ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "rheumatoid arthritis (RA) and synovial cells"

  • Abstract Number: 1782 • 2012 ACR/ARHP Annual Meeting

    Dual Effects of Soluble FasL and Membrane Bound FasL On Fibroblast-Like Synoviocytes Cells (FLS) From Rheumatoid Arthritis (RA) Patients

    Rachel Audo1, Flavia Calmon-Hamaty1, Bernard Combe2, Michael Hahne1 and Jacques Morel3, 1IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 2Rheumatology, Hopital Lapeyronie, Montpellier, France, 3Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France

    Background/Purpose: Membrane bound FasL (mFasL) is able to induce fibroblast-like synoviocytes (FLS) cell death. In experimental arthritis mouse models, injection of agonistic antibody  (Ab) anti-Fas…
  • Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting

    The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations

    Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
  • Abstract Number: 1601 • 2012 ACR/ARHP Annual Meeting

    Role of Focal Adhesion Kinase in Synovial Fibroblast Invasion and Arthritis

    Miriam A. Shelef1, David Bennin2 and Anna Huttenlocher3, 1Medicine, Univ of Wisconsin Schl of Med, Madison, WI, 2Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI, 3Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI

    Background/Purpose: Rheumatoid arthritis is an inflammatory arthritis characterized by joint erosions and destruction. This damage is mediated in part by invasion of synovial fibroblasts into…
  • Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting

    Analysis of Gene Expression Patterns in Rheumatoid  Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare

    Karen L. Berg1, Adedayo Hanidu1, Jon Hill2, Xiaoyu Jiang1, Tom Freeman2, Jennifer Swantek1, Anna Yarlina3, George D. Kalliolias4, Lionel B. Ivashkiv5 and Gerald H. Nabozny1, 1Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 2Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, 3Hospital for Special Surgery, New York, NY, 4Medicine, Hospital for Special Surgery, New York, NY, 5Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Synovial macrophages play a key role in RA pathogenesis.  Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…
  • Abstract Number: 1197 • 2012 ACR/ARHP Annual Meeting

    Porphyromonas Gingivalis and the Pathogenesis of Rheumatoid Arthritis: Analysis of the Synovial Tissue and of Other Compartments

    Michele C. Totaro1, Sara D'Onghia2, Elisa Gremese1, Luca Petricca1, Simona Marchetti2, Silvia Canestri1, Barbara Tolusso1, Stefano Alivernini1, Paola Cattani2 and Gianfranco Ferraccioli1, 1Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 2Laboratory of Clinical Analyses CIC, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Porphyromonas gingivalis (Pg), a periodontal anaerobic intracellular pathogen, has been recently associated to rheumatoid arthritis (RA) and the pathogenesis of the disease, due to…
  • Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting

    Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis

    Vijay Joshua1, Lena Israelsson2, Lars Klareskog3, Anca Catrina1 and Vivianne Malmström4, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
  • Abstract Number: 883 • 2012 ACR/ARHP Annual Meeting

    Role of Phospholipase D1 (PLD1) in the Expression of Proinflammatory Genes in Rheumatoid Arthritis Synovial Fibroblasts (RASF)

    Sean C. Friday1 and David A. Fox2, 1Rheumatology, The University of Michigan, Ann Arbor, MI, 2Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI

    Background/Purpose: Interleukin-17 (IL-17) and Tumor Necrosis Factor alpha (TNFa), when co-applied to RASF, induce synergistic expression of proinflammatory genes such as IL-6 and IL-8.  Work…
  • Abstract Number: 737 • 2012 ACR/ARHP Annual Meeting

    Citrullination of ENA-78/CXCL5 Results in Conversion From a Non-Monocyte Recruiting to a Monocyte Recruiting Chemokine

    Ken Yoshida1, Olex Korchynskyi2, Paul P. Tak3, Takeo Isozaki4, Jeffrey H. Ruth5, Phillip Campbell6, Dominique L. Baeten7, Danielle M. Gerlag7, M. Asif Amin8 and Alisa E. Koch9, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Department of Cellular Proliferation and Apoptosis, Institute of Cell Biology, Lviv, Ukraine, 3Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 6Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 7Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 8Department of Medicine, University of Michigan, Ann Arbor, MI, 9Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Citrullination is a post-translational modification that is the conversion of arginine to citrulline in proteins mediated by peptidylarginine deiminase (PAD). Antibodies directed towards the…
  • Abstract Number: 434 • 2012 ACR/ARHP Annual Meeting

