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Abstracts tagged "rituximab and systemic lupus erythematosus (SLE)"

  • Abstract Number: 2834 • 2018 ACR/ARHP Annual Meeting

    The Presence of Anti-Rituximab Antibodies Predicts Infusion-Related Reactions in Patients with Systemic Lupus Erythematosus

    Chris Wincup1, Madhvi Menon1, Edward Smith2, David A. Isenberg1, Elizabeth Jury3 and Claudia Mauri4, 1University College London, London, United Kingdom, 2Centre for Rheumatology Research, University College London, London, United Kingdom, 3Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, 4Division of Medicine, Centre for Rheumatology Research, University College London, University College London, London, United Kingdom

    Background/Purpose: Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody that is commonly used in the treatment of severe and refractory SLE. Although generally well…
  • Abstract Number: 24 • 2018 ACR/ARHP Annual Meeting

    Rituximab Induces an Early Re-Assessment of the Immune and Vascular Systems in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Chary Lopez-Pedrera1, Irene Cecchi2, Nuria Barbarroja3, Alejandra Maria Patiño-Trives1, María Luque Tevar1, Laura Pérez Sánchez4, Alejandro Ibáñez-Costa1, Ivan Arias de la Rosa5, Yolanda Jiménez-Gómez3, Massimo Radin6, Rafaela Ortega-Castro3, M. Carmen Castro-Villegas7, Jerusalem Calvo-Gutierrez3, Alejandro Escudero-Contreras5, Maria Jose Cuadrado8, Savino Sciascia9, Eduardo Collantes Estevez1, Maria Ángeles Aguirre Zamorano1 and Carlos Perez-Sanchez3, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 5Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 6Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 7Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 8Clinica Universidad de Navarra, Madrid, Spain, 9Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: While the role of Rituximab (RTX) in controlling the clinical manifestations of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) has been documented, the…
  • Abstract Number: 2682 • 2018 ACR/ARHP Annual Meeting

    Novel Antibody Against Commensal Bacterial Antigen in Prediction of the Response of Rituximab in Systemic Lupus Erythematosus

    Yu-Min Kuo1,2, Jenhao Chen3, Jean-san Chia4, Chiau-jing Jung5 and Song-Chou Hsieh6, 1Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 3Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital,Yunlin branch, Yunlin County, Taiwan, 4Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan, 5Department of Microbiology and Immunology, School of Medicine,, College of Medicine, Taipei Medical University, Taipei, Taiwan, 6National Taiwan University Hospital, Taipei, Taiwan

    Background/Purpose: Streptoccocal infections can cause rheumatic fever sharing clinical presentations similar to SLE. Whether oral commensal streptococci could induce cross-reactive and pathogenic antibodies remained unknown.…
  • Abstract Number: 890 • 2017 ACR/ARHP Annual Meeting

    Synergetic B-Cell Immunomodulation with Rituximab and Belimumab Combination Treatment in Severe, Refractory SLE

    Tineke Kraaij1, Sylvia W.A. Kamerling1, Esther N.M. de Rooij1, Paul L. van Daele2, O.W. Bredewold1, Jaap A. Bakker3, Ingeborg Bajema4, Hans U. Scherer5, Rene E.M. Toes5, Tom W.J. Huizinga5, Ton Rabelink1, Cees van Kooten1 and Y.K. Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 3Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands, 4Pathology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Neutrophil extracellular traps (NETs) are auto-antigenic DNA strands and potentially give rise to SLE-specific autoantibodies that can deposit in glomeruli. It has been shown…
  • Abstract Number: 2597 • 2017 ACR/ARHP Annual Meeting

    Explorer Study: Rituximab Use in Systemic Lupus Erythematosus, a New Look on Old Data

