Abstracts tagged "Psoriatic arthritis"

Abstract Number: 1453 • 2017 ACR/ARHP Annual Meeting
Impact of Biological and Targeted Synthetic Dmards on Work in Patients with Chronic Inflammatory Arthritides : A Meta Analysis of Randomized Controlled Trials and Controlled Cohorts
Charlotte Traverson¹, Amandine Tubery¹, Charlotte Hua², Françoise Barchechath-Flaisler¹, Cédric Lukas³, Bernard Combe², Jacques Morel² and Cécile Gaujoux-Viala⁴, ¹Rheumatology, Nîmes University Hospital, Nîmes, France, ²Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, ³Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, ⁴Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France
Background/Purpose: The addition of biological (b) and new targeted synthetic (ts) DMARDs agents in chronic inflammatory arthritides (CIAs) therapeutic strategies has improved the possibility of…
Abstract Number: 616 • 2017 ACR/ARHP Annual Meeting
Integrated Safety Summary of Tofacitinib in Psoriatic Arthritis Clinical Studies
Gerd R. Burmester¹, Oliver FitzGerald², Kevin Winthrop³, Valderilio F Azevedo⁴, William F C Rigby⁵, Keith S Kanik⁶, Cunshan Wang⁶, Pinaki Biswas⁷, Thomas Jones⁸, Sujatha Menon⁶, Niki Palmetto⁷ and Ricardo Rojo⁶, ¹Charité - University Medicine Berlin, Berlin, Germany, ²Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, ³Oregon Health & Science University, Portland, OR, ⁴Universidade Federal do Paraná, Curitiba, Brazil, ⁵Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, New York, NY, ⁸Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for psoriatic arthritis (PsA). We describe the safety profile of tofacitinib from integrated Phase (P)3…
Abstract Number: 1559 • 2017 ACR/ARHP Annual Meeting
Residual Disease Activity in Psoriatic Arthritis Triggers Treatment Adjustment in Only a Quarter of Patients in Daily Clinical Practice
Leonieke van Mens¹, Sadaf Atiqi², Inka Fluri², Marleen van de Sande³, Arno van Kuijk⁴ and Dominique Baeten¹, ¹AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ²Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: With expanding therapeutic possibilities for the treatment of psoriatic arthritis (PsA) it will be increasingly important to determine residual disease and define when to…
Abstract Number: 617 • 2017 ACR/ARHP Annual Meeting
Comparing Tofacitinib Safety Profile in Patients with Psoriatic Arthritis in Clinical Studies with Real-World Data
Jeffrey R. Curtis¹, Huifeng Yun¹, Oliver FitzGerald², Kevin Winthrop³, Valderilio F Azevedo⁴, Gerd R. Burmester⁵, William F C Rigby⁶, Keith S Kanik⁷, Ricardo Rojo⁷, Sujatha Menon⁷, Cunshan Wang⁷, Pinaki Biswas⁸, Thijs Hendrikx⁹ and Niki Palmetto⁸, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, ³Oregon Health & Science University, Portland, OR, ⁴Universidade Federal do Paraná, Curitiba, Brazil, ⁵Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ⁶Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁷Pfizer Inc, Groton, CT, ⁸Pfizer Inc, New York, NY, ⁹Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). Two Phase 3 studies have been completed (NCT01877668;…
Abstract Number: 1826 • 2017 ACR/ARHP Annual Meeting
Secukinumab Achievement of Psoriatic Arthritis Disease Activity Score (PASDAS) Related Remission: 2-Year Results from a Phase 3 Study
Laura C Coates¹, Dafna D Gladman², Peter Nash³, Oliver FitzGerald⁴, Arthur Kavanaugh⁵, Lawrence Rasouliyan⁶, Luminita Pricop⁷, Kevin Ding⁷ and Corine Gaillez⁸, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Toronto Western Hospital, Toronto, ON, Canada, ³University of Queensland, Brisbane, Australia, ⁴St Vincent's University Hospital, Dublin, Ireland, ⁵UC San Diego School of Medicine, La Jolla, CA, ⁶RTI Health Solutions, Barcelona, Spain, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Psoriatic arthritis (PsA) disease activity score (PASDAS) assessing multiple facets of PsA was demonstrated to distinguish treatment effect, perform better in statistical terms than…
Abstract Number: 619 • 2017 ACR/ARHP Annual Meeting
