ACR Meeting Abstracts

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Abstracts tagged "quality of life"

  • Abstract Number: 0773 • ACR Convergence 2021

    Janus Kinase (JAK) Inhibition with Baricitinib: Dosing and Patient-Reported Outcomes in Refractory Juvenile Dermatomyositis

    Hanna Kim1, Ly-Lan Bergeron2, Samantha Dill2, MIchelle O'Brien2, Xiaobai Li3, Jomy George3, April Brundidge2, Michelle Millwood2, Lisa Rider4 and Robert Colbert5, 1Juvenile Myositis Pathogenesis and Therapeutics Unit, NIAMS, National Institutes of Health, Bethesda, MD, 2Office of Clinical Director, NIAMS, National Institutes of Health, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4NIEHS, NIH, Garrett Park, MD, 5NIH/NIAMS, Bethesda, MD

    Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature. Treatment often requires prolonged high-dose steroids and other immunosuppressive medications.…
  • Abstract Number: 1289 • ACR Convergence 2021

    Patients Enrolled in the Accelerating Medicines Partnership (AMP) RA/SLE Network with Isolated Renal Disease Report Minimal Quality of Life Impairment on PROMIS-29 Compared to Patients with Extrarenal Symptoms

    Philip Carlucci1, Jessica Li2, Heather Gold3, Kristina Deonaraine1, Andrea Fava2, Jill Buyon4, Judith James5, Chaim Putterman6, Deepak Rao7, Betty Diamond8, Derek Fine2, Jose Monroy-Trujillo2, Kristin Haag9, Accelerating Medicines Partership (AMP) RA/SLE Network10, H. Michael Belmont4, Sean Connery11, Fernanda Payan-Schober12, Richard Furie13, Celine Berthier14, Maria Dall'Era15, Kerry Cho16, Diane Kamen17, Kenneth Kalunian18, The Accelerating Medicines Parternship In SLE Network19, Peter Izmirly1 and Michelle Petri20, 1New York University School of Medicine, New York, NY, 2Johns Hopkins University, Baltimore, MD, 3NYU Grossman School of Medicine, New York, NY, 4NYU School of Medicine, New York, NY, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Albert Einstein College of Medicine, Bronx, NY, 7Brigham and Women's Hospital, Boston, MA, 8Northwell Health, Manhasset, NY, 9Johns Hopkins School of Medicine, Baltimore, MD, 10Brigham and Women's Hospital, Everett, MA, 11Texas Tech University Health Sciences Center, Texas, TX, 12Texas Tech University Health Sciences Center, El Paso, TX, 13Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 14University of Michigan, Ann Arbor, MI, 15University of California San Francisco, Corte Madera, CA, 16University of California San Francisco, San Francisco, CA, 17Medical University of South Carolina, Charleston, SC, 18UC San Diego, La Jolla, CA, 19Multiple Institutions, Multiple Cities, 20Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Lupus nephritis can occur as an isolated component of disease activity or be accompanied by diverse extrarenal symptoms that can adversely affect a patient’s…
  • Abstract Number: 1863 • ACR Convergence 2021

    Consistent Efficacy with Apremilast in Men and Women to Treat Oral Ulcers Associated with Behçet’s Syndrome: Results from Phase 3 Researching Oral Apremilast Safety and Efficacy in Behçet’s Disease (RELIEF) Study

    Gülen Hatemi1, Alfred Mahr2, Mitsuhiro Takeno3, Doyoung Kim4, Melike Melikoğlu5, Sue Cheng6, Sven Richter6, Shauna Jardon7, Maria Paris6, Mindy Chen6 and Yusuf Yazici8, 1Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, İstanbul, Turkey, 2Kantonsspital St. Gallen, St.Gallen, Switzerland, 3Musashi Kosugi Hospital, Kawasaki, Japan, 4Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, 5Istanbul University‒Cerrahpaşa, İstanbul, Turkey, 6Amgen Inc., Thousand Oaks, CA, 7Amgen Inc., Gilbert, AZ, 8New York University School of Medicine, New York, NY

