Abstracts tagged "rheumatoid arthritis (RA) and therapy"

Abstract Number: 498 • 2015 ACR/ARHP Annual Meeting
Non-Adherence to Disease-Modifying Anti-Rheumatic Drugs in Patients with Rheumatoid Arthritis: An Italian Survey
Gerolamo Bianchi¹, Antonio Carletto², Oscar M. Epis³, Crescenzio Scioscia⁴, Angelo Semeraro⁵, Chiara Donati⁶, Laura Bazzichi⁷, Giovanni Lapadula⁸, Luigi Sinigaglia⁹ and Andrea Lo Monaco¹⁰, ¹Div Reumatologia, Ospedale La Colletta, Genoa, Italy, ²Rheumatology Unit, University of Verona, Verona, Italy, ³Rheumatology Unit, A.O. Ospedale Niguarda Ca' Granda, Milan, Italy, ⁴DIM - Sezione di Reuamtologia Università degli Studi di Bari "Aldo Moro", Bari, Italy, ⁵Unità Operativa di Reumatologia ASL Taranto, Taranto, Italy, ⁶Roche S.p.A., Monza, Italy, ⁷Division of Reumatology, Univeristy of Pisa, Pisa, Italy, ⁸D.I.M.I.M.P, Rheumatology Unit - University of Bari, Bari, Italy, ⁹Rheumatology Dep, I.O.G. Pini, Milan, Italy, ¹⁰Ospedale S. Anna, Ferrara, Italy
Background/Purpose: In patients (pts) with rheumatoid arthritis (RA), the non-adherence to therapy may impair the clinical outcomes, being often associated with the disease flare and…
Abstract Number: 2371 • 2014 ACR/ARHP Annual Meeting
Efficacy of First Line Biological Monotherapy in RA: Data from the Czech Registry Attra
Herman F. Mann^1,2, Sarka Forejtova³, Katerina Jarosova⁴, Ladislav Senolt⁵, Jakub Zavada⁶, Michal Uher⁷, Karel Hejduk⁷ and Karel Pavelka⁸, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ²1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Rheumatology, Institute of Rheumatology, Prague, Czech Republic, ⁴Na Slupi 4, Institute of Rheumatology, Prague, Czech Republic, ⁵Na Slupi 4, Revmatologicky ustav, Prague, Czech Republic, ⁶Charles University, Prague, Czech Republic, ⁷Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Background/Purpose: The biological disease-modifying anti-rheumatic drugs (bDMARDs) should be used for the treatment of rheumatoid arthritis (RA) in combination with conventional synthetic DMARDs (csDMARDs). However…
Abstract Number: 1963 • 2014 ACR/ARHP Annual Meeting
Hierarchical Role of PI3K/Akt/mTOR Signaling Cascade on: Tissue Inflammation, Organization and Angiogenesis in Autoimmune Arthritis
Siba Raychaudhuri¹, Anupam Mitra², Ananya Datta Mitra³, Christine Abria⁴ and Smriti K. Raychaudhuri³, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Research, VA Sacramento Medical Center, Mather, CA
Background/Purpose: The PI3K/Akt/mTOR signaling proteins are pro-growth/pro-survival and thus likely to regulate inflammatory cascades in autoimmune diseases (1). The key pathologic outcome in psoriatic arthritis…
Abstract Number: 1513 • 2014 ACR/ARHP Annual Meeting
Selection of Vagus Nerve Stimulation Parameters for a First-in-Human Study in Rheumatoid Arthritis: A Unique Translational Medicine Challenge
Frieda A. Koopman¹, Yaakov Levine², Mike Faltys², Ralph Zitnik² and Paul P. Tak³, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²SetPoint Medical Corporation, Valencia, CA, ³Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Cholinergic anti-inflammatory pathway (CAP) activation by electrical vagus nerve stimulation (VNS) is being studied in rheumatoid arthritis (RA) trials (NCT01552941). CAP signaling proceeds sequentially…
Abstract Number: 403 • 2014 ACR/ARHP Annual Meeting
Metaflammation, PEDF and Chemerin: Potential Systemic Factors Which Link Obesity to Response to Therapy in Early Rheumatoid Arthritis
Elisa Gremese, Barbara Tolusso, Anna Laura Fedele, Maria Rita Gigante, Silvia Canestri, Clara Di Mario, Angela Carbonella and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose . Obesity per se is a systemic, low-grade inflammatory state and the adipose tissue is an endocrine organ that releases bioactive substances, including pro-inflammatory…
Abstract Number: 1332 • 2013 ACR/ARHP Annual Meeting
Metaflammation, PEDF and Chemerin: Potential Systemic Factors Which Link Obesity To Response To Therapy In Early Rheumatoid Arthritis
Elisa Gremese, Barbara Tolusso, Anna Laura Fedele, Maria Rita Gigante, Angela Carbonella, Silvia Canestri, Clara Di Mario and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Obesity per se is a systemic, low-grade inflammatory state and the adipose tissue is an endocrine organ that releases bioactive substances, including pro-inflammatory cytokines,…
Abstract Number: 1287 • 2013 ACR/ARHP Annual Meeting
Pre-Clinical Proof-Of-Concept Of ALX-0761, a Nanobody^® Neutralizing Both IL-17A and F In a Cynomolgus Monkey Collagen Induced Arthritis Model
Katrien Vanheusden¹, Laurent Detalle¹, Alex Hemeryck¹, Alain Vicari², Roland Grenningloh³, Sofie Poelmans¹, Heidi Wouters⁴ and Thomas Stöhr¹, ¹Pharmacology, Ablynx NV, Gent, Belgium, ²Calypso Biotech, Geneva, Switzerland, ³Pharmacology, Merck-Serono, Darmstadt, Germany, ⁴Clinical Development, Ablynx nv, Zwijnaarde, Belgium
Background/Purpose: Interleukin (IL)-17 and Th17 cells are implicated in many auto-immune diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis. Although IL-17(A) is the…

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