ACR Meeting Abstracts

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Abstracts tagged "Randomized Trial"

  • Abstract Number: 1496 • ACR Convergence 2024

    Dysregulated Serum Cytokines in Association with Clinical Manifestations in Patients with Systemic Lupus Erythematosus

    Loqmane seridi1, Steven Leonardo2, Brittney Scott3, Robert Gordon1, cathye shu1, Kaiyin Fei1, Kim Lo3, Anne Stevens1 and Sheng Gao3, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, a Johnson & Johnson Company, Cambridge, MA, 3Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA

    Background/Purpose: SLE is a heterogeneous autoimmune disease affecting multiple organ systems, making clinical trial design challenging. Biomarkers that can identify patients with specific clinical manifestations…
  • Abstract Number: 1731 • ACR Convergence 2024

    Baricitinib in the Treatment of Adult Idiopathic Inflammatory Myopathy: A Randomized, Treatment Delayed-Start Clinical Trial

    hector Chinoy1, Ashma Krishan1, Yvonne Sylvestre1, James Lilleker2, Patrick Gordon3, Sarah Tansley4, Athiveeraramapandian Prabu5, Aamir Aslam6, Andrew Snedden7 and Janine Lamb8, 1The University of Manchester, Manchester, United Kingdom, 2Northern Care Alliance NHS Trust, Salford, United Kingdom, 3nhs, London, United Kingdom, 4University of Bath, Bath, United Kingdom, 5Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, 6Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 7Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom, 8University of Manchester, UK, Manchester, United Kingdom

    Background/Purpose: The aim of the study was to assess the effects of baricitinib, a JAK1/2 inhibitor, following 24 weeks of active treatment on disease activity…
  • Abstract Number: 2352 • ACR Convergence 2024

    Bimekizumab Treatment Was Efficacious to 2 Years Regardless of Duration of axSpA Symptoms: Results from Two Phase 3 Studies

    Sofia Ramiro1, Fabian Proft2, Raj Sengupta3, Astrid van Tubergen4, Anna Molto5, Lianne S Gensler6, Mitsumasa Kishimoto7, Vanessa Taieb8, Diana Voiniciuc9, Ute Massow10 and Victoria Navarro Compán11, 1Leiden University Medical Center, Bunde, Netherlands, 2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 3Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 4Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 5Groupe Hospitalier Cochin, AP-HP, Paris, France, 6Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 7Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, 8UCB Pharma, Colombes, France, 9UCB Pharma, Slough, United Kingdom, 10UCB Pharma, Monheim am Rhein, Germany, 11La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain

    Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A, showed efficacy to Week (Wk) 52 in patients (pts) with…
  • Abstract Number: 2675 • ACR Convergence 2024

    Which Arthralgia Patients at Risk for RA Benefited from Treatment with Methotrexate?; Results from the TREAT EARLIER Trial

    Stijn Claassen1, Quirine Dumoulin2, Kasper Glas3, Esmeralda Molenaar4, Hanna van Steenbergen1 and Annette van der Helm-van Mil5, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands, 3Reumazorg Zuid West Nederland, Goes, The Netherlands, Goes, Zeeland, Netherlands, 4Groene Hart Ziekenhuis, Gouda, The Netherlands, Gouda, Zuid-Holland, Netherlands, 5LUMC, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: A one-year methotrexate treatment in CSA has been shown to induce sustained reduction in subclinical inflammation during 2-years follow-up. We aim to study if…
  • Abstract Number: 0217 • ACR Convergence 2024

    Understanding Treatment Goals and Factors Influencing Decisions About Clinical Trial Participation in Lupus Patients from Diverse Backgrounds

    Joy Buie1, Safoah Agyemang1 and Joan Merrill2, 1Lupus Foundation of America, Washington, DC, 2Oklahoma Medical Research Foundation, Oklahoma City 73104, OK

    Background/Purpose: With many emerging treatments in development for lupus, clinical trial recruitment has become increasingly difficult. Growing appreciation of patient input into trial design may be of …
  • Abstract Number: 1131 • ACR Convergence 2024

    Zasocitinib (TAK-279), a Selective Oral Tyrosine Kinase 2 Inhibitor, Reduces Body Surface Area Involvement in a Phase 2b Trial in Moderate-to-Severe Plaque Psoriasis

    Vivian Laquer1, Leon Kircik2, Neil Sadick3, Jamie Weisman4, Yiwei Zhao5, Jessamyn Blau5, Wenwen Zhang6, Jonathan Uy5, Warren Winkelman6 and Melinda Gooderham7, 1First OC Dermatology Research, Fountain Valley, CA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Weill Cornell Medical College, New York, NY, 4Piedmont Atlanta, Atlanta, GA, 5Takeda Development Center Americas, Inc., Cambridge, MA, 6Takeda Development Center Americas, Inc., Cambridge, 7SKiN Centre for Dermatology and Probity Medical Research, Peterborough, ON, Canada