    Background/Purpose: Painful, recurring oral ulcers (OU) associated with Behçet’s syndrome negatively affect quality of life (QoL). Differences across sexes were reported in the frequency of…
  • Abstract Number: 0234 • ACR Convergence 2021

    Impact of Early Pain Improvement on Patient-reported Outcomes in Patients with Psoriatic Arthritis: Results from a Phase 3 Trial

    Louis Bessette1, Beatriz Joven-Ibáñez2, Carlo Selmi3, Naijun Chen4, Koji Kato5, Ralph Lippe6, Patrick Zueger7, Jayeshkumar Patel4 and Joseph Merola8, 1Centre de l'Ostoporose et de Rhumatologie de Qubec, Québec City, QC, Canada, 2University Hospital 12 de Octubre, Madrid, Spain, 3Humanitas Research Hospital and Humanitas University, Milan, Italy, 4AbbVie Inc., North Chicago, IL, 5AbbVie Inc, Shinagawa- Ku, Japan, 6AbbVie Deutschland GmbH & Co. KG, Berlin, Germany, 7AbbVie Inc., Mettawa, IL, 8Harvard Medical School, Brigham and Women’s Hospital, Boston, MA

    Background/Purpose: Pain is a dominant feature of PsA and has been identified by the GRAPPA-OMERACT working group as a core disease domain. Its control is…
  • Abstract Number: 0774 • ACR Convergence 2021

    The Impact of Patient/Provider Discordance on Changes on Mood and Behavior in Adolescents with Systemic Lupus Erythematosus

    Zanab Mian1, Terrence Calistro2, Kimberly Rapoza2, Shari Berkowitz2, Tamar Rubinstein3, Kathleen Kenney-Riley2 and Joyce Hui-Yuen4, 1Cohen Children's Medical Center, New Hyde Park, NY, 2Mercy College, Dobbs Ferry, NY, 3Albert Einstein College of Medicine, White Plains, NY, 4Cohen Childrens Medical Center, New Hyde Park, NY

    Background/Purpose: Discordance between physicians’ and patients’ perceptions of disease severity can negatively impact treatment and disease outcomes; this has not yet been studied in children…
  • Abstract Number: 1332 • ACR Convergence 2021

    Validation of the PROMIS-29 Profile in Patients with Active Psoriatic Arthritis Using Data from a Phase 3, Randomized, Placebo-Controlled Study Evaluating Guselkumab (TREMFYA®)

    Ana-Maria Orbai1, Laura Coates2, Atul Deodhar3, Christopher Ritchlin4, Alexa Kollmeier5, Marlies Neuhold6, Yi-Hsuan Liu7, Yan Liu7 and Chenglong Han7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 3Oregon Health & Science University, Portland, OR, 4Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 5Janssen Research & Development, LLC, La Jolla, CA, 6Janssen-Cilag, Zug, Switzerland, 7Janssen Research & Development, LLC, Spring House, PA

    Background/Purpose: It is important to assess symptoms of pain, fatigue, anxiety, depression, sleep disturbance, and impaired physical function in patients (pts) with psoriatic arthritis (PsA),…
  • Abstract Number: 1894 • ACR Convergence 2021

    Natural Language Processing Tool for Extraction of Patient-Reported Outcomes from a National Multi-Electronic Health Records Registry

    Marie Humbert-Droz1, Zara Izadi2, Gabriela Schmajuk2, Milena Gianfrancesco2, Jinoos Yazdany2 and Suzanne Tamang3, 1Stanford University, Stanford, 2University of California San Francisco, San Francisco, CA, 3Stanford Center for Population Health Sciences, Redwood City, CA

    Background/Purpose: Patient reported outcomes (PROs) are increasingly used to track disease activity and facilitate shared decision making in patients with RA. Assessments of disease activity…
  • Abstract Number: 0314 • ACR Convergence 2021

    PROMIS Provides a Broad Overview of Health-Related Quality of Life in the Evaluation of Sjogren’s Syndrome

