Abstracts tagged "pristane induced C57BL/6 mouse model"

Abstract Number: 1782 • 2019 ACR/ARP Annual Meeting
A Human SLE Variant NCF1-R90H Drives Lupus-like Kidney Disease in a Pristane-induced Murine Lupus Model
Lin-Yu Geng¹, Ivan Molano ², Ling-Xiao Xu ³, Qing Sun ¹, Phillip Ruiz ⁴, Quan-Zhen Li ⁵, Gary Gilkeson ⁶ and Betty Tsao ⁷, ¹Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ²Division of Rheumatology & Immunology/Medical University of South Carolina, Charelston, ³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charelston, SC, ⁴Department of Surgery/University of Miami School of Medicine, Charleston, ⁵Department of Immunology & Internal Medicine/University of Texas Southwestern Medical Center, Charleston, ⁶Division of Rheumatology & Immunology/Ralph H. Johnson VA Medical Center/Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston
Background/Purpose: We previously identify a p.Arg90His (p.R90H) substitution encoded in phagocyte neutrophil cytosolic factor (NCF1) as a novel risk variant for SLE, with decreased and…

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