Abstracts tagged "risk factors"

Abstract Number: 1186 • ACR Convergence 2023
Presence of Erosions Is Not a Risk Factor for the Development of Knee OA in a Hand OA Population: The Framingham OA Study
Tine Vanhaverbeke¹, Gabriela Rabasa², Ruth Wittoek¹, Ida Kristin Haugen³ and David Felson², ¹Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium, ²Boston University, Boston, MA, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Osteoarthritis (OA) is a prevalent musculoskeletal disease and can affect multiple joint sites in one patient. Studies have shown an association between hand and…
Abstract Number: 1895 • ACR Convergence 2023
Comparative Analysis of Existing Tools in Assessing Cardiovascular Risk in Patients with Rheumatoid Arthritis: Exploring the Inadequacies
Pritee Shrestha¹, Peter Larsen¹ and Pablo Weilg Espejo², ¹Mercy One North Iowa Medical Center, Mason City, IA, ²Boston Medical Center, Chelsea, MA
Background/Purpose: Patients with Rheumatoid Arthritis (RA) are at increased risk of cardiovascular disease (CVD). Despite multiple CVD risk tools available, reliability to RA population is…
Abstract Number: 2428 • ACR Convergence 2023
Unclosing Premature Mortality Gap Among Gout Patients in the US General Population, Independent of Serum Urate and Atherosclerotic Cardiovascular Risk Factors
Natalie McCormick¹, Kehuan Lin², Chio Yokose³, Na Lu⁴, Yuqing Zhang¹ and Hyon K. Choi⁵, ¹Massachusetts General Hospital, Boston, MA, ²Channing Division of Network Medicine, Boston, MA, ³Massachusetts General Hospital, Waltham, MA, ⁴Arthritis Research Canada, Vancouver, BC, Canada, ⁵Massachusetts General Hospital and Harvard Medical School, Lexington, MA
Background/Purpose: A recent UK study reported a transient increased cardiovascular risk after gout flare episodes [Cipolletta et al. JAMA 2022], which may translate to premature…
Abstract Number: 0115 • ACR Convergence 2023
Risk Factors of First Thrombosis in Obstetric Antiphospholipid Syndrome
liang luo¹, Qingmeng Cai², xiangjun liu², Yuke Hou³ and Chun Li⁴, ¹Department of Chinese Medicine, the People's Hospital of Yubei District of Chongqing City, Chongqing, China; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Xicheng District, Beijing, China, ³Peking University People's Hospital, Beijing, China, ⁴Peking University People’s Hospital, Beijing, China
Background/Purpose: Limited evidence exists regarding the long-term risk of thrombosis in patients with obstetric antiphospholipid syndrome (OAPS). This study aimed to investigate the clinical features…
Abstract Number: 0531 • ACR Convergence 2023
Effects of Anti-tumor Necrosis Factor Treatment on Lipid Profiles in Patients with Ankylosing Spondylitis
Inbeom Kwon¹, bora nam², Nayeon Choi³, Ji-Hui Shin², Seunghun lee⁴ and Tae-Hwan Kim², ¹Department of Medicine, Hanyang University College of Medicine, Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, South Korea, ⁴Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: To investigate the effects of anti-tumor necrosis factor (anti-TNF) treatment on lipid profiles and identify risk factors for elevated total cholesterol (TC) after the…
Abstract Number: 1205 • ACR Convergence 2023
Universal Social Determinants of Health Screening in a Pediatric Rheumatology Specialty Clinic: A Feasibility Study
Mia Chandler¹, Margart Taggart², Maria Alfieri², Olha Halyabar³, Joyce Chang², Mary Beth Son⁴ and Melissa Hazen², ¹Boston Children's Hospital, Milton, MA, ²Boston Children's Hospital, Boston, MA, ³Children's Hospital/Boston Medical Center, Newton, MA, ⁴Division of Immunology, Boston Children's Hospital, Boston, MA
