ACR Meeting Abstracts

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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 0227 • ACR Convergence 2024

    Active Hand Inflammation: Differing Clinical and Ultrasound Patterns in Patients with Rheumatoid Arthritis and Psoriatic Arthritis. A Cross-Sectional and Multicenter Study

    Julio Ramírez1, Vicenç Torrente-Segarra2, Andrea Cuervo3, Mireia Moreno4, Ana Belén Azuaga1, Lourdes Mateo5, Beatriz Frade-Sosa6, Andrea Zacarias1, Noemí Busquets Pérez7, Susana Holgado8, Paula Estrada-Alarcón9, Delia Reina10, Juan José De Agustín11, Carme Moragues12, María Bonet13, Sandra Farietta1, Patricia Corzo1, Andrés Ponce14, Virginia Ruiz Esquide1, Lucia Alascio1 and Juan Cañete15, and ECOCAT group, 1Hospital Clinic Barcelona, Barcelona, Spain, 2Hospital Comarcal Alt Penedès-Garraf, Vilafranca, Spain, 3Hospital General Granollers, Granollers, Spain, 4Hospital Parc Taulí, Sabadell, Spain, 5Hospital Germans Trias i Pujol, Badalona, Spain, 6Hospital Clínic, Barcelona, Spain, 7HOSP. GENERAL DE GRANOLLERS, GRANOLLERS, Spain, 8Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 9Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 10Hospital Moises Broggi, Barcelona, Spain, 11Image and Technics Unit, Department of Rheumatology. Hospital Universitari Vall d’Hebron, Barcelona, Spain, 12Hospital Bellvitge, Barcelona, Spain, 13Hospital Alt Penedés i Garraf, Barcelona, Spain, 14Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 15Hospital Clinic an IDIBAPS, Barcelona, Spain

    Background/Purpose: The ultrasound (US) finding of proliferative synovitis (PS) in Rheumatoid Arthritis (RA), is associated with ACPA, erosions and changes in therapy [1]. However, no…
  • Abstract Number: 0588 • ACR Convergence 2024

    Sex-Related Differences in Baseline Patient and Disease Characteristics: Post Hoc Analyses of Three Phase 3, Randomized, Double-blind, Placebo-Controlled Studies in Patients with Active Psoriatic Arthritis

    Laura Coates1, Carlo Selmi2, Philip Mease3, Alexis Ogdie4, Francois Nantel5, Frederic Lavie6, Mohamed Sharaf7, Oyediran Adelakun8, Emmanouil Rampakakis9, Laura Pina Vegas10 and Lihi Eder11, 1University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 2Department of Biomedical Sciences, Humanitas University, Rozzano, Italy, 3Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Nantel MedSci Consult, Montreal, QC, Canada, 6Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 7Johnson & Johnson, Middle East FZ LLC, Dubai, UAE, Dubai, United Arab Emirates, 8Janssen Research & Development, LLC, Titusville, NJ, 9McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 10Leiden University Medical Center, Leiden, Netherlands, 11University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada

    Background/Purpose: Although PsA occurs in males and females at similar rates, clinical manifestations and outcomes differ between sexes. Findings from real-world evidence (RWE) studies have…
  • Abstract Number: 0974 • ACR Convergence 2024

    Number of Days Between Prior Low-dose Weekly Methotrexate Administration and S1-RBD Antibody Response in Adults with Immune Mediated Inflammatory Diseases Vaccinated Against COVID-19: Secondary Analysis of the Vaccine Response On-Off Methotrexate (VROOM) Study Data

    Abhishek Abhishek1, Nicholas Peckham2 and Jonathan Cook2, and the VROOM Study Author Group, 1University of Nottingham, Nottingham, United Kingdom, 2Oxford University, Oxford, United Kingdom

    Background/Purpose: Immunosuppression attenuates immune response to vaccination. A 2-week interruption in low-dose weekly methotrexate immediately after COVID-19 booster improved antibody response to vaccination. There is…
  • Abstract Number: 1316 • ACR Convergence 2024

    Dual Therapy with a JAKi and bDMARD in Patients with Standard Treatment Resistant Rheumatic Disease: A Case Series

    Bella Garg1, John Antowan2 and daniel Furst3, 1Centinela Hospital Medical Center, Inglewood, CA, 2UCLA, Los Angeles, 3Pacific Arthritis Center, Inglewood

