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Abstracts tagged "pregnancy"

  • Abstract Number: 0423 • ACR Convergence 2024

    Higher Risk of Preterm Delivery in Women with Rheumatoid Arthritis: A Matched Comparative Analysis of the GR2 Prospective Cohort and the French National Perinatal Surveys

    Sabrina Hamroun1, Grégoire Martin De Frémont2, Nathalie Costedoat-chalumeau3, Marion couderc4, René-Marc Flipo5, Laure Gossec6, Christophe Richez7, Rakiba Belkhir8, Aline Frazier9, Valerie Devauchelle10, Hubert Marotte11, Jérémie Sellam12, Elisabeth Gervais13, Alban Deroux14, Cedric Lukas15, Emmanuelle Dernis16, Emmanuel Chatelus17, Véronique Le Guern18, Gaëlle Guettrot-Imbert19, Nathalie Lelong20, Camille Le Ray20, Raphaele Seror21 and Anna Molto22, and ENP 2021 and GR2 Study Groups, 1Cochin University Hospital, Paris, Ile-de-France, France, 2Le Kremlin-Bicêtre University Hospital, Le Kremlin-Bicêtre, Guyana, 3University Paris Cité, Paris, France, 4CHU de Clermont-Ferrand, Clermont-Ferrand, 5CHU Lille, Lille, Nord-Pas-de-Calais, France, 6Sorbonne Université, Paris, France, 7Pellegrin Hospital, Rheumatology, Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases, Bordeaux, France, 8Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France, 9Lariboisière University Hospital, Paris, France, 10UBO, Brest, France, 11Université Jean Monnet, CHU Saint-Etienne, Mines Saint-Etienne, INSERM SAINBIOSE 1059, Saint-Etienne, France, 12Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France, 13University hospital, Poitiers, France, 14Clinique Universitaire de Médecine Interne, Department of Internal Medicine, Grenoble University Hospital, Grenoble, France, 15Rheumatology department, CHU Montpellier, Montpellier, France, 16CH LE MANS, LE MANS, Pays de la Loire, France, 17Rheumatology department strasbourg, Strasbourg, France, 18APHP, Hôpital Cochin, Paris, 19Cochin Hospital, Paris, France, 20University of Paris, INSERM Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Paris, France, 21Service de Rhumatologie, Hôpital Bicêtre, AP-HP, le Kremlin Bicetre, Ile-de-France, France, 22Groupe Hospitalier Cochin, AP-HP, Paris, France

    Background/Purpose: Rheumatoid arthritis (RA) regularly affects women of childbearing age1. A higher obstetric morbidity in women with RA is suggested in the literature in several…
  • Abstract Number: 0444 • ACR Convergence 2024

    Deep Serologic Profiling Identifies Novel Autoantibodies Associated with Fetal Atrioventricular Block