Integrated Efficacy Analysis of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis
Peter Nash¹, Laura C Coates², Roy Fleischmann³, Kim Papp⁴, Juan J. Gomez-Reino⁵, Keith S Kanik⁶, Cunshan Wang⁶, Joseph Wu⁶, Thijs Hendrikx⁷ and William C Ports⁶, ¹Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, ⁴Probity Medical Research and K. Papp Clinical Research Inc, Waterloo, ON, Canada, ⁵Fundacion Ramon Dominguez, Hospital Clinico Universitario, Santiago de Compostela, Spain, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of psoriatic arthritis (PsA). We examined tofacitinib efficacy in patients (pts) with active…
Abstract Number: 1829 • 2017 ACR/ARHP Annual Meeting
Patterns and Predictors of Progression of Sacroiliitis in Psoriatic Arthritis and Its Relationship with Human Leukocyte Antigen (HLA) Alleles. Results from the Toronto Cohort
Musaab Elmamoun¹, Justine (Yang) Ye², Richard J. Cook³, Vinod Chandran⁴ and Dafna D Gladman⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Medicine, Krembil Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is clinically heterogeneous, with broad phenotypes of musculoskeletal (MSK) involvement including peripheral arthritis, enthesitis, dactylitis, and axial involvement. Sacroiliitis (SI) in…
Abstract Number: 620 • 2017 ACR/ARHP Annual Meeting
Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, up to 36 Months in Patients with Active Psoriatic Arthritis: Data from the Second Interim Analysis of OPAL Balance, an Open‑Label, Long-Term Extension Study
Peter Nash¹, Laura C Coates², Alan J. Kivitz³, Philip J Mease⁴, Dafna D Gladman⁵, Jose A Covarrubias-Cobos⁶, Dona Fleishaker⁷, Cunshan Wang⁷, Elizabeth Kudlacz⁷, Sujatha Menon⁷, Thijs Hendrikx⁸ and Keith S Kanik⁷, ¹Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, ⁴Swedish Medical Center and University of Washington, Seattle, WA, ⁵Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶Unidad Reumatologica Las Americas S.C.P, Yucatán, Mexico, ⁷Pfizer Inc, Groton, CT, ⁸Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for psoriatic arthritis (PsA). Interim data up to January 2017 (database not locked) report the…
Abstract Number: 1874 • 2017 ACR/ARHP Annual Meeting
Development of an Ultrasonographic Enthesitis Score for Psoriatic Arthritis Patients
Stephanie Tom^1,2, Yujie Zhong³, Richard J. Cook⁴, Sibel Z. Aydin^5,6, Gurjit S. Kaeley⁷ and Lihi Eder^8,9, ¹Women's College Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵The Ottawa Hospital, Ottawa, ON, Canada, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷University of Florida, Ponte Vedra Beach, FL, ⁸Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, ⁹Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Enthesitis affects approximately a third of patients with psoriatic arthritis (PsA) and is often considered the earliest site of inflammation. The accuracy of clinical…
Abstract Number: 623 • 2017 ACR/ARHP Annual Meeting
Tofacitinib Improves Composite Endpoint Measures of Disease in Patients with Psoriatic Arthritis
Philip S. Helliwell¹, Laura C Coates¹, Oliver FitzGerald², Peter Nash³, Enrique R Soriano⁴, M. Elaine Husni⁵, Ming-Ann Hsu⁶, Keith S Kanik⁶, Thijs Hendrikx⁷, Joseph Wu⁶ and Elizabeth Kudlacz⁶, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²ASRI, Dublin, Ireland, Dublin, Ireland, ³Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, ⁴Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Cleveland Clinic Lerner Research Institute, Cleveland, OH, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). PsA is a heterogeneous disease and composite endpoints…
Abstract Number: 2030 • 2017 ACR/ARHP Annual Meeting
Patient Motivation in Inflammatory Arthritis: The Use of Ultrasound-Guided Patient Education to Endorse Medication Adherence and Facilitate Cost-Effective Targeted Management
