Dijon, France, 22Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 23Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France

    Background/Purpose: MAINRITSAN trial (NCT 00748644) results demonstrated that 500 mg of rituximab (RTX) every 6 months was superior to azathioprine (AZA) to maintain ANCA-associated–vasculitis (AAV)…
  • Abstract Number: 2596 • 2012 ACR/ARHP Annual Meeting

    Rituximab Treatment for Antineutrophil Cytoplasmic Antibody – Associated Vasculitis in Children

    Katharine F. Moore1, Leonard L. Dragone2, Jennifer B. Soep3 and J. Roger Hollister4, 1Pediatric Rheumatology, Seattle Children's Hospital / University of Washington, Seattle, WA, 2Dept of Pediatrics, National Jewish Health, Denver, CO, 3Pediatric Rheumatology, Children's Hospital Colorado, Aurora, CO, 4Dept of Pediatrics, Children's Hospital Colorado, Aurora, CO

    Background/Purpose: The purpose of this study was to report the experience of a tertiary-care children’s hospital using rituximab in the treatment of pediatric antineutrophil cytoplasmic…
  • Abstract Number: 2383 • 2012 ACR/ARHP Annual Meeting

    Rituximab As Induction and Maintenance Therapies for ANCA-Associated Vasculitis: A Multicenter Retrospective Study On 80 Patients

    Pierre Charles1, Antoine Néel2, Nathalie Tieulié3, Arnaud Hot4, Grégory Pugnet5, Olivier Decaux6, Isabelle Marie7, Mehdi Khellaf8, Jean-Emmanuel Kahn9, Alexandre Karras10, Jean-Marc Ziza11, Christophe Deligny12, Colas Tchérakian13 and Loic Guillevin14, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 2Internal Medicine, Nantes University Hospital, Nantes, France, 3CHU Nice, Nice, France, 4Internal Medicine, Edouard Herriot University Hospital, Lyon, France, 5Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, 6Department of Internal Medicine, Rennes University Hospital, Rennes, France, 7Service de médecine interne, CHU de Rouen, Rouen, France., Rouen, France, 8Internal Medicine, Service de médecine interne, Université Paris Est Créteil, AP-HP, Hôpital Mondor Créteil, France, Creteil, France, 9Internal Medicine, Foch Hospital, Suresnes, France, 10Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 11Rheumatology, Croix Saint Simon Hospital, Paris, France, 12Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, 13Service de pneumologie, hôpital Foch, Suresnes, France, 14Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France

    Background/Purpose: Rituximab has been shown to induce remission of ANCA-associated vasculitis (AAV). Our study was undertaken to 1) describe the clinical response of AAV to…
  • Abstract Number: 1652 • 2012 ACR/ARHP Annual Meeting

    Rituximab Versus Azathioprine for Maintenance in Antineutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis

    Loic Guillevin1, Christian Pagnoux2, Alexandre Karras3, Chahera Khoutra4, Olivier Aumaitre5, Pascal Cohen6, Francois Maurier7, Olivier Decaux8, Hélène Desmurs-Clavel9, Pierre Gobert10, Thomas Quemeneur11, Claire Blanchard-Delaunay12, Pascal Godmer13, Xavier Puechal14, Pierre-Louis Carron15, Pierre yves Hatron16, Nicolas Limal17, Mohamed Hamidou18, Maize Ducret19, Florence Vende20, Elisa Pasqualoni21, Bernard Bonnotte22, Philippe Ravaud23, Luc Mouthon24 and French Vasculitis Study Group (FVSG)25, 1Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, 2Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 3Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 4Pneumology, Hospices Civils de Lyon, Hôpital Louis Pradel, Lyon, France, 5Department of Internal Medicine, Centre Hospitalier de Clermont-Ferrand, Clermont-Ferrand, France, 6National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 7HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 8Department of Internal Medicine, Rennes University Hospital, Rennes, France, 9Internal Medicine, Hospices Civils de Lyon, Hôpital Louis Pradel, Lyon, France, 10Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 11Internal medicine, CHR de Valenciennes, Valenciennes, France, 12Internal Medicine, Centre Hospitalier, Niort, France, 13Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France, 14Internal Medicine, Hôpital Cochin, Paris, France, 15Internal Medicine, Centre Hospitalier de Grenoble, Grenoble, France, 16Department of Internal Medicine, Hôpital Claude Huriez, Université Lille II, Lille, France, Paris, France, 17Department of Internal Medicine, Hôpital Henri Mondor, APHP, Creteil, France, 18Internal Medicine Department, Nantes University Hospital, Nantes, France, 19Department of Internal Medicine, Centre Hospitalier d'Annecy, Annecy, France, 20Nephrology, Hôpital Bicbat, APHP, Paris, France, 21Department of Internal Medicine, Hôpital Bicbat, APHP, Paris, France, 22Department of Internal Medicine, Centre Hospitalier de Dijon, Dijon, France, 23Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 24Internal Medicine, Hopital Cochin, Paris, France, 25Internal Medicine, Hôpital Cochin, Université Paris–Descartes, Paris, France

    Background/Purpose: Once ANCA-associated vasculitis (AAV) remission has been achieved with CS and cyclophosphamide (CYC), maintenance therapy usually relies on azathioprine (AZA) or methotrexate. However, 18-…
  • Abstract Number: 1542 • 2012 ACR/ARHP Annual Meeting

    The Efficacy of Rituximab Vs Cyclophosphamide for Treatment of Renal Disease in ANCA-Associated Vasculitis: The RAVE Trial Geetha D, Fervenza FC for the RAVE-Itn Research Group

    Duvuru Geetha1 and Fernando Fervenza2, 1Nephrology, Johns Hopkins University, Baltimore, MD, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA associated vasculitis (AAV) but details of outcomes among…
  • Abstract Number: 1543 • 2012 ACR/ARHP Annual Meeting

    Rituximab for ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Trials

    Carolina Mejia1 and Carlos J. Lozada2, 1Internal Medicine, Mount Sinai Medical Center, Miami, FL, 2Dept of Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose:  Over the past 40 years, cyclophosphamide/glucocorticoids combination therapy has been the standard regimen  for remission induction in ANCA-associated vasculitis.. Although a major advance in…
  • Abstract Number: 1547 • 2012 ACR/ARHP Annual Meeting

    A 4 Plus 2 Infusion Protocol of Rituximab Provides Long-Term Beneficial Effects in Patients with HCV-Associated Mixed Cryoglobulinemia with Membranoproliferative Nephritis and Severe Polyneuropathy

    Dario Roccatello1, Savino Sciascia2, Simone Baldovino3 and Daniela Rossi1, 1Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, 2Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, 3Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy

    Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitis characterized by multiple organ involvement due to the vascular deposition of immune-complexes, mainly the cryoglobulins. B…
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