Abstracts tagged "rheumatoid arthritis (RA) and sex hormones"

Abstract Number: 87 • ACR/ARHP Annual Meeting 2015
Rheumatoid Arthritis (RA) Risk Gene CCR6 Polymorphism: Drug-Induced “Reversal” of ER Binding and the Expression of Inflammatory Mediators -Potential Molecular Mechanism Links Between Estrogen and RA
Ming-Fen Ho¹, Richard M. Weinshilboum², Liewei Wang², James N. Ingle³ and Tim Bongartz⁴, ¹Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, Rochester, MN, ²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, ³Department of Medical Oncology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 SNP rs3093024, is in tight linkage disequilibrium with rs3093023 which has been associated with RA risk. RA…
Abstract Number: 2957 • ACR/ARHP Annual Meeting 2014
The Rheumatoid Arthritis -Risk Locus CCR6 and Its SNP-Dependent Response to Estrogen: A Possible Genomic Link Between Sex Hormones and the IL-17 Inflammatory Pathway
Ming-Fen Ho¹, Richard M. Weinshilboum², Liewei Wang² and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN
Background/Purpose: The CCR6-CCL20–mediated migration of Th17 cells to inflamed tissues may represent an important mechanism in the etiology of rheumatoid arthritis (RA). The CCR6 SNP rs3093023…