Abstracts tagged "Psoriatic arthritis"

Abstract Number: 814 • 2013 ACR/ARHP Annual Meeting
Results Of a Randomised Controlled Trial Comparing Tight Control Of Early Psoriatic Arthritis (TICOPA) With Standard Care: Tight Control Improves Outcome
Laura C. Coates^1,2, Anna R. Moverley^1,2, Lucy McParland³, Sarah Brown³, Howard Collier³, Jennifer Law³, Sarah R. Brown³, Neil Corrigan³, Nuria Navarro-Coy^3,4, Paul Emery^2,5, Philip G. Conaghan^1,2 and Philip S. Helliwell^1,6, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: The aim of this study was to assess the impact of tight control of early psoriatic arthritis (PsA) in a randomised-controlled trial (RCT) using…
Abstract Number: 319 • 2013 ACR/ARHP Annual Meeting
Secukinumab Shows Substantial Improvement In Both Psoriasis Symptoms and Physical Functioning In Moderate-To-Severe Plaque Psoriasis Patients With Psoriatic Arthritis: A Subanalysis Of a Phase 3, Multicenter, Double-Blind, Placebo-Controlled Study
Alice B. Gottlieb¹, Bardur Sigurgeirsson², Andrew Blauvelt³, Shephard Mpfofu⁴, Ruvie Martin⁵ and Charis Papavassilis⁴, ¹Tufts Medical Center, Boston, MA, ²University of Iceland, Kópavogur, Iceland, ³Oregon Health and Sciences University, Portland, OR, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharma AG, East Hanover, NJ
Background/Purpose: Since interleukin (IL)-17A has a potential role in the pathogenesis and chronic inflammation of psoriatic disease, with similar pathways impacting skin and joints, strategies…
Abstract Number: 815 • 2013 ACR/ARHP Annual Meeting
Long-Term (52-Week) Results Of a Phase 3, Randomized, Controlled Trial Of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, In Patients With Psoriatic Arthritis (PALACE 2)
Maurizio Cutolo¹, Gary E. Myerson², Roy Fleischmann³, Frédéric Lioté⁴, Federico Díaz-González⁵, Filip Van den Bosch⁶, Helena Marzo-Ortega⁷, Eugen Feist⁸, Kamal Shah⁹, ChiaChi Hu⁹, Randall M. Stevens⁹ and Airi Poder¹⁰, ¹University of Genova, Genova, Italy, ²Arthritis and Rheumatology of Georgia, Atlanta, GA, ³Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Hôpital Universitaire Lariboisière, Paris, France, ⁵Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Leeds Musculoskeletal Biomedical Research Unit and University of Leeds, Leeds, United Kingdom, ⁸Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁹Celgene Corporation, Warren, NJ, ¹⁰Clinical Research Centre Ltd, Tartu, Estonia
Background/Purpose: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate pro- and anti-inflammatory mediators. PALACE 2 compared the efficacy and safety of APR…
Abstract Number: 107 • 2013 ACR/ARHP Annual Meeting
Duration Of Symptoms Before Diagnosis In Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Merete Lund Hetland^1,2 and Jan Sørensen³, ¹The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, ²Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ³Center for Applied Health Services Research, University of South Denmark, Odensen, Denmark
Background/Purpose: Early diagnosis is important for the treatment of many rheumatic diseases. Little is known about the duration of symptoms before establishment of diagnosis, and if the…
Abstract Number: 2228 • 2012 ACR/ARHP Annual Meeting
The Caspar Classification Criteria and Response to TNF Blockade in Rheumatologists Practice: A Large Observational Cohort Study
Burkhard Moller¹, Almut Scherer², J. Dudler³, Bettina Weiss⁴, Nikhil Yawalkar⁵ and Peter M. Villiger⁶, ¹Rheumatology, Inselspital University Hospital, Bern, Switzerland, ²SCQM Foundation, Zurich, Switzerland, ³Rheumatology, Cantonal Hospital Fribourg, Fribourg, Switzerland, ⁴Division of Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ⁵Dermatology, MD, Bern, Switzerland, ⁶Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland
The CASPAR classification criteria and response to TNF blockade in Rheumatologists' practice: A large observational cohort study Burkhard Möller, Almut Scherer, Jean Dudler, Bettina Weiss,…
Abstract Number: 114 • 2012 ACR/ARHP Annual Meeting
US Examination of Wrists and Hands: A Comparison Between Rheumatoid Arthritis and Psoriatic Arthritis
Andrea Delle Sedie¹, Elisa Cioffi¹, Linda Carli², Elena Sardano³, Stefano Bombardieri¹ and Lucrezia Riente¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Immunology Unit, University of Pisa, Immunology Unit, University of Pisa, Italy
Background/Purpose: very little is known about the differences in joint and periarticular structure involvement in rheumatoid or psoriatic arthritis (PsA). The main pathological features detected…
Abstract Number: 2058 • 2012 ACR/ARHP Annual Meeting
Differences in Psychological Characteristics Between Patients with Rheumatoid and Psoriatic Arthritis
Panagiota Tsitsi¹, Athina Theodoridou¹, Foteini Lada¹, Konstantinos Papanikolaou², Despina Dimopoulou¹, Georgios Garyfallos³, Alexios Benos⁴ and Alexandros Garyfallos⁵, ¹4th Department of Internal Medicine,Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, ²Psychiatric Hospital of Petra Olympus, Katerini, Greece, Katerini, Greece, ³2nd Department of Psychiatry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁴Department of Hygiene, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁵4th Department of Internal Medicine, Aristotle University, Hippocratio Hospital, 4th Department of Internal Medicine, Aristotle University, Hippocratio Hospital, Thessaloniki, Greece