    Marc Scherlinger1,2,3, Claire Carcaud2,4, Thomas Barnetche1,5, Lionel Couzy2,6, Pierre Duffau3,7,8, Estibaliz Lazaro2,9 and Christophe Richez2,10,11, 1Rheumatology, Centre hospitalier universitaire de Bordeaux - Service de Rhumatologie, Bordeaux, France, 2FHU ACRONIM, Bordeaux, France, 3UMR CNRS 5164 - Immunoconcept, Bordeaux, France, 4Internal Medicine, Centre hospitalier universaire de Bordeaux, Bordeaux, France, 5FHU ACRONIM, Pellegrin Hospital, Bordeaux University, Bordeaux, France, 6Nephrology, Centre hospitalier universitaire de Bordeaux - Néphrologie, Bordeaux, France, 7Internal Medecine, Centre hospitalier universitaire de Bordeaux - Médecine interne, Bordeaux, France, 8FHU ACRONIM, bordeaux, France, 9Department of Internal Medecine and Clinical Immunology, Bordeaux University Hospital, Pessac, France, 10Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, 11UMR CNRS 5164 - Immunoconcept, bordeaux, France

    Background/Purpose: Even if randomized trials EXPLORER and LUNAR failed to prove the superiority of rituximab versus placebo in patients with systemic lupus erythematosus, several encouraging…
  • Abstract Number: 2602 • 2017 ACR/ARHP Annual Meeting

    Identification of Clinical and Serological Predictive Factors of Response to Rituximab Treatment in Systemic LUPUS Erythematosus (SLE) Patients

    Hiurma Sanchez-Perez1 and David A. Isenberg2, 1Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 2Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Response to Rituximab (RTX) varies significantly between Systemic Lupus Erythematosus (SLE) patients. Ethnicity may play a role in these differences, and a possible relationship…
  • Abstract Number: 739 • 2016 ACR/ARHP Annual Meeting

    Safety and Efficacy of Rituximab in the Treatment of Refractory Systemic Lupus Erythematosus: Results from a National Register

    Stephanie Nesbit1,2, John A. Reynolds3, Emily Sutton4, Eric F Morand2, Ian N. Bruce3 and BILAG Biologics Register Consortium, 1University of Manchester, Manchester, United Kingdom, 2Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 3NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 4University of Manchester, Manchester Academic Health Science Centre, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom

    Background/Purpose: Response to the anti-CD20 agent rituximab (RTX) in SLE is variable but it is still widely used for refractory SLE. Our aim was to…
  • Abstract Number: 762 • 2016 ACR/ARHP Annual Meeting

    Pragmatic Treatment of Patients with Systemic Lupus Erythematosus with Rituximab: Long-Term Effects on Serum Immunoglobulins

    Venkat Reddy1, Lina Martínez-Estupiñán2, David A. Isenberg3, Maria J. Leandro3 and Geraldine Cambridge3, 1Rheumatology, University College Hospital, London, United Kingdom, 2Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: B cell depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with Systemic Lupus Erythematosus (SLE). Hypogammaglobulinemia can be…
  • Abstract Number: 773 • 2016 ACR/ARHP Annual Meeting

    Risk Factors for Severe Infections in Rituximab Treated Patients: Comparison of Systemic Lupus Erythematosus and Inflammatory Myositis

    Cristiane Medeiros1, Luciana Seguro2, Fernando Henrique Carlos de Souza2, Nadia E Aikawa3 and Eloisa Bonfa4, 1Rheumatology, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 2Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Pediatric Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil

    Background/Purpose:  The use of Rituximab (RTX) in patients with autoimmune diseases has been associated with an increased incidence of infection and risk factors for this…
  • Abstract Number: 777 • 2016 ACR/ARHP Annual Meeting

    a Singlecenter Experience of Rituximab Treatment in 86 Patients with Systemic Lupus Erythematosus

    Bahar Artim-Esen1, Bahtiyar Toz1, Burak Erer1, Sevil Kamali1, Ahmet Gul1, Lale Ocal2 and Murat Inanc3, 1Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Istanbul Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey, 3Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, İstanbul, Turkey

    Background/Purpose:   Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical and serological manifestations. B-cell-targeted therapies have been promising new treatments for SLE.…
  • Abstract Number: 781 • 2016 ACR/ARHP Annual Meeting