    IL-22 Mediated Pannus Formation in Autoimmune Arthritis Is PI3K/Akt/mTOR Dependent

    Siba P. Raychaudhuri1, Anupam Mitra1, Ananya Datta Mitra2, Christine Abria2 and Smriti K. Raychaudhuri2, 1Rheumatology, VA Sacramento Medical CenterUC Davis School of Medicine, Mather, CA, 2Rheumatology, VA Sacramento Medical Center, Mather, CA

    Background/Purpose: IL-22, a Th17 cytokine plays a key role in the formation of “pannus” in autoimmune arthritis such as rheumatoid arthritis (RA) and psoriatic arthritis…
  • Abstract Number: 438 • 2012 ACR/ARHP Annual Meeting

    Methyl Supplementation of Rheumatoid Arthritis Synovial Fibroblasts Regulates the Expression of Transcription Factors and Matrix Metalloproteinases

    Edvardas Bagdonas1, Emmanuel Karouzakis2, Astrid Jungel2, Caroline Ospelt1, Renate E. Gay1, Steffen Gay1, Beat A. Michel1 and Michel Neidhart1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland

    Background/Purpose: Previously we reported that methyl supplementation can reverse the global hypomethylation of rheumatoid arthritis synovial fibroblasts (RASF) and attenuate their aggressive behaviour. Now we…
  • Abstract Number: 415 • 2012 ACR/ARHP Annual Meeting

    Hypoxia-Induced Endogenous Prostaglandin E2 Negatively Regulates Hypoxia-Enhanced Aberrant Overgrowth of Rheumatoid Synovial Tissue

    Hirofumi Mitomi1, Hidehiro Yamada1, Toshiko Nozaki Shibata1, Hiroshi Ito1, Yoshioki Yamasaki2, So Nomoto3, Atsushi Kusaba4, Hiroki Yamashita4 and Shoichi Ozaki1, 1Internal Medicine, St. Marianna University, Kawasaki, Japan, 2Medicine, St. Marianna University, Kawasaki, Japan, 3Department of Orthopedic Surgery and Rheumatology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan, 4Institute of Rheumatology, Ebina General Hospital, Ebina, Japan

    Background/Purpose: During isometric exercise, the synovial joint tissue is prone to hypoxia, which is further enhanced in the presence of synovial inflammation. Hypoxia is also…
  • Abstract Number: 51 • 2012 ACR/ARHP Annual Meeting

    Phosphodiesterase 4 Expression in Rheumatoid Arthritis Synovium and Anti-Inflammatory Effects of Apremilast On Synovial Fibroblasts

    Lei Wu, Mary Adams, Stacey Parton and Peter Schafer, Department of Translational Development, Celgene Corporation, Summit, NJ

    Background/Purpose: Apremilast (APR), a small molecule specific inhibitor of phosphodiesterase 4 (PDE4), works intracellularly to modulate pro- and anti-inflammatory mediator production in both immune and…
  • Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting

    IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis

    Bo Young Yoon1, Young-Mee Moon2, Yang-Mi Her2, Hye Jwa Oh2, Jae-Seon Lee2, Kyoung-Woon Kim3, Seon-Yeong Lee2, Yun-Ju Woo2, Kyung-Su Park2, Sung-Hwan Park4, Ho-Youn Kim2 and Mi-La Cho2, 1Inje University Ilsan Paik Hospital, Goyang, South Korea, 2Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, 3Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

    Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…
  • Abstract Number: 4 • 2012 ACR/ARHP Annual Meeting

    Pro-Inflammatory Effect of Extracellular RNA On Synovial Fibroblasts From Patients with Rheumatoid Arthritis

    Birgit Zimmermann1, Silvia Fischer2, Markus Rickert3, Stefan Rehart4, Angela Lehr5, Ulf Müller-Ladner6, Klaus T. Preissner2 and Elena Neumann7, 1Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Dept of Biochemistry, Justus-Liebig-University of Giessen, Medical School, Giessen, Germany, 3Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 4Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 5Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 6Dept of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 7Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany

    Background/Purpose: Extracellular RNA (exRNA) is present in the serum of patients suffering of different kinds of cancer. exRNA influences physiological processes like blood coagulation and…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology