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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 2368 • ACR Convergence 2025

    Inhibition of Structural Damage Progression with Guselkumab, a Selective IL-23i, in Participants with Active PsA: Results Through Week 24 of the Phase 3b, Randomized, Double-Blind, Placebo-Controlled APEX Study

    Philip J. Mease1, Christopher Ritchlin2, Laura Coates3, Alexa P. Kollmeier4, Bei Zhou5, Yusang Jiang5, Karen Bensley5, Koeun Im6, Rattandeep Batra7, Soumya Chakravarty8, Proton Rahman9 and Désirée Van Der Heijde10, 1Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 2University of Rochester Medical Center, Canandaigua, NY, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 4Johnson & Johnson, San Diego, CA, USA, San Diego, CA, 5Johnson & Johnson, Spring House, PA, USA, Spring House, PA, 6Johnson & Johnson, Cambridge, MA, USA, Cambridge, MA, 7Johnson & Johnson, Toronto, ON, Canada, Toronto, ON, Canada, 8Johnson & Johnson, Horsham, PA, USA; Drexel University College of Medicine, Philadelphia, PA, USA, Villanova, PA, 9Division of Rheumatology, Craig L. Dobbin Genetics Research Centre, Discipline of Medicine, Memorial University of Newfoundland, St. John's, Canada, 10Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Patients with active psoriatic arthritis (PsA) are at risk of irreversible joint damage that may significantly impact quality of life. Guselkumab (GUS), a fully…
  • Abstract Number: 2339 • ACR Convergence 2025

    Joint Groups Involved in Early Oligoarticular Psoriatic Arthritis and the Impact of Apremilast Treatment: Data From FOREMOST

    Alen Zabotti1, Joseph F Merola2, Ulrich Mrowietz3, Philip J. Mease4, Laure Gossec5, mitsumasa kishimoto6, Michele Brunori7, Lichen Teng8, Dafna D. Gladman9 and Laura Coates10, 1Division of Rheumatology, Department of Medicine (DMED), Academic Hospital "Santa Maria della Misericordia", ASUFC, University of Udine, Udine, Italy, Udine, Italy, 2Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 3Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel, Germany, 4Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 5Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 6Kyorin University School of Medicine, Tokyo, Japan, 7Amgen Inc, Zurich, Switzerland, 8Amgen Inc., Thousand Oaks, 9Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 10Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: Data on disease progression and joint involvement patterns in early oligoarticular (oligo) PsA are sparse. In the FOREMOST study (NCT03747939), apremilast (APR) decreased the…
  • Abstract Number: 2203 • ACR Convergence 2025

    Maternal and Fetal Outcomes Associated with IL-17 Inhibitor Exposure During Pregnancy in Patients with Seronegative Arthritis: A Case Series of Nine

    Arshdeep Waring1, Sofia Rieger-Torres2, Jeremiah Tan3, Viktoria Pavlova4 and Neda Amiri5, 1University of British Columbia, Abbotsford, BC, Canada, 2University of British Columbia, Vancouver, BC, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada, 4McMaster University, Ancaster, ON, Canada, 5University of British Columbia, North Vancouver, BC, Canada

    Background/Purpose: Interleukin-17 (IL-17) inhibitors, such as ixekizumab and secukinumab, are increasingly used in the treatment of seronegative inflammatory arthritis, including psoriatic arthritis and axial spondyloarthritis.…
  • Abstract Number: 1711 • ACR Convergence 2025

    Dysfunctional Neurobiology Of The Insula Characterizes Fatigue In Psoriatic Arthritis

    Andrew McGucken1, Flavia Sunzini2, Kristian Stefanov1, Joel Parkinson1, Salim Al-Wasity1, John McLean1, Gordon Waiter3, Stefan Siebert1 and Neil Basu4, 1University of Glasgow, Glasgow, United Kingdom, 2Glasgow University, Glasgow, United Kingdom, 3University of Aberdeen, Aberdeen, United Kingdom, 4Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Fatigue is a pervasive and burdensome symptom for people with psoriatic arthritis (PsA). The mechanisms underlying PsA related fatigue are unknown. In other clinical…
  • Abstract Number: 1442 • ACR Convergence 2025

    Modulation of Soluble Biomarkers of Cartilage and Bone Turnover and Inflammation by Zasocitinib (TAK-279), an Oral, Allosteric, Highly Selective and Potent TYK2 Inhibitor, is Associated with Clinical Response in Patients with Active Psoriatic Arthritis