    Background/Purpose: Zasocitinib (TAK-279) is a highly selective, allosteric, oral inhibitor of tyrosine kinase 2 (TYK2). TYK2 mediates signaling from cytokines involved in the pathogenesis of…
  • Abstract Number: 1542 • ACR Convergence 2024

    Efficacy and Safety Results from a Phase 2 Trial of Daxdilimab in Patients with Systemic Lupus Erythematosus

    Arezou Khosroshahi1, Sarah Welsh2, Liangwei Wang2, David Larson2 and Nisha Jain2, 1Emory University, Atlanta, GA, 2Amgen, Inc., Rockville, MD

    Background/Purpose: SLE, an autoimmune disease affecting multiple organ systems, is characterized by periods of flares and remission. Type I interferon secreted at high levels by…
  • Abstract Number: 1735 • ACR Convergence 2024

    High-Intensity Interval Training Outperforms Moderate Exercise in Aerobic Capacity for Recent-Onset Idiopathic Inflammatory Myopathies: A Randomized Controlled Trial

    Kristofer Andreasson1, Cecilia Leijding1, Maryam Dastmalchi2, Antonella Notarnicola3, Stefano Gastaldello1, Heléne Sandlund2, Daniel Andersson4, Ingrid Lundberg5 and Helene Alexanderson2, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska University hospital, Stockholm, Sweden, 3Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 4Karolinska Institutet, Solna, Sweden, 5Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Exercise is a recognized adjunctive therapy for patients with idiopathic inflammatory myopathies (IIM), enhancing physical capacity and reducing inflammation. Hitherto, moderate-to-intensive exercise has been…
  • Abstract Number: 2353 • ACR Convergence 2024

    Effects of Guselkumab on cDAPSA Disease Activity State and Its Association with Long-Term Radiographic Progression in a Cohort of Patients with Moderately-Highly Active Psoriatic Arthritis: Post Hoc Analyses of Phase 3 Randomized Controlled Studies

    Philip Mease1, Alice Gottlieb2, Iain McInnes3, Natalie J. Shiff4, Toby Thomas5, Emmanouil Rampakakis6, Francois Nantel7, Frederic Lavie8 and Proton Rahman9, 1Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 2Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, 3University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 4Janssen Scientific Affairs, LLC / University of Saskatchewan, Adjunct, Community Health and Epidemiology, Horsham, PA, 5Janssen Pharmaceuticals, Horsham, PA, 6McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 7Nantel MedSci Consult, Montreal, QC, Canada, 8Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 9Memorial University of Newfoundland, Faculty of Medicine, Division of Rheumatology, St. John's, Canada

    Background/Purpose: In the Phase 3 DISCOVER (D)-1 and -2 studies, guselkumab (GUS; IL-23p19-subunit inhibitor) 100 mg every 4 weeks (Q4W) or Q8W significantly improved joint…
  • Abstract Number: 2686 • ACR Convergence 2024

    Dose Escalation Safety Study of Brentuximab Vedotin for Diffuse Cutaneous Systemic Sclerosis:Clinical Results and Mechanistic Analysis of Skin and Peripheral Blood Mononuclear Cells

    David Fox1, Laura Cooney2, Lia Stelzig3, Robert Lafyatis4, Johann Gudjonsson5, Lam Tsoi6, Maureen Mayes7, Ankoor Shah8, Suzanne Kafaja9, William Barry3, Ellen Goldmuntz10, Dawn Smilek11 and Dinesh Khanna6, 1University of Michigan, Dexter, MI, 2University of Michigan and Immune Tolerance Network, Ann Arbor, MI, 3Rho, Durham, NC, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 5Department of Dermatology, University of Michigan, Ann Arbor, MI, 6University of Michigan, Ann Arbor, MI, 7UTHealth Houston Division of Rheumatology, Houston, TX, 8Duke University, Durham, NC, 9Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 10Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, 11Immune Tolerance Network, UCSF, San Francisco, CA

    Background/Purpose: Brentuximab vedotin (ADCETRIS®) is a drug antibody conjugate targeting CD30 approved for treatment of Hodgkin’s lymphoma (HL) and other hematologic malignancies. Association of CD30…
  • Abstract Number: 0290 • ACR Convergence 2024

    Deucravacitinib Long-term Efficacy Through 4 Years in Week 16 Placebo Crossover Patients in the Phase 3 POETYK PSO-1, PSO-2, and LTE Program

    Mark Lebwohl1, Richard Warren2, Shinichi Imafuku3, Jerry Bagel4, April W. Armstrong5, Thierry Passeron6, Subhashis Banerjee7, Renata M. Kisa8, Matthew J. Colombo7, Thomas Scharnitz8, Kim Hoyt8, Diamant Thaçi9 and Andrew Blauvelt10, 1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Dermatology Centre, Northern Care Alliance NHS Foundation Trust and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3Fukuoka University Hospital Faculty of Medicine, Fukuoka, Japan, 4Psoriasis Treatment Center of New Jersey, East Windsor, 5University of California Los Angeles, Los Angeles, 6Université Côte d’Azur, University Hospital of Nice, Nice, France, 7Bristol Myers Squibb, Princeton, NJ, 8Bristol Myers Squibb, Princeton, 9Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Schleswig-Holstein, Germany, 10Oregon Medical Research Center, Portland, OR

