Abstracts tagged "Psoriatic arthritis"

Abstract Number: 0569 • ACR Convergence 2021
All-Cause and Cause-Specific Mortality in Spondyloarthritis: A Systematic Review and Meta-Analysis
Haseeb Chaudhary¹, Nidrit Bohra², Khezar Syed², Anthony Donato², M.Hassan Murad³ and Paras Karmacharya⁴, ¹Tower Health System, Reading, PA, ²Reading Hospital, Tower Health System, Reading, PA, ³Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Mayo Clinic, Rochester, MN Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Spondyloarthritides (SpA) represent a group of chronic inflammatory diseases associated with a higher risk of cardio-metabolic comorbidities compared to the general population. It is…
Abstract Number: 0990 • ACR Convergence 2021
Lower Incidence of COVID-19 but Higher Mortality in Patients with Inflammatory Arthritis Compared to Controls in Wales, United Kingdom: A Population Epidemiological Study
Roxanne Cooksey¹, Mark Atkinson² and Ernest Choy³, ¹Cardiff University, Cardiff, Wales, United Kingdom, ²Swansea University, Swansea, Wales, United Kingdom, ³CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom
Background/Purpose: The COVID-19 pandemic has caused over 3 million deaths. Having inflammatory arthritis (IA) and anti-rheumatic medications increase the risk of infections. Comorbidities, common in…
Abstract Number: 1323 • ACR Convergence 2021
Uveitis in 406 Patients with Psoriatic Arthritis: Epidemiology, Clinical Characteristics and Relationship with Biological Treatment. Study of a Single University Center
Ana de Vicente Delmás¹, Lara Sánchez-Bilbao², Vanesa Calvo-Río³, David Martinez-Lopez², Alba Herrero-Morant², Eva Galindez-Agirregoikoa⁴, Iñigo Gonzalez-Mazon⁵, Nuria Barroso García⁶, NATALIA PALMOU FONTANA⁷, Ricardo Blanco³ and Miguel Ángel gonzalez-Gay⁸, ¹Hospital Punta de Europa, Cádiz, Spain, ²Hospital Universitario Marqués de Valdecilla, Santander, Spain, ³Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁴Hospital Universitario de Basurto, Bilbao, Spain, ⁵H. U. Marques de Valdecilla, Santander, Spain, ⁶Hospital Puerta del Mar, Cádiz, Spain, ⁷UNIVERSITARY HOSPITAL MARQUES VALDECILLA, Santander, Spain, ⁸Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Uveitis is the most common ocular manifestation of psoriatic arthritis (PsA). It has been described that uveitis in PsA tends to be insidious, chronic,…
Abstract Number: 1341 • ACR Convergence 2021
Ixekizumab Shows a Pattern of Pain Improvement in Patients with and Without Measurable Inflammation in Psoriatic Arthritis
Kurt de Vlam¹, Gaia Gallo², Philip Mease³, Proton Rahman⁴, Venkatesh Krishnan², David Sandoval², Chen Yen Lin², Danting Zhu², Rebecca Bolce² and Philip Conaghan⁵, ¹University Hospitals Leuven, Leuven, Belgium, ²Eli Lilly and Company, Indianapolis, IN, ³Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ⁴Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: The efficacy of ixekizumab (IXE) and adalimumab (ADA) in patients with psoriatic arthritis (PsA) has been previously reported using ACR 50 and Psoriasis Area…
Abstract Number: 1357 • ACR Convergence 2021
Clinical and Molecular Profiles Determining Cardiovascular Risk in Psoriatic Arthritis: Specific Response to Apremilast and Methotrexate
Nuria Barbarroja¹, Iván Arias de la Rosa¹, Cristobal Román-Rodriguez², Ignacio Gomez-Garcia³, Clementina López Medina⁴, M.Lourdes Ladehesa-Pineda⁵, Carlos Pérez-Sánchez⁶, Maria del Carmen Ábalos-Aguilera², Alejandra Patiño-Trives⁷, Isabel Añón-Oñate⁸, Maria Jose Pérez-Galán⁸, Rocio Guzmán-Ruiz², Maria del Mar Malagón², Chary Lopez-Pedrera², alejandro Escudero², Eduardo Collantes-Estevez² and Maria Dolores López-Montilla², ¹University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ³Rheumatology Department, Reina Sofia University Hospital. Cordoba (Spain) / University of Cordoba (Spain) / Maimonides Institute for Biomedical Research (IMIBIC). Cordoba (Spain) / Physical Medicine and Rehabilitation Department. Infanta Margarita Hospital. Cabra (Spain), Córdoba, Spain, ⁴Department of Rheumatology, Reina Sofia Hospital, IMIBIC, University of Cordoba, Cordoba, Spain/ Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France, ⁵Hospital Universitario Reina Sofía, Córdoba, Spain, ⁶IMIBIC, Córdoba, Spain, ⁷Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ⁸Rheumatology department, University Hospital of Jaen, Jaen, Spain
Background/Purpose: 1) to evaluate clinical and subclinical markers of cardiovascular (CV) disease risk and its relationship with inflammation, disease activity and metabolic comorbidities in PsA…
Abstract Number: 1774 • ACR Convergence 2021
Blood-based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients
Michelle Mulder¹, Xuehui He², Juul van den Reek², Paulo Urbano², Charlotte Kaffa², Xinhui Wang³, Bram van Cranenbroek², Esther van Rijssen², Frank van den Hoogen⁴, Irma Joosten², Wynand Alkema⁵, Elke de Jong², Ruben Smeets², Mark Wenink⁶ and Hans Koenen², ¹Sint Maartenskliniek, Nijmegen, Netherlands, ²Radboud University Medical Center, Nijmegen, Netherlands, ³University of Luxembourg, Belvaux, Luxembourg, ⁴Sint Maartenskliniek, Ubbergen, Netherlands, ⁵Hanze University of Applied Sciences, Groningen, Netherlands, ⁶Sint Maartenskliniek, Malden, Netherlands
Background/Purpose: Early detection of psoriatic arthritis (PsA) in psoriasis (Pso) patients is crucial for timely treatment and prevention of structural joint damage. We aimed to…
Abstract Number: 1792 • ACR Convergence 2021
Participation in Psoriatic Arthritis (PART2) – a Cross-sectional Study of Work Impairment in Psoriatic Arthritis Patients in the Netherlands
Tamara van Hal¹, Michelle Mulder¹, Mark Wenink² and Johanna Vriezekolk¹, ¹Sint Maartenskliniek, Nijmegen, Netherlands, ²Sint Maartenskliniek, Malden, Netherlands
Background/Purpose: Psoriatic arthritis (PsA) can lead to pain, disability and a loss of quality of life [Rosen, Rheumatology 2012]. PsA can also lead to impairments…
Abstract Number: 1809 • ACR Convergence 2021
Efficacy of Tofacitinib on Enthesitis in Patients with Active Psoriatic Arthritis
Philip Mease¹, Ana-Maria Orbai², Oliver FitzGerald³, Mohamed Bedaiwi⁴, Dona L Fleishaker⁵, Rajiv Mundayat⁶, Pamela Young⁷ and Philip S Helliwell⁸, ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland, ⁴Division of Rheumatology, College of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia, ⁵Pfizer Inc, Groton, CT, ⁶Pfizer Inc, New York, NY, ⁷Pfizer Inc, Collegeville, PA, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Enthesitis (inflammation where the tendon, ligament, or joint capsule insert into the bone) has been associated with higher disease activity and reduced quality of…
Abstract Number: 1827 • ACR Convergence 2021
Psoriatic Arthritis, Female Sex and Increased Baseline Skin Severity Are Associated with Drug Persistence in Ustekinumab-Treated Patients with Psoriasis in the BADBIR Cohort