    Amit Choudhury1, Jie Cheng2, Feng Hong1, Sachin Kumar1, Ayumu Sugiura3, Jay Tang1, Banishree Saha1, Vinayagam Arunachalam3, Ting Hong3, Elena Tomaselli Muensterman1, Haakan Wennbo3, Paresh Thakker1 and Iain McInnes4, 1Takeda Development Center Americas, Inc.,, Cambridge, MA, 2Takeda Development Center Americas, Inc., Cambridge, MA, 3Takeda Development Center Americas, Inc, Cambridge, MA, 4University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: As a chronic inflammatory disease, PsA is marked by cartilage and bone turnover and articular inflammation. Accordingly, elevated levels of inflammation and bone metabolism…
  • Abstract Number: 1261 • ACR Convergence 2025

    Use of telemedicine to address ‘off target’ symptoms in psoriatic arthritis (PsA): implementation of PsOWell™ in PsA

    Carter Pason1, Sarah Hopkins Gillespie1, Joelle Koplin2, Rachael Hewitt3, Christine Bundy3, Ethan Craig4, Laura Coates5, Jessica A. Walsh6 and Alexis Ogdie7, 1University of Pennsylvania, Philadelphia, PA, 2Penn Medicine, Philadelphia, PA, 3University of Cardiff, Cardiff, United Kingdom, 4University of Pennsylvania, Wallingford, PA, 5Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 6Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE

    Background/Purpose: Approximately 60-70% of patients with PsA do not reach minimal disease activity (MDA) on therapy. However, in many cases, this may not be related…
  • Abstract Number: 0577 • ACR Convergence 2025

    Persistence and Effectiveness Across PsA Patient Subgroups with Guselkumab and IL-17 Inhibitors: 6-Month Results of the PsABIOnd Observational Study

    Laure Gossec1, Mohamed Sharaf2, Xenofon Baraliakos3, mitsumasa kishimoto4, Ruben Queiro5, Ennio Lubrano6, Emmanouil Rampakakis7, László Köleséri8, Karissa Lozenski9, Enrique R. Soriano10, Proton Rahman11, Frank Behrens12 and Stefan Siebert13, 1Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 2Janssen - Johnson & Johnson, Dubai, United Arab Emirates, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 4Kyorin University School of Medicine, Tokyo, Japan, 5Hospital Universitario Central de Asturias, Oviedo. Asturias, Spain, 6Department of Medicine, Università deglia Studi del Molise, CAMPOBASSO, Italy, 7JSS Medical Research, Montréal, QC, Canada, 8IQVIA, Budapest, Hungary, 9Johnson & Johnson, Horsham, PA, 10Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires and University Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 11Division of Rheumatology, Craig L. Dobbin Genetics Research Centre, Discipline of Medicine, Memorial University of Newfoundland, St. John's, Canada, 12Goethe-University & Fraunhofer ITMP, Frankfurt, Germany, 13University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Randomized controlled trials have demonstrated the efficacy of IL-23 inhibitors (i) and IL-17i in PsA; however, real-world data on their effectiveness in heterogeneous patient…
  • Abstract Number: 0878 • ACR Convergence 2025

    Effects of IL-17A Inhibition on Entheseal Osteoblast and Fibroblast Dynamics in Psoriatic Arthritis: Insights from the EBIO Biopsy Study

    Maria Gabriella Raimondo1, Hashem Mohammadian2, Simon Rauber3, Stefano Alivernini4, Filippo Fagni5, Giulia Corte6, Koray Tascilar7, Alina Mihaela Ramming8, Juergen Rech2, Maria Antonietta D´Agostino9, Georg Schett2, Milena Pachowsky8, Arnd Kleyer10 and Andreas Ramming11, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 2Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, 3Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Bayern, Germany, 4Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 5Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Bayern, Germany, 6- Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 7Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 8Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 94Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, 10Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 11Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) & Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Enthesitis is an early event in the course of psoriatic arthritis (PsA) and a hallmark feature of the disease. Currently, much of the understanding…
  • Abstract Number: 0523 • ACR Convergence 2025

    SPECTREM: Guselkumab Significantly Improves Patient Reported Outcomes at Week 16 in Participants with Low Body Surface Area, Moderate Psoriasis with Special Sites Involvement

