ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "regulatory cells and systemic sclerosis"

  • Abstract Number: 797 • 2018 ACR/ARHP Annual Meeting

    Absolute Reduction of Peripheral CD4+ Regulatory T Cells in Patients with Systemic Sclerosis and Its Restoration By Short-Term and Low Dose IL-2 Treatment

    Lili Shang1, Jing Luo2, Chong Gao3, Jingman Yuan1, Qian Li1, Xiaoli Liu1, Huiying Gao1 and Xiao-Feng Li4, 1Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, 2the Second Hospital of Shanxi Medical University, Taiyuan, China, 3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, 4Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China

    Background/Purpose: The aim of the present study was to investigate whether the imbalance of CD4+ T subsets can be corrected by supplementing low dose interleukin -2 (IL-2).Methods:…
  • Abstract Number: 21 • 2017 ACR/ARHP Annual Meeting

    Reciprocal Regulation of B Cells on Bleomycin-Induced Scleroderma Model: IL-6-Producing Effector B Cells Play a Pathogenic Role, While IL-10-Producing Regulatory B Cells Play a Protective Role

    Takashi Matsushita1, Yasuhito Hamaguchi1, Minoru Hasegawa2, Manabu Fujimoto3 and Kazuhiko Takehara4, 1Department of Dermatology, Kanazawa University, kanazawa, Japan, 2Department of Dermatology, University of Fukui, Fukui, Japan, 3Department of Dermatology, University of Tsukuba, Tsukuba, Japan, 4Department of Dermatology, Kanazawa University, Kanazawa, Japan

    Background/Purpose: IL-10-producing regulatory B (Breg) cells negatively regulate autoimmune diseases. We reported that Breg cells play a protective role in a mouse model of systemic…
  • Abstract Number: 1718 • 2014 ACR/ARHP Annual Meeting

    B Cell Subsets Homeostasis and Functional Properties Are Altered in a Murine Model of Systemic Sclerosis

    Sébastien Sanges1,2,3, Niloufar Kavian4, Carine Hauspie1,3,5, Carole Nicco4, Thomas Guerrier1,3, Virginie Dutoit-Lefèvre1,3, Guillaume Lefèvre1,2,5,6, Alexandra Forestier1,2,3, Vincent Sobanski1,2,6, Christelle Faveeuw7, Myriam Labalette1,3,5, Frédéric Batteux4, David Launay1,2,3 and Sylvain Dubucquoi1,3,5, 1Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, 2Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, 3EA 2686, Lille, Lille, France, 4Université Paris Descartes, EA 1833, Hôpital Cochin, AP-HP, Paris, Paris, France, 5Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, 6EA 2686, Lille, LILLE, France, 7Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, Institut Fédératif de Recherche 142, Université de Lille Nord de France, Lille, France

    Background/Purpose Systemic sclerosis (SSc) is a multi-organ fibrotic disease associated with auto-immune abnormalities. Several clinical and experimental observations suggest that B cells are involved in…
  • Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting

    Increase of CD4+CD25+FoxP3+ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression

    Xinjuan Liu1, Na Gao1, Mengtao Li1, Dong Xu1, Yong Hou1, Qian Wang1, Guohua Zhang1, Qiuning Sun2, Henghui Zhang3 and Xiaofeng Zeng4, 1Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 2Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 3Hepatology Institute, Peking University, People's Hospital, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Background/Purpose:  Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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