Abstracts tagged "psoriasis and signal transduction"

Abstract Number: 922 • ACR/ARHP Annual Meeting 2016
Negative Regulation of IL-17 Receptor Signaling By Regnase-1 Limits Immunopathology in a Mouse Model of Psoriatic Skin Disease
Sarah L. Gaffen¹, Leticia Monin², Nicole Ward³, Johann Gudjonsson⁴, Abhishek Garg⁵, Alicia Mathers² and Pappachan Kolattukudy⁶, ¹Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Case Western Reserve University, Cleveland, OH, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Rheumatology/Clinical Immun, University of Pittsburgh, Pittsburgh, PA, ⁶University of Central Florida, Orlando, FL
Background/Purpose: IL-17 cytokines have emerged as drivers of autoimmunity. Indeed, the IL-17A-targeting antibody secukinumab (Cosentyx) was recently approved for treatment of plaque psoriasis, and shows…