ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and treatment"

  • Abstract Number: 2385 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Chinese Herbal Medicine Biqi Capsule Combined with Methotrexate in Patients with Rheumatoid Arthritis: A Pilot Study

    Runyue Huang1, Qingchun Huang 2, Jiaqi Wu 3, Xiao Cai 4, Xiumin Chen 4, Yue Zhao 4, Yongliang Chu 2, Jianyong Zhang 5, Jianhong Peng 6, Zhisheng Huang 7, Xianghong Chen 2, Zehao Liu 8 and Aihua Ou 2, 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China;, Guangzou, Guangdong, China (People's Republic), 2The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China (People's Republic), 3Section Rheumatology Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzou, China (People's Republic), 4The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzou, China (People's Republic), 5Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, China (People's Republic), 6Dongguan Hospital of Traditional Chinese Medicine, Dongguan, China (People's Republic), 7Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Huandu, China (People's Republic), 8Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China (People's Republic)

    Background/Purpose:  In recent years, the combination therapies of conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) with Chinses medicine has prevailed for the treatment of rheumatoid arthritis…
  • Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting

    Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis

    Paul Martin1, James Ding1, Ben Mulhearn1, Sebastien Viatte1 and Stephen Eyre1,2, 1Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

    Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…
  • Abstract Number: 2510 • 2018 ACR/ARHP Annual Meeting

    A Phase IIa Mechanistic Study of Anti-GM-CSF (GSK3196165) with Methotrexate Treatment in Patients with Rheumatoid Arthritis (RA) and an Inadequate Response to Methotrexate

    Mark C. Genovese1, Mario Berkowitz2, Philip G. Conaghan3, Katherine Davy4, David Inman5, Elena Fisheleva6,7, Anubha Gupta6, Robert Janiczek6, Mark Layton8, Nina Mitchell6,7, Jatin Patel9, Julia E. Smith10, Russell Williamson5 and Paul-Peter Tak11, 1Stanford University Medical Center, Palo Alto, CA, 2Leon Medical Research, Lauderdale Lakes, FL, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Statistics, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 5GlaxoSmithKline, Stockley Park, United Kingdom, 6GlaxoSmithKline, Stevenage, United Kingdom, 7Currently at Biomarin UK Ltd, London, United Kingdom, 8ImmunoInflammation, ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 9ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 10Immunoinflammation TA, GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, 11GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose: GSK3196165 is a high-affinity anti-GM-CSF cytokine IgG mAb currently in development for RA, with reported efficacy using IV dosing.  This study evaluated the effects…
  • Abstract Number: 555 • 2018 ACR/ARHP Annual Meeting

    Three Year Outcomes of Patients with Elderly-Onset Rheumatoid Arthritis Treated with a Therapeutic Strategy Targeting Low Disease Activity, and Impact of Adverse Events on Physical Function

    Takahiko Sugihara1, Tatsuro Ishizaki2, Hiroyuki Baba3, Takumi Matsumoto3, Shoko Iga1, Takeshi Kusuda1, Marina Tsuchida1, Mari Kamiya3, Yoji Komiya3, Fumio Hirano4, Tadashi Hosoya3, Nobuyuki Miyasaka3 and Masayoshi Harigai5, 1Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 2Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, 3Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, 4Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, 5Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: The aim of this study was to evaluate three year outcomes of patients with elderly-onset RA (EORA) who were treated with a therapeutic strategy…
  • Abstract Number: 2538 • 2018 ACR/ARHP Annual Meeting

    Rapamycin Induces Remission in Patients with Newly Diagnosed Rheumatoid Arthritis

    Min Chen1, Xiao-Feng Li2, Chong Gao3 and Cai-Hong Wang4, 1The Second Hospital of Shanxi Medical Univerity, Taiyuan City, China, 2Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, 3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, 4The Second Hospital of Shanxi Medical Univerity, Taiyuan, China

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints.We found that there was an imbalance between Th17 and Treg…
  • Abstract Number: 561 • 2018 ACR/ARHP Annual Meeting

    U-Act-Early Trial 3 Years Follow-up: Radiographic Joint Damage and Use of Bdmards over 5 Years in Early RA Patients Treated-to-Target with Strategies Initiating Tocilizumab, Methotrexate or Their Combination

