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Abstracts tagged "Randomized Trial"

  • Abstract Number: 2082 • ACR Convergence 2025

    Pharmacokinetic Profile of MM-II Following a Single Intra-Articular Injection in Patients with Knee Osteoarthritis in a Phase 2b Randomized, Controlled, Dose-Ranging Trial

    Thomas Schnitzer1, Xavier Chevalier2, Helene Rovsing3, Edith Lau4, Sidsel Boll5, Ballari Brahmachari6, Richard Chou7, Tarini Joshi8, Roni Wechsler9, Sveta Weiner10, Mudgal Kothekar11, Asger Bihlet12 and Philip Conaghan13, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Henri Mondor Hospital, University Paris XII UPEC, Créteil, France, 3Sanos Clinic, Gandrup, Denmark, 4Hong Kong Center for Clinical Research, Hong Kong, Hong Kong, 5Sanos Clinic, Vejle, Denmark, 6Sun Pharmaceuticals Industries Ltd., mumbai, Maharashtra, India, 7Sun Pharmaceutical Industries, Inc., Princeton, NJ, 8Sun Pharmaceutical Industries Limited, Mumbai, India, 9Moebius Medical, Tel Aviv, Israel, 10Sun Pharma Advanced Research Company Limited, Princeton, NJ, 11Sun Pharma Advanced Research Company Limited, Andheri (E), Princeton, NJ, 12NBCD A/S, Herlev, Denmark, 13University of Leeds, Leeds, United Kingdom

    Background/Purpose: MM-II is a first-in-class investigational treatment for knee OA pain that consists of a one-time IA injection of empty liposomes comprised of phospholipids dipalmitoylphosphatidylcholine…
  • Abstract Number: 1443 • ACR Convergence 2025

    Long-Term Safety and Efficacy of Upadacitinib in Patients With Psoriatic Arthritis: 5-Year Results From the Phase 3 SELECT-PsA 1 Study

    Iain McInnes1, Koji Kato2, Marina Magrey3, Joseph Merola4, mitsumasa kishimoto5, Derek Haaland6, Ivan Lagunes7, Laura Coates8, Yanxi Liu9, Erin Mancl10, Bhumik Parikh11 and Charles Phillips12, 1University of Glasgow, Glasgow, United Kingdom, 2Abbvie. Inc, North Chicago, IL, 3Case Western Reserve University School of Medicine/University Hospitals Cleveland, Richfield, OH, 4UT Southwestern Medical Center, Dallas, TX, 5Kyorin University School of Medicine, Tokyo, Japan, 6The Waterside Clinic, Oro Medonte, ON, Canada, 7Abbvie Inc, North Chicago, IL, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 9Abbvie Inc, Florham Park, NJ, 10AbbVie, Chicago, IL, 11AbbVie, Hillsborough Township, NJ, 12AbbVie Inc, Princeton, NJ

    Background/Purpose: We evaluated safety and efficacy of upadacitinib (UPA) versus adalimumab (ADA) at week 260 (5-years) from the long-term extension of SELECT-PsA 1.Methods: Randomized patients…
  • Abstract Number: 0589 • ACR Convergence 2025

    Comparing Efficacy of Upadacitinib in Male and Female Patients with axSpA: Results from the SELECT-AXIS 1 and 2 Trials

    Sofia Ramiro1, Anna Molto2, Elena Nikiphorou3, Marcelo Pinheiro4, Jamie Urbanik5, Tianming Gao6, Shirley Chen7, Jayne Stigler8, Jessica A. Walsh9 and Lihi Eder10, 1Leiden University Medical Center, Bunde, Netherlands, 2Assistance Publique Hôpitauxde Paris, Paris, France, 3King's College London, London, United Kingdom, 4UNIFESP/ EPM, São Paulo, São Paulo, Brazil, 5AbbVie, Grayslake, IL, 6AbbVie, North Chicago, IL, 7AbbVie, Somerset, NJ, 8AbbVie, Round Lake, IL, 9Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 10University of Toronto, Toronto, ON, Canada

    Background/Purpose: Evidence suggests that the treatment effectiveness of TNFis and IL-17is is higher in male (M) vs female (F) patients (pts) with axSpA.1,2 Data comparing…
  • Abstract Number: 0338 • ACR Convergence 2025

    Fractures and Changes in Bone Mineral Density During Two Years of Low Dose Glucocorticoid Treatment for Rheumatoid Arthritis: A Systematic Literature Review and Individual Participant Data Meta-Analysis

