Abstracts tagged "rheumatic disease and tolerance"

Abstract Number: 206 • 2015 ACR/ARHP Annual Meeting
Activation of Non-Canonical NF-Kappa B Signalling in Dendritic Cells Induces Extrathymic Autoimmune Regulator (AIRE) Expression
Leonie Huitema¹, Boy Helder¹, Ae-Ri Noort², Chrissta Maracle¹, Louis Boon³, Cristina Lebre⁴, Frans G.M. Kroese⁵ and Sander W. Tas⁶, ¹Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Bioceros, Utrecht, Netherlands, ⁴Div. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Immune regulation is necessary for limiting excessive immune responses and for preventing autoimmune diseases. Nuclear factor (NF)-κB signalling plays an important role in the…

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