Abstracts tagged "proteoglycans and transforming growth factor"

Abstract Number: 1147 • 2015 ACR/ARHP Annual Meeting
TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss
Arjan van Caam, Wojciech Madej, Henk van Beuningen, Esmeralda Blaney Davidson and Peter van der Kraan, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In osteoarthritis, cartilage degradation is partly due to chondrocytes gaining a hypertrophy-like phenotype. TGFβ1 is considered to be a protective factor for articular cartilage by blocking…

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Abstracts tagged "proteoglycans and transforming growth factor"

TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss