Abstracts tagged "rheumatoid arthritis (RA) and x-ray"

Abstract Number: 891 • 2018 ACR/ARHP Annual Meeting
A Phase 3, Randomized, Controlled Trial Comparing Upadacitinib Monotherapy to MTX Monotherapy in MTX-Naïve Patients with Active Rheumatoid Arthritis
Ronald van Vollenhoven¹, Tsutomu Takeuchi², Aileen L. Pangan³, Alan Friedman³, Mohamed-Eslam Mohamed⁴, Su Chen⁴, Maureen Rischmueller⁵, Ricardo Blanco⁶, Ricardo M. Xavier⁷ and Vibeke Strand⁸, ¹Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, ²Keio University School of Medicine, Tokyo, Japan, ³AbbVie, Inc., North Chicago, IL, ⁴AbbVie, Inc., North chicago, IL, ⁵The Queen Elizabeth Hospital and University of Adelaide, Adelaide, Australia, ⁶Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁷Universidade Federal do Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil, ⁸Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA
Background/Purpose: To compare the clinical efficacy, including inhibition of structural damage, and safety of upadacitinib (UPA), a JAK1-selective inhibitor, as monotherapy, vs methotrexate (MTX) monotherapy,…
Abstract Number: 2207 • 2018 ACR/ARHP Annual Meeting
Detecting Hand Joint Ankylosis in Radiographic Images Using Deep Learning: A Step in Development of Automatic Radiographic Scoring System for Bone Destruction
Keisuke Izumi^1,2, Masahiro Hashimoto³, Kanata Suzuki⁴, Toshio Endoh⁴, Kentaro Doi⁵, Yuki Iwai⁵, Masahiro Jinzaki³, Shigeru Ko⁶ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ³Department of Radiology, Keio University School of Medicine, Tokyo, Japan, ⁴Machine Learning Technology Project, Artificial Intelligence Laboratory, FUJITSU LABORATORIES LTD., Kawasaki, Japan, ⁵SOLUTIONS DEVELOPMENT DEPT.I, MEDICAL SOLUTIONS DIV.V, Healthcare Solutions Unit. II, FUJITSU LTD., Tokyo, Japan, ⁶Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Artificial intelligence (AI) techniques including deep learning have been rapidly evolving and shown good performance in many fields over recent years. However, there are…
Abstract Number: 1531 • 2016 ACR/ARHP Annual Meeting
Decrease in Bone Mineral Density during Three Months of Early RA Measured By DXR Predicts Radiographic Joint Damage after One Year
Michael Ziegelasch¹, Kristina Forslind², Thomas Skogh³, Katrine Riklund⁴, Alf Kastbom⁵ and E. Berglin⁶, ¹Rheumatology/AIR, Linköping, Sweden, ²Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, ³IKE/Rheumatology, Linköping University, Linköping, Sweden, ⁴Departments of Diagnostic radiology, Umeå university, Umeå, Sweden, ⁵Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping, Sweden, ⁶Department of Publiic Health and Clinical Medicin/Rheumatology, Umeå university, Umea, Sweden
Background/Purpose: Digital X-ray radiogrammetry (DXR) is a method to calculate peripheral bone mineral density (BMD) which calculates BMD of the hands (DXR-BMD). The aim…
Abstract Number: 2501 • 2016 ACR/ARHP Annual Meeting
Radiographic Damage in Patients with RA Increases By 8.3% per Year Disease Duration, in the Era of Biologic Dmards. Results from the Scqm Cohort
Ruediger Mueller¹, Katja Heinimann², Rafael Sauter³, Hendrik Schulze-Koops⁴, Tuulikki Sokka-Isler⁵, Michael Schiff⁶ and Johannes von Kempis⁷, ¹Rheumatology, MD, St. Gallen, Switzerland, ²Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Switzerland, ³Clinical Trials Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland, ⁴Division for Rheumatology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany, ⁵Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, ⁶Rheumatology, University of Colorado, Denver, CO, ⁷Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease leading to joint destructions, if untreated. Treatment with biologic DMARDs has shown to favourably influence disease…
Abstract Number: 1317 • 2015 ACR/ARHP Annual Meeting
Clinical Utility of Joint Space Width and X-Ray Radiogrammetry in RA: Markers for Early Radiographic Progression
Michael Platten¹, Yogan Kisten², Johan Kälvesten³, Kristina Forslind⁴ and Ronald F. van Vollenhoven⁵, ¹Medicine, Karolinska Institutet, Huddinge, Sweden, ²ClinTRID, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ³Sectra AB, Stockholm, Sweden, ⁴Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden
Background/Purpose: Early prediction of radiographic progression is beneficial in rheumatoid arthritis (RA) patient management. The van der Heijde modified Sharp score (SHS) is currently the…
Abstract Number: 2135 • 2014 ACR/ARHP Annual Meeting
Patients with Moderate Disease Activity in the First 5 Years of Rheumatoid Arthritis Still Progress Radiographically Despite Conventional Disease Modifying Therapy
Lewis Carpenter¹, Elena Nikiphorou², Sam Norton³, Keeranur Jayakumar⁴, Josh Dixey⁵ and Adam Young⁶, ¹Centre for Lifespan & Chronic Illness Research, University of Hertfordshire, Hatfield, United Kingdom, ²School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, ³Institute of Psychiatry, King's College London, London, United Kingdom, ⁴Rheumatology, Heart of England NHS Foundation Trust, Birmingham, United Kingdom, ⁵Rheumatology, New Cross Hospital, Wolverhampton, United Kingdom, ⁶Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom
Background/Purpose: Patients with moderate disease are an important, and often poorly studied, patient subgroup. The extent to which traditional DMARD therapies adequately control the disease…
Abstract Number: 2139 • 2014 ACR/ARHP Annual Meeting
Predictors of Radiologic Disease Progression during the Rheumatoid Arthritis Comparison of Active Therapies Trial
Alan Erickson¹, Denis Rybin², Mary Brophy³, Robert Lew³, Ted R. Mikuls¹, Timothy Moore⁴, Keri Hannagan², Edward Keystone⁵ and James O' Dell¹, ¹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²MAVERIC, VA Boston Heathcare System, Boston, MA, ³VA Boston Heathcare System, Boston, MA, ⁴Radiology, University of Nebraska Medical Center, Omaha, NE, ⁵University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose Halting joint damage is a central goal in the treatment of rheumatoid arthritis. Much research has been conducted to identify factors associated with progressive…
Abstract Number: 1424 • 2014 ACR/ARHP Annual Meeting
Bone Erosions in Patients with RA: Exploring the Impact of the Anatomy of Interest on the Relationship Between MRI and X-Ray Erosion Detection
Michael Tomizza¹, Isabel Rodrigues¹, Matthew Jessome¹, Joshua Barbosa¹, Karen Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Karen Finlay³, Chris Gordon², Lawrence Hart², George Ioannidis², Erik Jurriaans³, Melissa Koh¹, Maggie Larche², Arthur Lau², Naveen Parasu³, Ruben Tavares², Stephen Tytus², Hao Wu¹ and Jonathan D. Adachi^1,2, ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose: Detection of bone erosions in patients with RA is critical in clinical practice, with treatment initiation and effectiveness largely based on limiting erosive progression.…
Abstract Number: 187 • 2014 ACR/ARHP Annual Meeting
Revision Arthroplasty in Rheumatoid and Osteoarthritis: Does Methotrexate Decrease Radiographic Lucency in RA Patients?
Mike Wei¹, Douglas N. Mintz², Lisa A. Mandl³, Arielle Fein⁴, Jayme C. Burket⁵, Yuo-Yu Lee⁴, Wei-Ti Huang⁶, Vivian P. Bykerk⁴, Mark P. Figgie⁷, Edward F. DiCarlo⁸, Bruce N. Cronstein⁹ and Susan M. Goodman³, ¹Weill Cornell Medical College, New York, NY, ²Radiology, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ⁶Biostatistics, Hospital for Special Surgery, New York, NY, ⁷Orthopedics, Hospital for Special Surgery, New York, NY, ⁸Pathology, Hospital for Special Surgery, New York, NY, ⁹NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Rheumatoid arthritis (RA) patients have excellent total hip arthroplasty (THA) survival, and methotrexate (MTX), an anti-inflammatory disease modifying drug which may affect bone reabsorption,…
Abstract Number: 2260 • 2013 ACR/ARHP Annual Meeting
Smoking and Antibodies To Cyclic Citrullinated Peptides Predict Persistently High Levels Of Survivin In Early Rheumatoid Arthritis
Bjorn Svensson¹, Ingiäld Hafström², Malin Erlandsson³, Kristina Forslind⁴ and Maria Bokarewa³, ¹Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, ²Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden, ³Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden
Background/Purpose: High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor…
Abstract Number: 1965 • 2013 ACR/ARHP Annual Meeting
Performance Of a Computer-Based Method To Measure Erosions In Rheumatoid Arthritis: A Longitudinal Study
Jeremy Wortman¹, Stacy Smith¹, Frederick Wolfe² and Jeffrey W. Duryea¹, ¹Radiology, Brigham and Women's Hospital, Boston, MA, ²National Data Bank for Rheumatic Diseases, Wichita, KS
Background/Purpose: To describe the methodology of a novel computer-based technique for outlining erosions on plain radiographs in rheumatoid arthritis (RA) patients, and assess the responsiveness…
Abstract Number: 1308 • 2013 ACR/ARHP Annual Meeting
Low Accuracy Of Radiograph Reports In Identifying Patients With Rheumatoid Arthritis In The Veterans Affairs Rheumatoid Arthritis Registry
Maria P. Martes¹, Alan R. Erickson², Ted R. Mikuls² and Grant W. Cannon³, ¹Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose: The accurate interpretation of hand radiographs is critical in the diagnosis and management of rheumatoid arthritis (RA) patients. This project determined first,…
Abstract Number: 1011 • 2012 ACR/ARHP Annual Meeting
Structural Damage Is Reduced by Early Achievement of Clinical Remission
Paul Emery¹, Vibeke Strand², Andrew S. Koenig³, Ronald Pedersen³ and Eustratios Bananis⁴, ¹Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ²Biopharmaceutical Consultant, Portola Valley, CA, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Specialty Care, Pfizer Inc., Collegeville, PA
Background/Purpose: The importance of early, intensive treatment of rheumatoid arthritis (RA) to decrease disease activity and prevent structural damage is established.1 The objective of this…

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