Alexis Ogdie¹, William Tillett², Alun Passey³ and Patricia Gorecki⁴, ¹University of Pennsylvania, Philadelphia, PA, ²Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³Janssen Real World Evidence, HEMAR EMEA, High Wycombe, United Kingdom, ⁴Janssen Medical Affairs, London, United Kingdom
Background/Purpose: Skin and joint symptoms both contribute to the burden of disease in psoriatic arthritis (PsA).1 More severe skin symptoms in patients with both skin…
Abstract Number: 0183 • ACR Convergence 2021
Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 24-Week Results from the Phase 3, Randomized, Double-blind Clinical Trial for CsDMARD-IR and Bio-IR Patients
Merav Lidar¹, Jacob Aelion², Gareth Scott Tarr³, Kim Papp⁴, Lisa Barcomb⁵, Ahmed M. Soliman⁵, Wenjing Lu⁶, Ann Eldred⁵ and Andrew Ostor⁷, ¹Chaim Sheba Medical Center, Ramat Gan, Israel, ²Arthritis Clinic and West Tennessee Research Institute, Jackson, TN, ³Winelands Medical Research Centre and the Institute of Orthopaedics and Rheumatology (IOR), Winelands Medi-Clinic Orthopaedic Hospital, Stellenbosch, South Africa, ⁴K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada, ⁵Abbvie Inc., North Chicago, IL, ⁶AbbVie Inc., North Chicago, ⁷Monash University, Cabrini Hospital, and Emertius Research, Malvern, Australia
Background/Purpose: Risankizumab (RZB) is a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits interleukin 23 by binding to its p19 subunit. RZB is being investigated…
Abstract Number: 0571 • ACR Convergence 2021
The National Incidence of Clinically Diagnosed Psoriatic Arthritis in Sweden 2014-2016
Sofia Exarchou¹, Daniela Di Giuseppe², Gerd-Marie Alenius³, Eva Klingberg⁴, Valgerdur Sigurdardottir⁵, Sara Wedrén⁶, Ulf Lindström⁷, Carl Turesson⁸, Lennart Jacobsson⁷, Johan Askling² and Johan Karlsson Wallman⁹, ¹Lund University, Malmö, Sweden, ²Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ³Umeå University, Umeå, Sweden, Umeå, Sweden, ⁴University of Gothenburg, Gothenburg, Sweden and Sahlgrenska University Hospital, Gothenburg, Sweden, ⁵Uppsala University, Uppsala, Sweden and Falun Hospital, Falun, Sweden, ⁶Karolinska Institutet, Stockholm, Sweden and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁷University of Gothenburg, Gothenburg, Sweden, ⁸Lund University, Malm, Sweden, ⁹Lund University and Skane University Hospital, Hjarup, Sweden
Background/Purpose: Psoriatic arthritis (PsA) incidence estimates vary considerably, and nationwide estimates are sparse. In Sweden, PsA is typically diagnosed in specialized care, although a limited…
Abstract Number: 1005 • ACR Convergence 2021
CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration and Therapeutic Targeting
Viviana Marzaioli¹, Mary Canavan², Achilleas Floudas³, Keelin Flynn⁴, Ronan Mullan⁵, Douglas Veale⁶ and Ursula Fearon⁷, ¹Trinity College Dublin and University College Dublin, Dublin, Ireland, ²Trinity College, Santry, Ireland, ³Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, ⁴The Centre for Arthritis and Rheumatic Disease, EULAR Centre of Excellence, St. Vincent’s University Hospital and University College Dublin, Ireland, Dublin, Ireland, ⁵Tallaght University Hospital, Dublin, Ireland, ⁶University College Dublin, Dublin, Ireland, ⁷Trinity College Dublin, Dublin, Ireland
Background/Purpose: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which are at the interface between innate and adaptive immunity. A specific subset…
Abstract Number: 1325 • ACR Convergence 2021
