ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and rituximab"

  • Abstract Number: 1466 • 2017 ACR/ARHP Annual Meeting

    The Effects of Rituximab and B-Cells Depletion on the Inflammatory and Pro-Thrombotic Profile of Leucocytes of Rheumatoid Arthritis Patients and on the Vascular Endothelium

    Irene Cecchi1, Carlos Perez-Sanchez2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Maria Carmen Abalos-Aguilera3, Yolanda Jiménez-Gómez2, Rafaela Ortega-Castro2, Eduardo Collantes-Estévez2, Alejandro Escudero-Contreras3, Massimo Radin4, Nuria Barbarroja2, Dario Roccatello5, Savino Sciascia6 and Chary Lopez-Pedrera7, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 7IMIBIC/Reina Sofia Hospital/ University of Cordoba, Cordoba, Spain

    Background/Purpose: Cardiovascular disease (CVD) constitutes a relevant cause of morbidity and mortality in Rheumatoid Arthritis (RA) patients. Rituximab (RTX) has been proved to be effective…
  • Abstract Number: 1472 • 2017 ACR/ARHP Annual Meeting

    Body Mass Index Does Not Affect Response to Rituximab in Patients with Rheumatoid Arthritis: Results from Turkbio Registry

    Suleyman Serdar Koca1, Ahmet Karatas2, Burak Oz3, Ediz Dalkilic4, Gerçek Can5, Yavuz Pehlivan6, Ayten Yazici7, Nevsun Inanc8, Ayse Cefle9, Zeypen Erturk10, Servet Akar11, Soner Senel12, Merih Birlik13, Nurullah Akkoc14 and Fatos Onen15, 1Department of Rheumatology, Firat University School of Medicine, Elazig, Turkey, 2Department of Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 3Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 4Department of Internal Medicine, Division of Rheumatology, Uludag University, School of Medicine, Rheumatology, Bursa, Turkey, 5Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 6Department of Rheumatology, Uludag University, Bursa, Turkey, 7Rheumatology, Kocaeli University, Kocaeli, Turkey, 8Departement of İnternal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, 9Rheumatology, Kocaeli University, School of Medicine, Rheumatology, Kocaeli, Turkey, 10Department of Rheumatology, Marmara Univeristy School of Medicine, Istanbul, Turkey, 11Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, Izmir, Turkey, 12Rheumatology, Kayseri Erciyes University, School of Medicine, Rheumatology, Kayseri, Turkey, 13Department of Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, 14Rheumatology, Private Practice, Rheumatology, İzmir, Turkey, 15Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey

    Background/Purpose: Adipose tissue produces several inflammatory mediators. Thus, obesity affects the disease course and the responses to the anti-rheumatic agents in inflammatory diseases. Several previous…
  • Abstract Number: 366 • 2016 ACR/ARHP Annual Meeting

    Peripheral Osteoclastogensis Is Coming Back Along with Inflammation Twelve Months after Rituximab Therapy

    Mie Jin Lim1, Won Park2, Seong-Ryul Kwon3 and Kyong-Hee Jung4, 1Division of Rheumatology, Departments of Internal Medicine, Inha University Hospital, Incheion, South Korea, 2Medicine/Rheumatology, IN-HA University Hospital, Choong-Gu Incheon, Korea, Republic of, 3Center for Rheumatism, Inha University Hospital, Incheon, South Korea, 4Hospital for Rheumatic Disease, Hanyang Univ Medical Center, Seoul, South Korea

    Background/Purpose: We investigated change of bone turnover markers in peripheral blood before, 6 and 12 months after rituximab therapy in seropositive RA patients. Methods: Ten…
  • Abstract Number: 1580 • 2016 ACR/ARHP Annual Meeting

    Impact of Rituximab on Patient-Reported Outcomes in Patients with Rheumatoid Arthritis from the US Corrona Registry

    Leslie R Harrold1, Ani John2, Jennie Best2, Steve Zlotnick2, Chitra Karki3, YouFu Li4, Jeffrey D. Greenberg5 and Joel Kremer6, 1UMass Medical School, Worcester, MA, 2Genentech, Inc., South San Francisco, CA, 3Corrona, LLC, Southborough, MA, 4University of Massachusetts Medical School, Worcester, MA, 5New York University School of Medicine, New York, NY, 6The Center for Rheumatology, Albany Medical College, Albany, NY

    Background/Purpose: Patients with rheumatoid arthritis (RA) experience diminished quality of life and increased disability. Patient-reported outcomes (PROs) are important measures of response to therapy in…
  • Abstract Number: 1634 • 2016 ACR/ARHP Annual Meeting

    Pharmacokinetics and Safety of Three Formulations of Rituximab (CT-P10, US-sourced Innovator Rituximab and EU-sourced Innovator Rituximab) in Patients with Rheumatoid Arthritis: Results from Phase 3 Randomized Controlled Trial over 24 Weeks

    Chang-Hee Suh1, Alfredo Berrocal Kasay2, Elias Chalouhi El-Khouri3, Pedro Miranda4, Ljubinka Bozic Majstorovic5, Slawomir Jeka6, Pawel Hrycaj7, Dmytro Rekalov8, Piotr Wiland9, Andreas Krause10, Istvan Szombati11, Anna Mihailova12, Ihor Hospodarskyy13, Mariusz Piotrowski14, Seong-Ryul Kwon15, Eun-Young Lee16, Dae-Hyun Yoo17, Won Park18, Seung-Cheol Shim19, Sang-Joon Lee20 and Taek S. Kwon20, 1Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea, The Republic of, 2ABK Reuma SRL – Medicentro Biociencias, Lima, Peru, 3Clinica Internacional, Lima, Peru, 4Centro De Estudios Reumatológicos, Santiago, Chile, 5Clinical Centre Banja Luka, Bonja Luka, Bosnia and Herzegovina, 6Department of Rheumatology and Connective Tissue Diseases, 2nd University Hospital, CM UMK, Bydgoszcz, Poland, 7Rheumatology and Clinical Immunology, Poznañ University of Medical Sciences, Poznan, Poland, 8Department of Internal Diseases, Zaporizhzhia Regional Hospital, Zaporozhe, Ukraine, 9Uniwersytecki Szpital Kliniczny im. Jana Mikulicza- Radeckigo, Wroclaw, Poland, 10Medical Centre for Rheumatology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 11QUALICLINIC Kft., Budapest, Hungary, 12Orto clinic Ltd., Riga, Latvia, 13Ternopil State Medical University, Ternopil, Ukraine, 14Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland, Lublin, Poland, 15Internal Medicine/Rheumatology, Inha University Hospital, Incheon, South Korea, 16Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 17Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 18Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 19Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea, 20CELLTRION, Inc., Incheon, South Korea

    Pharmacokinetics and Safety of Three Formulations of Rituximab (CT-P10, US-sourced Innovator Rituximab and EU-sourced Innovator Rituximab) in Patients with Rheumatoid Arthritis: Result from Phase 3…
  • Abstract Number: 1635 • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of CT-P10, Rituximab Biosimilar Candidate, and Innovator Rituximab in Patients with Rheumatoid Arthritis: Results from Phase 3 Randomized Controlled Trial over 24 Weeks

    Dae-Hyun Yoo1, Ljubinka Bozic Majstorovic2, Alfredo Berrocal Kasay3, Elias Chalouhi El-Khouri4, Fedra Irazoque-Palazuelos5, Francisco Cons Molina6, Pedro Miranda7, Pavel Shesternya8, Francisco G. Medina-Rodriguez9, Piotr Wiland10, Slawomir Jeka11, Olena Garmish12, Pawel Hrycaj13, Dmytro Rekalov14, Natalia Fomina15, Devy Zisman16, Yong-Beom Park17, Young Mo Kang18, Chang-Hee Suh19, Seung Cheol Shim20, Sang Joon Lee21, Sung Young Lee22 and Won Park23, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Clinical Centre Banja Luka, Bonja Luka, Bosnia and Herzegovina, 3ABK Reuma SRL – Medicentro Biociencias, Lima, Peru, 4Clinica Internacional, Lima, Peru, 5Centro de Invstigacion y Tratamiento Reumatologico S.C, Mexico City, Mexico, 6Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Mexico, 7Centro De Estudios Reumatológicos, Santiago, Chile, 8State Budgetary Educational Institution of High Professional Education "Krasnoyarsk state medical university n.a. professor V.F.Voino-Yasenetsky" Ministry of Health of Russian Federation, Krasnoyarsk, Russian Federation, 9Biologics Especializados SA, Mexico City, Mexico, 10Uniwersytecki Szpital Kliniczny im. Jana Mikulicza- Radeckigo, Wroclaw, Poland, 11Department of Rheumatology and Connective Tissue Diseases, 2nd University Hospital, CM UMK, Bydgoszcz, Poland, 12Institute of Cardiology named by M.D. Strazhesko NAMS of Ukraine, Kyiv, Ukraine, 13Rheumatology and Clinical Immunology, Poznañ University of Medical Sciences, Poznan, Poland, 14Department of Internal Diseases, Zaporizhzhia Regional Hospital, Zaporozhe, Ukraine, 15Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation, 16The Lady Davis, Haifa, Israel, 17Dept of Internal Medicine, Severance Hospital, Seoul, Korea, The Republic of, 18Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of, 19Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea, The Republic of, 20Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea, 21CELLTRION, Inc., Incheon, South Korea, 22Clinical Planning Department, CELLTRION, Inc., Incheon, South Korea, 23Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea

    Efficacy and Safety of CT-P10, Rituximab Biosimilar Candidate, and Innovator Rituximab in Patients with Rheumatoid Arthritis: Result from Phase 3 Randomized Controlled Trial over 24…
  • Abstract Number: 2000 • 2016 ACR/ARHP Annual Meeting

    Incidence of Cancer in Patients with Rheumatoid Arthritis and a History of Cancer Treated with Rituximab or Abatacept

    Jacques-Eric Gottenberg1, Philippe Ravaud2, Thomas Bardin3, Alain Cantagrel4, Bernard Combe5, Maxime Dougados6, RENE MARC FLIPO7, Olivier Vittecoq8, Thierry Schaeverbeke9, Isabelle Pane10, Jean Sibilia11, Xavier Mariette12 and on behaf of all of the investigators of the AIR registry and of the French Society of Rheumatology , 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Epidemiology, Hotel Dieu, PARIS, France, 3Clinique de Rhumatologie, Hopital Lariboisiere, Paris Cedex 10, France, 4Rheumatology, INSERM CNRS UMR 1043, Paul Sabatier University Toulouse, Purpan Teaching Hospital, Toulouse, France, 5Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 6Rheumatology, Paris Descartes University, Paris, France, 7Rheumatology, Department of Rheumatology, CHU Teaching Hospital Lille, France., Lille, France, 8INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 9Rheumatology, CHU Bordeaux, Bordeaux, France, 10Epidemiology, Hotel Dieu, Paris, France, 11Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 12Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

    Background/Purpose: Patients with a history of cancer were excluded from pivotal clinical trials evaluating biologics. Therefore, only registries can inform us on the incidence of…
  • Abstract Number: 2117 • 2016 ACR/ARHP Annual Meeting

    B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab

    Geraldine Cambridge1, Rita A. Moura2, Venkat Reddy3 and Maria J. Leandro1, 1Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 2Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
  • Abstract Number: 3089 • 2016 ACR/ARHP Annual Meeting

    Predicting the Response to TNF Inhibition or B Cell Depletion Therapy from Peripheral Whole Blood Gene Expression Profiles in Patients with Rheumatoid Arthritis

    Duncan Porter1, C. S. Goodyear2, J. S. Nijjar1, Martina Messow3, Stefan Siebert1, Manikhandan Mudaliar4 and Iain B. McInnes5, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom, 4Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom, 5Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Great Britain

    Background/Purpose: The ORBIT study demonstrated that rituximab is non-inferior to a TNFi-first strategy in biologic naive, sero-positive patients with active RA over 12 months (Lancet…
  • Abstract Number: 1641 • 2015 ACR/ARHP Annual Meeting

    B Cell Depletion with Rituximab in Patients with Rheumatoid Arthritis: Multiplex Bead Array Reveals Kinetics of IgG and IgA Autoantibodies to Citrullinated Antigens

    Geraldine Cambridge1, Lauren J. Lahey2, Maria J. Leandro1, William H. Robinson3 and Jeremy Sokolove4, 1Rheumatology, University College London, London, United Kingdom, 2Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, 3VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 4Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA

    Background/Purpose: Seropositivity for rheumatoid factors and anti-citrullinated (Cit) protein antibodies (ACPA) are the strongest predictor for clinical response to rituximab (RTX) in rheumatoid arthritis (RA).…
  • Abstract Number: 1668 • 2015 ACR/ARHP Annual Meeting

    Patterns of Relapse in the Rheumatoid Arthritis Cohort Treated with Rituximab at University College London

    Elena Becerra, Geraldine Cambridge, Inmaculada de la Torre and Maria J. Leandro, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom

    Patterns of relapse in the Rheumatoid Arthritis cohort treated with Rituximab at University College LondonBackground/Purpose: Two patterns of relapse were defined in the first studies…
  • Abstract Number: 1942 • 2015 ACR/ARHP Annual Meeting

    B Cell Depletion By Rituximab in Lymphocyte Subpopulations from Peripheral Blood in Patients with Rheumatoid Arthritis

    Leticia Merino-Meléndez1, Jorge López-López2, Irene Llorente1, Santos Castañeda3, Federico Herrera2, Teresa Velasco4, Lorena Vega5, Francisco Rodriguez5, Jose María Alvaro-Gracia3, Rosario Garcia-Vicuña6, Cecilia Muñoz-Calleja2 and Isidoro Gonzalez-Alvaro7, 1Rheumatology, H.U. La Princesa, Madrid, Spain, 2Immunology, Hospital Universitario de La Princesa, Madrid, Spain, 3Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 4Rheumatology, H.U La Princesa, Madrid, Spain, 5H.U. La Princesa, Madrid, Spain, 6Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 7Hospital Univ. de La Princesa, IIS Princesa, Madrid, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease that leads to inflammation of the joints and other tissues. Rituximab (Rtx) is a therapeutic monoclonal antibody…
  • Abstract Number: 2058 • 2015 ACR/ARHP Annual Meeting

    Efficacy and Safety of Rituximab Biosimilar Candidate (CT-P10) and Innovator Rituximab in Patients with Rheumatoid Arthritis: Results from Phase I Randomized Controlled Trial over 72 Weeks

    Dae-Hyun Yoo1, Won Park2, Chang-Hee Suh3, Seung-Cheol Shim4, Slawomir Jeka5, Fidencio Cons Molina6, Pawel Hrycaj7, Wolfgang Spieler8, Piotr Wiland9, Jan Brzezicki10, Eun Young Lee11, Francisco G. Medina-Rodriguez12, Pavel Shesternya13, Sebastiao Radominski14, Marina Stanislav15, Volodymyr Kovalenko16, Donghyuk Sheen17, Leysan Myasoutova18, Mie Jin Lim19, Jung-Yoon Choe20, Taek S. Kwon21 and Sang Joon Lee21, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 3Department of Rheumatology, Ajou University Hospital, Suwon, South Korea, 4Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea, 5University Hospital Nr 2 Dr. Jan Biziel, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Clinic of Rheumatology and Connective Tissue Diseases, Bydgoszcz, Poland, 6Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Mexico, 7Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland, 8Osteologie und Rheumatologie, ZeFOR GmbH Zentrum für Forschung, Zerbst, Germany, 9Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland, 10Wojewodzki Szpital Zespolony w Elablagu, Elblag, Poland, 11Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 12Rheumatology, LaSalle University, Mexico City, Mexico, 13Rheumatology Department, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 14CETI-Centro de estudos em Terapias Inovadoras, Universidade Federal do Parana, Curitiba, Brazil, 15Research Rheumatology Institute n. a. V.A. Nassonova, Moscow, Russia, 16Section of Non-coronarogenic Myocardial Diseases and Clinical Rheumatology, National Scientific Center, Kiev, Ukraine, 17Rheumatology, Eulji University Hospital, Daejeon, South Korea, 18City Reumatology Center, Research Medical Complex Vashe Zdorovie, Kazan, Russia, 19Division of Rheumatology, Departments of Internal Medicine, Inha University Hospital, Incheion, South Korea, 20Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, South Korea, 21CELLTRION, Inc., Incheon, South Korea

    Background/Purpose: CT-P10 is a biosimilar candidate of innovator rituximab (RTX). PK profile and clinical data up to week 24 has been reported at ACR 20131.…
  • Abstract Number: 494 • 2015 ACR/ARHP Annual Meeting

    High C-Reactive Protein at Baseline Is Associated with Long-Term Treatment Persistence in Patients with Rheumatoid Arthritis Treated with Rituximab

    Maria Joao Gonçalves1,2, Geraldine Cambridge3 and Maria J. Leandro3, 1Rheumatology Department, Centre for Rheumatology and Bloomsbury Rheumatology Unit, University College London, London, United Kingdom, 2Rheumatology Department, Lisbon Academic Medical Centre, Lisbon, Portugal, 3Centre for Rheumatology and Bloomsbury Rheumatology Unit, University College London, London, United Kingdom

    Background/Purpose: B cell depletion with rituximab (RTX) is an established treatment for RA. It was first introduced at UCL in 1998 and at this centre…
  • Abstract Number: 565 • 2015 ACR/ARHP Annual Meeting

    Factors Associated with Sustained Response in Patients with Rheumatoid Arthritis Who Received Rituximab within the US Corrona Registry

    Leslie Harrold1,2, Ani John3, George W. Reed1, Chitra Karki2, Robert Magner1, Joel M. Kremer4, Ashwini Shewede3 and Jeffrey Greenberg2,5, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Southborough, MA, 3Genentech, Inc., South San Francisco, CA, 4Albany Medical College and The Center for Rheumatology, Albany, NY, 5NYU School of Medicine, New York, NY

    Background/Purpose: The goal of treatment for patients with rheumatoid arthritis (RA) is to achieve and maintain low disease activity (LDA) or remission. Little information is…
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