    Background/Purpose: Due to concerns about side effects, combined JAK inhibitors (JAKi) and biologic DMARDs (bDMARDs) have not been recommended for rheumatologic conditions. However, combining them…
  • Abstract Number: 1467 • ACR Convergence 2024

    Time to First Clinically Meaningful Efficacy Responses in Musculoskeletal and Patient Reported Outcomes in Patients with Active Psoriatic Arthritis Treated with Risankizumab: A Post Hoc Analysis of the Phase 3 KEEPsAKE 1 and KEEPsAKE 2 Trials

    William Tillett1, Simona Rednic2, Kristi Mizelle3, Christopher Ritchlin4, Saakshi Khattri5, Linyu Shi6, Brenton Bialik6, Thomas Iyile7 and Arthur Kavanaugh8, 1Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, 2Department of Rheumatology, "Iuliu Hațieganu" University of Medicine and Pharmacy and County Emergency Hospital, Cluj-Napoca, Romania, 3Tidewater Physicians Multispecialty Group (TPMG) Rheumatology, Newport News, VA, 4Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 5Mount Sinai Medical Center, New York, NY, 6AbbVie Inc., North Chicago, IL, 7AbbVie Inc., hyattsville, MD, 8University of California San Diego, La Jolla, CA

    Background/Purpose: The phase 3 KEEPsAKE 1 and KEEPsAKE 2 randomized double-blind clinical trials demonstrate that risankizumab (RZB) provides a high level of durable improvement in…
  • Abstract Number: 1904 • ACR Convergence 2024

    Evaluation of the Economic Burden of Psoriatic Arthritis: Assessment of Direct Costs Using National Administrative Databases at National Level

    Wilson Bautista-Molano1, Ingrid Ramirez-bolivar2, Cristina Pinilla-Forero3 and Luz A Ruiz4, 1University Hospital Fundación Santa Fe de Bogotá, Bogotá, Colombia, 2Janssen, Bogotá, Colombia, 3Janssen, Bogotá, 4CODENTMED, Bogotá, Colombia

    Background/Purpose: Psoriatic arthritis (PsA) is a high-cost disease due to its significant impact on patients' quality of life and the extensive resources required for its…
  • Abstract Number: 2316 • ACR Convergence 2024

    Gene Expression Profile Is Different Between Men and Women in Psoriatic Disease

    Pauline KRUG1, angela De Sousa Leite2, Frédéric Lecouvet1, Maria Simona stoenoiu1 and Adrien Nzeusseu Toukap3, 1Cliniques universitaires St-Luc, Brussel, Belgium, 2Cliniques universitaires St-Luc, Brussels, Belgium, 3Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium

    Background/Purpose: Psoriatic arthritis (PsA) is a highly heterogenous chronic inflammatory condition. Recent publications highlight differences between men and women in disease manifestation and response to…
  • Abstract Number: 2333 • ACR Convergence 2024

    Unveiling New Molecular Signatures in Psoriatic Arthritis Using Comprehensive Proteomic Analysis of Peripheral Mononuclear Cells

    Eduardo Martin-Salazar1, Iván Arias-de la Rosa2, Laura Cuesta-López3, María Lourdes Ladehesa-Pineda4, Miriam Ruiz-Ponce3, Antonio Barranco3, Maria Angeles Puche-Larrubia5, Carlos Perez-Sanchez3, Yas Hanaee3, Pedro Ortiz-Buitrago3, Rosario Lopez Pedrera3, Alejandro Escudero-Contreras3, Eduardo Collantes-Estevez6, Clementina López Medina7 and Nuria Barbarroja3, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordonba, Spain, 2Rheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Andalucia, Spain, 5Reina Sofía University Hospital, Cordoba, Spain, 6Rheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba 14012, Spain, 7Reina Sofia University Hospital, Cordoba, Spain

    Background/Purpose: Diagnosing psoriatic arthritis (PsA) is challenging, underscoring the importance of discovering novel biomarkers through proteomics for early and accurate detection. Molecular clustering can elucidate…
  • Abstract Number: 2354 • ACR Convergence 2024

    Predictors of Clinical Response to Intravenous Secukinumab Among Patients with PsA: A Post Hoc Analysis of a Phase 3 Trial

    Alan Kivitz1, Liliana Sedova2, Melvin Churchill3, Cynthia Vizcaya4, Reema Sutariya5, Wenhao Cao5 and Atul Singhal6, 1Altoona Center for Clinical Research, Duncansville, PA, 2Institute of Rheumatology, Prague, and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3Arthritis Center of Nebraska, Lincoln, NE, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ, 6Southwest Arthritis Research Group, Mesquite, TX

