Abstracts tagged "PPAR-gamma"

Abstract Number: 399 • ACR/ARHP Annual Meeting 2017
Therapeutic Effect of Rosiglitazone-Mediated Dendritic Cells in Established Arthritis in Mice
Jin Jung Choi¹, Sang-Yoon Jung², Kyung-Su Park³, Chong-Hyeon Yoon⁴ and Dae-Seog Lim⁵, ¹Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), ²Internal Medicine, Bundang CHA Medical Center, Seongnam, Korea, Republic of (South), ³Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), ⁴Rheumatology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of (South), ⁵Department of biotechnology, CHA University, Sungnam, Korea, Republic of (South)
Background/Purpose: Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-γ), which is expressed by antigen presenting cells (APCs) and plays a fundamental role in…
Abstract Number: 8 • ACR/ARHP Annual Meeting 2015
Bay 11-7085 Induces Glucocorticoid Receptor Activation and Autophagy to Initiate Human Synovial Fibroblast Cell Death
Biserka Relic¹, Edith Charlier², Céline Deroyer¹, Olivier Malaise¹, Sophie Neuville¹, Aline Desoroux¹, Philippe Gillet³, Michel G. Malaise¹ and Dominique de Seny¹, ¹Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, ²Department of Rheumatology, Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, ³Orthopaedic Surgery Department-University of Liège-CHU de Liège, Liège, Belgium
Background/Purpose: BAY 11-7085 is an inhibitor of IκBα phosphorylation that leads to NF-κB inactivation and downregulation of inflammation in mouse model of asthma, in articular…
Abstract Number: 2703 • ACR/ARHP Annual Meeting 2015
Reduction in Matrix Metalloproteinase-1 and -2 Secretion from Fibroblast-like Synoviocytes after Induction of Adipogenesis By a Natural Peroxisome Proliferator-Activated Receptor Gamma Ligand, Arterpilin-C
Eiji Sugiyama¹, Satoshi Yamasaki¹ and Je-Tae Woo^2,3, ¹Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ²Department of Biological Chemistry, Chubu University, Aichi, Japan, ³JT WOO, Okinawa Research Center Co., Ltd, Okiawa, Japan
Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles in rheumatoid arthritis (RA) by producing matrix metalloproteinase (MMP) and cytokines, and hence, these cells are a therapeutic…
Abstract Number: 3013 • ACR/ARHP Annual Meeting 2015
Adipose Loss of Co-Repressor Ncor Attenuates Bleomycin-Induced Skin Fibrosis By Enhancing PPAR-Gamma Signaling
Benjamin Korman¹, Roberta Goncalves Marangoni¹, Warren Tourtellotte² and John Varga³, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Department of Pathology, Ward, Northwestern University, Chicago, IL, ³Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: The adipogenesis master regulator PPAR-gamma (PPARg) is regulated by repressors such as NCoR. Systemic sclerosis (SSc) is associated with impaired PPARg expression and function…
Abstract Number: 763 • ACR/ARHP Annual Meeting 2014
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Rebecca Lee¹, Charles Reese², Michael Bonner¹, Beth Perry³, Richard M. Silver⁴, Richard P. Visconti⁵, Stanley Hoffman³ and Elena Tourkina⁶, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ⁵Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…
Abstract Number: 1504 • ACR/ARHP Annual Meeting 2013
Anti-Inflammation Effect Of Peroxisome Proliferator-Activated Receptor-ã (PPAR-ã) In Non-Obese Diabetic Mice With Sjogren’s Syndrome
Bei Xu¹ and Xiaomei Li², ¹Department of Rheumatology and Immunology, The third Affiliated Hospital of Anhui Medical University, The First Hospital of Hefei, Hefei, China, ²Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, Anhui, China
Background/Purpose: To investigate the anti-inflammation effect of peroxisome proliferator-activated receptor-γ (PPAR-γ) in non-obese diabetic mice (NOD mice) with sjogren`s syndrome.Methods: Twenty 8-weeks-old female NOD mice were randomly divided into…