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Abstracts tagged "psoriatic arthritis and quality of life"

  • Abstract Number: 964 • 2018 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Impact of Disease (PsAID12) Was Provisionally Endorsed at Omeract 2018 As Core Instrument to Measure Psoriatic Arthritis-Specific Health-Related Quality of Life in Randomized Controlled Trials and Longitudinal Observational Studies

    Richard Holland1, Robin Christensen2, Niti Goel3, Pil Hoejgaard4, William Tillett5, Laure Gossec6, Maarten de Wit7, Neil McHugh8, Philip J. Mease9, Beverly Shea10, Ying Ying Leung11, Dafna D Gladman12, Christine Lindsay13, Laura C. Coates14, Alexis Ogdie15, Vibeke Strand16, Lara Fallon17, Julie Birt18, Kristina Callis Duffin19, Oliver FitzGerald20, Peter Tugwell21, Dorcas Beaton22,23 and Ana-Maria Orbai24, 1Royal Prince Alfred Hospital Medical Centre, Sydney, Australia, 2Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, 3Kezar Life Sciences; Duke University School of Medicine, Durham, NC, 4Center for Rheumatology and Spine Diseases - Gentofte, Rigshospitalet, Hellerup, Denmark, 5Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, United Kingdom, 6Sorbonne Universités, Paris, France, 7EULAR standing committee of PARE, Zurich, Switzerland, 8Rheumatology, Royal National Hospital, Bath, Great Britain, 9Swedish Medical Center and University of Washington, Seattle, WA, 10School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, and Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, Canada, 11Singapore General Hospital, Singapore, Singapore, 12University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 13Medical Affairs, Amgen Inc, Thousand Oaks, CA, 14University of Oxford, Oxford, United Kingdom, 15Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 16Stanford University School of Medicine, Palo Alto, CA, 17Pfizer Canada, Montreal, QC, Canada, 18Eli Lilly and Company, Indianapolis, IN, 19Department of Dermatology, University of Utah, Salt Lake City, UT, 20Department of Rheumatology, St. Vincent’s University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, 21Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, 22University of Toronto, Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health, Toronto, ON, Canada, 23University of Toronto, Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, and the Institute for Health Policy Management and Evaluation, Toronto, ON, Canada, 24Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The GRAPPA-OMERACT PsA working group (WG) is using the OMERACT Filter 2.1 instrument selection algorithm1 to develop a Psoriatic Arthritis (PsA) core instrument set…
  • Abstract Number: 1610 • 2018 ACR/ARHP Annual Meeting

    Incremental Benefits to Quality of Life Associated with Achieving Higher Levels of American College of Rheumatology Response and Skin Clearance in Patients with Psoriatic Arthritis

    Josef S. Smolen1, David Shrom2, Chen-Yen Lin2, Julie Birt2, Georg Schett3 and Alice B Gottlieb4, 1Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 2Eli Lilly and Company, Indianapolis, IN, 3Medical Clinic 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany, 4Department of Dermatology, New York Medical College, New York, NY

    Background/Purpose: PsA is a chronic inflammatory disease associated with psoriasis. For optimal quality of life (QoL) improvements, all PsA symptoms should be managed. We examine…
  • Abstract Number: 1643 • 2018 ACR/ARHP Annual Meeting

    Psa Impact of Disease Questionnaire Scores Are Correlated with Disease Activity, As Measured By Cdapsa in Patients with Psa

    Ana-Maria Orbai1, Klaus Krüger2, Frank Behrens3, Uta Kiltz4, Benoit Guerette5, Lillian Mellars5, Michele Brunori5 and Jürgen Wollenhaupt6, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Medical Centre of Rheumatology, Munich, Germany, 3Clinical Research Rheumatology and Fraunhofer Institute IMETranslation, Goethe University, Frankfurt, Germany, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Celgene Corporation, Summit, NJ, 6Schön-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Background/Purpose: We examined clinical correlations between disease activity, as measured with the Clinical Disease Activity for PsA (cDAPSA) components and PsA life impact/health-related quality of…
  • Abstract Number: 2552 • 2018 ACR/ARHP Annual Meeting