    Dana DiRenzo1, Susan Robinson2, Clifton Bingham1, Alan Baer3 and Thomas Grader-Beck1, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Sjogren’s Syndrome (SS) is a systemic autoimmune disease that has considerable impact on health-related quality of life (HRQL). The European League Against Rheumatism (EULAR)…
  • Abstract Number: 0798 • ACR Convergence 2021

    The Impact of Comorbidities on the Simple Disease Activity Index (SDAI) and Its Components over the First Year of Follow-up – an Analysis from the Canadian Early Arthritis Cohort (CATCH)

    Lillian-Ruiheng Chen1, Orit Schieir2, Marie-France Valois3, Janet Pope4, Susan Bartlett3, Gilles Boire5, Glen Hazlewood6, Carol Hitchon7, Edward C. Keystone8, Diane Tin9, Carter Thorne10, Narcisse Singbo1, Vivian Bykerk11 and Louis Bessette12, 1Centre de recherche du CHU de Québec-Université Laval, Québec City, QC, Canada, 2Canadian Early Arthritis Cohort Study, Montréal, QC, Canada, 3McGill University, Montréal, QC, Canada, 4University of Western Ontario, London, ON, Canada, 5Universite de Sherbrooke, Sherbrooke, QC, Canada, 6University of Calgary, Calgary, AB, Canada, 7University of Manitoba, Winnipeg, MB, Canada, 8Mount Sinai Hospital, Toronto, ON, Canada, 9The Arthritis Program Research Group, Newmarket, ON, Canada, 10Southlake Regional Health Centre, Newmarket, ON, Canada, 11Hospital for Special Surgery, New York, NY, 12Centre de l'Ostoporose et de Rhumatologie de Qubec, Québec City, QC, Canada

    Background/Purpose: Comorbid conditions have been shown to negatively influence the achievement of treatment targets in rheumatoid arthritis (RA) patients. The comorbid conditions may bias the…
  • Abstract Number: 1344 • ACR Convergence 2021

    Impact of Achieving Minimal Disease Activity on Patient-Reported Outcome Measures and Disease Activity Among Patients with Psoriatic Arthritis Treated with Biologic and Targeted Synthetic DMARDs

    Alexis Ogdie1, Robert McLean2, Maya Marchese2, Taylor Blachley2, Laura Anatale-Tardiff3, Christopher Saffore4, Kevin Douglas5, Danny Quach5 and Philip Mease6, 1University of Pennsylvania, Philadelphia, PA, 2CorEvitas, LLC, Waltham, MA, 3CorEvitas, Waltham, MA, 4AbbVie, North Chicago, IL, 5AbbVie Inc., North Chicago, IL, 6Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA

    Background/Purpose: Minimal disease activity (MDA) is a common goal for disease control when managing PsA. The aim of this study was to assess the association…
  • Abstract Number: 1910 • ACR Convergence 2021

    Association Between Clinically Meaningful Improvements in Patient-Reported Outcomes and Stringent Measures of Disease Activity in Patients with Psoriatic Arthritis Treated with Upadacitinib versus Placebo or Adalimumab: Results from a Phase 3 Trial

    Laure Gossec1, Nemanja Damjanov2, Shigeyoshi Tsuji3, Apinya Lertratanakul4, Ralph Lippe5, Jayeshkumar Patel4, Patrick Zueger6 and Kurt de Vlam7, 1Sorbonne Université; APHP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, France, 2University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia, 3Department of Orthopaedics/Rheumatology, National Hospital Organization, Osaka Minami Medical Center, Osaka, Japan, 4AbbVie Inc., North Chicago, IL, 5AbbVie Deutschland GmbH & Co. KG, Berlin, Germany, 6AbbVie Inc., Mettawa, IL, 7Department of Rheumatology, Universitaire Ziekenhuizen Leuven, Leuven, Belgium

    Background/Purpose: The achievement of disease control has been shown to be associated with improved prognosis in PsA, though no single measure of low disease activity…
  • Abstract Number: 0168 • ACR Convergence 2020