    Philip Carlucci1, Robert Clancy2, Mala Masson3, Colin Phoon4, Ashley Roman4, Peter Izmirly5, Amit Saxena6, H Michael Belmont4, Christina Penfield4, Young Mi Lee4, Julie Nusbaum7, Andrew Rubenstein4, Ruben Acherman8, Elena Sinkovskaya9, Alfred Abuhamad9, Karla Bermudez-Wagner9, Majd Makhoul10, Gary Satou11, Whitnee Hogan12, Nelangi Pinto13, Anita Moon-Grady14, Lisa Howley15, Mary Donofrio16, Anita Krishnan16, Jaclyn Phillips17, Stephanie Levasseur18, Miwa Geiger19, Erin Paul20, Sonal Owens21, Kristopher Cumbermack22, Jyothi Matta23, Gary Joffe24, Christopher Lindblade25, Carl Weiner26, Caitlin Haxel27, Katherine Kohari28, Joshua Copel28, James Strainic29, Tam Doan30, Shreya Sheth30, Stacy Killen31, Theresa Tacy32, Michelle Kaplinski32, Nicola Fraser4, Kelly Ruggles33, Bettina Cuneo34 and Jill Buyon35, 1New York University School of Medicine, New York, NY, 2Columbia University Medical Center, New York, NY, 3NYU Langone Medical Center- Division of Rheumatology, New York, NY, 4NYU Langone Health, New York, NY, 5New York University Grossman School of Medicine, New York, NY, 6NYU Grossman School of Medicine, New York, NY, 7NYU Langone Hospital - Long Island, Internal Medicine - Rheumatology, Mineola, NY, 8Children's Heart Center, Las Vegas, NV, 9Eastern Virginia Medical School, Norfolk, VA, 10Atrium Health Levine Children's Hospital, Charlotte, NC, 11University of California Los Angeles, Los Angeles, CA, 12University of Utah, Salt Lake City, UT, 13Seattle Children's Hospital, Seattle, WA, 14University of California San Francisco, San Francisco, CA, 15Midwest Fetal Care Center, Children's Minnesota/Allina Health, Minneapolis, MN, 16Children's National Hospital, Washington, DC, 17George Washington University, Washington, DC, 18Columbia University, New York, NY, 19Mount Sinai School of Medicine, New York, NY, 20Atlantic Health System, Morristown, NJ, 21University of Michigan, Ann Arbor, MI, 22University of Kentucky, Lexington, KY, 23University of Louisville, Louisville, KY, 24Perinatal Associates of New Mexico, Albuquerque, NM, 25Phoenix Children's Hospital, Phoenix, AZ, 26Dignity Health, Phoenix, AZ, 27University of Vermont Children's Hospital, Burlington, VT, 28Yale University, New Haven, CT, 29UH Rainbow Babies, Cleveland, OH, 30Baylor College of Medicine, Houston, TX, 31Vanderbilt University, Nashville, TN, 32Stanford University, Stanford, CA, 33NYU Grossman School of Medicine, Brooklyn, NY, 34University of Arizona College of Medicine, Tucson, AZ, 35New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Maternal anti-SSA/Ro52/60kD autoantibodies are necessary for the development of fetal atrioventricular block (AVB) but titers alone are not sufficient to predict the likelihood of…
  • Abstract Number: 0872 • ACR Convergence 2024

    Investigating the Natural Improvement of Rheumatoid Arthritis During Pregnancy

    Matthew Wright1, Dana Goin2, Mette Kiel Smed3, Nicholas Jewell4, J Lee Nelson5, Merete Hetland6 and Damini Jawaheer7, 1Children's Hospital Oakland Research Institute/Northwestern University, Chicago, 2UCSF, San Francisco, CA, 3Juliane Marie Centret, Copenhagen, Denmark, 4UC Berkeley, Berkeley, CA, 5University of Washington and Fred Hutchinson Cancer Center, Seattle, WA, 6Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, 7Children's Hospital Oakland Research Institute/Northwestern University, Chicago, IL

    Background/Purpose: Pregnancy can induce a natural improvement of rheumatoid arthritis (RA) in 50-75% of women with the disease, while others may worsen or remain unchanged.…
  • Abstract Number: 0424 • ACR Convergence 2024

    The Clinical Utility of Serum BAFF Levels in Pregnant Patients with SLE

    Catherine Sims1, Amanda Eudy2, Samir Soneji3, Kateena Addae-Konadu3, Jennifer Gilner3, Andra James3, Jerome Federspiel4, Eugene Kovalik3, Anika Lucas4, Laura Neil5, Amanda Snyderman3 and Megan Clowse6, 1Duke University, Knightdale, NC, 2Duke University, Raleigh, NC, 3Duke University School of Medicine, Durham, 4Duke University School of Medicine, Durham, NC, 5Duke University, Durham, 6Duke University, Chapel Hill, NC

    Background/Purpose: The B cell Activating Factor (BAFF) signaling pathway plays an important role in the selection, maturation, and survival of B cells; it consequently contributes…
  • Abstract Number: 0445 • ACR Convergence 2024

    Evaluating Clinical Reasoning in Randomized Surveys of Lupus Nephritis and Preeclampsia Pregnancy Case Workups: A Clinical Conundrum