Background/Purpose: Both rheumatoid (RA) and psoriatic arthritis (PsA) seem to have a negative impact on patients’ psychological status mostly due to the chronic character of…
Abstract Number: L13 • 2012 ACR/ARHP Annual Meeting
Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results of a Phase 3, Randomized, Controlled Trial
Arthur Kavanaugh¹, Philip J. Mease², Juan J. Gomez-Reino³, Adebajo Adewale⁴, Jürgen Wollenhaupt⁵, ChiaChi Hu⁶ and Randall Stevens⁶, ¹UCSD School of Medicine, La Jolla, CA, ²Rheumatology Research, Swedish Medical Center, Seattle, WA, ³Rheumatology, Hospital Clinico Universitario, Santiago, Spain, ⁴University of Sheffield, Sheffield, United Kingdom, ⁵Schön Klinik Hamburg Eilbek, Hamburg, Germany, ⁶Celgene Corporation, Warren, NJ
Background/Purpose: Apremilast, an oral phosphodiesterase 4 inhibitor, works intracellularly to modulate a network of pro- and anti-inflammatory mediators, including those implicated in the etiopathogenesis of…
Abstract Number: 1369 • 2012 ACR/ARHP Annual Meeting
Severe Joint Damage in Psoriatic Arthritis: Mutilans and Ankylosis
Amir Haddad¹, Arane Thavaneswaran¹, Dafna D. Gladman² and Vinod Chandran³, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Patients with Psoriatic arthritis (PsA) who develop severe joint damage have severe functional disability and increased mortality risk. The most severe form of PsA…
Abstract Number: 1371 • 2012 ACR/ARHP Annual Meeting
Predictors of Erosion-Free Psoriatic Arthritis
Zahi Touma¹, Arane Thavaneswaran², Vinod Chandran³ and D. D. Gladman⁴, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: A number of patients with psoriatic arthritis (PsA) remain erosion-free despite years of disease. We aimed to determine the prevalence, characteristics and predictors of…
Abstract Number: 1348 • 2012 ACR/ARHP Annual Meeting
Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Psoriatic Arthritis
Amir Haddad¹, Arane Thavaneswaran¹, Sergio M.A. Toloza², Vinod Chandran³ and Dafna D. Gladman⁴, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Medicine, Hospital San Juan Bautista, Catamarca, Argentina, ³Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Spondylitis in Psoriatic Arthritis (PsA) sometimes resembles DISH because of the presence of juxta-vertebral calcification that resemble syndesmophytes. Distinguishing spondylitis from DISH has therapeutic…
Abstract Number: 1044 • 2012 ACR/ARHP Annual Meeting
Ultrasound Scores of Enthesitis and Dactylitis Do Not Correlate with Corresponding Clinical Findings in Psoriasis Arthritis
Rusmir Husic¹, Josef Hermann¹, Judith Gretler², Winfried B. Graninger³ and Christian Dejaco⁴, ¹Rheumatology, Medical University Graz, Graz, Austria, ²Med Univ Klinik Graz, Auenbruggerplatz 15, Graz, Austria, ³Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁴Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom
Background/Purpose: To compare sonography verified inflammation of entheses, tendons and joints with corresponding clinical findings in psoriasis arthritis (PsA) patients. Methods: Prospective study of 70 consecutive…
Abstract Number: 1002 • 2012 ACR/ARHP Annual Meeting
Microrna Expression Profiles in Peripheral Blood Mononuclear Cells of Early Onset Psoriatic Arthritis
G. Ciancio¹, Manuela Ferracin², Barbara Zagatti², Elena Saccenti², Valentina Bagnari¹, Ilaria Farina³, Matteo Colina⁴, Marco Seri⁵, Francesco Trotta¹, Massimo Negrini² and Marcello Govoni¹, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit-Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy, ²Department of Experimental and Diagnostic Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy, ³A.O.U. S.Anna di Cona, Ferrara, Italy, ⁴Department of Internal Medicine, Section of Internal Medicine A.Ospedale Maggiore, Bologna, Italy, ⁵Department of Gynecology, Obstetrics and Pediatric, St. Orsola-Malpighi, Medical Genetics Unit, Bologna, Italy
Background/Purpose: Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression. It is known that an altered miRNA expression plays an important role in…
Abstract Number: 573 • 2012 ACR/ARHP Annual Meeting
Differential Association Between Human Leukocyte Antigen (HLA) Alleles and Joint Subluxation and Ankylosis in Patients with Psoriatic Arthritis
Vinod Chandran¹, Arane Thavaneswaran², Amir Haddad², Fawnda Pellett³ and Dafna D. Gladman⁴, ¹Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously reported the association between HLA and KIR gene variants with the development of Arthritis Mutilans (AM) in psoriatic arthritis (PsA). However,…
Abstract Number: 2611 • 2012 ACR/ARHP Annual Meeting
Do Patients with Psoriatic Arthritis Fall Into Distinct Clinical Sub-Groups- a Cluster Analysis?
Arane Thavaneswaran¹, Vinod Chandran² and Dafna D. Gladman³, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: To determine if demographic and disease characteristics of patients with PsA at presentation to a PsA clinic cluster into distinct groups. Methods: 1058 patients…

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