    Jennifer Soung1, Virginie Kelly2, Marni Wiseman3, Adrian Rodriguez4, Theodore Alkousakis5, Olivia Choi5, Daphne Chan5, Katelyn Rowland5, Linda Hou6, Jenny Jeyarajah7, Nastaran Abbarin8, Elizabeth Skobelev5, Sancharitha Ramji5, James Krell9, Max Sauder10 and David Adam11, 1Southern California Dermatology, Inc, Santa Ana, CA, USA, Santa Ana, 2Saint-Louis Medical Clinic, Quebec, Canada, Quebec, Canada, 3SkinWise Dermatology, Manitoba, Canada, Manitoba, Canada, 4Nashville Skin Comprehensive Dermatology Center, Nashville, TN, USA, Nashville, TN, 5Johnson & Johnson, Horsham, PA, USA, Horsham, PA, 6Janssen Scientific Affairs, LLC, a Johnson & Johnson company, Horsham, 7Johnson & Johnson, Horsham, PA, USA, Horsham, 8Janssen Inc, Toronto, ON, Canada, Toronto, Canada, 9Total Skin & Beauty Dermatology Center, Birmingham, AL, USA, Birmingham, 10Probity Medical Research, ON, Canada; University of Toronto, ON, Canada, Toronto, Canada, 11CCA Medical Research, ON, Canada, Toronto, Canada

    Background/Purpose: Even low body surface area (BSA) psoriasis can be extremely bothersome to patients and can have a significant impact on their lives just as…
  • Abstract Number: 0108 • ACR Convergence 2025

    In Vivo and In Vitro Analysis of IL-23 Modulation Following Anti-TNF Therapy in Psoriatic Arthritis

    Jesús Eduardo Martín Salazar1, Clementina López Medina2, Carlos Pérez Sánchez3, María Ángeles Puche-Larrubia4, Pedro Ortiz Buitrago5, María Dolores López-Montilla6, Iván Arias de la Rosa7, Laura Cuesta López8, Miriam Ruiz Ponce8, Antonio Barranco8, Laura Romero Zurita8, Elena Moreno-Caño9, Rafaela Ortega-Castro10, Jerusalén Calvo11, M Carmen Abalos-Aguilera12, Desiree Ruiz-Vilchez13, Chary López pedrera14, Alejandro Escudero Contreras11, Eduardo Collantes estévez15 and Nuria Barbarroja16, 1Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba/ Reina Sofia University Hospital, Rheumatology service/Department of Medical and Surgical Sciences, Cordoba, Spain, Cordoba, Andalucia, Spain, 2Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, 3Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, 4Reina Sofia University Hospital, Granada, Spain, 5Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Cordoba, Andalucia, Spain, 6Rheumatology Department, Reina Sofía University Hospital, Cordoba/IMIBIC/University of Cordoba., CORDOBA, Spain, 7IMIBIC/FIBICO/Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) Toledo, Spain., Córdoba, Spain, 8Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba/ Reina Sofia University Hospital, Rheumatology service/Department of Medical and Surgical Sciences, Cordoba, Spain, Córdoba, Spain, 9IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Córdoba, Spain, 10Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 11IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, 12Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, 13Department of Rheumatology, Reina Sofía University Hospital / Maimonides Institute for Biomedical Research of Córdoba (IMIBIC) / Department of Medical and Surgical Sciences, Faculty of Medicine, University of Córdoba, Spain, Cordoba, Spain, 14Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, 15Maimonides Institute for Biomedical Research of Córdoba (IMIBIC) / Department of Medical and Surgical Sciences, Faculty of Medicine, University of Córdoba, Spain, Cordoba, Spain, 16Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disease for which TNFα inhibitors are the standard first-line biologic therapy. Nonetheless, a significant proportion of patients…
  • Abstract Number: 2690 • ACR Convergence 2025

    Dietary interventions in Psoriatic Arthritis: A Randomized controlled clinical trial

    Lihi Eder1, Sohan Shahab2, Sarah Hopkins Gillespie3, Laura Bumbulis4, Helen Emanoilidis5, Charlene Compher6, Jose Scher7, Dafna D. Gladman8, Richard Cook4, Vinod Chandran1 and Alexis Ogdie9, 1University of Toronto, Toronto, ON, Canada, 2Women’s College Research Institute, Women’s College Hospital, Toronto, Canada, 3University of Pennsylvania, Philadelphia, PA, 4University of Waterloo, Waterloo, Canada, 5Women’s College Hospital, Toronto, Canada, 6University of Pennsylvania School of Nursing and Hospital of the University of Pennsylvania, Philadelphia, 7New York University School of Medicine, New York, NY, 8Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 9Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE

    Background/Purpose: The Dietary Interventions in Psoriatic Arthritis (DIPSA) study is a multicentre randomized controlled trial (RCT) designed to evaluate the efficacy of two personalized dietary…
  • Abstract Number: 2367 • ACR Convergence 2025

    Real-World Effectiveness of Risankizumab on Axial Symptoms in Biologic-Naïve Patients With Psoriatic Arthritis in the United States and Europe

    Philip J. Mease1, Andrew Ostor2, Christopher Saffore3, Xiaolan Ye4, Manish Patel5, Ana Biljan6, Ralph Lippe5, Molly Edwards7, Iwan Armstrong7 and Xenofon Baraliakos8, 1Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 2Australian National University, Canberra, Australia, 3AbbVie Inc., waukegan, IL, 4AbbVie Inc., Mettawa, IL, 5AbbVie Inc., North Chicago, IL, 6AbbVie Inc., Buffalo Grove, IL, 7Adelphi Real World, Bollington, United Kingdom, 8Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany

    Background/Purpose: Axial involvement is a clinically relevant manifestation of psoriatic arthritis (PsA) that can influence management strategies. Evidence on the real-world effectiveness of advanced therapies,…
  • Abstract Number: 2332 • ACR Convergence 2025

    Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints: DAPSA44

    Dafne capelusnik1, Clementina López Medina2, Désirée Van Der Heijde3, Daniel Aletaha4, Josef Smolen5, Anna Molto6 and Sofia Ramiro7, 1Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, 2Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Medical University Vienna, Wien, Austria, 5Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 6Assistance Publique Hôpitauxde Paris, Paris, France, 7Leiden University Medical Center, Bunde, Netherlands

    Background/Purpose: Recent studies have highlighted the potential of composite scores such as the DAPSA for assessing peripheral arthritis in axSpA and pSpA. However, the swollen…
  • Abstract Number: 2036 • ACR Convergence 2025

    JAK1 selective inhibitors versus pan-JAK inhibitors: comparative real-world study of drug retention in chronic inflammatory arthritis

    LETICIA LEON1, Pedro Pablo Bermejo2, Leonor Laredo3, José Alberto Peña4, María Teresa Benítez5, DALIFER FREITES6, CLARA DE MIGUEL3 and lydia Abasolo Alcazar7, 1Fundación Investigación Biomédica Hospital Clínico San Carlos, IdISSC; Universidad Camilo Jose Cela, MADRID, Madrid, Spain, 2Clinical Pharmacology Service, San Carlos Clinical Hospital, MADRID, Madrid, Spain, 3Hospital Clinico San Carlos, MADRID, Madrid, Spain, 4Pharmacy Service San Carlos Clinical Hospital, MADRID, Madrid, Spain, 5San Carlos Clinical Hospital, MADRID, Madrid, Spain, 6Rheumatology Service, San Carlos Clinical Hospital, Madrid, Madrid, Spain, 7IdISSC. HCSC, Madrid, Madrid, Spain

    Background/Purpose: Janus kinase inhibitors (JAKis) are effective therapeutic agents against chronic inflammatory arthritis (CIA). Tofacitinib and baricitinib were defined as pan-JAK inhibitors, while upadacitinib and…
  • Abstract Number: 1710 • ACR Convergence 2025

    Defining sonographic enthesitis in psoriatic arthritis: Developing a data- and expert-driven definition for inflammatory enthesitis at the single enthesis level

    Andre Lucas Ribeiro1, Sibel Aydin2, Gurjit Kaeley3, Fahmeen J. Afgani4, Catherine Bakewell5, Marcos Rosemffet6, Minna Kohler7, Amir Haddad8, Maria S. Stoenoiu9, Ari Polachek10, josefina marin11, Arnon Katz12, Sahil Koppikar13 and Lihi Eder14, 1Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, 2Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3UF COM-J, Ponte Vedra Beach, FL, 4Women's College Hospital, Toronto, Canada, 5Intermountain Healthcare, Salt Lake City, UT, 6Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, 7Massachusetts General Hospital, Harvard Medical School, Boston, MA, 8Carmel Medical Centre, Haifa, Israel, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Rheumatology Institute of Beilinson Hospital, Petah Tikva, Israel, 11Hospital Universitario Rey Juan Carlos, Madrid, Spain, 12GRAPPA, Seattle, 13Women's College Hospital & University of Toronto, Markham, ON, Canada, 14University of Toronto, Toronto, ON, Canada

    Background/Purpose: Enthesitis affects 30–40% of PsA patients but remains difficult to diagnose due to overlap with non-specific entheseal pain. While OMERACT has standardized ultrasound (US)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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