ACR Meeting Abstracts

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Abstracts tagged "proteomics and systemic sclerosis"

  • Abstract Number: 1103 • 2018 ACR/ARHP Annual Meeting

    Systemic Sclerosis Has a Distinct Serum Protein Profile That Correlates with Its Clinical Manifestations

    Chiara Bellocchi1,2, Jun Ying3, Ellen Goldmuntz4, Lynette Keyes-Elstein5, John Varga6, Monique Hinchcliff6, Peter McSweeney7, Daniel E. Furst8, Richard Nash7, Leslie Crofford9, Beverly Welch10, Ashley Pinckney5, Maureen D. Mayes11,12, Keith Sullivan13 and Shervin Assassi12, 1University of Texas Health Science Center at Houston, Houston, TX, 2Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 3Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 4NIAID, National Institutes of Health, Bethesda, MD, 5Rho Federal Systems, Inc., Chapel Hill, NC, 6Northwestern University, Chicago, IL, 7Colorado Blood Cancer Institute, Denver, CO, 8University of California Los Angeles, Los Angeles, CA, 9Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 10National Institutes of Health, Bethesda, MD, 11Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 12Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 13Duke University Medical Center, Durham, NC

    Background/Purpose: Proteomic studies with an extensive panel of measured proteins are still scarce in systemic sclerosis (SSc). The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial showed…
  • Abstract Number: 769 • 2017 ACR/ARHP Annual Meeting

    Proteomic Analysis of Human Fibroblasts in Systemic Sclerosis Reinforces the Role of Transforming Growth Factor-ß and Points Toward Epidermal Growth Factor Receptor / Phosphatidylinositol 3 Kinase Pathway Inhibition

    Benjamin Chaigne1, Guilhem Clary2, Morgane Le Gall3, Nicolas Dumoitier4, Sebastien Lofek5, Philippe Chafey2, Pia Moinzadeh6, Thomas Krieg7, Christopher Denton8 and Luc Mouthon9, 1Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, hôpital Cochin, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France, 2INSERM U1016, Institut Cochin,, Paris, France, 3INSERM U1016 Institut Cochin, Paris, France, 4INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, 5INSERM U1016, paris, France, 6Department of Rheumatology, UCL Division of Medicine, London, United Kingdom, 7Universität zu Köln, Köln, Germany, 8Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, 9Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by autoimmunity, vasculopathy and fibrosis. Fibrosis is due to an exaggerated activation of…
  • Abstract Number: 1917 • 2015 ACR/ARHP Annual Meeting

    Developing and Validating a Serum Biomarker for the Extent of Skin Disease in Patients with Diffuse Cutaneous Systemic Sclerosis

    Lisa Rice1, Julio Mantero2, Giuseppina Stifano1, Jessica Ziemek3, Robyn T. Domsic4 and Robert Lafyatis1, 1Boston University School of Medicine, Boston, MA, 2Rheumatology, Boston University School of Medicine, Boston, MA, 3Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, 4Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: In this study we aimed to both agonistically investigate alterations in the serum proteome of patients with diffuse cutaneous systemic sclerosis (dcSSc), as well…
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