Abstracts tagged "pregnancy and rheumatoid arthritis (RA)"

Abstract Number: 3107 • 2015 ACR/ARHP Annual Meeting
Investigating the Ameliorating Effect of Pregnancy on Rheumatoid Arthritis Using Whole Transcriptome Analysis
Anuradha Mittal¹, Lior Pachter², J. Lee Nelson³, Hanne Kjaergaard⁴, Mette Smed⁴, Vibeke Zoffmann⁴, Jørn Olsen⁵, Merete Lund Hetland⁶, Ingileif Hallgrimsdottir² and Damini Jawaheer¹, ¹Children's Hospital Oakland Research Institute, Oakland, CA, ²University of California, Berkeley, Berkeley, CA, ³Immunogenetics, Fred Hutchinson Cancer Rsch, Seattle, WA, ⁴Juliane Marie Center, Copenhagen, Denmark, ⁵Aarhus University, Aarhus, Denmark, ⁶On behalf of all Depts of Rheumatology in Denmark, DANBIO, Glostrup Hospital, Glostrup, Denmark
Background/Purpose: Pregnancy is known to induce a natural improvement of Rheumatoid Arthritis (RA) symptoms in 50-75% of patients as gestation progresses. However, the underlying mechanisms…
Abstract Number: 2466 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Rheumatoid Arthritis (RA) Among Shared Epitope-Negative (SE-) Mothers with Shared Epitope-Positive (SE+) Children
Giovanna Cruz¹, Lindsey A. Criswell², Xiaorong Shao³, Hong L. Quach¹, Janelle Noble⁴, Nikolaos Patsopoulos⁵, Michael Busch⁶ and Lisa F. Barcellos¹, ¹Epidemiology, University of California, Berkeley, Berkeley, CA, ²Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, ⁴Children's Hospital Oakland Research Institute (CHORI), Oakland, CA, ⁵Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁶Blood Systems Research Institute, San Francisco, CA
Background/Purpose RA (RA [MIM 180300]) disproportionately affects women of reproductive age, implicating pregnancy-related factors. Fetal microchimerism (FMC), or the persistence of a small population of…
Abstract Number: 1439 • 2014 ACR/ARHP Annual Meeting
Miscarriage in Rheumatoid Arthritis – Association with Disease Characteristics and Medication Use
Jenny Brouwer^1,2, Joop SE Laven¹, Johanna MW Hazes² and Radboud JEM Dolhain², ¹Obstetrics & Gynaecology, division of Reproductive Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
Background/Purpose – The chance of miscarriage is increased after the diagnosis of rheumatoid arthritis (RA). The association of miscarriage with RA disease activity or anti-rheumatic…
Abstract Number: 1378 • 2014 ACR/ARHP Annual Meeting
the Impact of Rheumatoid Arthritis Activity and Medications on Pregnancy Outcomes
Megan E. B. Clowse, Rheumatology, Duke University Medical Center, Durham, NC
Background/Purpose: While rheumatoid arthritis (RA) has historically improved in pregnancy, recent studies suggest the improvement may not be dramatic now that we are able…
Abstract Number: 821 • 2014 ACR/ARHP Annual Meeting
Pregnancy Outcome in Women Treated with Adalimumab for the Treatment of Rheumatoid Arthritis: An Update
Christina D Chambers^1,2, Diana L Johnson¹, Yunjun Luo¹, Ronghui Xu^2,3 and Kenneth L Jones¹, ¹University of California San Diego Department of Pediatrics, La Jolla, CA, ²University of California San Diego Department of Family and Preventive Medicine, La Jolla, CA, ³University of California San Diego Department of Mathematics, La Jolla, CA
Background/Purpose Adalimumab is a fully human monoclonal antibody to tumor necrosis factor alpha and is approved for several indications including rheumatoid arthritis (RA). Methods The…
Abstract Number: 1892 • 2013 ACR/ARHP Annual Meeting
High-Throughput Immunoglobulin G Fab Glycosylation Profiling Reveals Differential Glycosylation On Fab and Fc
Albert Bondt^1,2, Yoann Rombouts³, Maurice H.J. Selman¹, Radboud JEM Dolhain⁴ and Manfred Wuhrer¹, ¹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
Background/Purpose: Rheumatoid arthritis is known to improve during pregnancy, and a flare of disease activity is observed after delivery (1). N-glycosylation of the constant region…
Abstract Number: 397 • 2013 ACR/ARHP Annual Meeting
Does Elevated Disease Activity Or Medication Use Influence The Bone Density Of The Prepubertal Offspring In Pregnant Women With Rheumatoid Arthritis?
