ACR Meeting Abstracts

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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 1479 • ACR Convergence 2024

    Effectiveness of B/tsDMARDs Including Ixekizumab Per Line of Therapy and Concomitant CsDMARDs in Psoriatic Arthritis: Real-World Data from a Prospective Observational Study

    Philipp Sewerin1, Nicola Gullick2, Hagen Russ3, Khai Jing Ng4, meadhbh O’Neill5, Sebastián Moyano6, Federica Giurdanella5, Adela Gallego- Flores7 and Francesco Ciccia8, 1Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany, 2University Hospitals Coventry & Warwickshire NHS trust, Warwickshire, United Kingdom, 3Eli Lilly, Indianopolis, 4Eli Lilly and Company, Madrid, Spain, 5Eli Lilly, Indianopolis, IN, 6Eli Lilly and Company, Alcobendas, Spain, 7Hospital Perpetuo Socorro, Badajoz, Spain, 8Università degli studi della Campania Luigi Vanvitelli, Naples, Italy

    Background/Purpose: Treatment (tx) guidelines for PsA recommend biologic DMARDs (bDMARDs) or targeted synthetic (ts) DMARDs after inadequate response to conventional synthetic DMARDs (csDMARDs)1. In clinical…
  • Abstract Number: 2153 • ACR Convergence 2024

    Construct Validity of the IDEOM Musculoskeletal Questionnaire (IDEOM MSK-Q) Using Data from the Cohort for Psoriasis and Psoriatic Arthritis Registry (COPPAR)

    Lourdes Perez Chada1, Ruogu Li2, vivi feathers2, Kumiko Schnock2, Helen Early2, Grace Carter2, Neda Shahriari2, Arianna Zhang2, Jing Cui3, Michael Weinblatt4, Nancy Shadick2, Alice Gottlieb5 and Joseph Merola6, 1Harvard Medical School, Wayland, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham Women's Hospital, Boston, MA, 4Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 5Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, 6UT Southwestern Medical Center, Newton, MA

    Background/Purpose: Patients with psoriasis often present with musculoskeletal (MSK) symptoms, yet validated instruments to measure MSK symptoms in this population are limited. The IDEOM MSK-Q…
  • Abstract Number: 2324 • ACR Convergence 2024

    Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients with and Without First-degree Relatives with Psoriatic Disease

    Catherine Howe1, Weixi Chen2, Jiyuan Hu2, Kyra Chen3, Adamary Felipe3, Stephanie Eichman3, Margaret Coyle4, Eileen Lydon5, Andrea Neimann3, Soumya Reddy6, Jose Scher7 and Rebecca haberman8, 1New York University Langone Medical Center, New York, NY, 2Division of Biostatistics, Department of Population Health, New York, NY, 3NYU Grossman School of Medicine, NYC, 4NYU Langone, Brooklyn, NY, 5NYU, New York, NY, 6NYU Grossman School of Medicine, New York, NY, 7New York University School of Medicine, New York, NY, 8NYU Langone Health, New York, NY

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease of the joints, affecting up to a third of individuals with cutaneous psoriasis. Pathogenesis remains…
  • Abstract Number: 2341 • ACR Convergence 2024

    Influence of Patient Baseline Characteristics on Zasocitinib (TAK-279) Efficacy, a Selective Oral Tyrosine Kinase 2 Inhibitor: A Randomized Phase 2b Trial in Psoriatic Arthritis

    Lihi Eder1, Elena Muensterman2, Desiree van der Heijde3, Alan Kivitz4, Mona Trivedi5, Ting Hong5, Muhammad Rehman5, Haoling Weng6, Jingjing Chen5 and Xenofon Baraliakos7, 1University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 2Takeda Development Center Americas, Cambridge, MA, 3Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, 4Altoona Center for Clinical Research, Duncansville, PA, 5Takeda Development Center Americas, Inc., Cambridge, MA, 6HW MedAdvice LLC, San Diego, CA, 7Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, Bochum, Germany

    Background/Purpose: Zasocitinib (TAK-279) is a potent, highly selective, oral allosteric tyrosine kinase 2 (TYK2) inhibitor. In a recent phase 2b trial in active psoriatic arthritis…
  • Abstract Number: 2368 • ACR Convergence 2024

    Bimekizumab-Treated Patients with Active Psoriatic Arthritis Showed Sustained Improvements in Pain and Fatigue: Up to 2-Year Results from Two Phase 3 Studies

    Philip Mease1, William Tillett2, Maarten de Wit3, Laure Gossec4, M. Elaine Husni5, Fabian Proft6, Barbara Ink7, Rajan Bajracharya7, Jason Coarse8, Jérémy Lambert9, Laura Coates10 and Alice Gottlieb11, 1Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 2Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, 3Stichting Tools, Patient Research Partner, Amsterdam, Netherlands, 4Sorbonne Université, Paris, France, 5Cleveland Clinic, Cleveland, OH, 6Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 7UCB Pharma, Slough, United Kingdom, 8UCB Pharma, Morrisville, NC, 9UCB Pharma, Colombes, France, 10University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 11Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA

    Background/Purpose: PsA significantly impacts patients' quality of life due to functional limitations, pain, and fatigue.1 Sustained relief from pain and fatigue are therefore important aims…
  • Abstract Number: 0205 • ACR Convergence 2024

    Cardiovascular Event Risks Among Members with Rheumatoid Arthritis, Psoriatic Arthritis, and Systemic Lupus Erythematosus

    Jean Park1, Cliff Rutter2, Elisea Avalos-Reyes3, Mary Anderson4, Will Cavers5, Dorothea Verbrugge6 and Kjel Johnson7, 1CVS Health, Hartford, CT, 2CVS Health, Fair Oaks Ranch, TX, 3CVS Health, Highland Village, TX, 4CVS Health, Irving, TX, 5CVS Health, Palm Beach Gardens, 6CVS Health, Salt Lake City, 7CVS Health, Tampa

    Background/Purpose: A growing body of evidence highlights a link between rheumatic diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PA), and systemic lupus erythematosus (SLE)…
  • Abstract Number: 0581 • ACR Convergence 2024

    Unmet Criteria for Achieving Minimal and Very Low Disease Activity Among Patients with Psoriatic Arthritis Initiating Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs in the CorEvitas PsA/SpA Registry

    Alexis Ogdie1, Chao Song2, Nicole Middaugh3, Maya Marchese3, Melissa Eliot3, Robert Low2 and Philip Mease4, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2UCB Pharma, Smyrna, GA, 3CorEvitas, LLC, Waltham, MA, 4Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Minimal disease activity (MDA) is associated with reduced radiographic progression and improved quality of life among patients (pts) with PsA.1 Clinical advances made MDA…
  • Abstract Number: 0601 • ACR Convergence 2024

    Early Improvement of Pain, Long-Term Disease Control, and Quality of Life Outcomes in Patients with Psoriatic Arthritis Treated with Upadacitinib

    Peter C. Taylor1, Lihi Eder2, Yael Klionsky3, Fabian Proft4, Thomas Iyile5, Erin Mancl6, Priscila Magalhaes Reis Nakasato7, Xiaolan Ye8, Limei Zhou6 and Philip Mease9, 1University of Oxford, Oxford, United Kingdom, 2University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 3Division of Rheumatology, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 4Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 5AbbVie Inc., hyattsville, MD, 6AbbVie Inc., North Chicago, IL, 7AbbVie Inc., Randolph, NJ, 8AbbVie Inc., Mettawa, IL, 9Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Severe musculoskeletal manifestations of PsA, particularly joint pain, can result in reduced physical function, decreased quality of life, and progressive and irreversible joint damage.1,2…
  • Abstract Number: 1133 • ACR Convergence 2024

    Relationship Between Nail Psoriasis Severity Index (NAPSI) and Cardiovascular Risk Assessed by Eight Cardiovascular Risk Calculators

    Maria F. Elizondo-Benitez1, Iris Jazmín Colunga Pedraza2, jose Ramon Azpiri-Lopez3, Dionicio Galarza-Delgado4, Jesus Cardenas-de la Garza5, Rosa Icela Arvizu-Rivera2, Andrea Guajardo Aldaco2 and Valeria Gonzalez-Gonzalez6, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 3Division of Cardiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 4UANL Hospital Universitario, Monterrey, Nuevo León, Mexico, 5Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 6Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic, inflammatory, and immune-mediated disease that affects up to 30% of psoriasis (PsO) patients. Nail psoriasis affects 80% of…
  • Abstract Number: 1457 • ACR Convergence 2024

    Treat-to-Target Approaches in Early Psoriatic Arthritis: Early Secukinumab versus Standard Care – 12- and 24-Week Results from a Multicenter, Open-Label, Randomized Controlled Trial

    Gonul Hazal Koc1, Marc R. Kok2, Fazira R. Kasiem3, Jolanda Luime3, Ilja Tchetverikov4, Kim Wilhelm - de Jong3, Lindy A. Korswagen5, Jessica Bijsterbosch6, Yvonne P. M. Goekoop-Ruiterman7, Paul Baudoin8, Petra Kok9, Reinhard Bos10, radboud J.e.m. Dolhain11 and Marijn Vis3, 1Erasmus MC, Rotterdam, Zuid-Holland, Netherlands, 2Maasstad Hospital, Rotterdam, Netherlands, 3Erasmus MC, Rotterdam, Netherlands, 4Albert Schweitzer Hospital, Dordrecht, Netherlands, 5Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands, 6Amphia Hospital, North Brabant, Netherlands, 7Haga Hospital, Den Haag, Netherlands, 8Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Reinier de Graaf Gasthuis, Delft, Netherlands, 10Medical Center Leeuwarden, Leeuwarden, Netherlands, 11Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: The Strategy Treatments aiming at Minimal Disease Activity in PsA (STAMP) is a one-year randomized controlled trial designed to investigate the efficacy of two…
  • Abstract Number: 1481 • ACR Convergence 2024