    Impact of Adalimumab (Humira) Therapy on Ocular Inflammation, Selected Health Care Resource Utilization, and Patient-Reported Outcomes in Patients with Active Non-infectious Intermediate, Posterior, or Panuveitis in Routine Clinical Practice

    Uwe Pleyer1, Salem Almutairi2, Conor Murphy3, Rola Hamam4, Karina Julian5, Shereen Hammad6, Orsolya Nagy7, Zohar Habot-Wilner8, Zsuzsanna Szepessy9, Yan Guex-Crosier10 and Sofia Androudi11, 1Charité Universitätsmedizin Berlin, Klinik für Augenheilkunde, Berlin, Germany, 2Al-Bahar Ophthalmology Center - Al-Sabah Hospital, Kuwait City, Kuwait, 3Royal Victoria Eye & Ear Hospital, Dublin, Ireland, 4American University of Beirut, Beirut, Lebanon, 5Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, 6AbbVie Biopharmaceuticals GmbH, Dubai, United Arab Emirates, 7AbbVie Kft, Budapest, Hungary, 8Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel, 9Semmelweis University, Budapest, Hungary, 10Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland, 11University of Thessaly, Larissa, Greece

    Background/Purpose: VISUAL clinical trials demonstrated efficacy and safety of adalimumab (ADA) in patients with active and inactive non-infectious, intermediate, posterior, or panuveitis (NIIPPU).1-3 The purpose…
  • Abstract Number: 0930 • ACR Convergence 2020

    Sexual Health Impairment in 90 Female Patients with Systemic Sclerosis

    Barbora Hermankova1, Maja Spiritovic2, Sabina Oreska3, Hana Storkanova4, Hana Smucrova5, Karel Pavelka6, Jiří Vencovský6, Ladislav Šenolt6, Radim Becvar4 and Michal Tomcik4, 1Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Hlavni mesto Praha, Czech Republic, 2Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha 2, Czech Republic, 4Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Systemic sclerosis (SSc) is a chronic, multisystem, connective tissue disorder characterized by fibrosis of the skin and internal organ involvement. These serious clinical manifestations…
  • Abstract Number: 1341 • ACR Convergence 2020

    Improvement in Patient-Reported Outcomes in Patients with Psoriatic Arthritis with Inadequate Response to Non-Biologic DMARDs Treated with Upadacitinib versus Placebo or Adalimumab: Results from a Phase 3 Study

    Vibeke Strand1, Philip Mease2, Enrique Soriano3, Mitsumasa Kishimoto4, Carlo Salvarani5, Nemanja Damjanov6, Jaclyn K Anderson7, Erin Blondell7, Patrick Zueger7, Christopher Saffore7 and Dafna Gladman8, 1Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 2Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, 3Department of Public Health, Instituto Universitario, Escuela de Medicina Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Capital Federal, Buenos Aires, Argentina, 4Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Yokohama, Japan, 5Rheumatology Units, University of Modena and Reggio Emilia, and Azienda USL-IRCCS di Reggio Emilia, REGGIO EMILIA, Italy, 6University of Belgrade Medical School, Belgrade, Serbia, 7AbbVie Inc., North Chicago, IL, 8Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Patient-reported outcomes (PROs) are important when evaluating treatment benefits in PsA. We present an analysis of PRO data from the SELECT-PsA 1 study.Methods: SELECT-PsA…
  • Abstract Number: 0198 • ACR Convergence 2020

    A Prospective Cohort Study of Vehicle Control as a Measure of Driving Performance in Patients with Rheumatoid Arthritis

    Kaleb Michaud1, Jennifer Merickel1, Yeongjin Gwon1, Harlan Sayles1, Haley Kampschnieder1, Rebecca Hiebert1, Alison Petro1, Bryant England1, Matthew Rizzo1 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Automobile driving is an instrumental activity of daily living. Owing to symptoms and functional impairment, patients with rheumatoid arthritis (RA) rely disproportionately on driving…
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