    Maxime MA Verhoeven1, Maria JH de Hair2, Paco MJ Welsing2, Attila Pethö-Schramm3, Michelle EA Borm4, Xavier M Teitsma2, Jacob van Laar2, Floris PJG Lafeber2, Johannes W. J. Bijlsma5 and Johannes W. G. Jacobs6, 1Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, 3F. Hoffmann-La Roche, Basel, Switzerland, 4Roche Nederland BV, Woerden, Netherlands, 5Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 6Rheumatolgy & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The U-Act-Early trial was a 2-year multicentre, double-blind, randomized, placebo-controlled trial in early (DMARD-naïve) RA patients treated to the target of remission, with step-up…
  • Abstract Number: 2540 • 2018 ACR/ARHP Annual Meeting

    Effect of Buccal Hygiene on the Systemic Activity of Patients with Rheumatoid Arthritis: A Randomized Clinical Trial

    Xavier Mariette1, Elodie Perrodeau2, Christian Verner3, Xavier Struillou4, Thierry Schaeverbeke5, Alain Cantagrel6, Philippe Ravaud7 and Philippe Bouchard8, 1Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 2Paris Hotel Dieu, Paris, France, 3Periodontology, UFR d'odontologie, University of Nantes, Nantes, France, 4Periodontology, UFR d'odontologie, University of Nantes,, Nantes, France, 5Rheumatology, CHU Bordeaux, Bordeaux, France, 6Rheumatology, CHU Toulouse, Toulouse, France, 7INSERM UMR1153, Paris Descartes University, Paris, France, 8Paris Diderot University, Paris, France

    Background/Purpose: Good evidence suggests a relationship between rheumatoid arthritis (RA) and periodontitis. We aimed to investigate if a good oral hygiene could improve activity of…
  • Abstract Number: 577 • 2018 ACR/ARHP Annual Meeting

    Expanded Autoantibody Profiles Predict Treatment Response to Biologic Therapy in Rheumatoid Arthritis

    Ted R. Mikuls1, Amrita Bath2, Bryant R. England3, Michael J. Duryee4, Carlos D. Hunter4, Joel Kremer5, Dimitrios A. Pappas6,7, William H. Robinson8, Jeffrey R. Curtis9 and Geoffrey M. Thiele10, 1Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 2Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Albany Medical Center, Albany, NY, 6Columbia University, New York, NY, 7Corrona, LLC, Waltham, MA, 8Stanford University, Palo Alto, CA, 9University of Alabama at Birmingham, Birmingham, AL, 10University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:  Although biologics represent a major advance in rheumatoid arthritis (RA), many patients fail to achieve adequate responses to these agents.  As previous studies have…
  • Abstract Number: 2543 • 2018 ACR/ARHP Annual Meeting

    Retention Rate and Safety Data of Biosimilar CT-P13 in Patients with Rheumatoid Arthritis: Data from the Korean College of Rheumatology Biologics Registry

    Hyoun-Ah Kim1, Eun-Young Lee2, Sun Kyung Lee3, Yong-Beom Park4, Young Nam Lee5, HeeJung Kang6 and Kichul Shin7, 1Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea, Republic of (South), 2Department of Medical Informatics, Ajou University School of Medicine, Suwon, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South), 4Yonsei University College of Medicine, Seoul, Korea, Republic of (South), 5Celltrion Healthcare Co. Ltd, Incheon, Korea, Republic of (South), 6Celltrion Healthcare Co.Ltd, Incheon, Korea, Republic of (South), 7Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South)

    Background/Purpose: CT-P13 is a biosimilar prescribed in a number of countries for indications approved for the reference infliximab (RINF) including rheumatoid arthritis (RA), ankylosing spondylitis…
  • Abstract Number: 579 • 2018 ACR/ARHP Annual Meeting

    Changes in DNA Methylation Identify Response to Treatment with Methotrexate and TNF Inhibitors Among RA Patients

    Cameron Adams1, Katie Marker1, Melissa Krueger2, Lisa Barcellos1 and Lindsey A. Criswell3, 1School of Public Health, UC Berkeley, Berkeley, CA, 2UC San Francisco, San Francisco,, CA, 3University of California San Francisco, San Francisco, CA

    Background/Purpose: Epigenetic modifications including DNA methylation are implicated in the development and progression of autoimmune diseases, such as rheumatoid arthritis  [MIM 180300]. Evidence indicates that…
  • Abstract Number: 2549 • 2018 ACR/ARHP Annual Meeting

    Patient-Reported Benefits of Sarilumab Monotherapy in Adult Patients with Active Rheumatoid Arthritis: Results from an Open-Label Extension Study

