ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and rheumatoid arthritis"

  • Abstract Number: 2437 • 2017 ACR/ARHP Annual Meeting

    Long-Term Effect of Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, on Radiographic Progression in Patients with Active Rheumatoid Arthritis Despite Disease-Modifying Anti-Rheumatic Drug Treatment: Results of a Global Phase 3 Trial

    George Karpouzas1, Tsutomu Takeuchi2, Carter Thorne3, Shihong Sheng4, Regina Kurrasch5, Kaiyin Fei4 and Benjamin Hsu4, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Keio University School of Medicine, Tokyo, Japan, 3University of Toronto, Newmarket, ON, Canada, 4Janssen Research & Development, LLC, Spring House, PA, 5GlaxoSmithKline, Collegeville, PA

    Background/Purpose: In the SIRROUND-D study, sirukumab (SIR), a human monoclonal antibody that selectively binds to the IL-6 cytokine with high affinity, significantly reduced radiographic progression…
  • Abstract Number: 2472 • 2017 ACR/ARHP Annual Meeting

    Integrated Phase 3 Safety Results of Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis

    Daniel Aletaha1, Carter Thorne2, Michael Schiff3, Masayoshi Harigai4, Prasheen Agarwal5, Ravi Rao6, Christopher Cohen7, Ben Cheng5, Kurt Brown7 and Benjamin Hsu5, 1Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2University of Toronto, Newmarket, ON, Canada, 3University of Colorado School of Medicine, Aurora, CO, 4Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 5Janssen Research & Development, LLC, Spring House, PA, 6GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, 7GlaxoSmithKline, Collegeville, PA

    Background/Purpose: Sirukumab (SIR), a human monoclonal antibody that selectively binds to the IL-6 cytokine with high affinity, is in development for rheumatoid arthritis (RA) in…
  • Abstract Number: 2473 • 2017 ACR/ARHP Annual Meeting

    Sirukumab Subcutaneous Dose Regimens Maintain Clinical Response over Dosing Intervals in Rheumatoid Arthritis Patients: Results from a Phase 3 Study

    David M. Brooks1, Michael Plotnick2, Nicola J. Williams3, Regina Kurrasch1, Yanli Zhuang2, Debra J. Tompson3, Benjamin Hsu2 and Ravi Rao3, 1GlaxoSmithKline, Collegeville, PA, 2Janssen Research & Development, LLC, Spring House, PA, 3GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose:   Sirukumab (SIR), a human monoclonal antibody that selectively binds to the IL-6 cytokine with high affinity, has demonstrated efficacy in rheumatoid arthritis (RA)…
  • Abstract Number: 988 • 2016 ACR/ARHP Annual Meeting

    Risk of Rheumatoid Arthritis after Transfusion of Blood from Donors Later Diagnosed with  Rheumatoid Arthritis: A Retrospective Cohort Study

    Søren Andreas Just1, Kjell Titlestad2, Gustaf Edgren3, Klaus Rostgaard4, Johan Askling5, Hanne Lindegaard1 and Henrik Hjalgrim4, 1Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, 2Department of Clinical Immunology, Department of Clinical Immunology, Odense Unversity Hospital, Odense, Denmark, Odense, Denmark, 3Department of Medical Epidemiology and Biostatistics, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 4Epidemiology Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Copenhagen, Denmark, 5Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Rheumatoid Arthritis (RA) is a disease that can have a long sub-clinical phase. During this phase the person with pre-RA could have factors in…
  • Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting

    Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis

    Adrienn Markovics1, Timea Ocsko1, Robert S. Katz2, Edit I Buzas3, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3Semmelweis University, Budapest, Hungary

    Background/Purpose:  Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
  • Abstract Number: 2650 • 2016 ACR/ARHP Annual Meeting

    Prediction of Inhibition of Radiographic Progression By Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis Despite Disease-Modifying Anti-Rheumatic Drug Treatment: Results of a Global, Phase 3 Trial

    George Karpouzas1, Tsutomu Takeuchi2, Carter Thorne3, Shihong Sheng4, Xiaoming Li4, Ravi Rao5, Kaiyin Fei4 and Benjamin Hsu4, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 3University of Toronto and Southlake Regional Health Centre, Toronto, ON, Canada, 4Janssen Research & Development, LLC, Spring House, PA, 5GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose:  In the SIRROUND-D study, sirukumab, a human anti–IL-6 cytokine monoclonal antibody, significantly reduced radiographic progression after 52 wks of treatment vs placebo in patients…
  • Abstract Number: 3150 • 2016 ACR/ARHP Annual Meeting

    The Initial Dose of Methotrexate per Weight Is Determinant of Disease Activity and Early DAS28 Remission in DMARD-Naive Early Rheumatoid Arthritis Patients Receiving Usual Care

    Tuomas Rannio1, Juha Asikainen2, Pekka Hannonen2, Timo Yli-Kerttula3, Päivi Ekman4, Laura Kuusalo5, Laura Pirilä6, Markku Mali7, Marja Puurtinen-Vilkki7, Satu Kortelainen7, Johanna Paltta6, Kirsi Taimen7, Markku J. Kauppi8, Kari Laiho9, Satu Nyrhinen9, Heidi Mäkinen10, Pia Isomäki10, Terhi Uotila10, Kalle Aaltonen11, Hannu Kautiainen12 and Tuulikki Sokka-Isler1, 1Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, 2Jyvaskyla Central Hospital, Jyväskylä, Finland, 3Sairaalantie 3, Satakunta Central Hospital, Rauma, Finland, 4Satakunta Central Hospital, Rauma, Finland, 5Rheumatology, Turku University Central Hospital, Turku, Finland, 6Turku University Hospital, Turku, Finland, 7Turku University Central Hospital, Turku, Finland, 8Department of Rheumatology, Päijät-Häme Central Hospital, Lahti, Finland, 9Päijät-Häme Central Hospital, Lahti, Finland, 10Tampere University Hospital, Tampere, Finland, 11Helsinki University, Helsinki, Finland, 12Unit of Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

      Background/Purpose: Methotrexate (MTX) is considered as the anchor disease modifying antirheumatic drug (DMARD) in treatment of rheumatoid arthritis (RA). However, there is no advice…
  • Abstract Number: 3217 • 2016 ACR/ARHP Annual Meeting

    Broad-Based Interrogation of the Serum Proteome Suggests That RA Onset Is Associated with Activation of the Intrinsic Coagulation Cascade

    Liam O'Neil1, Xiaobo Meng2, Irene Smolik3, Carol Hitchon2 and Hani El-Gabalawy4, 1Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba Arthritis Center, Winnipeg, MB, Canada

    Background/Purpose: The establishment of longitudinal pre-clinical RA cohorts is beginning to provide important insights into the mechanisms that precede the onset of clinically detectable disease.…
  • Abstract Number: 469 • 2016 ACR/ARHP Annual Meeting

    Role of Microbiota in Development of Autoimmune Arthritis

    Widian Jubair1, Jason Hendrickson2, Sumitra Adhikari3, Nirmal Banda3, Diana Ir4, Charles Robertson4, Daniel Frank4 and Kristine Kuhn2, 1Rheumatology, University of Colorado, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Division of Rheumatology, UC Denver School of Medicine, Denver, CO, 4Division of Infectious Disease, University of Colorado, Aurora, CO

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with an unknown cause. Observations of dysbiosis and mucosal inflammation in patients with RA has raised interest…
  • Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting

    Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis

    Hoshimi Kawaguchi1, Isao Matsumoto1, Hiroshi Ebe1, Naoto Umeda1, Yuya Kondo1, Hiroto Tsuboi2 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
  • Abstract Number: 635 • 2016 ACR/ARHP Annual Meeting

    Factors Associated to Lack of Adherence to Subcutaneous Biological Medications in Patients with Rheumatoid Arthritis from Spain. Arco Study

    Jaime Calvo-Alen1, Indalecio Monteagudo2, Georgina Salvador Alarcón3, Enrique Raya Álvarez4, Loreto Carmona5, Luis Cea-Calvo6 and Carlos Marras Fernandez-Cid7, 1Rheumatology, Txagorritxu Hospital, Araba, Vitoria, Vitoria, Spain, 2Rheumatology Unit, HGU Gregorio Marañón, Madrid, Madrid, Spain, 3Rheumatology, HU Mutua de Terrassa, Barcelona, Terrassa, Spain, 4Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 5Instituto de Salud Musculoesquelética, Madrid, Spain, 6Medical Affairs Department, Merck Sharp & Dohme, Madrid, Spain, 7Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain

    Background/Purpose: To investigate the variables associated to lack of adherence to subcutaneous (SC) biological drug in patients with rheumatoid arthritis (RA) after 1 year of…
  • Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting

    Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare

    Susan M. Goodman1, Rivka Friedlander2, Caroline Figgie2, Alessandra B. Pernis3, Cristina T. Rozo4, Ellen M. Gravallese5, Edward F. DiCarlo6, Laura T. Donlin7, Mark P. Figgie8, Reena Khianey9, Anh Hoang1, Kathleen Andersen10, Luvana Chowdhury11 and VP Bykerk12, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Research, Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 4535 East 70th Street, Hospital for Special Surgery, New York, NY, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Orthopaedics, Hospital for Special Surgery, New York, NY, 9Medicine, Hospital for Special Surgery, New York, NY, 10Hospital for Special Surgery, New York, NY, 11Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, 12Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
  • Abstract Number: 1318 • 2015 ACR/ARHP Annual Meeting

    Prediction of Large Joint Destruction in Patients with Rheumatoid Arthritis Using FDG-PET/CT: A Prospective Study

    Takahito Suto, Koichi Okamura, Yukio Yonemoto, Chisa Okura and Kenji Takagishi, Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Background/Purpose: The assessments of joint damage in patients with rheumatoid arthritis (RA) are mainly restricted to small joints in the hands and feet. However, the…
  • Abstract Number: 1647 • 2015 ACR/ARHP Annual Meeting

    A Randomized, Clinical Trial to Assess the Relative Efficacy and Tolerability of Two Doses of Etoricoxib in Patients with Rheumatoid Arthritis

    Kara Bickham1, Désirée van der Heijde2, Narinder Rawal3, Joachim Sieper4, Boyd Scott5, Nancy Frontera1, Sandhya Shah1, Paul Stryszak1, Dimitris Papanicolaou1, Zoran Popmihajlov1 and Paul Peloso1, 1Merck & Co., Inc., Kenilworth, NJ, 2University Hospital, Maastricht, Netherlands, 3Orebro University Hospital, Orebro, Sweden, 4Rheumatology, Charite - Campus Benjamin Franklin, Berlin, Germany, 5Merck Sharp & Dohme Corp., Whitehouse Station, NJ

    Background/Purpose: Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, provides symptom modification in RA patients. Previous dose-ranging studies in RA demonstrated the clinical efficacy of etoricoxib 90…
  • Abstract Number: 2138 • 2015 ACR/ARHP Annual Meeting

    Safety and Efficacy Results of a Phase 2, Double-Blind, Placebo-Controlled Clinical Study of Duvelisib with Background Methotrexate (MTX) in Adults with Moderate-to-Severe Rheumatoid Arthritis (RA)

    Richard Leff1, Sunil Kumar2, Natalia Nikulenkova3, Igor Kaidashev4, Kerstin Allen5, Joi Dunbar6, Howard Stern7, Julian Adams6 and Michael Weinblatt8, 1Clinical Research, Infinity Pharmaceuticals, Inc., Cambridge, MA, 2Centre for Clinical Research and Effective Practice (CCRep), Auckland, New Zealand, 3State Budgetary Healthcare Institution of Vladimir Region, Regional Clinical Hospital, Vladimir, Russia, 4City Clinical Hospital #1 of Poltava City, Poltava, Ukraine, 5Biostatistics, Infinity Pharmaceuticals, Inc., Cambridge, MA, 6Infinity Pharmaceuticals, Inc., Cambridge, MA, 7Translational Science, Infinity Pharmaceuticals, Inc., Cambridge, MA, 8Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose:  Duvelisib is a potent, oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ,γ being developed for hematologic malignancies, and was also explored in early phase studies in…
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