    Safety of Secukinumab in Patients with Psoriasis, Psoriatic Arthritis, Axial Spondyloarthritis and Hidradenitis Suppurativa: Updated Pooled Data from 69 Clinical Trials

    Atul Deodhar1, Iain McInnes2, Xenofon Baraliakos3, Alice Gottlieb4, Uta Kiltz5, Stefan Schreiber6, Braja Gopal Sahoo7, Weibin Bao8, Corine Gaillez9, Mercedes Bustamante9 and Philip Mease10, 1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 2University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 3Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, Bochum, Germany, 4Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, 5Rheumazentrum Ruhrgebiet Herne, Ruhr-University, D-44649 Herne, Germany, 6University Hospital Schleswig-Holstein, Kiel, Germany, Kiel, Germany, 7Novartis Healthcare Private Limited, Hyderabad, India, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, 9Novartis Pharma AG, Basel, Switzerland, 10Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Secukinumab, a fully human anti-interleukin (IL)-17A monoclonal antibody, is approved for multiple immunological disorders, including moderate-to-severe plaque psoriasis (PsO), psoriatic arthritis (PsA), axial spondyloarthritis…
  • Abstract Number: 2155 • ACR Convergence 2024

    Direct Comparison of Sleep Quality and Risk Factors for Poor Sleep Across Rheumatoid Arthritis, Axial Spondyloarthritis and Psoriatic Arthritis

    Dagna Polak1, Mateusz Wilk2, Piotr Kuszmiersz1, Glenn Haugeberg3, Mariusz Korkosz4 and Zofia Guła4, 1University Hospital in Cracow, Kraków, Poland, 2Univesity Hospital in Cracow, Kraków, Poland, 3Sørlandet Hospital, Kristiansand, Kristiansand, Norway, 4Department of Rheumatology and Immunology, Jagiellonian University Medical College, Kraków, Poland

    Background/Purpose: Sleep disorders are common among patients with inflammatory arthritis (IA) and have probably bilateral influence on disease activity and quality of life. Pathomechanism of…
  • Abstract Number: 2326 • ACR Convergence 2024

    Development and Evaluation of a Machine Learning Model for the Early Identification of Psoriatic Arthritis

    Michael Dreyfuss1, Dan Riesel2, Guy Shalev2, Benjamin Getz3, Or Ramni2, Yonatan Jenudi4, Dimid Duchovny2, Daniel Underberger5, Shlomit Steinberg-Koch2, Douglas White6 and Elena Myasoedova7, 1Predicta Med, Ramat Gan, Israel, 2Predicta Med Analytics Ltd., Ramat Gan, Israel, 3CTO, Ramat Gan, Israel, 4[email protected], Ramat Gan, Israel, 5Predicta Med Analytics Ltd., Bridgeport, CT, 6Gundersen Health System, Onalaska, WI, 7Mayo Clinic, Rochester, MN

    Background/Purpose: Delays in diagnosis of psoriatic arthritis (PsA) are associated with indolent and non-specific signs and symptoms, and often result in physical impairment and poorer…
  • Abstract Number: 2342 • ACR Convergence 2024

    Guselkumab Shows Similar Domain-Specific Efficacy in Females and Males with Active Psoriatic Arthritis: Post Hoc Analyses of Three Phase 3, Randomized, Double-blind, Placebo-Controlled Studies

    Lihi Eder1, Carlo Selmi2, Philip Mease3, Alexis Ogdie4, Francois Nantel5, Frederic Lavie6, Mohamed Sharaf7, Oyediran Adelakun8, Emmanouil Rampakakis9, Laura PINA VEGAS10 and Laura Coates11, 1University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 2IRCCS Istituto Clinico Humanitas, Rozzano, Italy, 3Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Nantel MedSci Consult, Montreal, QC, Canada, 6Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 7Johnson & Johnson, Middle East FZ LLC, Dubai, UAE, Dubai, United Arab Emirates, 8Janssen Research & Development, LLC, Titusville, NJ, 9McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 10Leiden University Medical Center, Leiden, Netherlands, 11University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom

    Background/Purpose: PsA occurs in males and females at similar rates. Females participating in randomized controlled trials (RCTs) have shown lower treatment efficacy based on composite…
  • Abstract Number: 2369 • ACR Convergence 2024

    Impact of Baseline Factors on Disease Progression and Apremilast Efficacy in Early Oligoarticular Psoriatic Arthritis

    Philip Mease1, Laura Coates2, Alexis Ogdie3, Dafna Gladman4, Alen Zabotti5, Xenofon Baraliakos6, Cynthia Deignan7, Shauna Jardon7, Rebecca Wang7, Lichen Teng7 and Laure Gossec8, 1Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 2University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 4University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Udine, Italy, 6Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 7Amgen Inc., Thousand Oaks, CA, 8Sorbonne Université, Paris, France

    Background/Purpose: In the FOREMOST study of early oligoarticular psoriatic arthritis (PsA), fewer patients (pts) receiving apremilast (APR) progressed from ≤4 active joints (all joints; oligoarthritis)…
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