    Liya Stolyar1, Sadaf Sediqi2, Richard Lafayette3, Maurice Druzin4, Saadiya Hawa5, Amanda Moyer6, Yashaar Chaichian2 and Julia Simard2, 1Palo Alto VA Medical Center/Stanford, Stanford, CA, 2Stanford School of Medicine, Stanford, CA, 3Stanford, Stanford, CA, 4Stanford University School of Medicine, Stanford, CA, 5Weiss Memorial Hospital, Chicago, IL, 6Stanford University, San Bruno, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) pregnancy is associated with a heightened risk of adverse pregnancy outcomes, including preeclampsia. Distinguishing preeclampsia from lupus nephritis (LN) presents…
  • Abstract Number: 1065 • ACR Convergence 2024

    A Quality Improvement Project to Improve Contraception Management in Patients with Systemic Lupus Erythematosus on Teratogenic Medications

    Marta Bean1, Brian Coburn1, Thomas Riley2, Elise Breed1, Carlos M García-González1, Akash Gupta1, Jonathan Kotzin1, Adam Mayer3, John Oghene1, Ellen Romich4, Michael George1, Rachel Dayno1, Nora Sandorfi1, Preethi Thomas1 and Anupama Shahane1, 1University of Pennsylvania, Philadelphia, PA, 2Hopsital of the University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania/Children's Hospital of Philadelphia, Philadelphia, PA, 4University of Pennsylvania, Media, PA

    Background/Purpose: Many patients with systemic lupus erythematosus (SLE) require teratogenic medications for management of their disease. Reliable contraception is important to avoid unintended pregnancy in…
  • Abstract Number: 0425 • ACR Convergence 2024

    Use of bDMARDs During Pregnancy After Preconceptional Counseling in Spanish Patients with Rheumatic Diseases

    Antia Garcia Fernandez1, Fernando Rengifo-Garcia1, Raquel Senosiain-Echarte1, Miguel Álvaro Navidad1, Miguel Angel Gonzalez-Gay2 and Juan Antonio Martínez - López1, 1Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 2University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain

    Background/Purpose: Current recommendations advocate maintaining pregnancy-compatible bDMARDs during pregnancy (mainly TNF inhibitors) and monitoring disease activity before conception to improve disease and pregnancy outcomes. Recently,…
  • Abstract Number: 0446 • ACR Convergence 2024

    Rheum for Improvement: Contraception Counseling and Adherence in Patients with Lupus and Rheumatoid Arthritis on Teratogenic Medications

    Kathryn Kompa1 and Vasileios Kyttaris2, 1Beth Israel Deaconess Medical Center, Boston, MA, 2BIDMC, Boston, MA

    Background/Purpose: Methotrexate (MTX) and mycophenolate (MMF) are two common medications for both lupus (SLE) and rheumatoid arthritis (RA). Both medications are contraindicated in pregnancy, necessitating…
  • Abstract Number: 1147 • ACR Convergence 2024

    Evaluation of Adverse Pregnancy Outcomes in Patients with Inflammatory Myopathies and Ro Positivity

    Hillary Weisleder1, Ana Valle2, Caroline Rourke3 and Shereen Mahmood4, 1Montefiore Einstein, New York, NY, 2Brigham and Women's Hospital, Boston, MA, 3Montefiore Medical Center, Bronx, NY, 4Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Anti-Ro/SSA antibodies are associated with poor prognostic outcomes in patients with autoimmune disease. The presence of these antibodies can also cause adverse pregnancy outcomes…
  • Abstract Number: 0428 • ACR Convergence 2024

    Placental Characteristics in Systemic Lupus Erythematosus Pregnancies Resulting in Small for Gestational Age Infants

    Rashmi Dhital1, Marni Jacobs2, Chelsey Smith3 and Mana Parast2, 1UC San Diego, Brentwood, TN, 2UC San Diego, San Diego, CA, 3UC San Diego, LA JOLLA, CA

    Background/Purpose: About a quarter of pregnant individuals with systemic lupus erythematosus (SLE) have small for gestational age (SGA) infants. We aim to characterize placental pathology…
  • Abstract Number: 0447 • ACR Convergence 2024

    Pregnancy Outcomes in Women Exposed to Guselkumab: Review of Cases Reported to the Manufacturer’s Global Safety Database

    Connie Lin1, Anja Geldhof2, Mauricio Ballina3, Hetal Patel4 and Hewei Li5, 1Janssen R&D US, Horsham, PA, 2Director Postmarketing Commitments, Leiden, Netherlands, 3Actelion Research & Development, Basel, Switzerland, Gewerbestrasse, Basel-Landschaft, Switzerland, 4Pharmaceutical Companies of Johnson & Johnson, Naperville, IL, 5Janssen Pharmaceutical, Hopewell Township, NJ

    Background/Purpose: Data pertaining to the use of biologics in immunologic diseases are limited on their use during pregnancy. Guselkumab (GUS) is a human IgG1λ mAb…
  • Abstract Number: 1322 • ACR Convergence 2024

    Maternal Antenatal Attachment in Women with Rheumatic Diseases

    Maria Corral-Trujillo1, Rodrigo Alfonso Cerda González2, Luis C Berlanga-Muñoz3, Rodrigo Cantú-Barreda4, Brayan U Montes-Rodríguez5, Anahí Carrazco Chapa6, América M Burciaga Garza5, Jesus Cardenas-de la Garza1, Lorena Perez-Barbosa7, CASSANDRA SKINNER TAYLOR8 and Dionicio Galarza-Delgado9, 1Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 2Universidad Autónoma de Nuevo León, Santa Catarina, Mexico, 3Hospital Universitario "Dr. José Eleuterio González", Monterre, Mexico, 4Hospital Universitario, Monterrey, Mexico, 5Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico, 6Hospital Universitario Jose Eleuterio Gonzalez, UANL, Rheumatology, Monterrey, Mexico, Monterrey, Mexico, 7Hospital Universitario, UANL, Monterrey, Mexico, 8HOSPITAL UNIVERSITARIO DR JOSE ELEUTERIO GONZALEZ, MONTERREY, Mexico, 9UANL Hospital Universitario, Monterrey, Nuevo León, Mexico

    Background/Purpose: The maternal antenatal attachment (MAA) is defined as the emotional bond between a pregnant woman and her unborn child. The quality of this relationship…
  • Abstract Number: 0430 • ACR Convergence 2024

    Clues from Early Gestational Mean Arterial Pressure in Predicting Preeclampsia Risk in Systemic Lupus Erythematosus (SLE)

    Rashmi Dhital1, Dilli Poudel2 and Ukachi Emeruwa3, 1UC San Diego, Brentwood, TN, 2Vanderbilt University, Nashville, TN, Brentwood, TN, 3UC San Diego, San Diego

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a known risk factor for chronic hypertension (cHTN) as well as preeclampsia. While the role of cHTN is known,…
  • Abstract Number: 0448 • ACR Convergence 2024

    A Pregnant Lupus Patient’s Journey: Single-Center Outcomes and Opportunities

    Divya Singh1, Maya Faison2, Molly Leavitt3, Megan Clowse4 and Cuoghi Edens5, 1University of Chicago, Chicago, IL, 2University of Chicago, Chapel Hill, NC, 3MacNeal Hospital/Loyola Medicine, Chicago, IL, 4Duke University, Chapel Hill, NC, 5Section of Pediatric Rheumatology, Section of Rheumatology, University of Chicago, Chicago, IL

    Background/Purpose: Nearly half of systemic lupus erythematosus (SLE) patients will experience pregnancy complications. These complications include increased rates of prematurity, miscarriage, pre-eclampsia, and mortality. Maternal…
  • Abstract Number: 1535 • ACR Convergence 2024

    Variations in Tacrolimus Whole Blood Concentrations During Pregnancy and Its Implications for Therapeutic Drug Monitoring: A Systematic Review and Meta-analysis

    Reem Farhat1, Arielle Mendel2, Isabelle Malhamé2, Ami Grunbaum3, Sasha Bernatsky4 and Evelyne Vinet2, 1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 4Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Tacrolimus is a pregnancy-compatible immunosuppressive increasingly used in systemic lupus erythematosus (SLE) pregnancies. Physiological changes throughout pregnancy impact tacrolimus pharmacokinetics, altering the drug’s whole…
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