ACR Meeting Abstracts

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Abstracts tagged "Randomized Trial"

  • Abstract Number: 0293 • ACR Convergence 2022

    Long-term Sustainability of Response to Upadacitinib Among Patients with Active Rheumatoid Arthritis Refractory to Biological Disease-Modifying Anti-Rheumatic Drugs: Results Through 5 Years from SELECT-BEYOND

    Ronald van Vollenhoven1, Stephen Hall2, Alvin Wells3, Sebastian Meerwein4, Yanna Song5, Jessica Suboticki6 and Roy Fleischmann7, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Emeritus Research and Monash University, Melbourne, Australia, 3Aurora Rheumatology and Immunotherapy Center, Franklin, WI, 4AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Mettawa, IL, 7Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: The primary treatment goal for patients with rheumatoid arthritis (RA) is sustained remission (REM), but low disease activity (LDA) is considered an appropriate target…
  • Abstract Number: 1435 • ACR Convergence 2022

    Effectiveness of Combination Therapy with Tocilizumab and Low-Dose Prednisolone as an Induction Therapy in Biologics-Naïve Patients with Rheumatoid Arthritis: A Prospective, Randomized, Controlled, Open-Label, Multicenter Study

    Kazuhiro Yokota1, Hayato Nagasawa2, Yuji Akiyama3 and Toshihide Mimura4, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma Saitama, 2Nagasawa Clinic, Kawagoe, Japan, 3Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma Saitama, Japan, 4Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Efficacy and safety of tocilizumab (TCZ) in the treatment of rheumatoid arthritis (RA) has demonstrated in randomized controlled trials. However, the clinical response to…
  • Abstract Number: 2151 • ACR Convergence 2022

    Izokibep Demonstrates Clinically Relevant Efficacy Benefits on Enthesitis, Dactylitis and Nail Outcomes in Active PsA Patients: A 16-week Randomized, Placebo-controlled Trial

    Kurt de Vlam1, Peter Taylor2, Philip J Mease3, Paul Peloso4, Dieter Wetzel5, Nicolai Brun5, Brian Wiens6, Jan Brandt-Juergens7, Edit Drescher8, Eva Dokoupilova9, Anna Rowinska-Osuch10, Nadia Abdel- Kader Martin11 and Frank Behrens12, 1University Hospitals Leuven, Leuven, Belgium, 2University of Oxford, Oxford, United Kingdom, 3Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 4ACELYRIN, Naples, FL, 5Affibody AB, Solna, Sweden, 6ACELYRIN, Inc., Los Angeles, CA, 7Rheumatologische Schwerpunktpraxis, Berlin, Germany, 8Veszprem Megyei Csolnoky Ferenc Korhaz, Budapest, Hungary, 9Medical Plus, s.r.o. & Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Brno, Prague, Czech Republic, 10ETG Network, Warsaw, Poland, 11Hospital Infanta Luisa Quiron, Rheumatology, Sevilla, Spain, 12Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany

    Background/Purpose: PsA is a chronic, inflammatory disease with multiple manifestations, with arthritis and skin involvement. Other areas of inflammation include enthesitis, dactylitis and nail involvement.…
  • Abstract Number: 0294 • ACR Convergence 2022

    Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biologic DMARDs: Results Through 5 Years from the SELECT-BEYOND Study

    Roy Fleischmann1, Sebastian Meerwein2, Christina Charles-Schoeman3, BERNARD COMBE4, Stephen Hall5, Nasser Khan6, Kyle Carter7, Heidi Camp8 and Andrea Rubbert-Roth9, 1Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 2AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, 3Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA, 4Montpellier University, Montpellier, France, 5Emeritus Research and Monash University, Melbourne, Australia, 6AbbVie, Inc., Abbott Park, IL, 7AbbVie, Inc., North Chicago, IL, 8Abbvie, Winnetka, IL, 9Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland

    Background/Purpose: To evaluate the long-term efficacy and safety of upadacitinib (UPA) over 5 yrs among patients with rheumatoid arthritis (RA) in a long-term extension (LTE)…
  • Abstract Number: 1579 • ACR Convergence 2022

    The TICOG Study: Tight Control of Gout – A Randomized, Controlled Trial of Targeted versus Conventional Treatment for Gout Including Ultrasonography

    Sarah Black, Natalie McKee, Jonathan McKnight, Annmarie McShane, Adrian Pendleton, Taggart Alister and Gary Wright, Musgrave Park Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom

    Background/Purpose: Gout is a common inflammatory arthritis triggered by deposition of monosodium urate crystals in joints, bone and soft tissues, with a prevalence of 1-4%…
  • Abstract Number: 2188 • ACR Convergence 2022

    The Effect of Group-based Cognitive Behavioral Therapy for Insomnia in People with Rheumatoid Arthritis: A Randomized Controlled Trial

    Kristine Latocha1, Katrine Loeppenthin2, Mikkel Østergaard3, poul jennum4, Merete L Hetland5, Henrik Rogind6, Tine Lundbak6, Julie Midtgaard7, Robin Christensen8 and Bente Esbensen5, 1Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark, 2Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 3Rigshospitalet, University of Copenhagen, Glostrup, Denmark, 4Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen University Hospital - Rigshospitalet, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, 5Rigshospitalet, Glostrup, Denmark, 6Center for Rheumatology and Spine Diseases, Copenhagen University Hospital -Rigshospitalet, Glostrup, Denmark, 7Mental Health Centre Glostrup, University of Copenhagen, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 8Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark

    Background/Purpose: Insomnia is highly prevalent in people with rheumatoid arthritis (RA) and may exacerbate symptoms and burdens, such as fatigue, depressive symptoms, and pain (1).…
  • Abstract Number: 0295 • ACR Convergence 2022

    Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response to Conventional Synthetic DMARDs: Results Through 5 Years from the SELECT-NEXT Study

    Gerd Burmester1, Filip Van den bosch2, John Tesser3, Anna K Shmagel4, Yuanyuan Duan4, Nasser Khan5, Heidi Camp6 and Alan Kivitz7, 1Charité University Medicine Berlin, Berlin, Germany, 2Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 3Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 4AbbVie, Inc., North Chicago, IL, 5AbbVie, Inc., Abbott Park, IL, 6Abbvie, Winnetka, IL, 7Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA

    Background/Purpose: In the phase 3 SELECT-NEXT study, upadacitinib (UPA) demonstrated efficacy at wk 12 and sustained efficacy up to wk 60 in patients with rheumatoid…
  • Abstract Number: 1597 • ACR Convergence 2022

    Achievement of Different Treatment Targets with Izokibep Demonstrates Efficacy Benefits in Patients with Active Psoriatic Arthritis: Results from a 16-Week Randomized, Placebo-Controlled Phase 2 Clinical Trial

    Frank Behrens1, Peter Taylor2, Philip J Mease3, Paul Peloso4, Dieter Wetzel5, Nicolai Brun5, Brian Wiens6, Jan Brandt-Juergens7, Edit Drescher8, Eva Dokoupilova9, Anna Rowińska-Osuch10, Nadia Abdel- Kader Martin11 and Kurt de Vlam12, 1Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany, 2University of Oxford, Oxford, United Kingdom, 3Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 4ACELYRIN, Naples, FL, 5Affibody AB, Solna, Sweden, 6ACELYRIN, Inc., Los Angeles, CA, 7Rheumatologische Schwerpunktpraxis, Berlin, Germany, 8Veszprem Megyei Csolnoky Ferenc Korhaz, Budapest, Hungary, 9Medical Plus, s.r.o. & Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Brno, Prague, Czech Republic, 10ETG Network - Rheumatology, Warsaw, Poland, 11Hospital Infanta Luisa Quiron, Rheumatology, Sevilla, Spain, 12University Hospitals Leuven, Leuven, Belgium

