ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and serologic tests"

  • Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting

    Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study

    Alistair Reid1,2,3, Michael D Wiese4, Robert Metcalf5, Mihir D Wechalekar6,7, Anita Lee8,9, Catherine Hill2,10,11, Cindy Hall8, Leah McWilliams5, Les Cleland8 and Susanna Proudman12, 1Rheumatology, Royal Adelaide Hospital, NORTH ADELAIDE, Australia, 2Medicine, The University of Adelaide, Adelaide, Australia, 3Medicine, University of Wollongong, Wollongong, Australia, 4School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 5Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, 7Rheumatology, Flinders University, Adelaide, Australia, 8Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 9Rheumatology, University of Adelaide, Adelaide, Australia, 10The Queen Elizabeth Hospital, Adelaide, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia

    Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…
  • Abstract Number: 1389 • 2017 ACR/ARHP Annual Meeting

    Serum Progranulin Antibodies (PGRN-abs) in Rheumatoid Arthritis Patients Being Negative for RF-IgM and ACCP-IgG

    Gunter Assmann1, Silke Zinke2, Moritz Gerling3, Natalie Fadle3, Klaus Dieter Preuss3, Michael Pfreundschuh3 and Lorenz Thurner3, 1Medicine I, University Medical School of Saarland, 66424, Germany, 2Rheumapraxis, Rheumatology Center Berlin - Lichtenberg, Berlin, Germany, 3Medicine I, Jose Carreras Center, University of Saarland, Homburg, Germany

    Background/Purpose: Until recently, most research on progranulin (PGRN) had been focused on its role in neurogenerative diseases as frontotemporal dementia. After the detection of elevated…
  • Abstract Number: 494 • 2016 ACR/ARHP Annual Meeting

    Sensitivity and Specificity of 14-3-3η, Anti-CEP-1 and Anti-Sa Antibodies in a Cohort of Seronegative and Suspected Rheumatoid Arthritis (RA) Patients from a Community Rheumatology Practice

    Dmitry Karayev1, Guoqiu Shen1, Yvonne Lam1, Andrew Rimmer1, Nayan Lal1, Eugene Karayev1, Kristine Azarraga1, Ronald A. Blum1, Allan L. Metzger1, Robert I. Morris1 and Arash A. Horizon2, 1Rheumatology Diagnostics Laboratory, Inc. (RDL), Los Angeles, CA, 2Center for Rheumatology Medical Group, Los Angeles, CA

    Background/Purpose: RA is the most common autoimmune inflammatory joint disease, affecting up to 1% of the world population. Detection of antibodies, specifically against IgM rheumatoid…
  • Abstract Number: 933 • 2016 ACR/ARHP Annual Meeting

    Erosion Patterns in Seropositive and Seronegative Rheumatoid Arthritis: A Joint-By-Joint Approach

    Ottar Gadeholt1, Katharina Hausotter2, Hannes Eberle3, Hans-Peter Tony4, Marc Schmalzing5 and Thorsten Klink2, 1Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 2Radiology, University Clinic Wuerzburg, Wuerzburg, Germany, 3Medicine, Kreiskliniken Esslingen, Nürtingen, Germany, 4Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, 5Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany

    Background/Purpose: Rheumatoid arthritis (RA) can be differentiated according to rheumatoid factor (RF) and citrullinated peptide antibodies (ACPA). It is unclear whether seropositive RA (spRA) and…
  • Abstract Number: 2697 • 2015 ACR/ARHP Annual Meeting

    Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association Between Seronegative Disease and Fibromyalgia

    Jayanth Doss1, Huan Mo2, Leslie J. Crofford1 and Joshua C. Denny2, 1Rheumatology, Vanderbilt University School of Medicine, Nashville, TN, 2Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN

    Background/Purpose: The differences between seronegative and seropositive rheumatoid arthritis (RA) have not been widely reported. We performed an electronic health record (EHR)-based phenome-wide association study…
  • Abstract Number: 2161 • 2014 ACR/ARHP Annual Meeting

    Interest of Systematic Lyme Serology in Context of Recent Onset Arthritis

    Dewi Guellec1, Valérie Narbonne2, Divi Cornec3, Thierry Marhadour4, Maxime Dougados5, Jean-Pierre Daures6, Sandrine Jousse-Joulin1, Valerie Devauchelle7 and Alain Saraux8, 1Rheumatology, CHU Brest, Brest, France, 2Microbiology, CHU Brest, Brest, France, 3Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, 4Rheumatology, CHU de la Cavale Blanche, Brest, France, 5INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, 6Biostatistic, INSERM, Montpellier, France, 7Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, 8Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France