    The Use of Rituximab in Newly Diagnosed Systemic Lupus Erythematosus Patients: Long Term Steroid Saving Capacity and Clinical Effectiveness

    Borja del Carmelo Gracia Tello Sr.1, David A. Isenberg2 and Amara Ezeonyeji3, 1Internal Medicina, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Zaragoza, Spain, 2Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 3Rheumatology, University College of London Hospital, London, London, United Kingdom

    Background/Purpose: To assess the long term steroid saving capacity and clinical effectiveness of B-cell depletion therapy (BCDT) in newly diagnosed SLE patients. Methods: Sixteen female…
  • Abstract Number: 1112 • 2015 ACR/ARHP Annual Meeting

    Obinutuzumab Outperforms Rituximab at Inducing B-Cell Cytotoxicity in Vitro through Fc-Mediated Effector Mechanisms in Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Venkat Reddy1, Christian Klein2, David A. Isenberg3, Geraldine Cambridge4, Martin Glennie5, Mark Cragg6 and Maria J. Leandro1, 1Rheumatology, University College London, London, United Kingdom, 2Roche Pharmaceutical Research & Early Development Oncology Discovery & Translational Area, Roche Glycart AG, Schlieren, Switzerland, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 4Rheumatology, Centre for Rheumatology and Bloomsbury Rheumatology Unit, University College London, London, United Kingdom, 5Antibody and Vaccine group, Southampton University, Southampton, United Kingdom, 6Antibody and Vaccine group, Cancer Sciences Unit, Faculty of Medicine, Southampton University, Southampton, United Kingdom

    Background/Purpose: Obinutuzumab (OBZ, a Type II anti-CD20 monoclonal antibody [mAb] with afucosylated Fc portion and enhanced affinity for Fcγ receptor III) is more efficient than…
  • Abstract Number: 2903 • 2015 ACR/ARHP Annual Meeting

    Late-Onset Neutropenia Following Rituximab Treatment in Patients with Systemic Lupus Erythematosus

    Ioannis Parodis, Frida Söder, Ronald F. van Vollenhoven, Elisabet Svenungsson and Iva Gunnarsson, Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The incidence and clinical consequences of rituximab-mediated late-onset neutropenia (LON) have been studied in various diseases, but data from Systemic Lupus Erythematosus (SLE) are…
  • Abstract Number: 989 • 2014 ACR/ARHP Annual Meeting

    Fcgamma Receptor IIb Facilitates Rapid Internalisation of Rituximab (type 1 anti-CD20 antibody) in B Cells from Patients with RA and SLE and Contributes to Less Efficient B Cell Lysis Than Type 2 Anti-CD20 Antibodies, in Vitro

    Venkat Reddy1, Geraldine Cambridge2, David A. Isenberg3, Mark Cragg4 and Maria J. Leandro2, 1Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, 2Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 3Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 4Antibody and Vaccine group, Cancer Sciences Unit, Faculty of Medicine, Southampton University, Southampton, United Kingdom

    Background/Purpose Incomplete B-cell depletion using rituximab (RTX) is associated with poor clinical response in some individuals with RA and SLE, in particular. However, the precise…
  • Abstract Number: 2164 • 2013 ACR/ARHP Annual Meeting

    Rituximab In The Treatment Of Children With Systemic LUPUS Erythematosus: ONE Year Analysis Of 12 Patients

    Ekaterina Alexeeva1,2, Rina Denisova2, Saniya Valieva2, Tatyana Bzarova2, Kseniya Isayeva2, Tatyana Sleptsova2, Elena Mitenko2, Evgeniya Chistyakova1,2, Anna Fetisova2 and Elena Semikina3, 1I.M.Sechenov First Moscow State Medical University, Moscow, Russia, 2Rheumatology, Scientific Center of Children's Health of RAMS, Moscow, Russia, 3Clinical Laboratory, Scientific Center of Children's Health of RAMS, Moscw, Russia

    Background/Purpose: Treatment of childhood systemic lupus erythematosus (SLE) is an ongoing problem because of the severity of the disease in some patients and the side-effects…
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