Abstracts tagged "RCT and systemic sclerosis"

Abstract Number: 876 • 2014 ACR/ARHP Annual Meeting
SAR100842, an Antagonist of Lysophaphatidic Acid Receptor 1, As a Potential Treatment for Patients with Systemic Sclerosis: Results from a Phase 2a Study
Dinesh Khanna¹, Christopher P. Denton², Alexandre Jagerschmidt³, Martine Jasson⁴, Oliver Distler⁵ and Yannick Allanore⁶, ¹University of Michigan Scleroderma Program, Ann Arbor, MI, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, ³Tissue Protection and Repear Unit, Sanofi-Aventis, Chilly-Mazarin, France, ⁴Clinical Development, Sanofi-Aventis, Paris, France, ⁵Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁶Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose Preclinical genetic and pharmacological studies suggest a role for Lysophosphatidic acid (LPA) involvement in three key processes of systemic sclerosis: fibrosis, microangiopathy and immunoinflammation.…

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