Abstracts tagged "regulatory cells and systemic sclerosis"

Abstract Number: 797 • 2018 ACR/ARHP Annual Meeting
Absolute Reduction of Peripheral CD4+ Regulatory T Cells in Patients with Systemic Sclerosis and Its Restoration By Short-Term and Low Dose IL-2 Treatment
Lili Shang¹, Jing Luo², Chong Gao³, Jingman Yuan¹, Qian Li¹, Xiaoli Liu¹, Huiying Gao¹ and Xiao-Feng Li⁴, ¹Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, ²the Second Hospital of Shanxi Medical University, Taiyuan, China, ³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁴Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: The aim of the present study was to investigate whether the imbalance of CD4+ T subsets can be corrected by supplementing low dose interleukin -2 (IL-2).Methods:…
Abstract Number: 21 • 2017 ACR/ARHP Annual Meeting
Reciprocal Regulation of B Cells on Bleomycin-Induced Scleroderma Model: IL-6-Producing Effector B Cells Play a Pathogenic Role, While IL-10-Producing Regulatory B Cells Play a Protective Role
Takashi Matsushita¹, Yasuhito Hamaguchi¹, Minoru Hasegawa², Manabu Fujimoto³ and Kazuhiko Takehara⁴, ¹Department of Dermatology, Kanazawa University, kanazawa, Japan, ²Department of Dermatology, University of Fukui, Fukui, Japan, ³Department of Dermatology, University of Tsukuba, Tsukuba, Japan, ⁴Department of Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: IL-10-producing regulatory B (Breg) cells negatively regulate autoimmune diseases. We reported that Breg cells play a protective role in a mouse model of systemic…
Abstract Number: 1718 • 2014 ACR/ARHP Annual Meeting
B Cell Subsets Homeostasis and Functional Properties Are Altered in a Murine Model of Systemic Sclerosis
Sébastien Sanges^1,2,3, Niloufar Kavian⁴, Carine Hauspie^1,3,5, Carole Nicco⁴, Thomas Guerrier^1,3, Virginie Dutoit-Lefèvre^1,3, Guillaume Lefèvre^1,2,5,6, Alexandra Forestier^1,2,3, Vincent Sobanski^1,2,6, Christelle Faveeuw⁷, Myriam Labalette^1,3,5, Frédéric Batteux⁴, David Launay^1,2,3 and Sylvain Dubucquoi^1,3,5, ¹Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ²Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ³EA 2686, Lille, Lille, France, ⁴Université Paris Descartes, EA 1833, Hôpital Cochin, AP-HP, Paris, Paris, France, ⁵Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, ⁶EA 2686, Lille, LILLE, France, ⁷Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, Institut Fédératif de Recherche 142, Université de Lille Nord de France, Lille, France
Background/Purpose Systemic sclerosis (SSc) is a multi-organ fibrotic disease associated with auto-immune abnormalities. Several clinical and experimental observations suggest that B cells are involved in…
Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting
Increase of CD4⁺CD25⁺FoxP₃⁺ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression
Xinjuan Liu¹, Na Gao¹, Mengtao Li¹, Dong Xu¹, Yong Hou¹, Qian Wang¹, Guohua Zhang¹, Qiuning Sun², Henghui Zhang³ and Xiaofeng Zeng⁴, ¹Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ²Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ³Hepatology Institute, Peking University, People's Hospital, Beijing, China, ⁴Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Background/Purpose: Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…