Abstracts tagged "regulatory cells and rheumatoid arthritis (RA)"

Abstract Number: 87 • 2017 ACR/ARHP Annual Meeting
A Novel Histone Deacetylase 6 Inhibitor, CKD-M808, Regulates the Adhesion and Migration of Fibroblast-like Synoviocytes, and Enhances Suppressive Function of Regulatory T Cells in Rheumatoid Arthritis
Sehui Shon¹, Ji Soo Park¹, Shin Eui Kang¹, Jeong Yeon Kim¹, Dong-Hyeon Suh², Daekwon Bae², Nina Ha², Young Il Choi², Jin Kyun Park^1,3, Eun Young Lee³, Eun Bong Lee³ and Yeong Wook Song^3,4, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), ²Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁴Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Koer, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by bone and cartilage destruction with leukocyte infiltration and activation at synovial tissue. Recently,…
Abstract Number: 866 • 2017 ACR/ARHP Annual Meeting
Interferon-Alpha Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis
Matthieu Ribon^1,2, Katarzyna Matyja^2,3, Roxane Hervé^2,3, Delphine Lemeiter^2,3, François Santinon^2,3, Ken Tsumiyama⁴, Shunichi Shiozawa⁴, Marie-Christophe Boissier^3,5,6, Natacha Bessis^2,3 and Patrice Decker^2,3, ¹li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²UMR 1125, INSERM, Bobigny, France, ³Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁴Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁶74 rue Marcel Cachin, INSERM, Bobigny, France
Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
Abstract Number: 1628 • 2015 ACR/ARHP Annual Meeting
A Novel Histone Deacetylase 6 Inhibitor, CKD-H059 Inhibits the Inflammatory Response in Rheumatoid Arthritis
Yu Jin Jang¹, Bo Ram Oh², Hyojin Lim³, Daekwon Bae³, Nina Ha³, Young il Choi⁴, Jin Kyun Park⁵, Eun Young Lee⁵, Eun Bong Lee⁵ and Yeong Wook Song^5,6, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Parmarcy, Seoul National University, Seoul, South Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, South Korea, ³Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, ⁴315-20 dongbaekjukjeon-daero, giheung-gu, Pharmacology lab, Hyo-Jong Research Laboratories, CKD Pharmaceutical Company, Yongin-si, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ⁶Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea
Background/Purpose: Epigenetic changes including histone modification play an important role in development of rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) increases transcription of numerous genes…
Abstract Number: 1110 • 2015 ACR/ARHP Annual Meeting
A Proliferative Inducing Ligand (APRIL) Promotes IL-10 Production of Human B Cells
Charlotte Hua¹, Rachel Audo², Nataliya Yeremenko³, Dominique Baeten⁴, Michael Hahne², Bernard Combe⁵, Jacques Morel⁵ and Claire I. Daien⁵, ¹Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ²IGMM-CNRS UMR5535, Montpellier, France, ³Academic medical center, University of Amsterdam, Amsterdam, France, ⁴1Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: B cells may have a negative regulatory role, mainly mediated by interleukin 10 (IL-10). We recently showed that regulatory B-cell functions are impaired in…
Abstract Number: 1103 • 2015 ACR/ARHP Annual Meeting
Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion By Human Regulatory B Cells
Charlotte Hua¹, Rachel Audo², Michael Hahne², Bernard Combe³, Jacques Morel³ and Claire I. Daien³, ¹Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ²IGMM-CNRS UMR5535, Montpellier, France, ³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: B cells can have a negative regulatory role, mainly mediated by interleukin 10 (IL-10) and we recently showed that IL-10 producing B cells (B10…
Abstract Number: 1402 • 2013 ACR/ARHP Annual Meeting
Regulatory B10 Cells Are Decreased In Patients With Rheumatoid Arthritis and Inversely Correlated With Disease Activity
Claire I. Daien^1,2, Sarah Gailhac³, Thibault Mura⁴, Bernard Combe⁵, Michael Hahne¹ and Jacques Morel⁶, ¹IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ²Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ³Igmm UMR3555, CNRS, Montpellier, France, ⁴CIC, Hopital Gui De Chauliac, Montpellier, France, ⁵Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁶Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France
Background/Purpose: Regulatory IL-10 producing B cells (B10) have been shown to prevent and cure collagen-induced arthritis in mice. In human, very little is known about…
Abstract Number: 917 • 2013 ACR/ARHP Annual Meeting
B-Regulatory-, CD19⁺CD20⁺CD24^highCD38^high -Cells Are Functionally Impaired In Patients With Rheumatoid Arthritis and Healthy First Degree Relatives Compared With Controls
Mikael Brink¹, Kristina Lejon², Lisbeth Ärlestig³ and Solbritt Rantapää Dahlqvist⁴, ¹Rheumatology, Umeå University, Umea, Sweden, ²Clinical Microbiology, Division of Immunology, Umeå Universitet, Umeå, Sweden, ³Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ⁴Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex disease with both genetic- and environmental risk factors. By studying first degree relatives (FDR) of RA patients which…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
Abstract Number: 1745 • 2012 ACR/ARHP Annual Meeting
Amelioration of Experimental Autoimmune Arthritis by Adoptive Transfer of Foxp3-Expressing Regulatory B Cells Is Associated with the Regulatory T Cell/T helper 17 cell Balance
Young Ok Jung¹, Yu Jung Heo², Mi Kyung Park³, Mi-La Cho⁴, Seung Ki Kwok⁵, Ji Hyeon Ju², Kyung Su PARK², Sung Hwan PARK², Ho Youn Kim² and Jun-Ki Min⁶, ¹Internal Medicine Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ²Catholic University, Seoul, South Korea, ³Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, South Korea, ⁴Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁵The Catholic University, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted.…
Abstract Number: 1743 • 2012 ACR/ARHP Annual Meeting
IL-5-Induced FasL⁺ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine
Matthew W. Klinker¹, Brian R. Alzua¹, Tamra J. Reed², David A. Fox³ and Steven K. Lundy⁴, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ⁴Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: We previously identified a subset of regulatory B cells that express the apoptosis-inducing molecule Fas ligand (FasL), and reported that these B cells were…
Abstract Number: 2344 • 2012 ACR/ARHP Annual Meeting
Transcriptional Regulation of Garp Expression
Sonja Haupt¹, Qihui Zhou¹, Johannes Thomas Kreuzer¹, Simon Herrmann¹, Hendrik Schulze-Koops¹ and Alla Skapenko², ¹Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Regulatory T cells (Tregs) contribute to immune tolerance and play a pivotal role in the prevention of autoimmune diseases such as rheumatoid arthritis (RA).…
Abstract Number: 2508 • 2012 ACR/ARHP Annual Meeting
miR142-3p Interfers with T Cell Proliferation by Targeting the Expression of Garp in Patients with Rheumatoid Arthritis
Qihui Zhou¹, Sonja Haupt¹, Johannes Thomas Kreuzer¹, Hendrik Schulze-Koops¹ and Alla Skapenko², ¹Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a systematic chronic inflammatory disorder, characterized by severe joint destruction. Regulatory T cells (Tregs) have been implicated to be important…