Osteoporosis in Psoriatic Arthritis
Sara M. Rojas Herrera¹, Ignacio Braña Abascal¹, Maria Priego Fernanddez-Martos¹, Delia Fernandez Lozano¹, Lara M. Chaves Chaparro¹, Raul Veroz Gonzalez¹, Juan J. Aznar Sanchez² and Eugenio Chamizo Carmona¹, ¹Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Merida, Spain
Background/Purpose: Osteoporosis (OP) is a frequently underestimated comorbidity in immune-mediated inflammatory diseases (IMIDs). Its association with IMIDs is worse characterized in Psoriatic Arthritis (PsA) than…
Abstract Number: 1342 • ACR Convergence 2021
Low Incidence of Gastrointestinal-related and Overall Serious Adverse Events Among Guselkumab-treated Patients: Pooled Analyses of VOYAGE 1 & 2 and DISCOVER 1 & 2 Through 1-Year
Philip Mease¹, Peter Foley², Kristian Reich³, Jerry Bagel⁴, Mark Lebwohl⁵, Ya-Wen Yang⁶, May Shawi⁷, Megan Miller⁸, Alexa Kollmeier⁹, Elizabeth Hsia⁸, Xie Xu⁸, Miwa Izutsu¹⁰, Paraneedharan Ramachandran¹⁰, Shihong Sheng⁸, Yin You⁸, Philip S Helliwell¹¹ and Wolf-Henning Boehncke¹², ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ²University of Melbourne, Carlton, Australia, ³University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Psoriasis Treatment Center of Central New Jersey, Department of Dermatology, East Windsor, NJ, USA, East Windsor, NJ, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Janssen Global Services, LLC, Horsham, PA, ⁷Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, ⁸Janssen Research & Development, LLC, Spring House, PA, ⁹Janssen Research & Development, LLC, La Jolla, CA, ¹⁰Janssen Research & Development, LLC, Immunology, Spring House, PA, ¹¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ¹²Geneva University Hospitals, Geneva, Switzerland
Background/Purpose: Guselkumab (GUS), an anti-interleukin (IL)-23p19-subunit mAb, demonstrated efficacy in VOYAGE (VOY) 1&2 patients (pts) with moderate to severe plaque psoriasis (PsO)1,2 and in DISCOVER…
Abstract Number: 1358 • ACR Convergence 2021
Clusters of Psoriatic Arthritis Patients at Baseline Based on Different Ultrasound Detected Synovitis: Exploratory Analysis from a Phase III Study
Maria Antonietta D'Agostino¹, Georg Schett², Corine Gaillez³, Philip Conaghan⁴, Esperanza Naredo⁵, Philippe Carron⁶, Ruben Burgos-Vargas⁷, Peter Mandl⁸, Javier Rosa⁹, Maarten Boers¹⁰, Punit Goyanka¹¹, Weibin Bao¹² and David Demanse³, ¹Rheumatology, Fondazione Policlinico Universitario “Gemelli”, IRCCS, Rome, Italy, ²Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, ³Novartis Pharma AG, Basel, Switzerland, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Department of Rheumatology and Joint and Bone Research Unit, Hospital Fundación Jiménez Díaz and Autónoma University, Madrid, Spain, ⁶Department of Rheumatology, University Hospital Ghent, University of Ghent, Ghent, Belgium, ⁷Department of Rheumatology, General Hospital of Mexico, Ciudad de Mxico, Mexico, ⁸Medical University of Vienna, Vienna, Austria, ⁹Rheumatology Unit, Internal Medical Services, and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹⁰Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, ¹¹Novartis Healthcare Pvt Ltd, Hyderabad, India, Hyderabad, India, ¹²Novartis, East Hanover, NJ
Background/Purpose: Psoriatic arthritis (PsA) is characterized by inflammation of synovial membranes and entheseal sites leading to pain, structural damage, impairment of physical function and quality…

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