    Andriko Palmowski1, Tobias Haugegaard2, Ingiäld Hafstörm3, Henning Bliddal4, Judith Oldenkott5, Siegfried Wassenberg6, Ernest Choy7, John Kirwan8, Robin Christensen9, Maarten Boers10 and FRANK BUTTGEREIT11, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2The Parker Institute, Kopenhagen, Denmark, 3Karolinska Institutet, Stockholm, Sweden, 4The Parker Institute, Frederiksberg, Denmark, 5Charité, Berlin, Germany, 6Rheumazentrum Ratingen, Ratingen, Germany, 7Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom, 8University of Bristol, Bristol, United Kingdom, 9Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Hovedstaden, Denmark, 10Amsterdam UMC, Vrije Universiteit, Amersfoort, Netherlands, 11Charité University Medicine Berlin, Berlin, Berlin, Germany

    Background/Purpose: It is unclear to what extent low dose glucocorticoids (GCs) impact bone health in patients with rheumatoid arthritis (RA). RA leads to bone loss…
  • Abstract Number: 2006 • ACR Convergence 2025

    Storytelling and Navigation to Improve Gout Follow-up: A Multicenter, Randomized Controlled Trial

    Lesley Jackson1, Rahima Begum2, Gary Cutter2, Hyon K. Choi3, Brett Faine4, Nora G. Singer5, Natalie McCormick6, hamid shokoohi7, Blair Parry7, Oliva Nelson7, James Booth1, Zachary Armor1, John Osborne1, Kenneth Saag8 and Maria I. ("Maio") Danila9, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, 4University of Iowa, Iowa City, IA, 5The MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH, 6Massachusetts General Hospital, Boston, 7Massachusetts General Hospital, Boston, MA, 8The University of Alabama at Birmingham, Birmingham, AL, 9University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL

    Background/Purpose: Patients with gout are frequently treated in the emergency department (ED) for flares but may not receive consistent outpatient care. Approaches to mitigate this…
  • Abstract Number: 1353 • ACR Convergence 2025

    Phase 3 Study of the Efficacy, Safety and Immunogenicity of the Proposed Tocilizumab Biosimilar RGB-19, Intravenously Administered to Participants With Active Rheumatoid Arthritis: 52-Week Data

    Gerd Burmester1, Hiroaki Matsuno2, Ernest Choy3, Masato Okada4, Roshan Dias5, Károly Horvát-Karajz5, Gordana Dancer5, Yusuke Karibe6, Suguru Masuda6, Joachim Kiefer5 and Paul Emery7, 1Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Matsuno Clinic for Rheumatic Disease, Toyama, and Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 3Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom, 4Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 5Gedeon Richter Plc, Budapest, Hungary, 6Mochida Pharmaceutical Co., Ltd, Tokyo, Japan, 7University of Leeds, Leeds, England, United Kingdom

    Background/Purpose: RGB-19 is a proposed biosimilar to tocilizumab, a monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor. Results of a…
  • Abstract Number: 0576 • ACR Convergence 2025

    Factors impacting progression from oligoarticular to polyarticular PsA: Data from the FOREMOST study

    Laura Coates1, Philip J. Mease2, Joseph Merola3, Lourdes Perez Chada4, Dafna D. Gladman5, Alen Zabotti6, Ulrich Mrowietz7, mitsumasa kishimoto8, Cynthia Deignan9, Siddharth Chaudhari10, Lichen Teng11 and Laure Gossec12, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 2Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 3UT Southwestern Medical Center, Dallas, TX, 4Harvard Medical School, Wayland, MA, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 6Division of Rheumatology, Department of Medicine (DMED), Academic Hospital "Santa Maria della Misericordia", ASUFC, University of Udine, Udine, Italy, Udine, Italy, 7Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel, Germany, 8Kyorin University School of Medicine, Tokyo, Japan, 9Amgen, Inc., Agoura Hills, CA, 10Amgen Inc., Thousand Oaks, CA, 11Amgen Inc., Thousand Oaks, 12Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France

    Background/Purpose: FOREMOST (NCT03747939)1 offers novel insights on early oligoarticular (oligo, ≤4 active joints) PsA. Our aim was to analyse progression to polyarticular (poly; >4 active…
  • Abstract Number: 0335 • ACR Convergence 2025

    Discontinuation and Non-Publication of Osteoarthritis Clinical Studies: A Cross-Sectional Analysis of 10,686,413 Patients