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic, inflammatory disease with multiple clinical manifestations (arthritis, spondylitis, enthesitis, dactylitis, skin, nails). IL-17 inhibitors have shown efficacy across…
  • Abstract Number: 2209 • ACR Convergence 2022

    Efficacy of Secukinumab in Enthesitis-related Arthritis and Juvenile Psoriatic Arthritis Subtypes of Juvenile Idiopathic Arthritis: Results from a Randomized, Phase 3 Study

    Hermine Brunner1, Elena Chertok2, Joke Dehoorne3, Gerd Horneff4, Tilmann Kallinich5, Ingrid Louw6, Maria Alessio7, Sandrine Compeyrot-Lacassagne8, Bernard Lauwerys9, Neil Martin10, Katherine Marzan11, W Patrick Knibbe12, Ruvie Martin13, Xuan Zhu14, sarah whelan15, Luminita Pricop16, Daniel Lovell17, Alberto Martini18 and Nicola Ruperto19, 1Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Department of Pediatrics, Cincinnati, OH, 2Voronezh State Medical University, Voronezh, Russia, 3University Hospital Gent, Gent, Belgium, 4Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 5Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 6Panaroma Medical Centre, Cape Town, South Africa, 7Policlinico Federico II di Napoli, Napoli, Italy, 8Great Ormond Street Hospital for Children, London, United Kingdom, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Royal Hospital for Children, Glasgow, Scotland, United Kingdom, 11Children's Hospital Los Angeles, Los Angeles, CA, 12St. Luke's Hospital System, Meridian, ID, 13Novartis Pharmaceutical Corporation, East Hanover, NJ, 14Novartis Pharmaceuticals Corporation, Basking Ridge, NJ, 15Novartis Ireland Ltd, Crumlin, Dublin, Ireland, 16Novartis Pharmaceuticals Corporation, East Hanover, NJ, 17Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 18Istituto Giannina Gaslini, Genova, Italy, 19IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy

    Background/Purpose: Juvenile idiopathic arthritis (JIA) categories of enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) represent pediatric counterparts of adult non-radiographic axial spondyloarthritis and psoriatic…
  • Abstract Number: 0307 • ACR Convergence 2022

    Reduction in Structural Damage Progression and Improvement in Clinical Response with Abatacept Treatment in Patients with ACPA+, Early RA: Results from a Post Hoc Analysis of the AVERT-2 Study by Baseline Erosion Scores

    Chahin Pachai1, Sean E Connolly2, Yoshiya Tanaka3, Vivian Bykerk4, Tom Huizinga5, Gustavo Citera6, Clifton O. Bingham III7, Shuyan Du1, Godehard Hoexter8, Roy Fleischmann9, Subhashis Banerjee1 and Paul Emery10, 1Bristol Myers Squibb, Princeton, NJ, 2Bristol-Myers Squibb, Morrisville, PA, 3University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 4Hospital for Special Surgery, New York, NY, 5Leiden University Medical Center, Leiden, Netherlands, 6Instituto de Rehabilitación Psicofísica (IREP), Buenos Aires, Argentina, 7Johns Hopkins University, Baltimore, MD, 8Bristol Myers Squibb GmbH & Co. KGaA, Munich, Germany, 9University of Texas Southwestern Medical Center and Metroplex Clinical Research Center, Dallas, TX, 10Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Presence of structural damage is an important risk factor for further damage progression over time in RA. Inhibition of damage progression is a key…
  • Abstract Number: 1603 • ACR Convergence 2022

    Intervention with Methotrexate in Arthralgia at Risk for Rheumatoid Arthritis to Reduce the Development of Persistent Arthritis and Its Disease Burden (TREAT EARLIER): A Double-blind, Randomized, Placebo-controlled Trial

    Doortje Krijbolder1, Marloes Verstappen1, Bastiaan van Dijk2, Yousra Dakkak1, Aleid Boer1, Yune-Jung Park1, Marianne E. de Witt-Luth3, Karen Visser4, Marc Kok5, Esmeralda T.H. Molenaar6, Pascal de Jong7, Stephan Böhringer8, Tom Huizinga1, CF Allaart1, Ellis Niemantsverdriet9 and Annette van der Helm-van Mil10, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Centre (LUMC), Leiden, Netherlands, 3Reinier de Graaf Ziekenhuis, Delft, Netherlands, 4Haga Ziekenhuis, Amsterdam, Netherlands, 5Department of Rheumatology and Clinical immunology, Maasstad Hospital, Rotterdam, Netherlands, 6Groene Hart Ziekenhuis, Gouda, Netherlands, 7ErasmusMC, Hendrik Ido Ambacht, Netherlands, 8Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Leiden, Netherlands, 9LUMC, Leiden, Netherlands, 10Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is the most common autoimmune disease and requires long term treatment to suppress inflammation. Currently, treatment is started when arthritis is…
  • Abstract Number: 2243 • ACR Convergence 2022

    Patient Reported Outcomes from a Randomized Phase 3 Trial of Sarilumab in Polymyalgia Rheumatica

    Vibeke Strand1, Jennifer Sloane Lazar2, Michael C Nivens3, Jingdong Chao4, Stefano Fiore5, Angeliki Giannelou6, Lita Araujo7 and Jerome Msihid8, 1Stanford University School of Medicine, Stanford, CA, 2Sanofi, Delray Beach, FL, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, NY, 4Regeneron Pharmaceuticals, Inc.,, Tarrytown, NY, 5Sanofi, Bridgewater, NJ, 6Regeneron Pharmaceuticals, Inc., Hoboken, NJ, 7Sanofi, Cambridge, MA, 8Sanofi, Chilly-Mazarin, France

    Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease in the elderly. The phase 3 SAPHYR trial (NCT03600818) assessed the efficacy and safety of…
  • Abstract Number: 0411 • ACR Convergence 2022

    Bimekizumab Improves Signs and Symptoms Including Inflammation in Patients with Active Ankylosing Spondylitis: 24-Week Efficacy & Safety from a Phase 3, Multicenter, Randomized, Placebo Controlled Study

    Désirée van der Heijde1, Xenofon Baraliakos2, Maxime Dougados3, Matthew Brown4, Denis Poddubnyy5, Filip Van den bosch6, Nigil Haroon7, Huji Xu8, Tetsuya Tomita9, Lianne Gensler10, Marga Oortgiesen11, Carmen Fleurinck12, Natasha de Peyrecave13, Thomas Vaux14, Alexander Marten15 and Atul Deodhar16, 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, 2Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 3Department of Rheumatology, Hôpital Cochin, Paris, France, Paris, France, 4Genomics England, London, United Kingdom, 5Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 6Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 7Schroeder Arthritis Institute, University Health Network; University of Toronto, Toronto, ON, Canada, 8Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Affiliated to Second Military Medical University, Shanghai, China, 9Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan, Suita Osaka, Japan, 10Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA, 11UCB Pharma, Raleigh, NC, 12UCB Pharma, Brussels, Belgium, Oosterzele, Belgium, 13UCB Pharma, Brussels, Belgium, 14UCB Pharma, Slough, United Kingdom, 15UCB Pharma, Monheim am Rhein, Germany, 16Oregon Health & Science University, Portland, OR, USA, Portland, OR

    Background/Purpose: Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In a phase 2b study, BKZ showed rapid and…
  • Abstract Number: 1628 • ACR Convergence 2022

    The Sjogren Tool for Assessing Response (STAR): Assessment of Response Rates Overall, According to Baseline Activity and by Domain: Reanalysis of 9 Clinical Trials in Primary Sjogren Syndrome

