ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and synovium"

  • Abstract Number: 1064 • 2018 ACR/ARHP Annual Meeting

    Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients

    Cristina Ruiz-Romero1, Florencia Picchi2, Patricia Fernández3, Lucia González2, Rebecca Hands4, Valentina Calamia2, Maria Camacho2, Conrad Bessant5, Costantino Pitzalis4 and Francisco J Blanco6, 1Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Rheumatology Research Group, Proteomics Unit-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, 3Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, 4Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 5School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, 6Rheumatology Divison, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by high clinical variability and an underlying cellular and molecular heterogeneity. Efforts to find tools for the classification of…
  • Abstract Number: 179 • 2017 ACR/ARHP Annual Meeting

    Mass Spectrometry Imaging of Synovium: A Novel Approach to Classify the Rheumatoid and Psoriatic Arthritis Patients

    Beatriz Rocha1,2, Berta Cillero-Pastor3, Gert Eijkel3, Lennart R. Huizing3, Cristina Ruiz-Romero1,4, Andrea Cuervo5,6, Ron M A Heeren3, Juan D. Cañete5,6 and Francisco J Blanco1,6, 1Rheumatology Division, ProteoRed/ISCIII Proteomics Group, INIBIC - Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Spain, 2The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Masstricht, Netherlands, 3The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Maastricht, Netherlands, 4CIBER-BBN Instituto de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain., A Coruña, Spain, 5Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain, Barcelona, Spain, 6RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain

    Background/Purpose: Psoriatic arthritis (PsA) and Rheumatoid arthritis (RA) are immune-mediated chronic inflammatory diseases. Synovial membrane is the initial site of inflammation in PsA and RA…
  • Abstract Number: 1406 • 2017 ACR/ARHP Annual Meeting

    Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network

    Deepak Rao1, Laura T. Donlin2, Kevin Wei3, Nida Meednu4, Jason Turner5, Mandy J. McGeachy6, Fumitaka Mizoguchi7, Joshua Keegan8, James Lederer9, Maria Gutierrez-Arcelus10, Kamil Slowikowski11, Kaylin Muskat12, Joshua Hillman12, Cristina Rozo13, Edd Ricker14, Thomas Eisenhaure15, David Lieb15, Shuqiang Li15, Edward Browne15, Chad Nusbaum15, William H. Robinson16, Stephen Kelly17, Alessandra B. Pernis18, Lionel Ivashkiv19, Susan M. Goodman20, Ellen M. Gravallese21, Michael Holers22, Nir Hacohen23, Costantino Pitzalis17, Peter Gregersen24, Vivian P. Bykerk25, Larry W. Moreland26, Gary Firestein27, Soumya Raychaudhuri28, Andrew Filer29, David L. Boyle30, Michael Brenner10 and Jennifer H. Anolik4, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 5Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 6Medicine, University of Pittsburgh, Pittsburgh, PA, 7Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 8Brigham and Women's Hospital, Boston, MA, 9Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 11Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, 12University of California, San Diego, San Diego, CA, 13Hospital for Special Surgery, New York, NY, 14Weill Cornell Graduate School of Medical Sciences, New York, NY, 15Broad Institute, Cambridge, MA, 16Stanford University School of Medicine, Stanford, CA, 17Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 18David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 19Medicine, Hospital for Special Surgery, New York, NY, 20Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 21Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, 22Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, 23Harvard Medical School, Boston, MA, 24The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 252-005, Mt Sinai Hospital, Toronto, ON, Canada, 26Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 27EGG, St Cloud, France, 28Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 29Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, 30University of California San Diego, La Jolla, CA

    Background/Purpose: Detailed analyses of cells from rheumatoid arthritis (RA) synovium may identify cell phenotypes and functions that drive tissue pathology and joint damage. The AMP…
  • Abstract Number: 1410 • 2017 ACR/ARHP Annual Meeting

    Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity

    Alessandra Nerviani1, Sara Pagani1, Daniele Mauro1, Frances Humby1, Stephen Kelly1, Felice Rivellese1, Gloria Lliso Ribera1, Myles J. Lewis2, Michele Bombardieri3 and Costantino Pitzalis1, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 2Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 3Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Emerging evidence highlighted the role of Tyro3, Axl and Mer Tyrosine Kinase receptors (TAMs) and their ligands Gas6 and ProteinS in the pathogenesis of…
  • Abstract Number: 2416 • 2017 ACR/ARHP Annual Meeting

    Histopathological Change Caused By Biological Treatment in Rheumatoid Arthritis Synovial Tissue

    Ayako Kubota, Toru Suguro, Masayuki Sekiguchi and Kazuaki Tsuchiya, Toho University Omori Medical Center, Tokyo, Japan

    Background/Purpose: Multiple studies addressing the effects of biologics on the synovial tissue in rheumatoid arthritis (RA) patients have been reported. There are, however, few studies…
  • Abstract Number: 2792 • 2017 ACR/ARHP Annual Meeting

    Th22 Cells Are a Potent Inducer of Osteoclastogenesis in Rheumatoid Arthritis

    Yusuke Miyazaki1, Shingo Nakayamada2, Satoshi Kubo1, Kazuhisa Nakano2, Kei Sakata3, Shigeru Iwata4, Ippei Miyagawa5 and Yoshiya Tanaka6, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyshu, Japan, 4First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 5University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 6The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Background/Purpose: CD4+ T cells can differentiate into functionally distinct subsets and play a pivotal role in rheumatoid arthritis (RA). Th22 cells have been identified as…
  • Abstract Number: 1362 • 2015 ACR/ARHP Annual Meeting

    Investigating the Role of Dendritic Cell Maturation & T Cell Activation within the Inflamed Synovium in Rheumatoid Arthritis

    Mary Canavan1, Micheal O'Rourke2, Carl Orr2, Sharee Basdeo3, Jean Fletcher3, Douglas J. Veale4 and Ursula Fearon5, 1St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, 2Dublin Academic Medical Centre, Translational Rheumatology Research Group, St Vincent's University Hospital, Dublin, Ireland, 3Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, 4St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, 5St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland

    Background/Purpose: Dendritic cells (DC) are a heterogeneous population of antigen presenting cells which link both innate & adaptive immunity. To date their classification within blood…
  • Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting

    Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation

    Man Wai Tang1, Samuel Garcia2, Danielle M. Gerlag3,4, Kris A. Reedquist5 and Paul P. Tak6,7, 1Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4GlaxoSmithKline, Cambridge, United Kingdom, 5Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 7University of Cambridge, Cambridge & GlaxoSmithKline, UK, Stevenage, United Kingdom

    Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…
  • Abstract Number: 38 • 2014 ACR/ARHP Annual Meeting

    Angiopoietin-like 4 Is over-Expressed in Rheumatoid Arthritis: A Potential Role in Pathological Bone Resorption

    Catherine Swales1, Nick Athanasou2 and Helen Knowles3, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, Oxford, United Kingdom, 2Nuffield Orthopaedic Centre, Department of Pathology, Oxford, United Kingdom, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford, United Kingdom

    Background/Purpose In contrast to normal synovial tissue, rheumatoid synovium is hypoxic, and expresses the hypoxia-inducible transcription factors HIF-1α and HIF-2α which allow the transcription of…
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