    Mohamed Abdelsalam1, Hadeer Hafez2, Maryam Lasheen3, Bassant Elaraby Elsayed Badwy4, Omar Sameh Nabil El Sedafy1, Abdelrahman M Hafez5, Omnia Samy El-Sayed4, Menat Alla Ayman Ali Mahdy4, Ali Tarek Hassanin3, Mohamed Reda Awad6 and Mohammed Safwat Kamal Hamza7, 1Misr University For Science and Technology, 6 october, Al Jizah, Egypt, 26th October University, 6 october, Al Jizah, Egypt, 3Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, 4Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, 5Faculty of medecine, Damietta university, Mansoura, Ad Daqahliyah, Egypt, 6Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt, 7Faculty of Medicine, Misr University for Science and Technology, 6 october, Al Jizah, Egypt

    Background/Purpose: Osteoarthritis (OA) is rising at an alarming rate, affecting millions worldwide and threatening mobility, independence, and quality of life. High-quality evidence is essential to…
  • Abstract Number: 1999 • ACR Convergence 2025

    Characterization of Infusion Reactions Within 1 Hour of Treatment With Nanoencapsulated Sirolimus Plus Pegadricase: Pooled Results From the Phase 3 DISSOLVE I and DISSOLVE II Trials

    Herbert Baraf1, Andrew J. Sulich2, Guillermo J. Valenzuela3, Rehan Azeem4, Ben Peace5, Bhavisha Desai6 and Puja Khanna7, 1The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA; Division of Rheumatology, The George Washington University, Washington, DC, 2Shores Rheumatology, St. Clair Shores, MI, 3Iris Rheumatology, Plantation, FL, 4Global MACD, Sobi Inc., Waltham, MA, 5Statistical Science, Sobi, Stockholm, Sweden, 6Sobi, Glastonbury, CT, 7Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Uricase-based therapies may profoundly lower serum uric acid (sUA) in patients (pts) with uncontrolled gout (UG) but often lead to anti-drug antibody (ADA) formation,…
  • Abstract Number: 1232 • ACR Convergence 2025

    Does Social Support Reduce Bodily Pain among African American Women with SLE?: Findings from a Randomized Controlled Trial

    Jerik Leung1, Tomika Caldwell2, Paul Nietert3, Clara Dismuke4, Hetlena Johnson5, Edith Williams6 and Everette Keller3, 1Emory University, Rollins School of Public Health, Atlanta, GA, 2Medical University of Souty Carolina, Charleston, 3Medical University of South Carolina, Charleston, SC, 4VA Palo Alto Health Care System, Menlo Park, 5Lupus Community Advocate/Researcher, Columbia, SC, 6University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Peer mentoring has been shown to be an effective intervention for chronic conditions with evidence to suggest that it might improve health related bodily…
  • Abstract Number: 0573 • ACR Convergence 2025

    Effects of Sonelokimab, an IL-17A- and IL-17F-Inhibiting Nanobody, on Patient-Reported Symptoms and Quality of Life in Psoriatic Arthritis: Results From the Randomized, Double-Blind, Placebo-Controlled Phase 2 ARGO Trial

    Joseph F Merola1, Alexis Ogdie2, Alice B. Gottlieb3, Fabian Proft4, Nuala Brennan5, Alex Godwood5, Matthew R. Thomas5, Eva Cullen5, Kristian Reich6, Laura Coates7 and Laure Gossec8, 1Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 2University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, 4Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 5MoonLake Immunotherapeutics AG, Zug, Switzerland, 6MoonLake Immunotherapeutics AG and Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Zug, Switzerland, 7Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 8Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France

    Background/Purpose: Sonelokimab (SLK) is a novel IL-17A- and IL-17F-inhibiting Nanobody designed to target difficult-to-reach sites of inflammation due to its small size and albumin-binding domain.…
  • Abstract Number: 0332 • ACR Convergence 2025

    Safety, Short- and Long-Term Efficacy of Methotrexate in Osteoarthritis: A Systematic Review and Meta-Analysis

    Mohamed Abdelsalam1, Maryam Lasheen2, Hadeer Hafez3, Bassant Elaraby Elsayed Badwy4, Omar Sameh Nabil El Sedafy1 and Mohamed Reda Awad5, 1Misr University For Science and Technology, 6 october, Al Jizah, Egypt, 2Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, 36th October University, 6 october, Al Jizah, Egypt, 4Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, 5Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt

    Background/Purpose: Methotrexate (MTX), traditionally used for inflammatory conditions like rheumatoid arthritis, has well-established anti-inflammatory properties, recently gained interest as a potential therapeutic option for osteoarthritis…
  • Abstract Number: 1769 • ACR Convergence 2025

    Classification of Relapses of Eosinophilic Granulomatosis with Polyangiitis After Two-Years of Treatment with Anti-Interleukin-5/Receptor Therapy