    Fatigue in Psoriatic Arthritis Patients Treated with Intravenous Golimumab: Early Improvement Is Associated with Week 24 Outcomes in Acr 20, 50, and Health-Related Quality of Life

    Arthur Kavanaugh1, M. Elaine Husni2, Eric K. H. Chan3, Diane D. Harrison4, Lilianne Kim4, Kim Hung Lo4, Elizabeth C Hsia5 and Chenglong Han6, 1University of California, San Diego, School of Medicine, La Jolla, CA, 2Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, 3Janssen Global Services, LLC, Raritan, NJ, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, 6Janssen Global Services, LLC, Malvern, PA

          Background/Purpose: To investigate improvement in fatigue in adult patients with active psoriatic arthritis (PsA) treated with intravenously administered (IV) golimumab, an anti-TNFα…
  • Abstract Number: 2562 • 2018 ACR/ARHP Annual Meeting

    Secukinumab Improves Grappa-Omeract Core Domains of Psoriatic Arthritis

    Ana-Maria Orbai1, Iain B. McInnes2, Laura C. Coates3, M. Elaine Husni4, Dafna D Gladman5, Laure Gossec6, Luminita Pricop7, Olivier Chambenoit8, Xiangyi Meng8 and Philip J. Mease9, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2University of Glasgow, Glasgow, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Cleveland Clinic, Cleveland, OH, 5Toronto Western Research Institute and University of Toronto, Toronto, ON, Canada, 6Université Pierre et Marie Curie and Hôpital Pitié-Salpêtrière, Paris, France, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, 9Swedish Medical Center and University of Washington, Seattle, WA

    Background/Purpose: Secukinumab, a fully human monoclonal antibody that selectively neutralizes IL-17A, has demonstrated efficacy for patients with psoriatic arthritis (PsA) in multiple phase 3 clinical…
  • Abstract Number: 2567 • 2018 ACR/ARHP Annual Meeting

    Clinically Meaningful Improvement in Skin and Nail Psoriasis in Bio-Naïve Active Psoriatic Arthritis Patients Treated with Intravenous Golimumab: Results through Week 24 from a Phase 3 Study

    M. Elaine Husni1, Philip J. Mease2, Soumya D Chakravarty3, Shelly Kafka4, Diane D. Harrison5, Dennis Parenti4, Lilianne Kim5, Kim Hung Lo5, Elizabeth C Hsia6 and Arthur Kavanaugh7, 1Cleveland Clinic, Cleveland, OH, 2Swedish Medical Center & U of Wash School of Medicine, Seattle, WA, 3Janssen Scientific Affairs, LLC/Drexel U School of Medicine, Horsham/Phila, PA, 4Janssen Scientific Affairs, LLC, Horsham, PA, 5Janssen Research & Development, LLC, Spring House, PA, 6Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, 7UCSD, San Diego, CA

    Background/Purpose: GO-VIBRANT was a Phase 3 trial of intravenous (IV) golimumab (GLM) in adult patients (pts) w/active psoriatic arthritis (PsA). To evaluate improvement in skin,…
  • Abstract Number: 2600 • 2018 ACR/ARHP Annual Meeting

    Clinically Meaningful Improvement in Health-Related Quality of Life and the Association with Disease Activity in Psoriatic Arthritis after Treatment with Guselkumab: Results from a Randomized Placebo-Controlled Phase II Clinical Trial

    Laure Gossec1, Bruce Kirkham2, Proton Rahman3, Philip Helliwell4, Alice B Gottlieb5, Wolf-Henning Boehncke6 and Chenglong Han7, 1Rheumatology Department, Hôpital Pitié Salpêtrière, Paris 06 University, Paris, France, 2Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, 3Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 4LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 5Department of Dermatology, New York Medical College, Metropolitan Hospital, New York, NY, 6Department of Dermatology and Venereology, Geneva University Hospital, Geneva, Switzerland, 7Janssen Global Services, LLC, Malvern, PA

    Background/Purpose: To evaluate the effect of guselkumab (GUS) on Health-Related Quality of Life (HRQOL) and correlate changes of HRQOL and disease activity in patients with…
  • Abstract Number: 2606 • 2018 ACR/ARHP Annual Meeting

    Long-Term Inhibition of Radiographic Progression with Originator Adalimumab in Patients with Moderate to Severe Psoriatic Arthritis with or without Radiographic Damage at Baseline

    Laura C. Coates1, Philip J. Mease2, Kun Chen3, Maja Hojnik4, Wendell Valdecantos3, Pranav Sheth5, Daniel Aletaha6 and Fabiana Ganz7, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Swedish Medical Centre and University of Washington, Seattle, WA, 3AbbVie Inc., North Chicago, IL, 4AbbVie, Ljubljana, Slovenia, 5Group Health Associates, Trihealth, Cincinnati, OH, 6Medical University of Vienna, Vienna, Austria, 7AbbVie AG, Baar, Switzerland

    Background/Purpose: Adalimumab (ADA) inhibited radiographic progression in patients (pts) with moderate to severe PsA in the ADEPT study and its open label extension (OLE). These…
  • Abstract Number: 358 • 2017 ACR/ARHP Annual Meeting

    Patients and Physicians Have Different Perceptions of the Relative Bother of the Symptoms and Impacts on Daily Activities in Psoriasis and Psoriatic Arthritis

    M. Elaine Husni1,2, Anthony Fernandez1, Rakesh Singh3, Brett Hauber4, Jessie Sutphin4, Joshua Posner4 and Arijit Ganguli3, 1Cleveland Clinic, Cleveland, OH, 2Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH, 3AbbVie Inc., North Chicago, IL, 4RTI Health Solutions, Research Triangle Park, NC

    Background/Purpose: Psoriasis and psoriatic arthritis arise from the same immune system response but result in different symptoms and impacts on daily activities. A patient with…
  • Abstract Number: 630 • 2017 ACR/ARHP Annual Meeting

    Effects of Intravenous Golimumab, an Anti-Tnfα Monoclonal Antibody, on Mental and Physical Functioning and Health-Related Quality of Life in Active Psoriatic Arthritis: 24-Week Results of a Phase 3 Trial

    M. Elaine Husni1, Arthur Kavanaugh2, Eric K. H. Chan3, Nan Li4, Steven Peterson4, Elizabeth C. Hsia5, Lilianne Kim4, Kim Hung Lo4 and Diane D. Harrison4, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Medicine, University of California, San Diego, La Jolla, CA, 3Janssen Global Services, LLC, Raritan, NJ, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA

    Background/Purpose: To evaluate physical and mental health functioning, health state, and health-related quality of life (HRQoL) in patients with active psoriatic arthritis (PsA) treated with…
  • Abstract Number: 2538 • 2017 ACR/ARHP Annual Meeting

    Change in Self-Reported Health Status and Fatigue before and after the Diagnosis of Psoriatic Arthritis- the Nord-Trondelag Health Study (HUNT)

    Mari Hoff1, Tom Ivar Lund Nilsen2, Ruth Stoklund Thomsen3, Agnete Malm Gulati4, Arthur Kavanaugh5 and Glenn Haugeberg4, 1Rheumatolgy, University Hospital, St. Olavs Hospital, NTNU, Trondheim, Norway, 2Faculty of medicine, Department of public health and nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 3Faculty of Medicine, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 4NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 5Medicine, University of California, San Diego, La Jolla, CA

    Background/Purpose: Psoriatic arthritis (PsA) is a systemic inflammatory disease that can involve skin, nails, joints, enthuses, and can be associated with systemic symptoms such as…
  • Abstract Number: 2542 • 2017 ACR/ARHP Annual Meeting

    Measuring Psoriasis Specific Impact on Quality of Life: Performance of Dlqi and Skindex-17 in Early Psoriatic Arthritis

    Kim Wervers1, Jolanda J. Luime2, Ilja Tchetverikov3, Andreas H. Gerards4, Marc R Kok5, Cathelijne W. Y. Appels6, Wiebo L. van der Graaff7, Johannes H. L. M. van Groenendael8, Lindy-Anne Korswagen9, Jozien Veris10, J.M.W. Hazes2 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Sint Franciscus Vlietland Group, Schiedam, Netherlands, 5Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 6Rheumatology, Amphia Hospital, Breda, Netherlands, 7Rheumatology, Rivas hospital, Gorinchem, Netherlands, 8Rheumatology, Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Sint Franciscus Vlietland Group, Rotterdam, Netherlands, 10Rheumatology, Reumazorg Zuid West Nederland, Goes, Netherlands

    Background/Purpose: Impact of dermatological disease is measured with the Dermatology Life Quality Index (DLQI) and Skindex-17.  DLQI is commonly used in dermatology trials but the…
  • Abstract Number: 2544 • 2017 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Impact of Disease (PSAID12) in Early Psoriatic Arthritis: Pain As One of the Main Determinants of Disease Impact

    Kim Wervers1, Jolanda J. Luime2, Ilja Tchetverikov3, Andreas H. Gerards4, Marc R Kok5, Cathelijne W. Y. Appels6, Wiebo L. van der Graaff7, Johannes H. L. M. van Groenendael8, Lindy-Anne Korswagen9, Jozien Veris10, J.M.W. Hazes2 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Sint Franciscus Vlietland Group, Schiedam, Netherlands, 5Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 6Rheumatology, Amphia Hospital, Breda, Netherlands, 7Rheumatology, Rivas hospital, Gorinchem, Netherlands, 8Rheumatology, Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Sint Franciscus Vlietland Group, Rotterdam, Netherlands, 10Rheumatology, Reumazorg Zuid West Nederland, Goes, Netherlands

    Background/Purpose: The Psoriatic Arthritis Impact of Disease 12-item questionnaire (PsAID12) has been developed to measure impact of Psoriatic Arthritis (PsA) for purposes of monitoring and…
  • Abstract Number: 2878 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety Results of Guselkumab in Patients with Active Psoriatic Arthritis over 56 Weeks from a Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study

    Atul A. Deodhar1, Alice B Gottlieb2, Wolf-Henning Boehncke3, Bin Dong4, Yuhua Wang4, Yanli Zhuang4, William Barchuk5, Xie L. Xu5 and Elizabeth Hsia4, 1Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 2Department of Dermatology, New York Medical College, Valhalla, NY, 3Geneva University Hospital and University of Geneva, Geneva, Switzerland, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC, San Diego, CA

    Background/Purpose: Evaluate efficacy and safety of guselkumab (GUS) in patients (pts) with active psoriatic arthritis (PsA) over 56 weeks (wks). Methods: Pts w/active PsA (defined…
  • Abstract Number: 1706 • 2016 ACR/ARHP Annual Meeting

    Quality of Life at Baseline in Early Psoriatic Arthritis Related to Disease Domains

    Kim Wervers1, Jolanda J. Luime2, Ilja Tchetverikov3, Andreas H. Gerards4, Marc R. Kok5, Cathelijne W. Y. Appels6, Wiebo L. van der Graaff7, Hans L. M. van Groenendael8, Lindy-Anne Korswagen9, Jozien Veris10, Johanna M.W. Hazes11 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 5Maasstadweg 21, Maasstad Ziekenhuis, Rotterdam, Netherlands, 6Rheumatology, Amphia Hospital, Breda, Netherlands, 7Rheumatology, Rivas hospital, Gorinchem, Netherlands, 8Rheumatology, Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Sint Franciscus Gasthuis, Rotterdam, Netherlands, 10Rheumatology, Reumazorg Zuid West Nederland, Goes, Netherlands, 11Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses and dactylitis, its impact on health-related quality-of-life (HRQoL) could be substantial. Up to…
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