Abstracts tagged "rheumatoid arthritis (RA) and transcriptional regulation"

Abstract Number: 991 • 2018 ACR/ARHP Annual Meeting
Critical Role of Interleukin-1α (IL-1α) in IL-1β-Induced Inflammatory Responses: Cooperation with NF-κBp65 in Transcriptional Regulation
Anil K. Singh¹, Sabrina Fechtner¹, Mukesh Chourasia², Jerry Sicalo¹ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India
Background/Purpose: Interleukin-1β (IL-1β) and IL-1α are cytokines of IL-1 family that orchestrate acute and chronic inflammatory diseases. However, their distinct role or the extent of…
Abstract Number: 2039 • 2018 ACR/ARHP Annual Meeting
A Survey of Blood and Synovial Tissue Myeloid Cells in RA Patients By Transcriptional Profiling
Shurui Bian¹, Arthur M. Mandelin II², Salina Dominguez³, Philip J. Homan⁴, Gaurav Gadhvi¹, Hiam Abdala-Valencia¹, Alexander Misharin⁵, Eric M. Ruderman⁶, Carla M. Cuda³, Richard M. Pope⁶, Harris Perlman³ and Deborah R. Winter³, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Myeloid cells – including dendritic cells (DCs), monocytes, and macrophages – are critical to the pathogenesis of rheumatoid arthritis (RA) through production of pro-inflammatory…
Abstract Number: 2899 • 2018 ACR/ARHP Annual Meeting
Sustained Drug-Free Remission in Early RA Following Methotrexate-Based Strategy: Role of the JAK-STAT Pathway
Xavier M Teitsma¹, Johannes W. G. Jacobs², Arno N Concepcion³, Attila Pethö-Schramm⁴, Michelle EA Borm⁵, Jacob van Laar¹, Johannes W. J. Bijlsma⁶ and Floris PJG Lafeber¹, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, ²Rheumatolgy & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴F. Hoffmann-La Roche, Basel, Switzerland, ⁵Roche Nederland BV, Woerden, Netherlands, ⁶Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: We previously identified several co-expressed genes associated with achieving sustained drug-free remission (sDFR) following a methotrexate (MTX)-based strategy in early rheumatoid arthritis (RA).1 The…
Abstract Number: 174 • 2017 ACR/ARHP Annual Meeting
Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity
Philip J. Homan¹, Arthur M. Mandelin II², Salina Dominguez¹, Emily Bacalao³, S. Louis Bridges Jr.⁴, Joan M. Bathon⁵, John Atkinson⁶, David Fox⁷, Eric L. Matteson⁸, Chris Buckley⁹, Costantino Pitzalis¹⁰, Deborah Parks¹¹, Laura Hughes¹², Laura Geraldino-Pardilla¹³, Robert Ike¹⁴, Kristine Phillips¹⁵, Kerry Wright¹⁶, Andrew Filer¹⁷, Stephen Kelly¹⁸, Eric M. Ruderman¹⁹, Carla Cuda¹, Hiam Abdala-Valencia³, Alexander Misharin³, G. R. Scott Budinger³, Richard M. Pope¹⁹, Harris Perlman²⁰ and Deborah R. WInter¹, ¹Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁵Division of Rheumatology, Columbia University Medical Center, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI, ⁸Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁹University of Birmingham, Birmingham, United Kingdom, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Washington University School of Medicine in St. Louis, St. Louis, MO, ¹²University Alabama Birmingham, Birmingham, AL, ¹³Columbia University, New york, NY, ¹⁴Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶Rheumatology, Mayo Clinic, Rochester, MN, ¹⁷Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹⁸William Harvey Research Institute, London, United Kingdom, ¹⁹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²⁰Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL
Background/Purpose: In a given patient with rheumatoid arthritis (RA), it is difficult to predict disease progression or identify to which treatments they will respond. Macrophages…
Abstract Number: 1411 • 2017 ACR/ARHP Annual Meeting
Protein Tyrosine Phosphatase Non-Receptor 22 / C-Src Tyrosine Kinase Complex Down-Regulated in Patients with Rheumatoid Arthritis
Sara Remuzgo-Martínez¹, Fernanda Genre¹, Raquel López-Mejías¹, Santos Castañeda², Alfonso Corrales¹, Pablo Moreno Fresneda^2,3, Begoña Ubilla¹, Verónica Mijares¹, Virginia Portilla¹, Jesús González-Vela¹, Trinitario Pina¹, J. Gonzalo Ocejo-Vinyals⁴, Juan Irure-Ventura⁴, Ricardo Blanco¹, Javier Martin⁵, Javier Llorca⁶ and Miguel Angel González-Gay⁷, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ²Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, ³Rheumatology, Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, ⁴Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁵Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Protein tyrosine phosphatase non-receptor 22 (PTPN22) binds to C-Src tyrosine kinase (CSK) forming a key regulator complex in autoimmunity1. In this regard, PTPN22 is…
Abstract Number: 1564 • 2016 ACR/ARHP Annual Meeting
The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients
Haruka Tsuchiya¹, Shuji Sumitomo¹, Kazuyoshi Ishigaki², Akari Suzuki², Yuta Kochi², Mineto Ota¹, Yumi Tsuchida¹, Hiroshi Inui³, Shuji Taketomi³, Yuho Kadono⁴, Sakae Tanaka³, Keishi Fujio¹ and Kazuhiko Yamamoto^1,2, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Fibroblast-like synoviocyte (FLS) is expected to be a novel therapeutic target for rheumatoid arthritis (RA) because of their contribution to pathogenesis. FLS expresses…
Abstract Number: 18 • 2015 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts
Anil Singh^1,2, Mukesh Chourasia³ and Salahuddin Ahmed⁴, ¹Department of Pharmaceutical Science, Washington State University, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: TAK1 is one of the most important proteins in IL-1β signaling cascade that mediates downstream p38/JNK and NF-κB activation. In the present study, we…
Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Anna-Karin Ekwall¹, Deepa Hammaker², John W. Whitaker³, William Bugbee⁴, Wei Wang⁵ and Gary S. Firestein⁶, ¹Medicine, UC San Diego, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³860 island ave, UCSD, San Diego, CA, ⁴Orthopaedics, Scripps Clinic, La Jolla, CA, ⁵Chemistry, UCSD, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…
Abstract Number: 2734 • 2013 ACR/ARHP Annual Meeting
Epigenetic Control Of a Gene Regulatory Network Associated With Experimental Autoimmune Arthritis and Rheumatoid Arthritis
Andras Vida¹, Janos Gal², Gyorgyi Soos², Attila Balog³, Laszlo G. Puskas⁴, Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, ⁴Laboratory of Functional Genomics, Biological Research Center, Szeged, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that mainly affects the synovial joints, leading to destruction of articular cartilage and bone. There is…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].