Abstracts tagged "rheumatoid arthritis (RA) and safety"

Abstract Number: 1045 • 2013 ACR/ARHP Annual Meeting
Under Reporting Of Cataracts In Randomised Controlled Trials Investigating The Use Of Systemic Glucocorticoids In Patients With Rheumatoid Arthritis
Rachel J. Black^1,2 and William G. Dixon³, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Department of Medicine, The University of Adelaide, Adelaide, Australia, ³The University of Manchester, Manchester, United Kingdom
Background/Purpose: Oral glucocorticoid (GC) therapy is used in more than half of patients with rheumatoid arthritis (RA). Cataracts are a recognised treatment-related side effect of…
Abstract Number: 433 • 2013 ACR/ARHP Annual Meeting
Retrospective Analysis Of Certolizumab Pegol Use During Pregnancy: Update Of Impact On Birth Outcomes
Megan E. B. Clowse¹, Douglas C. Wolf², Frauke Förger³, John J. Cush⁴, Christian Stach⁵, Gordana Kosutic⁶, Susan Williams⁶, Chidi Maduka⁶ and Uma Mahadevan⁷, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Atlanta Gastroenterology Associates, Atlanta, GA, ³Department of Rheumatology and Clinical Immunology and Allergology, Inselspital, University of Bern, Bern, Switzerland, ⁴Baylor Research Institute and Baylor University Medical Center, Dallas, TX, ⁵UCB Pharma, Monheim, Germany, ⁶UCB Pharma, Raleigh, NC, ⁷UCSF Medical Center, San Francisco, CA
Background/Purpose: Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF approved in 45 countries for the treatment of rheumatoid arthritis (RA) and/or Crohn's disease (CD). An…
Abstract Number: 2378 • 2013 ACR/ARHP Annual Meeting
Safety Of Mavrilimumab In Cynomolgus Monkeys: Relevance Of Nonclinical Findings In Lung To Human Safety
Patricia C. Ryan¹, Matthew A. Sleeman², Marlon Rebelatto¹, Bing Wang³, Hong Lu⁴, Chi-Yuan Wu³, Dee Wilkins¹, Susan Spitz¹, Gopi Ranganna⁵, Alex Godwood⁶, Alex Michaels⁷, Didier Saurigny⁶, Lorin Roskos⁸, David Close⁶, Heidi Towers⁹, Kathleen McKeever¹ and Rakesh Dixit⁷, ¹Translational Sciences, MedImmune, Gaithersburg, MD, ²Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, United Kingdom, ³Clinical Pharmacology and DMPK, Medimmune, Mountain View, CA, ⁴Translational Sciences, MedImmune, Hayward, CA, ⁵Clinical Development, MedImmune, LLC, Cambridge, United Kingdom, ⁶MedImmune, Ltd, Cambridge, United Kingdom, ⁷MedImmune, Gaithersburg, MD, ⁸One MedImmune Way, Medimmune, Gaithersburg, MD, ⁹MedImmune, LLC, Cambridge, United Kingdom
Background/Purpose: GM-CSF plays a central role in the pathogenesis of rheumatoid arthritis (RA) through the activation, differentiation, and survival of macrophages and neutrophils. Mavrilimumab (CAM-3001)…
Abstract Number: 1573 • 2012 ACR/ARHP Annual Meeting
Baseline Screening Recommendations for Rheumatoid Arthritis Patients Treated with Disease Modifying Anti-Rheumatic Drugs: Does an Educational Intervention Change Practice in an Outpatient Clinic?
Debra C. Lloyd¹, John N. Mecchella² and Daniel Albert³, ¹Rheumatology, Dartmouth-Hitchcock Med Ctr, Lebanon, NH, ²Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ³Rheumatology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Lebanon, NH
Background/Purpose: In 2008, the American College of Rheumatology (ACR) developed recommendations for use of non-biologic and biologic DMARDs in the treatment of rheumatoid arthritis (RA). …
Abstract Number: 486 • 2012 ACR/ARHP Annual Meeting
Impact of Adalimumab Therapy On Laboratory Parameters of Interest in Patients with Early or Long-Standing Rheumatoid Arthritis
Daniel Furst¹, Ana P. Lacerda², Nupun Andhivarothai³, Jasmina Kalabic⁴ and Neelufar Mozaffarian³, ¹David Geffen School of Medicine, Div of Rheumatology, University of California at Los Angeles, Los Angeles, CA, ²Abbott Laboratories, São Paulo, Brazil, ³Abbott Laboratories, Abbott Park, IL, ⁴Abbott GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: The systemic inflammation of rheumatoid arthritis (RA) can have detrimental effects on the hematopoietic and cardiovascular systems. Additionally, effective DMARD treatments for RA can…
Abstract Number: 342 • 2012 ACR/ARHP Annual Meeting
Novel Combination Therapy of Existing Repurposed Therapies, Designed by Predictive Software Modeling, Shows Profound Impact On Disease Progression in a Murine Collagen-Induced Arthritis Model
Shireen Vali¹, Canio Refino², Jay Dela Cruz², Robinson Vidva¹, Prashant Nair¹, Saumya Radhakrishnan¹, Pradeep Fernandes¹, Taher Abbasi¹ and Gurkirpal Singh³, ¹CellWorks Group, Saratoga, CA, ²InTouch Bio, Alameda, CA, ³Gastroenterology/Hepatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Rheumatoid Arthritis (RA) involves a complex interaction of multiple cell systems, cytokines and mediators. We recently developed a predictive software-based mathematical model that emulates…

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