Background/Purpose: Social determinants of health (SDoH) significantly impact health outcomes. Practice guidelines from a national pediatric organization and federal agencies recommend routine assessment of SDoH.…
Abstract Number: 1957 • ACR Convergence 2023
Non-Linear Mendelian Randomization Analyses Support a Role for Low Vitamin D Status in Sarcopenia Risk
Tingting Sha¹, Yilun Wang², Yuqing Zhang³, Nancy Lane⁴, Changjun Li⁵, Jie Wei⁶, Chao Zeng² and Guanghua Lei², ¹Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China, ²Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ³Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, ⁴University of California, Hillsborough, CA, ⁵National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China, ⁶Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Vitamin D deficiency is commonly associated with sarcopenia; however, the latest International Clinical Practice Guidelines for Sarcopenia do not recommend vitamin D supplementation for…
Abstract Number: 2451 • ACR Convergence 2023
TET2 Clonal Hematopoiesis and Incident Rheumatoid Arthritis: Results from the UK Biobank
Karen Costenbader¹, Zhi Yu², Emily G. Oakes³, Michelle Robinette⁴, Mridul Agarwal⁵, Buu Truong⁶, Md Mesbah Uddin⁶, Alexander Bick⁷, Abhishek Niroula⁶, Daniel Solomon³ and Pradeep Natarajan⁸, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Broad Institute; Massachusetts General Hospital, Cambridge, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA, ⁵Dana-Farber Cancer Institute, Boston, MA, ⁶Broad Institute, Cambridge, MA, ⁷Broad Institute; Vanderbilt University Medical Center, Nashville, TN, ⁸Broad Institute; Massachusetts General Hospital, Boston, MA
Background/Purpose: Clonal hematopoiesis (CH), the clonal expansion of somatically mutated blood cells in people without hematologic malignancy, is found in ~10% of people age ≥…
Abstract Number: 0130 • ACR Convergence 2023
Association of HLA-DRB1 Alleles with Coronary Artery Calcium, Abdominal Aortic Calcium, and Carotid Intima-media Thickness in a Multi-ethnic Community-living Population
Manmeet Kaur¹, Ronit Katz², Michael H. Criqui¹, Maripat Corr³, Wendy S. Post⁴, Matthew Budoff⁵, Gerald P. Morris³ and Jan M. Hughes-Austin³, ¹University of California San Diego, San Diego, CA, ²University of Washington, Seattle, WA, ³University of California San Diego, La Jolla, CA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Human leukocyte antigen (HLA) DRB1 alleles with specific common amino acids referred to as the shared epitope (SE) have been linked to endothelial dysfunction…
Abstract Number: 0532 • ACR Convergence 2023
Factors Associated with Cause-specific Discontinuation of Long-term Anti-tumor Necrosis Factor Agent Use in Patients with Ankylosing Spondylitis
bora nam¹, Nayeon Choi², Bon San Koo³, Jiyeong Kim², Ji-Hui Shin¹, Seunghun lee⁴, kyung bin Joo⁴ and Tae-Hwan Kim¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, South Korea, ³Inje University Seoul Paik Hospital, Seoul, South Korea, ⁴Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Anti-tumor necrosis factor (TNF) agents have proven to be effective in treating Ankylosing spondylitis (AS). However, a significant number of patients discontinue or switch…
Abstract Number: 1258 • ACR Convergence 2023
“What Is My Risk Really?”: A Qualitative Exploration and Ideal-Type Analysis of Preventive Interventions Among Individuals at Risk of Rheumatoid Arthritis
Lara S Chapman¹, Heidi J Siddle¹, Stefan Serban², Kulveer Mankia¹, Christopher Rooney³, Zhain Mustufvi⁴, Simon Pini⁵ and Karen Vinall-Collier⁴, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Public Health Directorate, NHS England North West Region, Manchester, United Kingdom, ³University of Leeds, Leeds, United Kingdom, ⁴School of Dentistry, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom
Background/Purpose: A preclinical phase of rheumatoid arthritis (RA), in which ‘at-risk’ individuals develop autoantibodies and/or symptoms and progress to clinical arthritis and classifiable RA, is…
Abstract Number: 2010 • ACR Convergence 2023
B-FROST: Chronic OBstructive Pulmonary Disease and Vertebral FRacture of OSTeoporotic Origin: Results of a Real-life Cohort
Amine Mouamnia, Armentieres Hospital Center, Armentieres, France
Background/Purpose: Chronic obstructive pulmonary disease (COPD) is a chronic disease of the airways. It is mainly caused by smoking. Active smoking is a risk factor…
Abstract Number: 2516 • ACR Convergence 2023
The Effect of Starting Prednisone Dose on the Treatment of Polymyalgia Rheumatica
Katrina Nguyen¹, Jennifer Du¹, Jiaxiao shi² and Antony Lin¹, ¹Kaiser SCAL, Fontana, CA, ²SCPMG, Pasadena, CA
Background/Purpose: Polymyalgia rheumatica (PMR) is a systemic inflammatory syndrome that is characterized by widespread pain and stiffness around the shoulders, pelvic girdle and neck. PMR…
Abstract Number: 0134 • ACR Convergence 2023
Stressful Life Events in the Year Prior to Their Diagnosis Are Associated with Adult and Pediatric Systemic Rheumatic Diseases
Iazsmin Bauer Ventura¹, Maya Goldberg², Adam Schiffenbauer³, Min Shi⁴, Rita Volochayev⁵, Sharon H. Jackson⁶, Anna Jansen⁵, Nastaran Bayat⁷, Christine Parks⁸, Clarice R. Weinberg⁴, Angelo Picardi⁹, Frederick Miller¹⁰ and Lisa Rider³, ¹University of Chicago, Chicago, IL, ²National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³NIEHS, NIH, Bethesda, MD, ⁴Biostatitstics & Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, ⁵Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁷Social Scientific Systems, DLH Holdings Corp, Silver Spring, MD, ⁸Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, ⁹Centre for Behavioral Sciences and Mental Health, Italian National Institute of Health, Rome, Italy, ¹⁰NIH, NIEHS, Chapel Hill, NC
Background/Purpose: Systemic rheumatic diseases (SRDs) are complex multi-organ immune-mediated disorders that arise from the interaction of environmental exposures in genetically predisposed individuals. Stressful life events…
Abstract Number: 0659 • ACR Convergence 2023
Cigarette Exposure in Systemic Sclerosis: Impact on Autoantibody Expression and Disease Manifestations: Analysis of the EUSTAR Cohort
Jacopo Ciaffi¹, Sophie Liem², Saad Ahmed², Eva Hoekstra², Piotr Wiland³, Tatsuya Atsuma⁴, Gabriella Szucs⁵, Alexandra Balbir-Gurman⁶, Laszlo Czirjak⁷, Elisabetta Zanatta⁸, Ina Koetter⁹, Joerg Henes¹⁰, marco Matucci Cerinic¹¹, Paolo Airò¹², Francesco Ursini¹³, Thomas Huizinga² and Jeska de Vries-Bouwstra², ¹IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy, ²Leiden University Medical Center, Leiden, Netherlands, ³Wroclaw University of Medicine, Wroclaw, Poland, ⁴Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan, ⁵University of Debrecen, Department of Rheumatology, Debrecen, Hungary, ⁶Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, ⁷Dept. Rheumatol Immunol, Medical School, university of Pecs, Pecs, Hungary, ⁸Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy, ⁹University Hospital Eppendorf, Prisdorf, Germany, ¹⁰University Hospital Tuebingen, Tuebingen, Germany, ¹¹Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, ¹²Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, ¹³IRCCS Istituto Ortopedico Rizzoli, Bologna, Netherlands
Background/Purpose: In rheumatoid arthritis, cigarette smoking confers a risk for anti-CCP positive disease and the risk further increases in smokers carrying specific HLA DRB1-variants. These…

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