    Vibeke Strand1, Matthew Reaney2, Erin Mangan3, Hubert van Hoogstraten4, Susan Boklage3 and Chih-Chi Hu5, 1Stanford University School of Medicine, Palo Alto, CA, 2Sanofi, Guildford, United Kingdom, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4Sanofi Genzyme, Bridgewater, NJ, 5Sanofi, Bridgewater, NJ

    Background/Purpose: Sarilumab is a human monoclonal antibody that binds to membrane and soluble IL-6R, which is approved for the treatment of moderate to severe rheumatoid…
  • Abstract Number: 587 • 2018 ACR/ARHP Annual Meeting

    The Superiority of a Treat to Target Strategy over Conventional Treatment with Fixed Csdmard and Corticosteroids: A Multi-Centre Randomized Controlled Trial in RA Patients with Inadequate Response to Conventional Synthetic Dmards, and a New Therapy with Certolizumab Pegol

    Ruediger Mueller1, Michael Spaeth2, Cord von Restorff3, Christoph Ackermann4 and Johannes von Kempis5, 1Division of Rheumatology, Kantonsspital St Gallen, St. Gallen, Switzerland, 2Division of Rheumatology, Spital Linth, Uznach, Switzerland, 3Private rheumatologic practice, Männedorf, Switzerland, 4Private rheumatologic practice, Triesen, Liechtenstein, 5Division of Rheumatology and Immunology, Kantonsspital St. Gallen, St. Gallen, Switzerland

    The superiority of a treat to target strategy over conventional treatment with fixed csDMARD and corticosteroids: a multi-centre randomized controlled trial in RA patients with…
  • Abstract Number: 2870 • 2018 ACR/ARHP Annual Meeting

    Thresholds for Disease Activity Measures DAS28, CDAI, and RAPID3 Do Not Align with Clinical Practice Patterns of Rheumatoid Arthritis (RA) Disease Management Decisions

    Brian C. Sauer1, Chia-Chen Teng, MS1, Neil A. Accortt2, David H. Collier2, Tzu-Chieh Lin2 and Grant W. Cannon1, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Amgen Inc., Thousand Oaks, CA

    Background/Purpose:   Treatment guidelines recommend using disease activity measures (DAMs) to guide RA therapy, but DAM use in real-world treatment decisions is not defined.  We…
  • Abstract Number: 604 • 2018 ACR/ARHP Annual Meeting

    Combining Observational and Randomized Controlled Trial Data Evidence to Jointly Estimate Remission and Response for Biologic and Non-Biologic Therapies in Rheumatoid Arthritis: A Bivariate Network Meta-Analysis

    Gyanendra Pokharel1, Rob Deardon1, Cheryl Barnabe2, Vivian P. Bykerk3, Susan J. Bartlett4, Louis Bessette5, Gilles Boire6, Carol Hitchon7, Edward C. Keystone8, Janet E. Pope9, Diane Tin10, Carter Thorne11 and Glen Hazlewood12, 1Department of Mathematics and Statistics, University of Calgary, Calgary, AB, Canada, 2Medicine, University of Calgary, Calgary, AB, Canada, 3Hospital for Special Surgery, New York, NY, 4Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, 6Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 7University of Manitoba, Winnipeg, MB, Canada, 8Mount Sinai Hospital, Toronto, ON, Canada, 9Department of Medicine, University of Western Ontario, London, ON, Canada, 10The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 11University of Toronto, Newmarket, ON, Canada, 12Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Remission is the goal of rheumatoid arthritis (RA) treatment, but ACR responses are more commonly measured in clinical trials. As such, data on remission…
  • Abstract Number: 2875 • 2018 ACR/ARHP Annual Meeting

    Identifying Trends in Lines of Therapy Following Initial Biologic Disease-Modifying Antirheumatic Drug in Patients with Rheumatoid Arthritis

    Jay Lin1, Jeannie Choi2, Jeffrey R. Curtis3, Melissa Lingohr-Smith1 and Susan Boklage4, 1Novosys Health, Green Brook, NJ, 2Sanofi, Bridgewater, NJ, 3University of Alabama at Birmingham, Birmingham, AL, 4Regeneron Pharmaceuticals, Inc., Tarrytown, NY

    Background/Purpose: Among patients with rheumatoid arthritis (RA) who have an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), the addition of a biologic DMARD…
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