ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and signal transduction"

  • Abstract Number: 85 • 2017 ACR/ARHP Annual Meeting

    Enhanced IFN-γ STAT1 Signaling in CD4 T Cell Populations and Attenuated IL-2 STAT5 Signaling Contribute to the Pathogenesis of Rheumatoid Arthritis (RA)

    Brandon Pope1, Vishal Sharma2, Molly Boland2, Richard Reynolds2, S. Louis Bridges Jr.3 and Chander Raman4, 1Medicine, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 4Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Type I (IFN-α) and type II (IFN-γ) interferons are important mediators of autoimmunity. However, there is conflicting evidence regarding the contribution of IFN-γ to…
  • Abstract Number: 1409 • 2017 ACR/ARHP Annual Meeting

    Ursolic Acid Promotes Apoptosis of Rheumatoid Athritis Synovial Fibroblasts By Upregulating Noxa Expression and Recruiting E3 Ligase Mule to Degrade Mcl-1

    Eugene Kim1, Solomon Agere1, Sadik Khuder2 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Medicine, University of Toledo, Toledo, OH

    Background/Purpose: In our previous study, we discovered that ursolic acid (UA), a pentacyclic triterpenoid with anti-inflammatory properties, induces apoptosis in synovial fibroblasts from rheumatoid arthritis…
  • Abstract Number: 2790 • 2017 ACR/ARHP Annual Meeting

    Regulation of ASK1 Expression and Its Role in Rheumatoid Arthritis (RA)

    Gyrid Nygaard1, Deepa Hammaker2, David L. Boyle3, Li Li4, Julie Di Paolo5 and Gary S. Firestein6, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3University of California San Diego, La Jolla, CA, 4Gilead Sciences, South San Francisco, CA, 5Immunology and Inflammation Biology, Gilead Sciences, Foster City, CA, 6Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) reside in the synovial intimal lining. They display a unique aggressive phenotype, invading the articular cartilage and promoting…
  • Abstract Number: 329 • 2016 ACR/ARHP Annual Meeting

    Explore the Possible Mechanisms of 1,25(OH)2D3 on the Formation of Osteoclasts in Rheumatoid Arthritis

    Hong-yan WEN1, Dan-dan LIU2, Dan-dan WEI2, Fang-fang ZHAO2 and Xiao-feng LI2, 1Rheumatology, Shanxi Medical University, The Second Hospital of Shanxi Medical University, Taiyuan, China, 2Shanxi Medical University, The Second Hospital of Shanxi Medical University, Taiyuan, China

    Background/Purpose: In our previous study, several conclusions are reached like: (1) IL-22 can promote inflammation and osteoclast formation in the process of RA;(2) 1,25(OH)2D3 decreases serum IL-22 level in RA patients, and acts as a…
  • Abstract Number: 3215 • 2016 ACR/ARHP Annual Meeting

    ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS)

    Gyrid Nygaard1, Deepa Hammaker2, David L. Boyle3, Astrid Clarke4, Li Li5, Julie Dipaolo6 and Gary Firestein7, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 4GIlead, South San Francisco, CA, 5Gilead Sciences, South San Francisco, CA, 6Gilead, South San Francisco, CA, 7Medicine, UCSD, La Jolla, CA

    Background/Purpose: RA fibroblast-like synoviocytes (FLS) possess a unique aggressive phenotype characterized by increased cell growth, cytokine production and invasion. Previous unsuccessful attempts to target the…
  • Abstract Number: 1033 • 2015 ACR/ARHP Annual Meeting

    Novel Ligand-Independent Peptide Inhibitors of Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) and T Cell Receptor (TCR): Efficacy in a Collagen-Induced Arthritis Model Suggests New Targeted Treatment for Rheumatoid Arthritis

    Zu T. Shen and Alexander B. Sigalov, SignaBlok, Inc., Shrewsbury, MA

    Background/Purpose: Macrophages and T cells are central to the pathophysiology of autoimmune diseases. Synovial macrophages, synovial fibroblasts and infiltrating T lymphocytes are the most abundant…
  • Abstract Number: 2015 • 2015 ACR/ARHP Annual Meeting

    Targeting Non-Canonical NF-Kappa B Signaling Inhibits Angiogenesis in a Novel 3D Model of Rheumatoid Arthritis Synovial Angiogenesis

    Chrissta X. Maracle1, Paulina Kucharzewska2, Boy Helder1, Arjan W. Griffioen3, Henric K. Olsson2 and Sander W. Tas4, 1Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, 2Astra Zeneca, Mölndal, Sweden, 3Medical Oncology, VU University Medical Center, Amsterdam, Netherlands, 4Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Pathological angiogenesis is a crucial part of disease progression in rheumatoid arthritis (RA) and is often considered the switch from acute to chronic inflammation.…
  • Abstract Number: 1459 • 2014 ACR/ARHP Annual Meeting

    IL-22 Secreted By NKp44+NK Cells Promote the Proliferation of Synovium in Patients with Rheumatoid Arthritis By Activation of STAT3

    Junqing Zhu1, Juan Li1 and Xiaoguang Chen2, 1Nanfang Hospital, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China, 2School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Background/Purpose: Although CD3-CD56+NKp44+ natural Killer cells (NKp44+NK cells) have been linked to autoimmune diseases including inflammatory bowel disease, ankylosing spondylitis, and primary Sjogren's syndrome, the…
  • Abstract Number: 1027 • 2014 ACR/ARHP Annual Meeting

