Abstracts tagged "rheumatoid arthritis (RA) and transcription factor"

Abstract Number: 992 • 2018 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Suppresses Systemic Inflammation By Inhibiting IL-6-Induced STAT3 Activation in Cultured Hepatocytes and in Liver Tissue of Adjuvant-Induced Arthritis (AIA) Rats
Anil K. Singh¹, Sabrina Fechtner², Dorothy Wang², Mukesh Chourasia³ and Salahuddin Ahmed^2,4, ¹Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: In rheumatoid arthritis (RA), the pro-inflammatory cytokine interleukin-6 (IL-6) induces systemic inflammation by activating hepatocytes through IL-6 receptor (IL-6R)- mediated JAK/STAT3 signaling pathway. The…
Abstract Number: 1059 • 2018 ACR/ARHP Annual Meeting
Differentially-Utilized Transcription Factors and Enhancers in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes
Jonathan Mills¹, Gary S. Firestein² and Brian Pedersen², ¹Rheumatology, University of California, San Diego, San Diego, CA, ²Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display a unique aggressive phenotype with a distinct epigenetic profile marked by altered chromatin accessibility. We hypothesized that differentially utilized…
Abstract Number: 166 • 2017 ACR/ARHP Annual Meeting
Integrative Systems Biology Approach Identifies Key Transcription Factors and Novel Rheumatoid Arthritis (RA) and Individualized Therapeutic Targets
RIchard Ainsworth¹, Kai Zhang², Gary S. Firestein³ and Wei Wang⁴, ¹UC San Diego, La Jolla, CA, ²UCSD School of Engineering, San Diego, CA, ³Medicine, University of California San Diego, La Jolla, CA, ⁴Chemistry and Biochemistry, UC San Diego, La Jolla, CA
Background/Purpose: The search for novel targets in RA requires novel computational methods and in silicosystems to identify non-obvious pathways that account for the diversity of…
Abstract Number: 1131 • 2016 ACR/ARHP Annual Meeting
Regulation of Rheumatoid Arthritis Synovial Fibroblast Cytokine Production By Inhibitor of DNA Binding-1 Via Crispr/Cas9 Transfection
Ray A. Ohara¹, Gautam Edhayan¹, Thomas L. Saunders², Thomas M. Lanigan³, Rachel Morgan¹, W. Alexander Stinson⁴, Phillip L. Campbell⁵, Jerry Graham⁴, David A. Fox⁵ and Jeffrey H. Ruth⁵, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, ³Vector Core, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear protein actively transcribed in endothelial progenitor cells (EPCs) and synovial fibroblasts. We previously identified Id1 as…
Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Wendy Dankers³, Patrick Asmawidjaja², Anne-Marie Otten-Mus² and Erik Lubberts², ¹Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…
Abstract Number: 3020 • 2016 ACR/ARHP Annual Meeting
Citrullination of Inhibitor of DNA Binding-1 at Specific Locations Leads to Autoantigenicity in Rheumatoid Arthritis
Ray A. Ohara¹, Henriette A. Remmer², Phillip L. Campbell³, David A. Fox³ and Jeffrey H. Ruth³, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear transcription factor that regulates cell growth and differentiation via selective binding and sequestering of other transcription…
Abstract Number: 1617 • 2015 ACR/ARHP Annual Meeting
Evidence for Citrullinated Inhibitor of DNA Binding 1 (Id1) As a Novel Autoantigen Candidate in Rheumatoid Arthritis
Ray A. Ohara¹, Gautam Edhayan¹, W. Alexander Stinson², Phillip L. Campbell¹, Henriette A. Remmer³, M. Asif Amin¹, David A. Fox¹ and Jeffrey H. Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Biomedical Research Core Facilities, Proteomics & Peptide Synthesis Core, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA-binding 1 (Id1) is a nuclear transcription factor actively transcribed in endothelial progenitor cells and in cells that exhibit hyperproliferative responses such…
Abstract Number: 92 • 2014 ACR/ARHP Annual Meeting
Long Noncoding RNA Nron Regulates the Activity of NFAT5 through Ubiquitin-Independent Proteasome Pathway in Rheumatoid Arthritis
Kunihiko Umekita^1,2, Michelle Trenkmann¹, Christoph Kolling³, Akihiko Okayama⁴, Renate Gay¹, Steffen Gay¹ and Mojca Frank Bertoncelj⁵, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Rheumatology, Infectious diseases and Laboratory medicine, University of Miyazaki, Miyazaki, Japan, ³Schulthess Clinic, Zurich, Switzerland, ⁴Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are increasingly recognized as master regulators of gene expression. The lncRNA NRON, noncoding repressor of nuclear factor of activated T…
Abstract Number: 1857 • 2013 ACR/ARHP Annual Meeting
Identification Of SOX5 and SOX6 As Potent Regulators Of RANKL Expression Contributing To Bone Erosion In Rheumatoid Arthritis and Experimental Arthritis Model
Wenfeng Tan¹, Xiaoke Feng², Lingxiao Xu³, Ke Gan⁴, Fang Wang³, Miaojia Zhang⁵, Hui Wu⁶ and Betty P. Tsao⁷, ¹Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ³Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ⁴Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁵Department of Rheumatology, Jiangsu Provincial People's Hospital, Nanjing, China, ⁶Rheumatology, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁷Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA
Background/Purpose: We previously reported a RANKLpromoter SNP confers an elevated promoter activity after stimulation via binding to a SOX family transcription factor SOX5 and is…
Abstract Number: 1284 • 2013 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and Resolution
Jordan Everett¹, Fiona E. McCann², Andrew C. Palfreeman², Anita T. Shaw³, Ellen M. Gravallese⁴ and Kimberlee S. Mix¹, ¹Biological Sciences, Loyola University New Orleans, New Orleans, LA, ²NDORMS, The Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ³Division of Rheumatology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ⁴Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nuclear receptor 4A2 (NR4A2 / nuclear receptor related 1 / Nurr1) is a constitutively active transcription factor with diverse roles in normal physiology and…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 425 • 2012 ACR/ARHP Annual Meeting
Slug Is Induced by Benzo(a)Pyrene and EGF Through PI3K/Akt/mTOR Pathway and Is Closely Involved in the Regulation of the Invasive Properties of FLS in Rheumatoid Arthritis
Jaejoon Lee¹, Jiwon Hwang¹, Chan Hong Jeon², Joong Kyong Ahn³, Hoon-Suk Cha¹ and Eun-Mi Koh⁴, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: Slug, a Snail family of zinc finger transcription factor, plays a critical role in tumor proliferation, invasion and metastasis. We have previously shown that…

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