    Christian Pagnoux1, Arnaud Bourdin2, Bernhard Hellmich3, Nader Khalidi4, David Jackson5, David Jayne6, Parameswaran Nair7, Ulrich Specks8, Benjamin Terrier9, Lena Börjesson Sjö10, Priya Jain11, Aadarsh Lal12, Sofia Necander13, Claire Walton14, Michael Wechsler15 and Peter Merkel16, 1Mount Sinai Hospital, University Health Network, Toronto, and Canadian Vasculitis Research Network (CanVasc), Toronto, ON, Canada, 2Department of Respiratory Diseases, Montpellier University Hospitals, Arnaud de Villeneuve Hospital, Montpellier, France, 3Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius Kliniken, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, 4Department of Medicine, McMaster University and St. Joseph’s Healthcare, Hamilton, Canada, 5Guy’s Severe Asthma Centre, Guy's and St Thomas’ NHS Trust, London, and School of Immunology and Microbial Sciences, King's College London, London, United Kingdom, 6University of Cambridge, Cambridge, United Kingdom, 7Department of Medicine, McMaster University and St. Joseph’s Healthcare, Hamilton, ON, Canada, 8Mayo Clinic, Rochester, MN, 9Cochin Hospital, Paris, France, 10Late-stage Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca,, Gothenburg, Sweden, 11BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, 12Respiratory & Immunology, AstraZeneca, Bengaluru, Karnataka, India, 13Late-stage Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 14Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 15Department of Medicine, National Jewish Health, Denver, 16University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Results from the ongoing open-label extension (OLE) of the MANDARA trial (NCT04157348) have demonstrated the efficacy of two years of anti-interleukin-5/receptor (anti-IL-5/R) therapies in…
  • Abstract Number: 1176 • ACR Convergence 2025

    VISIBLE Post-Inflammatory Pigmentation Journeys: Exploring the Impact of Pigmentation

    Tarek Dawamne1, Olivia Choi, MD, PhD, FAAD2, Alison Tran3, Jacob Beer4, Katelyn Rowland2, Theodore Alkousakis2, Oyediran Adelakun2, Elizabeth Skobelev2, Sancharitha Ramji2, Tony Ma5, Daphne Chan2 and Jenna Lester6, 1Texas A&M School of Engineering Medicine, Houston, TX, USA, Houston, TX, 2Johnson & Johnson, Horsham, PA, USA, Horsham, PA, 3Lake Granbury Medical Center, Department of Dermatology, Dallas, TX, USA, Dallas, TX, 4Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami, FL, USA, Miami, FL, 5Johnson & Johnson, Spring House, PA, USA, Spring House, PA, 6University of California, San Francisco, CA, USA, San Francisco, CA

    Background/Purpose: Post-inflammatory pigment alteration (PIPA) following resolution of psoriasis plaques is an important, neglected problem that disproportionately impacts people of color.1-3 VISIBLE, an ongoing Phase…
  • Abstract Number: 0567 • ACR Convergence 2025

    Sonelokimab in Biologic-Experienced Patients With Active Psoriatic Arthritis: Results From a Phase 2 Trial (ARGO) and Study Design of a Phase 3 Trial (IZAR-2) in Patients With Inadequate Response or Intolerance to Biologic TNFi, Including a Risankizumab Reference Arm

    Atul Deodhar1, Laure Gossec2, Philip J. Mease3, Xenofon Baraliakos4, Lihi Eder5, Alan Kivitz6, Helena Marzo-Ortega7, Frank Behrens8, Ana-Maria Orbai9, Georg Schett10, Arthur Kavanaugh11, Dennis McGonagle12, Christopher Ritchlin13, Nuala Brennan14, Ben Porter-Brown14, Eva Cullen14, Matthew R. Thomas14, Marius Albulescu14, Alex Godwood14, Kristian Reich15 and Laura Coates16, 1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 2Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 3Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5University of Toronto, Toronto, ON, Canada, 6Altoona Center for Clinical Research, Duncansville, PA, 7NIHR Leeds Biomedical Research Centre, The Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom, 8Rheumatology, Immunology - Inflammation Medicine, University Hospital Goethe-University & Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany, 9Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 10Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, 11University of California, San Diego, School of Medicine, San Diego, CA, 12Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom, 13University of Rochester Medical Center, Canandaigua, NY, 14MoonLake Immunotherapeutics AG, Zug, Switzerland, 15MoonLake Immunotherapeutics AG and Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Zug, Switzerland, 16Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: Sonelokimab (SLK), a novel Nanobody that binds to both IL-17A and IL-17F with similarly high affinity, is designed to target difficult-to-reach sites of inflammation.…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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