ACR Meeting Abstracts

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Abstracts tagged "proteomics and rheumatoid arthritis (RA)"

  • Abstract Number: 583 • 2018 ACR/ARHP Annual Meeting

    Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients

    Cristina Ruiz-Romero1, Florencia Picchi2, Lucia González2, Rebecca Hands3, Valentina Calamia2, Patricia Fernández4, Maria Camacho2, Rocío Paz2, Conrad Bessant5, Costantino Pitzalis3 and Francisco J Blanco6, 1Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Rheumatology Research Group, Proteomics Unit-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, 3Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 4Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, 5School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, 6Rheumatology Divison, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: Among the best known disease-modifying antirheumatic drugs, Methotrexate (MTX) is one of the most effective and widely used medications. It is used as a…
  • Abstract Number: 1467 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Activity Monitoring and Multiplex Biomarker Verification By Tageted Proteomics

    Lucía González-Rodríguez1, Valentina Calamia1, Patricia Fernández2, Cristina Ruiz-Romero3, Antonio Julià4, Antonio Fernández-Nebro5, Jesús Tornero6, Sara Marsal4 and Francisco J Blanco3, 1Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, 3Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 4Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Spain, 5UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Spain., Málaga, Spain, 6Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…
  • Abstract Number: 2051 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Factor Peptide Expression By Quantitative Proteomics Delineates Responsive and Resistant Clones after Treatment of Early Rheumatoid Arthritis

    Jing Jing Wang1, William Murray-Brown2, Alexander Colella1, Malcolm D. Smith3, Tim Chataway4, Jenny Walker2, William H. Robinson5, Mihir D Wechalekar2 and Tom Gordon1,6, 1Immunology, Flinders University, Adelaide, Australia, 2Rheumatology, Flinders University, Adelaide, Australia, 3Rheumotology, Flinders University, Adelaide, Australia, 4Proteomic Facility, Flinders University, Adelaide, Australia, 5Stanford University, Palo Alto, CA, 6Immunology, SA Pathology, Adelaide, Australia

    Background/Purpose: Rheumatoid factors (RFs) are associated with disease activity and joint damage in rheumatoid arthritis (RA) and thought to play a pathogenic role in disease.…
  • Abstract Number: 1019 • 2017 ACR/ARHP Annual Meeting

    Molecular Profiling of RA Patients Suggests a Differential Involvement of Adaptive and Innate Cell Populations in Response to Anti-TNF Treatment

    Victor Farutin1, Thomas Prod'homme1, Kevin McConnell1, Nathaniel Washburn1, Patrick Halvey1, Jamey Guess1, Nur Sibel Gunay1, Jan Hillson2, Carol J. Etzel3, Katherine C. Saunders3, Dimitrios A. Pappas3,4, Anthony Manning1, Leona Ling1 and Ishan Capila1, 1Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, 2Clinical Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, 3Corrona, LLC, Southborough, MA, 4Columbia University, New York, NY

    Background/Purpose: Despite the success of anti-TNF therapies in RA, ~ 30 % of patients are non-responders. Several studies have focused on understanding the biology underlying…
  • Abstract Number: 1358 • 2017 ACR/ARHP Annual Meeting

    Relationship between Serum Protein Pattern and High Disease Activity in Patients with Rheumatoid Arthritis

    Pavel Horak1, Anna Petráčková2, Martina Skácelová3, Eva Kriegová4, Petra Schneiderová5 and František Mrázek5, 1III. Department of internal medicine, III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, 2Department of Immunology, Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, 3III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, 4Department of Immunology,, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, 5Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects joints. There is still limited information of serum biomarkers suitable for effective monitoring…
  • Abstract Number: 595 • 2015 ACR/ARHP Annual Meeting

    Discovery of Serum Protein Biomarkers of Response to Adalimumab in Rheumatoid Arthritis and Their Relationship to Biomarkers of Response to Infliximab

    Ignacio Ortea1, Bernd Roschitzki2, Eva Tomero3, Juan G. Ovalles-Bonilla4, Javier Lopez-Longo5, Inmaculada de la Torre5, Isidoro Gonzalez-Alvaro6, Juan J Gomez-Reino7 and Antonio Gonzalez8, 1Maimónides Health Research Institute (IMIBIC), Cordoba, Spain, 2Functional Genomics Center Zurich, University and ETH Zurich, Zurich, Switzerland, 3Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 4Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 5Gregorio Marañon Hospital, Madrid, Spain, 6Hospital Univ. de La Princesa, IIS Princesa, Madrid, Spain, 7Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 8Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain

    Background/Purpose: Biomarkers of response to treatment in rheumatoid arthritis (RA) are sorely needed given the large inter-individual variability in efficacy of the available drugs. However,…
  • Abstract Number: 2092 • 2014 ACR/ARHP Annual Meeting

    Proteomic Phenotyping of Rheumatoid Arthritis Disease Activity

    Yauheniya Cherkas, Sarah Lamberth, Carrie Brodmerkel and Mark Curran, Janssen Research & Development, LLC., Spring House, PA

    Background/Purpose The use of objective biomarkers of clinical disease characteristics such as disease activity would be beneficial in informing patients, physicians and payers. Recently, a…
  • Abstract Number: 1691 • 2012 ACR/ARHP Annual Meeting

    Early Signs of Subclinical Inflammation and Local Antibody Production in Early Rheumatoid Lungs

    Gudrun Reynisdottir1, Reza Karimi2, Jimmy Ytterberg3, Vijay Joshua1, Helga Olsen2, Aase Haj Hensvold1, Anders Harju4, Johan Grunewald2, Sven Nyren5, Anders Eklund2, Lars Klareskog6, Roman Zubarev7, Magnus Skold2 and Anca Catrina1, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 5Radiology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 6Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 7Karolinska Institutet, Stockholm, Sweden

    Background/Purpose:  The aims of the current study was to investigate if inflammatory lung changes are present in RA patients early in the disease process and…
  • Abstract Number: 2579 • 2012 ACR/ARHP Annual Meeting

    Novel Autoantibodies to 14-3-3 Eta Are Highly Specific for Rheumatoid Arthritis

    Walter P. Maksymowych1, Désirée van der Heijde2, R. Landewe3, Vivian P. Bykerk4 and Anthony Marotta5, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 4Rheumatology, Hospital for Special Surgery, New York, NY, 5Augurex Life Sciences Corp, North Vancouver, BC, Canada

    Background/Purpose: Serum 14-3-3 eta, a protein biomarker that is differentially expressed in rheumatoid arthritis (RA), has been reported to add incrementally to rheumatoid factor (RF)…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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