Florentien D.O. de Steenwinkel¹, Anita C.S. Hokken-Koelega², Johanna Hazes³ and Radboud J.E.M. Dolhain¹, ¹Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ²Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, Netherlands, ³Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Elevated rheumatoid arthritis disease activity and prednisone use during pregnancy are both associated with a lower bone mineral density (BMD) of the patients, but…
Abstract Number: 398 • 2013 ACR/ARHP Annual Meeting
Does Elevated Disease Activity Or Medication Use Influence The Body Composition Of The Prepubertal Offspring In Pregnant Women With Rheumatoid Arthritis?
Florentien D.O. de Steenwinkel¹, Radboud J.E.M. Dolhain¹, Johanna M.W. Hazes² and Anita C.S. Hokken-Koelega³, ¹Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, Netherlands
Background/Purpose: Elevated rheumatoid arthritis (RA) disease activity during pregnancy is associated with lower birth weight and rapid post-natal growth. Lower birth weight and rapid post-natal…
Abstract Number: 399 • 2013 ACR/ARHP Annual Meeting
Nausea and Vomiting During Pregnancy and Spontaneous Abortion In Women With Rheumatoid Arthritis
Balambal Bharti¹, Diana L. Johnson² and Christina D. Chambers³, ¹Pediatrics, University of California San Diego, La Jolla, CA, ²University of California San Diego Department of Pediatrics, La Jolla, CA, ³Pediatrics, University of California, San Diego, La Jolla, CA
Background/Purpose: Nausea and Vomiting during Pregnancy (NVP) has been associated with a decreased risk for spontaneous abortion (SAB). However, the Th1/Th2 imbalance that occurs in…
Abstract Number: 1643 • 2012 ACR/ARHP Annual Meeting
Outcomes of Pregnancy in Subjects Exposed to Certolizumab Pegol
Megan E. B. Clowse¹, Douglas C. Wolf², Christian Stach³, Gordana Kosutic⁴, Susan Williams⁴, Ido Terpstra⁵ and Uma Mahadevan⁶, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Atlanta Gastroenterology Associates, Atlanta, GA, ³UCB Pharma, Monheim, Germany, ⁴UCB Pharma, Raleigh, NC, ⁵UCB Pharma, Brussels, Belgium, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Certolizumab pegol (CZP) is an Fc-free, PEGylated, anti-TNF approved in the US for the treatment of Crohn's disease (CD) and rheumatoid arthritis (RA). Pre-clinical…
Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting
Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Cecilia Orellana¹, Lars Klareskog², Lars Alfredsson¹ and Camilla Bengtsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
Abstract Number: 1176 • 2012 ACR/ARHP Annual Meeting
Galactosylation, and Not Sialylation, of Immunoglobulin G Is Associated with Improvement of Rheumatoid Arthritis During Pregnancy
Albert Bondt¹, Maurice H.J. Selman², André M. Deelder³, Johanna M.W. Hazes¹, Manfred Wuhrer² and Radboud J.E.M. Dolhain¹, ¹Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ²Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ³Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is known to improve during pregnancy and to flare after delivery [1]. Changes in the glycosylation of immunoglobulin G’s fragment crystallizable…
Abstract Number: 424 • 2012 ACR/ARHP Annual Meeting
Influence of Pregnancy On Disease Activity-Associated Genes in Rheumatoid Arthritis
Erik J. Peterson¹, Shreyasee Amin², Hatice Bilgic³, Emily Baechler Gillespie³, Jane E. Salmon⁴, Ann M. Reed⁵, Weihua Guan⁶ and Daniel L. Mueller¹, ¹Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³University of Minnesota Medical School, Minneapolis, MN, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶University of Minnesota School of Public Health, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) disease activity can often quiesce during pregnancy. Nevertheless, most women will experience a disease flare postpartum (PP). We hypothesized that changes…

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