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Abstracts tagged "Psoriatic arthritis"

  • Abstract Number: 0573 • ACR Convergence 2025

    Effects of Sonelokimab, an IL-17A- and IL-17F-Inhibiting Nanobody, on Patient-Reported Symptoms and Quality of Life in Psoriatic Arthritis: Results From the Randomized, Double-Blind, Placebo-Controlled Phase 2 ARGO Trial

    Joseph F Merola1, Alexis Ogdie2, Alice B. Gottlieb3, Fabian Proft4, Nuala Brennan5, Alex Godwood5, Matthew R. Thomas5, Eva Cullen5, Kristian Reich6, Laura Coates7 and Laure Gossec8, 1Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 2University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, 4Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 5MoonLake Immunotherapeutics AG, Zug, Switzerland, 6MoonLake Immunotherapeutics AG and Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Zug, Switzerland, 7Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 8Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France

    Background/Purpose: Sonelokimab (SLK) is a novel IL-17A- and IL-17F-inhibiting Nanobody designed to target difficult-to-reach sites of inflammation due to its small size and albumin-binding domain.…
  • Abstract Number: 0873 • ACR Convergence 2025

    Sex Differences in Proteomic Profiles and the Impact of Deucravacitinib Treatment in Patients with Active Psoriatic Arthritis: A Pooled Phase 3 Analysis

    Lihi Eder1, Shangzhong Li2, Philip J. Mease3, Christopher Ritchlin4, Walter P Maksymowych5, Hendrik Schulze-Koops6, Josef Smolen7, Oliver FitzGerald8, Vinod Chandran9, Chun Wu10 and Jinqi Liu2, 1University of Toronto, Toronto, ON, Canada, 2Bristol Myers Squibb, Princeton, NJ, 3Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 4University of Rochester Medical Center, Canandaigua, NY, 5Department of Medicine, University of Alberta, Edmonton, AB, Canada, 6LMU Hospital, Division for Rheumatology and Clinical Immunology, Munich, Bayern, Germany, 7Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 8UCD, Dublin 6, Dublin, Ireland, 9Division of Rheumatology, Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, and Gladman Krembil Psoriatic Arthritis Research Program, Krembil Research Institute, University Health Network, Toronto, Canada, 10Bristol Myers Squibb, Princeton

    Background/Purpose: PsA affects male and female patients equally; however, variations in manifestations and treatment response exist between sexes. Deucravacitinib is an oral, selective, allosteric tyrosine…
  • Abstract Number: 0475 • ACR Convergence 2025

    Drug Discontinuation in Inflammatory Arthritis Following Mandatory Non-Medical Switching from Originator to Biosimilar in Quebec, Canada

    Cristiano Moura1, Luck Lukusa2, Denis Choquette3, Gilles Boire4, Nathalie Carrier5, Autumn Neville2 and Sasha Bernatsky6, 1Research Institute of the McGill University Health Center, Montréal, Canada, 2Research Institute of the McGill University Health Centre, Montreal, Canada, 3Institut de Rhumatologie de Montréal, Saint-Donat-de-Montcalm, Canada, 4Retired, Sherbrooke, QC, Canada, 5Centre integré universitaire de santé et de services sociaux de l’Estrie – Centre hospitalier universitaire de Sherbrooke (CIUSSS de l’Estrie-CHUS), Sherbrooke, Canada, 6Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: In April 2022, the Canadian province of Quebec introduced a mandatory non-medical switch to biosimilars for persons on bio-originators to manage healthcare costs. Our…
  • Abstract Number: 0581 • ACR Convergence 2025

    Effects of Apremilast on Body Mass Index, Weight, and HbA1c as Cardiometabolic Outcomes in Patients With Early Oligoarticular Psoriatic Arthritis in the FOREMOST Study

    Philip J. Mease1, Álvaro González Cantero2, Jennifer Soung3, April Armstrong4, Joseph F Merola5, Fabian Proft6, Laure Gossec7, Dafna D. Gladman8, Laura Coates9, Lichen Teng10, Jimena Vázquez11, Cynthia Deignan12 and Arthur Kavanaugh13, 1Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 2Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain, 3Southern California Dermatology, Inc, Santa Ana, CA, USA, Santa Ana, 4University of California Los Angeles, Los Angeles, 5Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX, 6Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 7Sorbonne Université, Pitié Salpêtrière Hospital, Paris, France, 8Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 9Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 10Amgen Inc., Thousand Oaks, 11Amgen Inc., Thousand Oaks, CA, 12Amgen, Inc., Agoura Hills, CA, 13University of California, San Diego, School of Medicine, San Diego, CA

