Abstracts tagged "pregnancy"

Abstract Number: 2427 • 2018 ACR/ARHP Annual Meeting
Adequate Vaccine Response According to the Italian Schedule Among the Offspring of Women Affected By Rheumatoid Arthritis and Treated throughout Pregnancy By Certolizumab Pegol: Case Series
Marianna Meroni¹, Maria De Santis², Elena Generali², Angela Ceribelli³, Marta Caprioli³, Giacomo Maria Guidelli², Natasa Isailovic², Gaetano Maria Fara⁴, Carlo Selmi² and Maurizio Cutolo⁵, ¹Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Italy, ²Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, ³Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, ⁴Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy
Background/Purpose: Certolizumab pegol (CTZ) is a TNFα inhibitor indicated for the treatment of women affected by rheumatoid arthritis (RA) throughout the whole pregnancy. Some concern,…
Abstract Number: 2432 • 2018 ACR/ARHP Annual Meeting
Peripartum Issues in the Inflammatory Arthritis (IA) Patient: A Survey of the Rapport (Rheumatoid Arthritis Pharmacovigilence Program and Outcomes Research in New Therapies) Registry
Tharindri Dissanayake¹, Stephanie Keeling² and Walter P. Maksymowych³, ¹Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada
Background/Purpose: Multiple issues surround the peripartum period for IA patients including medication use, risk of disease flare and potential impact on neonatal outcomes. We aimed…
Abstract Number: 2438 • 2018 ACR/ARHP Annual Meeting
Risk and Severity of Adverse Pregnancy Outcomes in Women with Systemic Sclerosis in Taiwan
Chen I Hsieh¹, Shue Fen Luo² and Chang-Fu Kuo³, ¹Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Chang Gung University, Taoyuan County, Taiwan, ³Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: Patients with different autoimmune rheumatic diseases are subject to different pregnancy outcomes because of deviant immunity. Systemic sclerosis is known to be associated with…
Abstract Number: 2850 • 2018 ACR/ARHP Annual Meeting
Human Toll-like Receptor 8 Adversely Affects Placental Development and Pregnancy Outcomes in a Mouse Model of Systemic Lupus Erythematosus
Naomi I. Maria¹, Shani Martinez¹ and Anne Davidson², ¹Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Systemic Lupus Erythematosus (SLE) predominantly affects women of childbearing age and is associated with adverse pregnancy outcomes including pre-eclampsia, intrauterine fetal growth restriction (IUGR),…
Abstract Number: 1309 • 2017 ACR/ARHP Annual Meeting
Characteristics and Outcomes of Prospectively Reported Pregnancies Exposed to Certolizumab Pegol from a Safety Database
Megan E. B. Clowse¹, Angela E. Scheuerle², Christina D Chambers³, Anita Afzali⁴, Alexa Kimball⁵, John J. Cush⁶, Maureen Cooney⁷, Laura Shaughnessy⁷, Mark Vanderkelen⁸ and Frauke Förger⁹, ¹Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, ²UT Southwestern Medical Center, Dallas, TX, ³UC San Diego School of Medicine, San Diego, CA, ⁴University of Washington Harborview Medical Center, Seattle, WA, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶Baylor Scott & White Research Institute, Dallas, TX, ⁷UCB Pharma, Raleigh, NC, ⁸UCB Pharma, Braine-l’Alleud, Belgium, ⁹Inselspital, University of Bern, Bern, Switzerland
Background/Purpose: Anti-tumor necrosis factor medications (anti-TNFs) are effective in controlling chronic inflammatory diseases, but information about their use and safety in pregnancy is limited. Consequently,…
Abstract Number: 1812 • 2017 ACR/ARHP Annual Meeting
Preeclampsia and Incident Cardiovascular Disease in SLE Pregnancy
Julia F Simard¹, Marios Rossides², Elizabeth V. Arkema³, Elisabet Svenungsson⁴, Anna-Karin Wikstrom⁵, Murray Mittleman⁶ and Jane E. Salmon⁷, ¹Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA, ²Medicine Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, ³Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁵Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁶Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, ⁷Medicine/Rheumatology, Hospital of Special Surgery, New York, NY
Background/Purpose: Pre-pregnancy cardiovascular health has been associated with preeclampsia during pregnancy, as well as future cardiovascular disease (CVD). Preeclampsia is related to endothelial dysfunction, hypertension,…
Abstract Number: 1957 • 2017 ACR/ARHP Annual Meeting
Impact of Maternal Systemic Autoimmune Rheumatic Diseases on Neonatal Outcomes: A Population-Level Analysis
Stephanie Keeling¹, Anamaria Savu² and Padmaja Kaul³, ¹Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, ²Canadian Vigour Center, Edmonton, AB, Canada, ³Cardiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The impact of systemic autoimmune rheumatic diseases (SARDS) on peripartum outcomes is not well described at a population level despite the potential for active…
Abstract Number: 5 • 2017 ACR/ARHP Annual Meeting
Clinical Utility of the Global Antiphospholipid Syndrome Score (GAPSS) for Risk Stratification: A Pooled Analysisfrom 2273 Patients
