Abstracts tagged "Redox Balance"

Abstract Number: 2261 • 2016 ACR/ARHP Annual Meeting
Methotrexate Inhibits Intracellular Redox Signaling Induced By the Reactive Oxygen Species; Malondialdehyde and Acetaldehyde
Andrew Chiou¹, Michael J. Duryee^1,2, Cleofes Sarmiento³, Matthew Zimmerman⁴, Carlos D. Hunter¹, Lynell W. Klassen⁵, James R. O'Dell⁵, Daniel R. Anderson³, Geoffrey M. Thiele³ and Ted R Mikuls⁶, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Research Services, Omaha VA Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Inflammatory diseases such as rheumatoid arthritis (RA) are associated with oxidative stress as a result of elevated levels of reactive oxygen species (ROS). Oxidative…
Abstract Number: 1127 • 2015 ACR/ARHP Annual Meeting
Downregulation of nuclear Factor-Erythroid 2-Related Factor (Nrf2)/Heme Oxygenase-1 Axis in Diabetic Cartilage: Towards a Better Phenotyping of diabetes-Related Osteoarthritis
Carlos Vaamonde Garcia^1,2, Ayah Langar², Marie-Charlotte Laiguillon², Alice Courties², Xavier Houard², Saadia Kerdine-Romer³, Francis Berenbaum^2,4 and Jeremie Sellam^2,4, ¹Tissue Engineering and Cellular Therapy Group. Medicine Department. University of A Coruña, A Coruña, Spain, ²Inserm UMRS_938, CDR St-Antoine, Univ Paris 06 UPMC, Paris, France, ³UniverSud, Paris-Saclay, INSERM UMR-S 996, Châtenay-Malabry, France, ⁴Department of Rheumatology, Assistance Publique – Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France
Background/Purpose: Epidemiological findings support the hypothesis that type 2 diabetes (DB) is an independent risk factor of osteoarthritis (OA). Likewise, we have recently reported a…
Abstract Number: 2134 • 2015 ACR/ARHP Annual Meeting
Metabolic Reprogramming in the Inflamed Joint Inhibits Pro-Inflammatory Mechanisms
Monika Biniecka¹, Mary Canavan¹, Chin Teck Ng², Wei Gao¹, Thomas Smith³, Trudy McGarry⁴, Douglas J. Veale⁵ and Ursula Fearon⁴, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ²Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, ³Department of Endocrinology, St Vincent’s University Hospital, Dublin, Ireland, ⁴St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁵St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: To examine the relationship between synovial hypoxia, cellular bioenergetics and mitochondrial dysfunction with synovial inflammation. Methods: Primary RASFC were cultured with 3% hypoxia, DMOG…
Abstract Number: 2398 • 2013 ACR/ARHP Annual Meeting
Redox Mediated Angiogenesis In The Hypoxic Joint Of Inflammatory Arthritis
Monika Biniecka¹, Chin Teck Ng¹, Emese Balogh¹, Douglas J. Veale² and Ursula Fearon³, ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ³Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: To investigate whether in vivo synovial hypoxia and TNF blocking therapy determine expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase (Nox2) - a key source of…
Abstract Number: 946 • 2013 ACR/ARHP Annual Meeting
Interleukin-34 Regulates Angiogenesis and Cell Proliferation In Inflammatory Arthritis, This Effect Is Potentiated By Hypoxia
Emese Balogh¹, Mary Connolly¹, Monika Biniecka¹, Jennifer McCormick², Douglas J. Veale³ and Ursula Fearon², ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: Interleukin-34 (IL-34) is a cytokine implicated in macrophage differentiation, angiogenesis and osteoclastogenesis in inflammatory arthritis (IA). IA is characterized by synovial hypoxia, increased oxidative…

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