    Hematopoietic Cell Kinase (HCK) As a Novel Regulator of Fibroblast-like Synoviocyte Function in RA

    Ying Wang1, Deepa Hammaker2, David L. Boyle3, Toshio Yoshizawa4 and Gary S. Firestein3, 1Medicine, UCSD, La Jolla, CA, 2Medicine, University of California San Diego, La Jolla, CA, 3Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, 4Exploratory Research Laboratories 1, Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key mediators of inflammation and joint damage in rheumatoid arthritis (RA) through the production of cytokines and matrix metalloproteinases (MMPs)…
  • Abstract Number: 2735 • 2013 ACR/ARHP Annual Meeting

    Integrative Analysis Of Multiple Omics Technologies Reveals a Novel Therapeutic Target For Rheumatoid Arthritis (RA)

    David L. Boyle1, John Whitaker2, Beatrix Bartok3, Wei Wang4 and Gary S. Firestein5, 1Div of Rheum, UCSD School of Medicine, La Jolla, CA, 2Chemistry, UCSD School of Medicine, La Jolla, CA, 3Rheumatology, UCSD School of Medicine, La Jolla, CA, 4Chemistry, UCSD, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose:   Identifying novel therapeutic targets for immune-mediated disease has become increasingly challenging. We used an unbiased method to integrate multiple “omics” methodologies and evaluate…
  • Abstract Number: 2426 • 2013 ACR/ARHP Annual Meeting

    Signaling Abnormalities In Neutrophil Granulocytes Of Rheumatoid Arthritis Patients Are Associated With Increased Extracellular Trap Formation and Provide a Basis For The Induction Of Anti-Citrullinated Peptide Antibodies

    Chanchal Sur Chowdhury1, Stavros Giaglis2,3, Ulrich A. Walker4, Andreas Buser5, Paul Hasler2 and Sinuhe Hahn6, 1Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, 2Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, 4Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, 5Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, 6Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) is often associated with anti-citrullinated peptide antibodies (ACPAs) in the serum. While ACPAs have been associated with increased inflammation, joint destruction…
  • Abstract Number: 2288 • 2013 ACR/ARHP Annual Meeting

    Novel Biomarkers From Peripheral Blood Mononuclear Cells Indicate Disease Activity In Rheumatoid Arthritis Patients

    Jason Ptacek1, Rachael Hawtin2, Brent Louie1, Erik Evensen1, James Cordeiro1, Barbara Mittleman1, Michelle Atallah1, Alessandra Cesano2, Clifton O. Bingham III3, Stacey Cofield4, Jeffrey R. Curtis5, Maria I. Danila4, Richard A. Furie6, MC Genovese7, Marc C. Levesque8, Larry W. Moreland8, Peter A. Nigrovic9, James R. O'Dell10, William H. Robinson11, Nancy A. Shadick9, E. William St Clair12, Christopher C. Striebich13, Geoffrey M Thiele14, Peter K. Gregersen6 and S. Louis Bridges Jr.4, 1Nodality, Inc., South San Francisco, CA, 2Nodality Inc., South San Francisco, CA, 3Rheumatology, Johns Hopkins University, Baltimore, MD, 4University of Alabama at Birmingham, Birmingham, AL, 5Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, 6The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, 7Stanford University, Palo Alto, CA, 8University of Pittsburgh, Pittsburgh, PA, 9Brigham and Women's Hospital/Harvard University, Cambridge, MA, 10Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 11VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 12Medicine, Duke Unversity Medical Center, Durham, NC, 13University of Colorado Denver, Aurora, CO, 14Omaha VA and the University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Biomarkers reflecting immune function and associating with disease activity can help stratify rheumatoid arthritis (RA) patients (pts) in practice and in clinical trials.…
  • Abstract Number: 1859 • 2013 ACR/ARHP Annual Meeting

    OX40+ T Cells and OX40L+ B Cells Accumulate In The Inflamed Joints and OX40 Signalling Is Skewed Towards Autoreactivity

    Julie Kristine Laustsen1, Tue Rasmussen2, Malene Hvid3 and Bent Deleuran4, 1Department of Medical Biomedicine, Aarhus University, Aarhus N, Denmark, 2Dept of Biomedicine, Aarhus University, Aarhus, Denmark, 3Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies and autoreactive T cells, leading to synovitis and joint destruction. The…
  • Abstract Number: 773 • 2013 ACR/ARHP Annual Meeting

    Adioponectin-Induced p38 MAPK and AMPK Pathways In Rheumatoid Arthritis Synovial Fibroblasts Are Adiponectin Isoform Dependent

    Kiran Khawaja1, Klaus W. Frommer1, Stefan Rehart2, Ulf Müller-Ladner1 and Elena Neumann3, 1Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 3Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany

    Background/Purpose: Adiponectin, a C1q/tumour necrosis factor (TNF) homologue, was previously known to be secreted by adipocytes. Additionaly, it was found to be synthesized by other…
  • Abstract Number: 1775 • 2012 ACR/ARHP Annual Meeting

    The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocyte Invasion

    Beatrix Bartok1, Deepa Hammaker2 and Gary S. Firestein3, 1Rheumatology, UCSD, La Jolla, CA, 2MC 0656, Univ of California San Diego, La Jolla, CA, 3Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of RA. Increased cell migration and degradation of extracellular matrix…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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