    Background/Purpose: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for treatment of adults with moderate…
  • Abstract Number: 1137 • ACR Convergence 2024

    Deucravacitinib, an Oral,Selective,Allosteric Tyrosine Kinase 2 Inhibitor, in Patients WithModerate to Severe Scalp Psoriasis: Efficacy and Safety Results of a Phase 3b/4, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial (PSORIATYK SCALP)

    Kristina Callis Duffin1, Christopher E. M. Griffiths2, Matthias Hoffmann3, Andrew Blauvelt4, Eugene Balagula5, Andrew Napoli5, Ying-Ming Jou5, Rachel Dyme5, Virginia Hala5, andreas pinter6 and Mark Lebwohl7, 1University of Utah, Salt Lake City, 2Dermatology Centre, University of Manchester, Manchester, and King’s College Hospital and King’s College London, London, United Kingdom, 3Private Practice, Witten, Germany, 4Oregon Medical Research Center, Portland, OR, 5Bristol Myers Squibb, Princeton, 6University Hospital of the Goethe University, Frankfurt am Main, Frankfurt, Germany, 7Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, is approved in the US, EU, and other countries for treatment of adults with…
  • Abstract Number: 1552 • ACR Convergence 2024

    Kinetics of Mucocutaneous and Musculoskeletal Responses to Deucravacitinibin Patients with Active SLE in the Phase 2 PAISLEY Trial

    Ronald Van Vollenhoven1, Joseph Merola2, Kathryn H. Dao3, Piotr Leszczynski4, Marilyn Pike5, Samantha Pomponi6, Coburn Hobar6, Matthew J. Colombo6, Ravi Koti6, Subhashis Banerjee6, Thomas Wegman7 and Eric Morand8, 1Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centers, Amsterdam, Netherlands, 2UT Southwestern Medical Center, Newton, MA, 3Department of Internal Medicine, Division of Rheumatology, The University of Texas Southwestern Medical Center, Dallas, 4Department of Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland, 5Rheumatology, MedPharm Consulting, Inc., Raleigh, NC, 6Bristol Myers Squibb, Princeton, NJ, 7Bristol Myers Squibb, Beaver Falls, PA, 8School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia

    Background/Purpose: Deucravacitinib is a first-in-class, oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor approved in multiple countries for the treatment of moderate to severe plaque…
  • Abstract Number: 1988 • ACR Convergence 2024

    A Randomized, Open-Label Study on the Effect of Nipocalimab on Vaccine Responses in Healthy Participants

    Marta Cossu1, Carolina Bobadilla Mendez2, Amanda Jackson3, Eugene Myshkin4, Grace Liu5, Edwin Lam6, Ulf H. Beier2, Kathleen Weisel2, Brittney Scott2, Jocelyn H. Leu6, Sheng Gao2 and Dessislava Dimitrova2, 1Janssen Pharmaceutical Research and Development, a Johnson & Johnson company, Leiden, Netherlands, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, 3Janssen Research & Development, LLC, La Jolla, CA, 4Janssen Research & Development, LLC, a Johnson & Johnson company, Cambridge, MA, 5Janssen Research & Development, LLC, a Johnson & Johnson company, Raritan, NJ, 6Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, PA

    Background/Purpose: Nipocalimab is a human IgG1 monoclonal antibody targeting the neonatal Fc receptor (FcRn) that selectively reduces IgG levels without impacting antigen presentation, T- and…
  • Abstract Number: 2355 • ACR Convergence 2024

    Efficacy of Risankizumab Across Distinct PsA Phenotypes Identified with Machine Learning Analytics Using Data from Biologic DMARD-Naive Patients in Two Phase 3 Clinical Trials

    Laure Gossec1, Andra Balanescu2, Maria Antonietta D'Agostino3, Alexis Ogdie4, Philipp Sewerin5, Yu Deng6, Linyu Shi6, Yoshiyuki Sugimoto7, Sheng Zhong6, Yunzhao Xing6, Ralph Lippe6 and Mitsumasa Kishimoto8, 1Sorbonne Université, Paris, France, 2UNIVERSITY OF MEDICINE AND PHARMACY CAROL DAVILA, Bucharest, Romania, 3Versailles-Saint-Quentin University (INSERM U1173, Laboratoire d’Excellence INFLAMEX); University Hospital Ambroise Paré, Versailles, France, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Rheumazentrum Ruhrgebiet, Ruhr University Bochum, Bochum, Germany, 6AbbVie Inc., North Chicago, IL, 7AbbVie GK, Tokyo, Tokyo, Japan, 8Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Risankizumab (RZB), an IL-23 p19 inhibitor, is well tolerated and provides long-term efficacy through 100 weeks in adults with PsA, demonstrated by the phase…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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