Abstracts tagged "Pulmonary Involvement and connective tissue diseases"

Abstract Number: 844 • 2016 ACR/ARHP Annual Meeting
Bardoxolone Methyl Produces Durable Benefits in Participants with Pulmonary Arterial Hypertension: Data from an Open-Label Extension Study
Ron Oudiz¹, Colin Meyer², Melanie Chin², Jeremy Feldman³, Angie Goldsberry², John McConnell⁴, Peter A. McCullough⁵, Megan O'Grady², Victor Tapson⁶, Fernando Torres⁷, Aaron B. Waxman⁸ and R. James White⁹, ¹Los Angeles Biomedical Research Inst. at Harbor-UCLA Medical Center, Torrance, CA, ²Reata Pharmaceuticals, Irving, TX, ³Arizona Pulmonary Specialists, Phoenix, AZ, ⁴Kentuckiana Pulmonary Associates, Louisville, KY, ⁵Baylor University Medical Center, Dallas, TX, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷University of Texas, Southwestern Medical Center, Dallas, TX, ⁸Harvard Medical School, Boston, MA, ⁹University of Rochester Medical Center, Rochester, NY
Background/Purpose: Bardoxolone methyl (BARD), an activator of the transcription factor Nrf2, and inhibitor of NF-kB, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. In an initial…

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