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Abstracts tagged "rheumatoid arthritis (RA) and synovial cells"

  • Abstract Number: 2462 • 2014 ACR/ARHP Annual Meeting

    Centrosomal Protein 70kDa Is Down-Regulated By Decoy Receptor 3 in Specifically Rheumatoid Synovial Fibroblasts

    Koji Fukuda1,2, Yasushi Miura2,3, Toshihisa Maeda2, Shinya Hayashi2 and Masahiro Kurosaka2, 1Orthopaedic Surgery, Kakogawa City Hospital, Kakogawa, Japan, 2Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 3Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand, LIGHT, and…
  • Abstract Number: 2450 • 2014 ACR/ARHP Annual Meeting

    Downregulation of Mirna-196a and Its Downstream HOXC8 Target Gene in Rheumatoid Arthritis Synovial Fibroblasts

    Maria Filkova1, Michelle Trenkmann1, Borbala Aradi-Vegh1, Lenka Pleštilová1, Joanna Stanczyk1, Beat A. Michel2, Ladislav Senolt3, Renate Gay1, Steffen Gay4 and Astrid Juengel1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose Comprehensive analysis of 260 miRNAs suggested a downregulation of miR-196a in rheumatoid arthritis (RA) synovial fibroblasts (SF) compared with osteoarthritis (OA) SF. Mature miR-196a…
  • Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting

    Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis

    Yingni Li1, Fanlei Hu2, Li Zheng1, Linchong Su3, Lianjie Shi2, Pei Song1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 3Hubei Minzu University, Enshi, China

    Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
  • Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting

    Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential

    Manuel J. Del Rey1, Regina Faré1, Gabriel Criado2, Alicia Usategui1, Vanessa Miranda1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…
  • Abstract Number: 1461 • 2014 ACR/ARHP Annual Meeting

    Quantitave Analysis of Cadherin-11 and Beta-Catenin Signaling during Proliferation of Rheumatoid Arthritis-Derived Synovial Fibroblast Cells

    Ryosuke Yoshioka, Yasuhiro Kita, Asako Nagahira, Atsushi Manno, Naoyuki Makita, Urara Tomita and Masao Murakawa, Asubio Pharma Co., Ltd., Kobe, Japan

    [Background/Purpose ] Cadherin-11 (CDH11) is a cadherin adhesion molecule that anchors b-catenin, and is involved with various functions of synovial fibroblast cells (SFCs) during the development…
  • Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting

    Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis

    Emiko Shindo, Tomoko Hasunuma, Shotaro Masuoka, Mai Kawazoe, Hiroshi Sato, Natsuki Fujio, Kotaro Shikano, Makoto Kaburaki, Sei Muraoka, Nahoko Tanaka, Kaichi Kaneko, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan

    Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor.  Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…
  • Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting

    Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis

    Lenka Pleštilová1, Niharika Gaur1, Mária Filková2, Borbala Aradi-Vegh1, Ladislav Senolt3, Adrian Ciurea1, Renate E. Gay4, Jiri Vencovsky3, Michel Neidhart5, Steffen Gay5 and Astrid Juengel1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…
  • Abstract Number: 2731 • 2013 ACR/ARHP Annual Meeting

    An Acetyl-Histone Mimetic Blocks Proinflammatory Activation Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    P. A. Kabala1, A.M. Grabiec1, C. Angiolilli1, Nicholas Smithers2, Jason Witherington3, Paul Peter Tak4, Rabinder Prinjha3 and Kris A. Reedquist5, 1Department of Experimental Immunology, Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, 3GlaxoSmithKline, Stevenage, United Kingdom, 4Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, 5Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Genetic backgrounds and environmental factors do not completely explain the etiology of disease and predisposition to rheumatoid arthritis (RA), and increasing attention has turned…
  • Abstract Number: 2424 • 2013 ACR/ARHP Annual Meeting

    Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts

    Sarah Hawtree1, Munitta Muthana1, Sarah Aynsley1, J. Mark Wilkinson2 and Anthony G. Wilson3, 1Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, 3Infection & Immunity, University of Sheffield, Sheffield, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS).…
  • Abstract Number: 1403 • 2013 ACR/ARHP Annual Meeting

    Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Is Expressed In a TNF-Dependent Manner In RA Synovial Tissues

    Borbala Aradi1, Masaru Kato1, Mária Filková2, Stephanie Kasper3, Kerstin Klein1, Michael Bader1, Michael Scharl3, Beat A Michel4, Renate E Gay1, Edit I Buzas5, Steffen Gay1 and Astrid Jüngel1, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3Division of Gastroenterology and Hepatology, University Hospital Zürich and Zürich Center for Integrative Human Physiology, Zurich, Switzerland, 4Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary

    Background/Purpose: Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2) is a protein phosphatase that has been associated with the development of autoimmune diseases in GWA studies.…
  • Abstract Number: 1380 • 2013 ACR/ARHP Annual Meeting

    Histone Modifications In The Interluekin-6 Gene Promoter Region Of Rheumatoid Arthritis Synovial Fibroblasts

    Takuma Tsuzuki Wada1,2, Yasuto Araki1,2, Kazuhiro Yokota1, Fumihiko Miyoshi1, Kojiro Sato1 and Toshihide Mimura1,2, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: , Rheumatoid arthritis (RA) is a disease of unknown origin, which develops continuous inflammation and progressive joint destruction resulting from an autoimmune response mainly…
  • Abstract Number: 1298 • 2013 ACR/ARHP Annual Meeting

    Statin Alleviates Rheumatoid Arthritis Progression Through Diminishing Inflammation Or Oxidative Stress-Induced Cyr61 Synthesis

    Kuo Liang Hou and Sze Kwan Lin, School of Dentistry, College of Medicine National Taiwan University, Taipei, Taiwan

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease stimulated by inflammatory mediators and oxygen species within joint space cause joint deformity and destruction. Excess amounts…
  • Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting

    Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis

    Katalin Mikecz1, Julia Kurko1, Timea Ocsko1, Andras Vida1, Beata Tryniszewska1, Tibor A. Rauch1, Joel A. Block2, Robert S. Katz3, Anjali Nair2, Carla R. Scanzello4 and Tibor T. Glant1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Section of Rheumatology, Rush University Medical Center, Chicago, IL, 3Rush Medical College, Chicago, IL, 4Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
  • Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting

    Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts

    Munitta Muthana1, Holly Davies2, Sachin Khetan3, Gbadebo Adeleke Adeleke4, Sarah Hawtree1 and Anthony G. Wilson5, 1Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 2University of Sheffield, Sheffield, United Kingdom, 3Infection and immunity, Dr, Sheffield, United Kingdom, 4Infection and Immunity, Dr, Sheffield, United Kingdom, 5Infection & Immunity, University of Sheffield, Sheffield, United Kingdom

    Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
  • Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting

    Elevated Frequency of Synovial Interleukin-21+ CD4+ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis

    Maria C. Lebre1, Pedro L. Vieira2, Saïda Aarrass3, Thomas Newsom-Davis2, Paul P. Tak4 and Gavin R. Screaton2, 1Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, 2Department of Immunology, Imperial College London, London, United Kingdom, 3Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, 4Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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