ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and abatacept"

  • Abstract Number: 534 • 2019 ACR/ARP Annual Meeting

    CXCL13 Serum Levels and Circulating Follicular Helper T-Cells Decrease After Co-stimulation Blockade with Abatacept in Rheumatoid Arthritis

    Silvia Piantoni1, Francesca Regola 2, Laura Andreoli 3, Angela Tincani 3 and Paolo AirĂ² 4, 1ASST Spedali Civili and University of Brescia, Brescia, Italy, 2Rheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy, Brescia, Italy, 3Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy, 4UO Reumatologia e Immunologia Clinica, Spedali Civili di Brescia, Brescia, Italy, Brescia, Italy

    Background/Purpose: CXCL13 chemokine, by interacting with CXCR5 receptor, attracts B-lymphocytes and CD4+CXCR5+ICOS+ follicular helper T-lymphocytes (THFs) in lymphoid follicles. In rheumatoid arthritis (RA) CXCL13 is…
  • Abstract Number: 1531 • 2019 ACR/ARP Annual Meeting

    ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Underlying Rheumatoid and Psoriatic Arthritis

    Lawrence Evans1, Stacey Dillon 1, Katherine Lewis 1, Susan Bort 1, Erika Rickel 1, Jing Yang 1, Martin Wolfson 1, Sherri Mudri 1, Kayla Susmilch 1, Steven Levin 1, Sean MacNeil 1, Mark Rixon 1, Jan Hillson 2, Stanford Peng 1 and Kristine Swiderek 1, 1Alpine Immune Sciences, Seattle, WA, 2Alpine Immune Sciences, Seattle, WI

    Background/Purpose: ALPN-101 is an Fc fusion protein of a human inducible T cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgDTM) designed to simultaneously inhibit the…
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