    Background/Purpose Lyme arthritis is a late manifestation of a tick-transmitted spirotechal infection, mainly caused by Borrelia burdorgferi. Lyme arthritis typically presents as a mono- or…
  • Abstract Number: 1054 • 2014 ACR/ARHP Annual Meeting

    Rheumatoid Factor, Not ACPA, Is Associated with Disease Activity in Rheumatoid Arthritis

    Daniel Aletaha1, Farideh Alasti2 and Josef Smolen3, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3PsAID taskforce, EULAR, Zurich, Switzerland

    Background/Purpose To investigate the associations of rheumatoid factor (RF) and autoantibodies against citrullinated proteins (ACPA) with rheumatoid arthritis (RA) disease activity.Methods We analyzed the association…
  • Abstract Number: 1788 • 2013 ACR/ARHP Annual Meeting

    The Multi-Biomarker Disease Activity Test (Vectra® DA) Estimates Risk Of Radiographic Progression For Patients With Rheumatoid Arthritis From The Leiden Early Arthritis Clinic

    Wanying Li1, DJ Haney1, Guy Cavet1, Thomas W. Huizinga2, Eric H. Sasso1 and A. H. M. van der Helm-van Mil3, 1Crescendo Bioscience Inc., South San Francisco, CA, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The multi-biomarker disease activity (MBDA) blood test assesses disease activity in patients with rheumatoid arthritis (RA) using a validated algorithm to provide a score…
  • Abstract Number: 1704 • 2013 ACR/ARHP Annual Meeting

    Mapping The Shared and Distinct HLA Alleles For Seropositive and Seronegative Rheumatoid Arthritis

    Buhm Han1, Stephen Eyre2, Dorothee Diogo1, John Bowes3, Yukinori Okada1, Leonid Padyukov4, Robert M. Plenge5, Lars Klareskog6, Jane Worthington7, Peter K. Gregersen8, Paul de Bakker9 and Soumya Raychaudhuri1, 1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 4Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 5Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 6Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 7Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 8Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 9Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Investigators have long speculated that the two subtypes of rheumatoid arthritis (RA), anti-citrullinated protein autoantibody positive (ACPA+) and negative (ACPA-), have distinct underlying genetic…
  • Abstract Number: 2118 • 2012 ACR/ARHP Annual Meeting

    Validation of Prognostic Biomarkers for RA: Testing of 14-3-3 Eta According to the Omeract Soluble Biomarker Criteria

    Walter P. Maksymowych1, Désirée van der Heijde2, R. Landewe3, George A. Wells4, Joan M. Bathon5, Clifton O. Bingham III6, Vivian P. Bykerk7, Mikkel Ostergaard8, Hilde B. Hammer9, Maarten Boers10, Paul Peter Tak11, Oliver M. FitzGerald12, Christopher T. Ritchlin13, Dafna D. Gladman14, Philip J. Mease15, Dirkjan van Schaardenburg16, Marina Backhaus17, Bernard Combe18, Gianfranco Ferraccioli19 and Anthony Marotta20, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 4Epidemiology & Community Med, Univ of Ottawa Faculty of Med, Ottawa, ON, Canada, 5Columbia University, New York, NY, 6Rheumatology, Johns Hopkins University, Baltimore, MD, 7Rheumatology, Hospital for Special Surgery, New York, NY, 8Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, 9Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 10Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 11Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 12Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 13Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 14Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 15Swedish Rheumatology Research Group, Seattle, WA, 16Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 17Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, 18Rheumatology, Hopital Lapeyronie, Montpellier, France, 19Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 20Augurex Life Sciences Corp, North Vancouver, BC, Canada

    Background/Purpose: The OMERACT soluble biomarker sub-committee has published validation criteria related to truth, discrimination and feasibility for biomarkers reflecting structural damage1. The large majority of…
  • Abstract Number: 977 • 2012 ACR/ARHP Annual Meeting

    14-3-3 Eta Is a Novel Citrullination Target in Rheumatoid Arthritis That Enhances Diagnostic Utility in Anti-CCP Negative Patients

    Walter P. Maksymowych1, Vivian P. Bykerk2, Désirée van der Heijde3, R. Landewe4 and Anthony Marotta5, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 5Augurex Life Sciences Corp, North Vancouver, BC, Canada

    Background/Purpose: 14-3-3 eta is normally an intracellular protein and only in the disease state is it released into the extracellular space. We have previously presented…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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