    Background/Purpose: The prevalence of cardiometabolic diseases, including obesity and diabetes, is higher in patients with psoriatic arthritis (PsA) than those without PsA.1,2 Metabolic syndrome is…
  • Abstract Number: 2687 • ACR Convergence 2025

    Glucagon-like peptide-1 receptor agonists therapy is associated in improvement in psoriatic arthritis-related and metabolic outcomes: A retrospective analysis of two cohorts

    Lihi Eder1, Uma Scher2, Kyra Chen3, Alexandra L. Rice3, Sydney Thib4 and Rebecca Haberman5, 1University of Toronto, Toronto, ON, Canada, 2NYU School of Medicine, Scarsdale, NY, 3NYU Grossman School of Medicine and NYU Langone Health Psoriatic Arthritis Center, New York, 4Women's College Research Institute, Women's College Hospital, Toronto, Canada, 5NYU Langone Health, New York, NY

    Background/Purpose: Obesity is highly prevalent in psoriatic arthritis (PsA) and is associated with reduced therapeutic response, worse disease outcomes, and increased cardiometabolic risk. Glucagon-like peptide-1…
  • Abstract Number: 2364 • ACR Convergence 2025

    Real-World Characteristics and Treatment Patterns of Difficult-to-Treat Psoriatic Arthritis

    Milad Heydari-Kamjani1, Jennifer Murphy2 and Marina Magrey3, 1University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH, 2University Hospitals, Cleveland Medical Center, cleveland, OH, 3Case Western Reserve University School of Medicine/University Hospitals Cleveland, Richfield, OH

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease with variable clinical presentation and treatment response. A subset of PsA patients are difficult to treat…
  • Abstract Number: 2325 • ACR Convergence 2025

    Association of Galectin-3 and Myocardial Dysfunction in Patients with Psoriatic Arthritis

    Natalia Guajardo-Jauregui1, Iris J. Colunga-Pedraza2, Dionicio A. Galarza-Delgado2, Jose R Azpiri-Lopez3, Jesus Alberto Cardenas-de la Garza4, Diana E. Flores-Alvarado5 and Rosa Arvizu-Rivera6, 1Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Mexico, 2Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico, 3Cardiology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico, 4Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, 5Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Nuevo Leon, Mexico, 6Hospital Universitario "Dr. José Eleuterio Gonzalez", Escobedo, Nuevo León, Mexico

    Background/Purpose: Psoriatic arthritis (PsA) is an immune-mediated condition associated with an increased risk of cardiovascular (CV) events due to disease-specific characteristics. Galectin-3 (Gal-3) is a…
  • Abstract Number: 1959 • ACR Convergence 2025

    The development and validation of a Diagnostic Ultrasound Enthesitis Score (DUET) for Psoriatic Arthritis

    Lihi Eder1, Ricardo Acayaba de Toledo2, Catherine Bakewell3, Philippe Carron4, Basant Elnady5, Amir Haddad6, Arthur Kavanaugh7, Fahmeen J. Afgani8, Arnon Katz9, Minna Kohler10, josefina marin11, Nam Nguyen12, Adrien NZEUSSEU TOUKAP13, Ari Polachek14, Ernesto Rodriguez15, Marcos Rosemffet16, Abha Singh17, Maria S. Stoenoiu18, Agnes Szentpetery19, Iliara Tinazzi20, Janeth Yinh21, Mu Yang22, Richard Cook22, Gurjit Kaeley23 and Sibel Aydin24, 1University of Toronto, Toronto, ON, Canada, 2Centro Integrado de Pesquisas (CIP) do Hospital de Base de São José do Rio Preto, São José do Rio Preto, Brazil, 3Intermountain Healthcare Medical Group, Salt Lake City, 4Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 5Research Centre at Al Hada Armed Forces Hospital, Cairo, Egypt, 6Carmel Medical Center, Haifa, Israel, 7University of California, San Diego, School of Medicine, San Diego, CA, 8Women's College Hospital, Toronto, Canada, 9GRAPPA, Seattle, 10Massachusetts General Hospital, Harvard Medical School, Boston, MA, 11Hospital Universitario Rey Juan Carlos, Madrid, Spain, 12University of Toronto, Toronto, Canada, 13Cliniques Universitaires Saint-Luc, St.-Lambrechts-Woluwe, Belgium, 14Rheumatology Institute of Beilinson Hospital, Petah Tikva, Israel, 15Florida Medical Clinic, Tampa, 16Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, 17Altman Clinical and Translational Research Institute, University of California San Diego, San Diego, CA, 18Cliniques Universitaires Saint-Luc, Brussels, Belgium, 19Uppsala University Hospital, Djursholm, Sweden, 20Ospedale Sacro Cuore-Don Calabria, Verona, Italy, 21Massachusetts General Hospital, Boston, MA, 22University of Waterloo, Waterloo, Canada, 23UF COM-J, Ponte Vedra Beach, FL, 24Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Background/Purpose: Enthesitis is a key lesion in psoriatic arthritis (PsA). The Diagnostic Ultrasound Enthesitis Tool (DUET) study aimed to develop and validate a novel sonographic…
  • Abstract Number: 1462 • ACR Convergence 2025