    Raphaèle Seror1, Gabriel Baron2, Divi CORNEC3, Elodie Perrodeau2, Marine Camus4, Professor Simon Bowman5, Michele Bombardieri6, Hendrika Bootsma7, Suzanne Arends7, jacques-eric gottenberg8, Benjamin A. Fisher9, Wolfgang Hueber10, Joel Van Roon11, Valerie Devauchelle12, Liseth de Wolff13, Peter Gergely14, Xavier Mariette15 and Raphaël Porcher16, 1University Hospital Paris-Saclay, Le Kremlin Bicêtre, France, 2AP-HP Hôtel Dieu Hospital, Université Paris Descartes, Paris, France, 3CHRU Brest, Brest, France, 4Department of Rheumatology, Université Paris-Saclay, APHP Hôpital Bicêtre, Le Kremlin Bicêtre, France, 5University Hospitals Birmingham, Birmingham, United Kingdom, 6Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University, London, United Kingdom, 7University Medical Center Groningen, Groningen, Netherlands, 8Strasbourg University Hospital, Strasbourg, France, 9University of Birmingham, Birmingham, United Kingdom, 10Novartis Pharmaceuticals, Basel, Switzerland, 11Rheumatology & Clinical Immunology, University of Utrecht, Utrecht, Netherlands, 12Université de Bretagne Occidentale, Brest, France, 13UMCG, Zwolle, Netherlands, 14Novartis Pharma, Basel, Switzerland, 15Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 16Université Paris Cité, Hôtel-Dieu, Paris, France

    Background/Purpose: The ESSDAI and ESSPRI, used alone, are not able to capture all features of primary Sjögren's syndrome (pSS). The NECESSITY consortium developed the Sjögren's…
  • Abstract Number: 2273 • ACR Convergence 2022

    Waning Vaccine Response After Primary Vaccine Series: Results from the Covid19 Vaccine Response in Rheumatology Patients (COVER) Study

    Amy Mudano1, Gary Cutter2, Ted Mikuls3, Geoffrey Thiele4, Mark Law4, Bart Hamilton4, Michael Zikry5, Kelly Y. Chun6, Monique Bastidas7, Michael George8, Lisa Williams9, Kevin Winthrop10, Mark Busch11, Stanley Cohen12, Roman Czubatyj13, Rajesh Kataria14, Reshma Khan15, Soha Mousa16, Jose Pando17, Elizabeth Perkins18, Shanmugapriya Reddy19, Delfin Santos20, Joy Schechtman21, Frank Scott22, Sucharitha Shanmugam23, Atul Singhal24, John Tesser25, John Tower26, Swamy Venuturupalli27, Sean Joseph Wollaston28, Conrad Ziembinski29 and Jeffrey Curtis30, 1Illumination Health, Hoover, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5LabCorp, Burlington, NC, 6Labcorp, Calabasas, CA, 7LabCorp, Northridge, CA, 8University of Pennsylvania, Philadelphia, PA, 9Illumination Heath, Hoover, AL, 10Oregon Health & Science University, Portland, OR, 11Family Arthritis Center-Jupiter, Jupiter, FL, 12Metroplex Clinical Research Center, Pittsburgh, PA, 13Arthritis Physicians LLC, Rochester Hills, MI, 14Southern Ohio, Wheelersburg, OH, 15Palm Beach Rheumatology and Wellness, Jupiter, FL, 16Arthritis and Rheumatology of Southwest Ohio, Liberty Township, OH, 17Rheumatology Consultants of DE, Lewes, DE, 18Rheumatology Care Center, Hoover, AL, 19Southwest Florida Rheumatology, Riverview, FL, 20Rochester Rheumatology, Rochester Hills, MI, 21SunValley Arthritis Center, Peoria, AZ, 22Arthritis Medical Center, Arroyo Grande, CA, 23Rheumatology and Arthritis Care Center, Exton, PA, 24Southwest Rheumatology Research, Mesquite, TX, 25Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 26Arthritis Physicians LLC, Rochester, MI, 27Cedars-Sinai Medical Center, Los Angeles, CA, 28Rheumatology Associates, North Hollywood, CA, 29CZ Rheumatology, Coral Springs, FL, 30Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Given possible increased risk of COVID-19 in patients with autoimmune conditions, there is a need to better understand the immunogenicity and safety of SARS-CoV-2…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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