Savino Sciascia¹, Massimo Radin², Giovanni Sanna³, Irene Cecchi⁴, Dario Roccatello⁵ and Maria Laura Bertolaccini⁶, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, ²Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom, ⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ⁶Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom, London, United Kingdom
Background/Purpose: Recently, our group conceived a risk score for clinical manifestations of APS [the global APS score or GAPSS] that takes into account the combination…
Abstract Number: 1295 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcome in Patients with SLE Compared to Patients with Other Inflammatory Rheumatic Diseases: Real World Data from a Prospective Pregnancy Register
Rebecca Fischer-Betz¹, Christina Bungartz², Matthias Schneider¹, Jutta Richter¹, Anja Weiss², Angela Zink³ and Anja Strangfeld⁴, ¹Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ²German Rheumatism Research Center, Berlin, Germany, ³Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany, ⁴Epidemiology, German Rheumatism Research Center, Berlin, Germany
Background/Purpose: SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. With careful pre-pregnancy counseling and monitoring…
Abstract Number: 1299 • 2017 ACR/ARHP Annual Meeting
Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Nathaniel Harris¹, Amanda M. Eudy² and Megan E. B. Clowse², ¹Duke University School of Medicine, Durham, NC, ²Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Patient-reported measures of disease activity may provide useful adjuncts to physician-reported measures in identifying pregnancies at greater risk for adverse pregnancy outcomes. Little is…
Abstract Number: 1533 • 2016 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Women with Rheumatoid Arthritis : A Systematic Review and Meta-Analyses
Anne-Lise Gaillard¹, Thomas Barnetche² and Thierry Schaeverbeke³, ¹Rhumatologie, CHU Bordeaux Pellegrin, Bordeaux, France, ²Rheumatology Department, Pellegrin University Hospital, BORDEAUX, France, ³Rheumatology Department, Bordeaux Hospital, Bordeaux, France
Background/Purpose: Actually better control of rheumatoid arthritis (RA) activity leads to new interrogations and daily questions about pregnancy. Only few studies have studied pregnancy outcomes…
Abstract Number: 2045 • 2016 ACR/ARHP Annual Meeting
Early Preeclampsia Risk in Lupus Pregnancy: A Swedish Population-Based Register Investigation
Julia F Simard^1,2, Elizabeth V. Arkema³, Cathina Nguyen⁴, Elisabet Svenungsson⁵, Anna-Karin Wikstrom^6,7, Kristin Palmsten⁸ and Jane E. Salmon⁹, ¹Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA, ²Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Health Research & Policy, Stanford School of Medicine, Stanford, CA, ⁵Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden, ⁷Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁸Department of Pediatrics, University of California, San Diego, La Jolla, CA, ⁹Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Early preeclampsia is a serious pregnancy complication characterized by abnormal placentation and diffuse maternal endothelial cell dysfunction, and requires emergent delivery which may be…
Abstract Number: 2437 • 2016 ACR/ARHP Annual Meeting
Causes of Cesarean Section and Labor Induction in Systemic Lupus Erythematosus and Rheumatoid Arthritis Pregnancies
Amanda M. Eudy, Laura Neil and Megan E. B. Clowse, Rheumatology, Duke University Medical Center, Durham, NC
Background/Purpose: Women with SLE and RA have an increased risk of delivering a preterm infant. However, the causes of these preterm births remain unknown. Some…
Abstract Number: 2439 • 2016 ACR/ARHP Annual Meeting
Effect of Pregnancy Counseling on the Outcome of Pregnancies in Women with Systemic Lupus Erythematosus: A Prospective Observational Study
Rebecca Fischer-Betz¹, Lisa Kueppers², Ralph Brinks², Oliver Sander³, Christof Specker⁴ and Matthias Schneider³, ¹Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine University, Duesseldorf, Duesseldorf, Germany, ²Department of Rheumatology&Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ³Department of Rheumatology & Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ⁴Rheumatology and Clinical Immunology, Kliniken Essen Sued, Essen, Germany
Background/Purpose: Pregnancies in women with systemic lupus erythematosus (SLE) are associated with increased frequencies of adverse pregnancy outcomes (APOs). Preconception counseling including risk stratification and…
Abstract Number: 2440 • 2016 ACR/ARHP Annual Meeting
First Results from the Prospective German Pregnancy Register
Rebecca Fischer-Betz¹, Christina Bungartz², Jutta Richter¹, Angela Zink³, Matthias Schneider¹, Anja Weiss², Joachim Listing⁴ and Anja Strangfeld⁵, ¹Department of Rheumatology & Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Epidemiology Unit, German Rheumatism Research Center and Charité University Medicine, Berlin, Germany, ⁴German Rheumatism Research Center, Berlin, Germany, ⁵Epidemiology, German Rheumatism Research Center, Berlin, Germany
Background/Purpose: There is limited evidence on the safety of treatment during pregnancy and lactation. With the increasing number of new therapeutic options for inflammatory rheumatic…

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