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Abstracts tagged "regulatory cells and rheumatoid arthritis (RA)"

  • Abstract Number: 87 • 2017 ACR/ARHP Annual Meeting

    A Novel Histone Deacetylase 6 Inhibitor, CKD-M808, Regulates the Adhesion and Migration of Fibroblast-like Synoviocytes, and Enhances Suppressive Function of Regulatory T Cells in Rheumatoid Arthritis

    Sehui Shon1, Ji Soo Park1, Shin Eui Kang1, Jeong Yeon Kim1, Dong-Hyeon Suh2, Daekwon Bae2, Nina Ha2, Young Il Choi2, Jin Kyun Park1,3, Eun Young Lee3, Eun Bong Lee3 and Yeong Wook Song3,4, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 2Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 4Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Koer, Seoul, Korea, Republic of (South)

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by bone and cartilage destruction with leukocyte infiltration and activation at synovial tissue. Recently,…
  • Abstract Number: 866 • 2017 ACR/ARHP Annual Meeting

    Interferon-Alpha Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis

    Matthieu Ribon1,2, Katarzyna Matyja2,3, Roxane Hervé2,3, Delphine Lemeiter2,3, François Santinon2,3, Ken Tsumiyama4, Shunichi Shiozawa4, Marie-Christophe Boissier3,5,6, Natacha Bessis2,3 and Patrice Decker2,3, 1li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2UMR 1125, INSERM, Bobigny, France, 3Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, 5Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, 674 rue Marcel Cachin, INSERM, Bobigny, France

    Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
  • Abstract Number: 1103 • 2015 ACR/ARHP Annual Meeting

    Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion By Human Regulatory B Cells

    Charlotte Hua1, Rachel Audo2, Michael Hahne2, Bernard Combe3, Jacques Morel3 and Claire I. Daien3, 1Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 2IGMM-CNRS UMR5535, Montpellier, France, 3Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: B cells can have a negative regulatory role, mainly mediated by interleukin 10 (IL-10) and we recently showed that IL-10 producing B cells (B10…
  • Abstract Number: 1110 • 2015 ACR/ARHP Annual Meeting

    A Proliferative Inducing Ligand (APRIL) Promotes IL-10 Production of Human B Cells

    Charlotte Hua1, Rachel Audo2, Nataliya Yeremenko3, Dominique Baeten4, Michael Hahne2, Bernard Combe5, Jacques Morel5 and Claire I. Daien5, 1Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 2IGMM-CNRS UMR5535, Montpellier, France, 3Academic medical center, University of Amsterdam, Amsterdam, France, 41Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 5Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: B cells may have a negative regulatory role, mainly mediated by interleukin 10 (IL-10). We recently showed that regulatory B-cell functions are impaired in…
  • Abstract Number: 1628 • 2015 ACR/ARHP Annual Meeting

    A Novel Histone Deacetylase 6 Inhibitor, CKD-H059 Inhibits the Inflammatory Response in Rheumatoid Arthritis

    Yu Jin Jang1, Bo Ram Oh2, Hyojin Lim3, Daekwon Bae3, Nina Ha3, Young il Choi4, Jin Kyun Park5, Eun Young Lee5, Eun Bong Lee5 and Yeong Wook Song5,6, 1Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Parmarcy, Seoul National University, Seoul, South Korea, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, South Korea, 3Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, 4315-20 dongbaekjukjeon-daero, giheung-gu, Pharmacology lab, Hyo-Jong Research Laboratories, CKD Pharmaceutical Company, Yongin-si, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 6Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea

    Background/Purpose: Epigenetic changes including histone modification play an important role in development of rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) increases transcription of numerous genes…
  • Abstract Number: 1402 • 2013 ACR/ARHP Annual Meeting

    Regulatory B10 Cells Are Decreased In Patients With Rheumatoid Arthritis and Inversely Correlated With Disease Activity

    Claire I. Daien1,2, Sarah Gailhac3, Thibault Mura4, Bernard Combe5, Michael Hahne1 and Jacques Morel6, 1IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 2Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 3Igmm UMR3555, CNRS, Montpellier, France, 4CIC, Hopital Gui De Chauliac, Montpellier, France, 5Rheumatology, Lapeyronie Hospital, Montpellier, France, 6Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France

    Background/Purpose: Regulatory IL-10 producing B cells (B10) have been shown to prevent and cure collagen-induced arthritis in mice. In human, very little is known about…
  • Abstract Number: 917 • 2013 ACR/ARHP Annual Meeting

    B-Regulatory-, CD19+CD20+CD24highCD38high -Cells Are Functionally Impaired In Patients With Rheumatoid Arthritis and Healthy First Degree Relatives Compared With Controls

    Mikael Brink1, Kristina Lejon2, Lisbeth Ärlestig3 and Solbritt Rantapää Dahlqvist4, 1Rheumatology, Umeå University, Umea, Sweden, 2Clinical Microbiology, Division of Immunology, Umeå Universitet, Umeå, Sweden, 3Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 4Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a complex disease with both genetic- and environmental risk factors. By studying first degree relatives (FDR) of RA patients which…
  • Abstract Number: 2508 • 2012 ACR/ARHP Annual Meeting

    miR142-3p Interfers with T Cell Proliferation by Targeting the Expression of Garp in Patients with Rheumatoid Arthritis

    Qihui Zhou1, Sonja Haupt1, Johannes Thomas Kreuzer1, Hendrik Schulze-Koops1 and Alla Skapenko2, 1Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a systematic chronic inflammatory disorder, characterized by severe joint destruction.  Regulatory T cells (Tregs) have been implicated to be important…
  • Abstract Number: 2344 • 2012 ACR/ARHP Annual Meeting

    Transcriptional Regulation of Garp Expression

    Sonja Haupt1, Qihui Zhou1, Johannes Thomas Kreuzer1, Simon Herrmann1, Hendrik Schulze-Koops1 and Alla Skapenko2, 1Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: Regulatory T cells (Tregs) contribute to immune tolerance and play a pivotal role in the prevention of autoimmune diseases such as rheumatoid arthritis (RA).…
  • Abstract Number: 1743 • 2012 ACR/ARHP Annual Meeting

    IL-5-Induced FasL+ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine

    Matthew W. Klinker1, Brian R. Alzua1, Tamra J. Reed2, David A. Fox3 and Steven K. Lundy4, 1Internal Medicine, University of Michigan, Ann Arbor, MI, 2Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, 3Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, 4Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: We previously identified a subset of regulatory B cells that express the apoptosis-inducing molecule Fas ligand (FasL), and reported that these B cells were…
  • Abstract Number: 1745 • 2012 ACR/ARHP Annual Meeting

    Amelioration of Experimental Autoimmune Arthritis by Adoptive Transfer of Foxp3-Expressing Regulatory B Cells Is Associated with the Regulatory T Cell/T helper 17 cell Balance

    Young Ok Jung1, Yu Jung Heo2, Mi Kyung Park3, Mi-La Cho4, Seung Ki Kwok5, Ji Hyeon Ju2, Kyung Su PARK2, Sung Hwan PARK2, Ho Youn Kim2 and Jun-Ki Min6, 1Internal Medicine Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, 2Catholic University, Seoul, South Korea, 3Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, 5The Catholic University, Seoul, South Korea, 6Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted.…
  • Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting

    The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4+t�ACD4+Foxp3+t Cell in Patients with Rheumatoid Arthritis

    Ning Li1, Tianrui Ma2, Jie Han1, Jieru Zhou1 and Songguo Zheng3, 1Rheumatology, Shanghai East Hospital, Shanghai, China, 2Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, 3Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA

    Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
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