    Background/Purpose: To assess baseline demographics and clinical characteristics of patients with PsA that are most associated with achievement of clinical response to intravenous (IV) secukinumab…
  • Abstract Number: 2586 • ACR Convergence 2024

    Results from the Biopsy Driven Ebio Study: Entheseal Tissue Signature in Response to IL-17 Blockade in Psoriatic Arthritis

    Maria Gabriella Raimondo1, Hashem Mohammadian2, Stefano Alivernini3, Simon Rauber1, Filippo Fagni4, Giulia Corte5, Koray Tascilar2, Maria Antonietta D´Agostino6, Georg Schett7, Arnd Kleyer8 and Andreas Ramming1, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 2Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nurnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 3Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, Rome, Italy, 4Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 5Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Bayern, Germany, 6Catholic University of Sacred Heart, Rome, Italy, Rome, Italy, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8Charité - Universittsmedizin Berlin, Erlangen, Germany

    Background/Purpose: Enthesitis is considered to be an early event in psoriatic arthritis (PsA) course, representing a hallmark feature of the disease. So far, most of…
  • Abstract Number: 0067 • ACR Convergence 2024

    Psoriasis Patients at Risk for Psoriatic Arthritis Have Increased Levels of Circulating Pro-migratory Dendritic Cells

    Shashank Cheemalavagu, Unnikrishnan Chandrasekharan, Oliver Wessely, Uyen Tran and M. Elaine Husni, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Early diagnosis of Psoriatic Arthritis (PsA) is critical for timely intervention to prevent poor clinical outcomes. Despite well-known clinical predictors of PsA, the mechanisms…
  • Abstract Number: 0231 • ACR Convergence 2024

    Imaging Characteristics and Demographic Variations in Patients with Axial Spondylarthritis, Axial Psoriatic Arthritis, and Inflammatory Bowel Disease-Related Arthritis with Axial Involvement: Insights from a Single Center at Cleveland Clinic Abu Dhabi

    Rajaie Namas1, Ahlam Almarzooqi2, Sarah Al Qassimi3 and Esat Memisoglu3, 1Cleveland Clinic Abu Dhabi, Detroit, MI, 2Emirates Health Services, Sharjah, United Arab Emirates, 3Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

    Background/Purpose: Spondyloarthropathies (SpAs) are a group of seronegative, inflammatory arthritides, including axial spondylarthritis (ax-SpA), axial psoriatic arthritis (ax-PsA), and inflammatory bowel disease related arthritis with…
  • Abstract Number: 0589 • ACR Convergence 2024

    Time to Clinical Response to Secukinumab Across Disease Domains Among Patients with Psoriatic Arthritis: A Pooled Post Hoc Analysis of 4 Phase 3 Trials

    Laura Coates1, Iain McInnes2, M. Elaine Husni3, Cynthia Vizcaya4, Weibin Bao5 and Philip Mease6, 1University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 2University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 3Cleveland Clinic, Cleveland, OH, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ, 6Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory disease that can manifest with considerable clinical heterogeneity. Secukinumab demonstrated improvements across the updated Group for Research and…
  • Abstract Number: 1006 • ACR Convergence 2024

    Associations Between Rheumatic Diseases and Mental Health Disorders

    Thoai Vu, Sivam Bhatt and Janet Lewis, University of Virginia, Charlottesville, VA

    Background/Purpose: Rheumatic diseases are frequently linked to a reduced quality of life (QoL), particularly as disease severity escalates. Patients with rheumatic conditions often exhibit high…
  • Abstract Number: 1389 • ACR Convergence 2024

    Cohort Study on Drug Survival and Tolerability of Adalimumab Biosimilar Transitioning: Pharmaceutical Properties Do Matter

    Amy Peeters1, Maike Wientjes2, Wieland Müskens1, David Ten Cate3, Bart van den Bemt4, Noortje van Herwaarden1 and Alfons den Broeder2, 1Sint maartenskliniek, Nijmegen, Netherlands, 2Sint Maartenskliniek, Ubbergen, Netherlands, 3Sint Maartenskliniek, Rotterdam, Netherlands, 4Sint Maartenskliniek / Radboudumc, Ubbergen, Netherlands

    Background/Purpose: Since the compound patent on the bio-originator of adalimumab expired, several adalimumab biosimilars (BS) have been introduced. Extensive research shows equivalence in effectiveness and…
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