Yasser M. El Miedany^1,2, Maha El Gaafary³, Nadia El Aroussy¹, Sally Youssef⁴ and Deborah Palmer⁵, ¹Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt, ²Rheumatology, Darent Valley Hospital, Dartford, United Kingdom, ³Community, Environmental and Occupational Medicine, Ain Shams University, Abbassia, Egypt, ⁴Rheumatology & Rehabilitation, Ain Shams University, Cairo, Egypt, ⁵Rheumatology, North Middlesex University Hospital, London, United Kingdom
Background/Purpose: To assess the value of sharing the real-time ultrasound (US) images of the inflamed joints/ tendons with inflammatory arthritis patients and its impact on:…
Abstract Number: 179 • 2017 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging of Synovium: A Novel Approach to Classify the Rheumatoid and Psoriatic Arthritis Patients
Beatriz Rocha^1,2, Berta Cillero-Pastor³, Gert Eijkel³, Lennart R. Huizing³, Cristina Ruiz-Romero^1,4, Andrea Cuervo^5,6, Ron M A Heeren³, Juan D. Cañete^5,6 and Francisco J Blanco^1,6, ¹Rheumatology Division, ProteoRed/ISCIII Proteomics Group, INIBIC - Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Spain, ²The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Masstricht, Netherlands, ³The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands, Maastricht, Netherlands, ⁴CIBER-BBN Instituto de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain., A Coruña, Spain, ⁵Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁶RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain
Background/Purpose: Psoriatic arthritis (PsA) and Rheumatoid arthritis (RA) are immune-mediated chronic inflammatory diseases. Synovial membrane is the initial site of inflammation in PsA and RA…
Abstract Number: 627 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Apremilast through 104 Weeks in Subjects with Moderate to Severe Psoriasis Randomized to Placebo, Apremilast, or Etanercept Who Continued on or Switched to Apremilast after Week 16 in a Phase 3b Study
Kristian Reich¹, Mark Goodfield², Lawrence Green³, Kristine Nograles⁴, Rongdean Chen⁴, Eugenia Levi⁴ and Richard G.B. Langley⁵, ¹Dermatologikum Hamburg, Hamburg, Germany, ²Leeds General Infirmary, Leeds, United Kingdom, ³George Washington University School of Medicine, Washington, DC, WA, ⁴Celgene Corporation, Summit, NJ, ⁵Dalhousie University, Halifax, NS, Canada
Background/Purpose: Many subjects (sbj) with chronic plaque psoriasis exhibit nail and scalp involvement that can markedly affect quality of life and be difficult to treat.…
Abstract Number: 2438 • 2017 ACR/ARHP Annual Meeting
Open Label Transitioning from Originator Etanercept to Biosimilar SB4 Compared to Continuing Treatment with Originator Etanercept in a Historical Cohort in Rheumatic Diseases in Daily Practice
L. Tweehuysen¹, V.J.B. Huiskes², B.J.F. Van den Bemt (PharmD, PhD)³, S. Teerenstra⁴, F.H.J. van den Hoogen⁵, C.H.M. van den Ende⁵ and A.A. Den Broeder⁵, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands, ³Pharmacy, Sint Maartenskliniek and Radboudumc, Nijmegen, Netherlands, ⁴Biostatistics, Radboudumc, Nijmegen, Netherlands, ⁵Rheumatology, Sint Maartenskliniek and Radboudumc, Nijmegen, Netherlands
Background/Purpose: Blinded transitioning from originator infliximab (INX) to biosimilar CT-P13 was not inferior to continuing INX treatment.1 Open label mandatory transitioning resulted in a slightly…
Abstract Number: 254 • 2017 ACR/ARHP Annual Meeting
Psoriatic Arthritis Sonographic Enthesitis Scores – Systematic Review of the Literature
Ofir Elalouf¹, Sibel Bakirci², Zahi Touma³, Melanie A Anderson⁴, Gurjit S. Kaeley⁵, Sibel Z. Aydin⁶ and Lihi Eder^7,8, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Fellow in Rheumatology, Antalya, Turkey, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵University of Florida, Ponte Vedra Beach, FL, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷Medicine, University of Toronto, Toronto, ON, Canada, ⁸Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a prominent feature of spondyloarthropathy (SpA), including psoriatic arthritis (PsA). The evaluation of enthesitis has conventionally been conducted by clinical exam, a…

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