    Five-Year Results of Secukinumab on Minimal Disease Activity (MDA) Components and the Impact of Biologic Treatment Status on Effectiveness and Safety in Patients With Psoriatic Arthritis: Real-World Data From the SERENA Study

    Uta Kiltz1, Petros Sfikakis2, Andreas Bounas3, Nicola Gullick4, Eric LESPESSAILLES5, Jan Brandt-Juergens6, Rasho Rashkov7, Cynthia Vizcaya8, Andreas Clemens8, Kim Hoyt9, Weibin Bao10 and Karl Gaffney11, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 2NKUA - SCHOOL OF MEDICINE, Athens, Greece, 3‘OLYMPION’, General Clinic of Patra, Patra, Greece, 4Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK, Coventry, United Kingdom, 5University Hospital of Orléans, Orleans, France, 6Rheumatologische Schwerpunktpraxis, Berlin, Germany, 7Clinic of Rheumatology, University Hospital St. Ivan Rilski, Sofia, Bulgaria, 8Novartis Pharma AG, Basel, Switzerland, 9Novartis Pharmaceuticals Corporation, East Hanover, NJ, 10Novartis Pharmaceuticals Corporation, Hanover, NJ, 11Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom

    Background/Purpose: Secukinumab has demonstrated long-lasting efficacy and a favorable safety profile across multiple clinical trials and domains of psoriatic disease. Real-world data provides additional valuable…
  • Abstract Number: 1431 • ACR Convergence 2025

    Radiographic Sacroiliitis in Psoriatic Arthritis: Clinical, Laboratory, and Spinal Radiographic Correlates in an Indian Cohort

    SUBIN PHILIP1, RITESH KUMAR MISHRA2, RIZWANA NAUSHAD1, Lovely Kumari3, Vishnu Koneru4, Aishwarya Gopal5, Christina Mariaselvam6, Chengappa Kavadichanda7, Ananthakrishnan Ramesh1, Molly Thabah1 and VIR SINGH NEGI1, 1JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, PUDUCHERRY, Puducherry, India, 2JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, Bhubaneswar, India, 3Jawaharlal Institute of Postgraduate Medical Education and Research,PUDUCHERRY, PUDUCHERRY, Puducherry, India, 4JIPMER, Hyderabad, Telangana, India, 5Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Puducherry, India, 6Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Puducherry, India, 7Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India

    Background/Purpose: Axial involvement in psoriatic arthritis (PsA) is variable and influences treatment choices. Data on axial PsA in Indian patients, especially its clinical and radiographic…
  • Abstract Number: 1165 • ACR Convergence 2025

    Real-World On-Label Treatment Persistence Through 24 Months in Biologic-Naïve and Biologic-Experienced Patients with Psoriatic Arthritis: Comparison of Guselkumab versus Subcutaneous Tumor Necrosis Factor Inhibitors

    Philip J. Mease1, Jessica A. Walsh2, Timothy P. Fitzgerald3, Soumya Chakravarty4, Elizabeth Adamson5, Bruno Emond6, Carmine Rossi7, Samuel Schwartzbein7, Kana Yokoji7, Yuxi Wang7, Patrick Lefebvre7, Dominic Pilon7, Shikha Singla8 and Joseph F Merola9, 1Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 2Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 3Johnson & Johnson, Horsham, PA, USA, PA, 4Johnson & Johnson, Horsham, PA, USA; Drexel University College of Medicine, Philadelphia, PA, USA, Villanova, PA, 5Johnson & Johnson, Horsham, PA, USA, Horsham, PA, 6Analysis Group, Inc., Montreal, QC, Canada, QC, 7Analysis Group, Inc., Montreal, QC, Canada, QC, Canada, 8Medical College of Wisconsin, Milwaukee, WI, 9Department of Dermatology and Department of Medicine, UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: A prior analysis found that patients (pts) with psoriatic arthritis (PsA) treated with guselkumab (GUS), an IL-23p19 subunit inhibitor, were approximately 2× more likely…
  • Abstract Number: 0572 • ACR Convergence 2025

    Real-World Treat-to-Target Strategy in Psoriatic Arthritis: 48-week Results from the MONITOR-PsA Cohort

    Jean-Guillaume Letarouilly1, Elnaz Saeedi2, Raphaël Hurtubise3, Lija James4, Nicola Gullick5, Deepak Jadon6, William Tillett7, Yvonne Sinomati4, Laura Tucker4, Nadia Mian8, Sophia Massa3 and Laura Coates9, 1Université de Lille, CHU Lille, Service de rhumatologie, Lille, France, LILLE, Nord-Pas-de-Calais, France, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Oxford, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Oxford, United Kingdom, 4Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK, Oxford, United Kingdom, 5Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK, Coventry, United Kingdom, 6Department of Medicine, University of Cambridge, Cambridge, UK, Cambridge, United Kingdom, 7Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, 8BM BS, MMedSc,, Oxford, United Kingdom, 9Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: A treat-to-target (T2T) strategy in psoriatic arthritis (PsA) is supported by International PsA recommendations but not widely practiced in clinic. The aim of the…
  • Abstract Number: 0849 • ACR Convergence 2025

    Mortality and Major Adverse Cardiac Events (MACE) with GLP-1 Receptor Agonists in Psoriatic Arthritis

    Nanuka Tsibadze1, Irakli Tskhakaia1 and Irene Tan2, 1Jefferson Health - Einstein, Philadelphia, PA, 2Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA

    Background/Purpose: Glucagon-like-peptide-1 receptor agonists (GLP-1 RAs) are the novel drug class that has gained widespread attention for its cardiovascular, renal and weight loss benefits in…
  • Abstract Number: 0474 • ACR Convergence 2025

    Real-World Experience of Janus Kinase Inhibitors; Retention and Factors Associated with Discontinuation

    Joseph Nathan1, Bayram Farisogullari2, Nicholas Jones3, Mohammad Ayoub3, James Brown3, Sarah Levy3, James Brader4, Ayse Ersoy4, Blossom Israni4, Mark Lloyd4, Afzal Latheef5, Diane Hill5, Amybel Taylor6, Darshani Arachchige6, Hlaing Chitsu6, Helen Linklater6, Kunal Lather7, Luke Gompels7, Eman Elfar8, Ritu Malaiya8, Pedro Machado9 and Patrick Kiely10, 1St George's Hospital, London, United Kingdom, 2University College London, London, 3Croydon Health Services NHS Trust, Croydon, England, United Kingdom, 4Frimley Health NHS Foundation Trust, Frimley, England, United Kingdom, 5St George's University Hospitals NHS Foundation Trust, London, England, United Kingdom, 6Surrey and Sussex Healthcare NHS Trust, Redhill, England, United Kingdom, 7Somerset NHS Foundation Trust, Taunton, England, United Kingdom, 8Epsom and St Helier University Hospitals NHS Trust, Carshalton, England, United Kingdom, 9Department of Rheumatology, University College London, and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 10St George's University Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: The use of Janus Kinase inhibitors (JAKi) to treat RA and PsA in a real-world setting has not been well described. Our aim was…
  • Abstract Number: 0042 • ACR Convergence 2025

    Serum Proteomic Analysis of Cellular Immune Clusters in Psoriatic Arthritis

    Steven Dang1, Xianwei Li2, Sydney Thib3, Darshini Ganatra4, liqun Diao5, Igor Jurisica6, Vinod Chandran7 and Lihi Eder8, 1Institute of Medical Science, University of Toronto, Toronto, Canada, 2Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Canada, 3Women’s College Research Institute, Toronto, Canada, 4Gladman Krembil Psoriatic Arthritis Research Program; Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada, 5Department of Statistics and Actuarial Science, University of Waterloo, Toronto, Canada, 6University Health Network, Toronto, Canada, 7Division of Rheumatology, Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, and Gladman Krembil Psoriatic Arthritis Research Program, Krembil Research Institute, University Health Network, Toronto, Canada, 8University of Toronto, Toronto, ON, Canada

    Background/Purpose: Our recent study characterized immune endotypes in psoriatic arthritis (PsA) patients using mass cytometry of peripheral blood1. We identified an endotype characterized by high…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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